FR2248834A1 - 3-Pyraxolidinones and pyrazolidines - e.g. N-(6-carboxy-N-hexyl)-N'-(3'-hydroxy-8',8',8'-trifluoro-N-octyl)-- pyrazolidine - Google Patents

3-Pyraxolidinones and pyrazolidines - e.g. N-(6-carboxy-N-hexyl)-N'-(3'-hydroxy-8',8',8'-trifluoro-N-octyl)-- pyrazolidine

Info

Publication number
FR2248834A1
FR2248834A1 FR7436144A FR7436144A FR2248834A1 FR 2248834 A1 FR2248834 A1 FR 2248834A1 FR 7436144 A FR7436144 A FR 7436144A FR 7436144 A FR7436144 A FR 7436144A FR 2248834 A1 FR2248834 A1 FR 2248834A1
Authority
FR
France
Prior art keywords
pyraxolidinones
pyrazolidines
pyrazolidine
trifluoro
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7436144A
Other languages
French (fr)
Other versions
FR2248834B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US411033A external-priority patent/US3873566A/en
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of FR2248834A1 publication Critical patent/FR2248834A1/en
Application granted granted Critical
Publication of FR2248834B1 publication Critical patent/FR2248834B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A cpd. of formula (I) (where A is -CH=CH-, -C=C- or C6H4; R is H, alkali metal, amine salt, (cyclo)alkyl each of =12C; m is 0 or 1; n is 0-6; p is 0-6; Y and Z are O or H2 with the proviso that where one is O, the other is H2; R1 is H or (m)ethyl; R2 is H, (m)ethyl, -CH=CH2 or -C-CH; R3 is H or 2-4C alkanoyl; R4 and R5 are H, F or (m)ethyl; Q is H, CH3, CF2CH3 or CF3; with the proviso that R1, R4 and R5 are each H when R2 is other than H) and its salts with a pharmaceutically acceptable acid are novel cpds.
FR7436144A 1973-10-30 1974-10-29 3-Pyraxolidinones and pyrazolidines - e.g. N-(6-carboxy-N-hexyl)-N'-(3'-hydroxy-8',8',8'-trifluoro-N-octyl)-- pyrazolidine Granted FR2248834A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US411033A US3873566A (en) 1973-02-28 1973-10-30 3-Pyrazolidinones and pyrazolidines

Publications (2)

Publication Number Publication Date
FR2248834A1 true FR2248834A1 (en) 1975-05-23
FR2248834B1 FR2248834B1 (en) 1977-11-04

Family

ID=23627283

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7436144A Granted FR2248834A1 (en) 1973-10-30 1974-10-29 3-Pyraxolidinones and pyrazolidines - e.g. N-(6-carboxy-N-hexyl)-N'-(3'-hydroxy-8',8',8'-trifluoro-N-octyl)-- pyrazolidine

Country Status (4)

Country Link
JP (1) JPS5071675A (en)
CA (1) CA1047503A (en)
DE (1) DE2451160A1 (en)
FR (1) FR2248834A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL57504A0 (en) * 1978-06-15 1979-10-31 Beecham Group Ltd Prostagandin analogues,their preparation and pharmaceutical compositions containing
AU4778279A (en) * 1978-06-15 1979-12-20 Beecham Group Limited Prostaglandin analogues
DE2965099D1 (en) * 1978-06-15 1983-05-05 Beecham Group Plc Prostaglandin analogue triazole derivatives, processes for their preparation and a pharmaceutical composition containing them
EP1439837B1 (en) * 2001-10-23 2008-04-09 Laboratoires Serono SA Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors
IL162602A0 (en) * 2001-12-20 2005-11-20 Applied Research Systems Pyrrolidine derivatives as prostaglandin modulators

Also Published As

Publication number Publication date
FR2248834B1 (en) 1977-11-04
DE2451160A1 (en) 1975-05-07
JPS5071675A (en) 1975-06-13
CA1047503A (en) 1979-01-30

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Legal Events

Date Code Title Description
ST Notification of lapse