FI954088A - Pyrrolopyridiinijohdannaisia - Google Patents

Pyrrolopyridiinijohdannaisia Download PDF

Info

Publication number
FI954088A
FI954088A FI954088A FI954088A FI954088A FI 954088 A FI954088 A FI 954088A FI 954088 A FI954088 A FI 954088A FI 954088 A FI954088 A FI 954088A FI 954088 A FI954088 A FI 954088A
Authority
FI
Finland
Prior art keywords
pyrrolopyridine
Prior art date
Application number
FI954088A
Other languages
English (en)
Swedish (sv)
Other versions
FI954088A0 (fi
Inventor
Raymond Baker
Neil Roy Curtis
Janusz Jozef Kulagowski
Paul David Leeson
Mark Peter Ridgill
Adrian Leonard Smith
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304111A external-priority patent/GB9304111D0/en
Priority claimed from GB939316275A external-priority patent/GB9316275D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of FI954088A0 publication Critical patent/FI954088A0/fi
Publication of FI954088A publication Critical patent/FI954088A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI954088A 1993-03-01 1995-08-31 Pyrrolopyridiinijohdannaisia FI954088A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939304111A GB9304111D0 (en) 1993-03-01 1993-03-01 Therapeutic agents
GB939316275A GB9316275D0 (en) 1993-08-05 1993-08-05 Therapeutic agents
PCT/GB1994/000337 WO1994020497A1 (en) 1993-03-01 1994-02-21 Pyrrolo-pyridine derivatives

Publications (2)

Publication Number Publication Date
FI954088A0 FI954088A0 (fi) 1995-08-31
FI954088A true FI954088A (fi) 1995-08-31

Family

ID=26302519

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954088A FI954088A (fi) 1993-03-01 1995-08-31 Pyrrolopyridiinijohdannaisia

Country Status (20)

Country Link
US (1) US5432177A (fi)
EP (1) EP0623618A3 (fi)
JP (1) JP2710751B2 (fi)
KR (1) KR960701052A (fi)
CN (1) CN1118598A (fi)
AU (1) AU674373B2 (fi)
BG (1) BG99885A (fi)
BR (1) BR9406128A (fi)
CA (1) CA2116213A1 (fi)
CZ (1) CZ224195A3 (fi)
FI (1) FI954088A (fi)
HU (1) HUT71799A (fi)
IL (1) IL108729A0 (fi)
NO (1) NO953406L (fi)
NZ (1) NZ261593A (fi)
PL (1) PL310443A1 (fi)
SI (1) SI9400091A (fi)
SK (1) SK106395A3 (fi)
WO (1) WO1994020497A1 (fi)
YU (1) YU9194A (fi)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2134929T3 (es) * 1993-03-01 1999-10-16 Merck Sharp & Dohme Derivados de pirrolo-piridina como ligandos para receptores de dopamina.
US5622950A (en) * 1993-03-01 1997-04-22 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en) 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
US6077846A (en) * 1993-09-10 2000-06-20 Ucb, S.A. Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
WO1995032196A1 (en) * 1994-05-19 1995-11-30 Merck Sharp & Dohme Limited Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
WO1996010571A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. 2,7-SUBSTITUTED OCTAHYDRO-1H-PYRIDO[1,2-a]PYRAZINE DERIVATIVES
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
EP0809642A1 (en) * 1995-02-15 1997-12-03 PHARMACIA & UPJOHN COMPANY Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
GB9507291D0 (en) * 1995-04-07 1995-05-31 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
US5725838A (en) * 1996-05-31 1998-03-10 Resolution Pharmaceuticals, Inc. Radiolabeled D4 receptor ligands
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands
WO1999000386A1 (en) * 1997-06-27 1999-01-07 Resolution Pharmaceuticals Inc. Dopamine d4 receptor ligands
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
DE60011269T2 (de) * 1999-08-12 2005-06-23 Nps Allelix Corp., Mississauga Azaidole mit serotonin rezeptor affinität
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
CA2414115A1 (en) * 2000-06-29 2002-01-03 Jakob Felding Indole derivatives useful for the treatment of cns disorders
AU2001283955B2 (en) 2000-07-31 2006-05-18 F. Hoffmann-La Roche Ag Piperazine derivatives
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
EP1406631A4 (en) * 2001-06-13 2005-03-23 Univ Michigan DOPAMINE RECEPTOR LIGANDS AND CORRESPONDING THERAPEUTIC METHODS
US7354928B2 (en) 2001-11-01 2008-04-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
CN100347171C (zh) * 2002-02-08 2007-11-07 中国科学院上海原子核研究所 一种吡啶类化合物及其制备方法和作为多巴胺d4受体拮抗剂的应用
CN1305873C (zh) * 2002-07-12 2007-03-21 中国科学院上海原子核研究所 [18f]氟标记的吡啶类化合物及其制备方法和作为多巴胺d4受体显像剂的应用
JP2004123562A (ja) * 2002-09-30 2004-04-22 Japan Science & Technology Corp 神経細胞死抑制作用を有する化合物を用いた医薬
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
PL1696920T3 (pl) * 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
KR20080097496A (ko) 2004-03-25 2008-11-05 더 리젠츠 오브 더 유니버시티 오브 미시간 고시폴 공결정 및 그의 용도
CA2570817A1 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
BRPI0610066A2 (pt) * 2005-05-17 2010-05-25 Plexxikon Inc compostos que modulam atividade de c-kit e c-fms e usos para estes
BRPI0611863B1 (pt) * 2005-06-22 2021-11-23 Plexxikon, Inc Composto, bem como composição e kit compreendendo o mesmo, composto intermediário na preparação do mesmo, método para tratamento e uso do mesmo
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
CA2637531A1 (en) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
AU2007336811A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
AR078033A1 (es) 2009-04-03 2011-10-12 Plexxikon Inc Una dispersion solida, que contiene al compuesto {3-[5-(4-(cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico, composiciones y formulaciones que comprenden a dicha dispersion solida; metodos para fabricar dicha dispersion solida, formas 1 y 2 de
US8546377B2 (en) * 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
BR112013012494A2 (pt) * 2010-12-02 2016-09-06 Lilly Co Eli compostos de 6-(piridinilmetóxi)-pirrolopiridina substitu-ídos em 3
MA34948B1 (fr) 2011-02-07 2014-03-01 Plexxikon Inc Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JP5857168B2 (ja) * 2012-11-08 2016-02-10 ファイザー・インク ドーパミンｄ１リガンドとしての複素芳香族化合物およびその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3511841A (en) * 1967-05-29 1970-05-12 Sterling Drug Inc 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines
US5422265A (en) * 1990-12-07 1995-06-06 State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The Oregon Health Sciences University DNA sequence for the human dopamine receptor D4 and expression thereof in mammalian cells

