FI973469A - Menetelmä tekijän IX valmistamiseksi biologisista lähteistä - Google Patents

Menetelmä tekijän IX valmistamiseksi biologisista lähteistä Download PDF

Info

Publication number
FI973469A
FI973469A FI973469A FI973469A FI973469A FI 973469 A FI973469 A FI 973469A FI 973469 A FI973469 A FI 973469A FI 973469 A FI973469 A FI 973469A FI 973469 A FI973469 A FI 973469A
Authority
FI
Finland
Prior art keywords
pct
factor
preparation
biological sources
sec
Prior art date
Application number
FI973469A
Other languages
English (en)
Swedish (sv)
Other versions
FI119377B (fi
FI973469A0 (fi
Inventor
Djuro Josic
Lutz Hoffer
Frank Morfeld
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octapharma Ag filed Critical Octapharma Ag
Publication of FI973469A publication Critical patent/FI973469A/fi
Publication of FI973469A0 publication Critical patent/FI973469A0/fi
Application granted granted Critical
Publication of FI119377B publication Critical patent/FI119377B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI973469A 1995-02-25 1997-08-22 Menetelmä tekijän IX valmistamiseksi biologisista lähteistä FI119377B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19506633 1995-02-25
DE19506633A DE19506633A1 (de) 1995-02-25 1995-02-25 Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
EP9600636 1996-02-14
PCT/EP1996/000636 WO1996027003A1 (en) 1995-02-25 1996-02-14 A process for the preparation of factor ix from biological sources

Publications (3)

Publication Number Publication Date
FI973469A true FI973469A (fi) 1997-08-22
FI973469A0 FI973469A0 (fi) 1997-08-22
FI119377B FI119377B (fi) 2008-10-31

Family

ID=7755037

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973469A FI119377B (fi) 1995-02-25 1997-08-22 Menetelmä tekijän IX valmistamiseksi biologisista lähteistä

Country Status (20)

Country Link
US (1) US5919909A (fi)
EP (1) EP0811058B1 (fi)
JP (1) JPH11500910A (fi)
KR (1) KR100436857B1 (fi)
CN (1) CN1105779C (fi)
AT (1) ATE194167T1 (fi)
AU (1) AU697217B2 (fi)
CA (1) CA2213577C (fi)
DE (2) DE19506633A1 (fi)
DK (1) DK0811058T3 (fi)
EA (1) EA000222B1 (fi)
ES (1) ES2147365T3 (fi)
FI (1) FI119377B (fi)
GR (1) GR3034035T3 (fi)
IL (1) IL117157A (fi)
MY (1) MY119366A (fi)
PT (1) PT811058E (fi)
UA (1) UA46005C2 (fi)
WO (1) WO1996027003A1 (fi)
ZA (1) ZA961450B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
AT405608B (de) * 1997-04-08 1999-10-25 Immuno Ag Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
WO2005033140A1 (ja) * 2003-09-30 2005-04-14 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 高純度血液凝固ｉｘ因子調製物およびその精製方法
KR100567448B1 (ko) * 2003-11-05 2006-04-04 주식회사 인투젠 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법
WO2005094873A1 (en) 2004-03-19 2005-10-13 Baxter International Inc. Factor ixa for the treatment of bleeding disorders
US10928366B2 (en) * 2007-01-26 2021-02-23 Sigma-Aldrich Co. Llc Compositions and methods for combining protein precipitation and solid phase extraction
US10434492B2 (en) * 2007-01-26 2019-10-08 Sigma-Aldrich Co. Llc Compositions and methods for solid phase extraction of lipids
DK3133157T3 (da) * 2010-03-30 2019-08-12 Octapharma Ag Fremgangsmåde til oprensning af vitamin k-afhængige proteiner
CN104560925B (zh) * 2014-12-30 2017-11-03 山东泰邦生物制品有限公司 一种从人凝血因子ⅸ层析废液中激活制备人凝血酶的方法
CN107540743A (zh) * 2017-10-11 2018-01-05 南岳生物制药有限公司 一种双层析法制备人纤维蛋白原的方法
CN111378029B (zh) * 2018-12-29 2023-05-05 四川远大蜀阳药业有限责任公司 一种人凝血因子ix的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3473407D1 (en) * 1983-05-02 1988-09-22 Immuno Ag Method of inactivating pathogens
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
ES2045167T5 (es) * 1987-10-23 1996-07-01 Centre Regional De Transfusion Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.
AT402261B (de) * 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
BR9205700A (pt) * 1991-03-01 1994-06-28 Rhone Poulenc Rorer Int Aperfeiçoamento em um processo para purificar e preservar fator IX derivado de plasma do sangue humano ou outra fonte, processos para a preparação de uma composição terapêutica, e para estabilizar fator IX, solução aquosa de fator IX parcialmente purificado, composição terapêutica e processo para tratar doença de christmas.
WO1994017834A1 (de) 1993-02-09 1994-08-18 Octapharma Ag Verfahren zur inaktivierung von viren, die nicht mit lipidhüllen versehen sind
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen

