FR2312501A1 - Procede de synthese de composes de la serie des vinblastine-vincristine - Google Patents

Procede de synthese de composes de la serie des vinblastine-vincristine

Info

Publication number
FR2312501A1
FR2312501A1 FR7615882A FR7615882A FR2312501A1 FR 2312501 A1 FR2312501 A1 FR 2312501A1 FR 7615882 A FR7615882 A FR 7615882A FR 7615882 A FR7615882 A FR 7615882A FR 2312501 A1 FR2312501 A1 FR 2312501A1
Authority
FR
France
Prior art keywords
vinblastine
vincristine
synthesis
compounds
series
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7615882A
Other languages
English (en)
Other versions
FR2312501B1 (fr
Inventor
James Peter Kutney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Commerce
Original Assignee
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Commerce filed Critical US Department of Commerce
Publication of FR2312501A1 publication Critical patent/FR2312501A1/fr
Application granted granted Critical
Publication of FR2312501B1 publication Critical patent/FR2312501B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR7615882A 1975-05-30 1976-05-26 Procede de synthese de composes de la serie des vinblastine-vincristine Granted FR2312501A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/582,373 US4279817A (en) 1975-05-30 1975-05-30 Method for producing dimer alkaloids

Publications (2)

Publication Number Publication Date
FR2312501A1 true FR2312501A1 (fr) 1976-12-24
FR2312501B1 FR2312501B1 (fr) 1981-10-09

Family

ID=24328899

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7615882A Granted FR2312501A1 (fr) 1975-05-30 1976-05-26 Procede de synthese de composes de la serie des vinblastine-vincristine

Country Status (11)

Country Link
US (2) US4279817A (fr)
JP (1) JPS5231099A (fr)
BE (1) BE842200A (fr)
CA (1) CA1140545A (fr)
DD (1) DD125217A5 (fr)
DE (1) DE2622894A1 (fr)
FR (1) FR2312501A1 (fr)
GB (1) GB1552610A (fr)
IE (1) IE43226B1 (fr)
IL (1) IL49572A0 (fr)
NL (1) NL7605663A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544319A1 (fr) * 1983-04-14 1984-10-19 Fabre Sa Pierre Procede de preparation de l'anhydrovinblastine

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (fr) * 1974-12-30 1978-07-21 Anvar
FR2387237A2 (fr) * 1977-04-13 1978-11-10 Anvar Procede perfectionne de synthese de la leusorosine et de ses derives
US4191688A (en) * 1977-08-08 1980-03-04 Eli Lilly And Company Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4307100A (en) * 1978-08-24 1981-12-22 Agence Nationale De Valorisation De La Recherche (Anvar) Nor bis-indole compounds usable as medicaments
FR2443470A1 (fr) * 1978-12-08 1980-07-04 Anvar Nouveau procede de synthese de la vinblastine et de la leurosidine
FR2461714A1 (fr) * 1979-07-17 1981-02-06 Anvar Nouvelle classe de composes bis-indoliques utiles comme medicaments et procede pour leur preparation
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
US4841045A (en) * 1985-03-12 1989-06-20 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
US4897477A (en) * 1985-03-12 1990-01-30 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
US4778885A (en) * 1986-09-18 1988-10-18 Allelix Inc. Production of alkaloid dimers using ferric ion
CA1341261C (fr) * 1987-01-22 2001-06-26 James P. Kutney Procede pour la synthese de 3',4'-anhydrovinblastine, de la vinblastine et de la vincristine
AU1066888A (en) * 1987-01-22 1988-08-04 University Of British Columbia, The Process for the synthesis of vinblastine and vincristine
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
CA1341262C (fr) * 1987-08-06 2001-06-26 Camille A. Boulet Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
US5037977A (en) * 1988-08-11 1991-08-06 Mitsui Petrochemical Industries Ltd. Method for production of dimeric alkaloids
GB9303719D0 (en) * 1993-02-24 1993-04-14 Wellcome Found Antiviral therapy
US6011041A (en) * 1995-07-28 2000-01-04 University Of British Columbia Use of anhydrovinblastine
CA2219095A1 (fr) 1997-03-04 1998-09-04 Bruce Schmidt Anhydro-vinblastine pour le traitement du cancer du col uterin et du cancer du poumon
US20030162803A1 (en) * 1997-03-04 2003-08-28 Bruce Schmidt Anhydrovinblastine for the treatment of cancer
EP1229934B1 (fr) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
EP1235598A2 (fr) * 1999-11-12 2002-09-04 Angiotech Pharmaceuticals, Inc. Compositions et methodes destinees au traitement de maladies utilisant une therapie radioactive et des inhibiteurs du cycle cellulaire combines
JP3808735B2 (ja) * 2001-08-24 2006-08-16 独立行政法人科学技術振興機構 ビンブラスチン合成用中間体類、それらの製法、およびビンブラスチン類の合成方法
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
HU180924B (en) * 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NV134A/76 *
NV6015D/75 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544319A1 (fr) * 1983-04-14 1984-10-19 Fabre Sa Pierre Procede de preparation de l'anhydrovinblastine

Also Published As

Publication number Publication date
CA1140545A (fr) 1983-02-01
BE842200A (fr) 1976-09-16
FR2312501B1 (fr) 1981-10-09
NL7605663A (nl) 1976-12-02
DE2622894A1 (de) 1976-12-16
US4279817A (en) 1981-07-21
US4144237A (en) 1979-03-13
IE43226B1 (en) 1981-01-14
JPS5231099A (en) 1977-03-09
DD125217A5 (fr) 1977-04-06
GB1552610A (en) 1979-09-19
IL49572A0 (en) 1976-07-30
IE43226L (en) 1976-11-30

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Legal Events

Date Code Title Description
ST Notification of lapse