Also Published As

Publication number Publication date
WO1994020497A1 (en) 1994-09-15
SI9400091A (en) 1994-12-31
BR9406128A (pt) 1996-02-27
EP0623618A3 (en) 1997-04-02
BG99885A (en) 1996-02-29
PL310443A1 (en) 1995-12-11
SK106395A3 (en) 1995-12-06
JPH06279442A (ja) 1994-10-04
CN1118598A (zh) 1996-03-13
AU5647094A (en) 1994-09-08
HU9501871D0 (en) 1995-08-28
AU674373B2 (en) 1996-12-19
US5432177A (en) 1995-07-11
HUT71799A (en) 1996-02-28
EP0623618A2 (en) 1994-11-09
YU9194A (sh) 1997-08-22
IL108729A0 (en) 1994-05-30
KR960701052A (ko) 1996-02-24
NZ261593A (en) 1996-09-25
FI954088A0 (fi) 1995-08-31
NO953406L (no) 1995-10-31
JP2710751B2 (ja) 1998-02-10
NO953406D0 (no) 1995-08-30
CA2116213A1 (en) 1994-09-02
CZ224195A3 (en) 1996-03-13

Similar Documents

Publication Publication Date Title
FI954088A (fi) Pyrrolopyridiinijohdannaisia
DE69407573D1 (de) Fluorsiloxanhydrogele
DE69411848D1 (de) Furanylinsektizide
BR9405832A (pt) Imidazoazinas
NO20004389L (no) Alkandehydrogeneringskatalysator
DE69413933T2 (de) Antitussiva
FI951330A0 (fi) Sihti
DE69331809D1 (de) Viskosimeter
NO942095D0 (no) Imidazopyridiner
DE59407673D1 (de) 2-Oximino-2-phenyl-acetamide
DE69410500T2 (de) Mehrplattenspieler
DE59407205D1 (de) Gerippestruktur
DE59410180D1 (de) 4-Cyanophenyliminoheterocyclen
DE59309062D1 (de) Mischer-Trockner
DE69330490T2 (de) Ladungsabtastschaltung
DK103393D0 (da) Praeparat
DK95593D0 (da) Praeparat
DE59410298D1 (de) Hefeerntetank
DE69409638T2 (de) 2-methylbutoxyethoxyethanol
BR9302792A (pt) Loto-fone
BR9304108A (pt) Tobograma
FI933191A0 (fi) Pilkspoe foer baoda haender
FIU930135U0 (fi) Kaenselorganskydd
FIU930255U0 (fi) Sulstruktur
ITCO930005V0 (it) Bloccatelefono

Legal Events

Date Code Title Description
FD Application lapsed