Also Published As

Publication number Publication date
FI119377B (fi) 2008-10-31
DE69609054T2 (de) 2001-03-08
CN1105779C (zh) 2003-04-16
AU4876196A (en) 1996-09-18
EA000222B1 (ru) 1998-12-24
ZA961450B (en) 1996-08-27
EP0811058B1 (en) 2000-06-28
DK0811058T3 (da) 2000-10-16
UA46005C2 (uk) 2002-05-15
US5919909A (en) 1999-07-06
PT811058E (pt) 2000-10-31
KR100436857B1 (ko) 2004-09-21
JPH11500910A (ja) 1999-01-26
DE19506633A1 (de) 1996-08-29
FI973469A0 (fi) 1997-08-22
IL117157A (en) 1999-12-22
MY119366A (en) 2005-05-31
WO1996027003A1 (en) 1996-09-06
EP0811058A1 (en) 1997-12-10
ES2147365T3 (es) 2000-09-01
CA2213577C (en) 2005-01-04
GR3034035T3 (en) 2000-11-30
CA2213577A1 (en) 1996-09-06
EA199700196A1 (ru) 1998-02-26
KR19980702453A (ko) 1998-07-15
DE69609054D1 (de) 2000-08-03
AU697217B2 (en) 1998-10-01
ATE194167T1 (de) 2000-07-15
IL117157A0 (en) 1996-06-18
CN1181782A (zh) 1998-05-13

Similar Documents

Publication Publication Date Title
DE59100830D1 (de) Verfahren zur Herstellung von 3-Aminomethyl-3,5,5,-trimethyl-cyclohexylamin.
DE59606355D1 (de) Verfahren zur Herstellung von chlorfunktionellen Organosilanen armen bzw. freien aminofunktionellen Organosilanen
ATE193020T1 (de) Verfahren zur herstellung von immunoglobulin g konzentrat
EE200000318A (et) Uudsed ühendid
ATE110265T1 (de) Verwendung von sigma-rezeptor-liganden zur herstellung eines anxiolytikums.
FI980862A (fi) Kiraalisia metyylifenyylioksatsolidinoneja
DK0828753T3 (da) A1/Fe-behandling af en proteinopløsning efterfulgt af membranopkoncentrering
FI973469A (fi) Menetelmä tekijän IX valmistamiseksi biologisista lähteistä
DE59300243D1 (de) Verfahren zur Herstellung von 3,5-Difluoranilin.
DE59309420D1 (de) Verfahren zur kontinuierlichen Herstellung von Flüssigsiliconkautschuken
DE69109510D1 (de) Verfahren zur Herstellung von Glycin.
DE59201325D1 (de) Verbessertes Verfahren zur Herstellung von Polyenen.
ATE239695T1 (de) Stereoselektive verfahren zur herstellung von gabapentinanalogen
DE69939751D1 (de) Verfahren zur Herstellung von S-Aryl-Cystein
DE59603295D1 (de) Verfahren zur herstellung von dolastatin 15 und deren zwischenprodukten
ATE43610T1 (de) Acino-foetale differenzierungsproteine verbunden mit krebs des pankreas, antiserum und monoklonale antikoerper gegen diese proteine und verfahren zu ihrer herstellung.
DE59103040D1 (de) Verfahren zur Herstellung von symmetrischen 2,2'-Methylen-bis-benztriazolylphenolen.
ATE309371T1 (de) Protein mit dnase-aktivität
DE69014747D1 (de) Verfahren zur Herstellung von Kaliumtitanarsenat-Einkristallen.
DE59106016D1 (de) Verfahren zur Herstellung von 2,3-Dihydrobenzofuranen.
DE59809481D1 (de) Verfahren zur Herstellung von Aminocyanacetamid
DE59603908D1 (de) Verfahren zur Herstellung von N',N'-disubstituierten 1,4-Diaminoanthrachinonen
DE59007022D1 (de) Verfahren zur kontinuierlichen Herstellung von Nylon 4,6.
DE69802171T8 (de) Verfahren zur Herstellung von 5,6-Dihydro-11H-dibenzo[a,d]cyclohept-11-enen
DE59605866D1 (de) Verfahren zur Herstellung von 2,2-Dialkylaryliden-cycloalkanonen

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 119377

Country of ref document: FI

MM Patent lapsed