BG99885A - Pyrene-pyridine derivatives - Google Patents

Pyrene-pyridine derivatives

Info

Publication number
BG99885A
BG99885A BG99885A BG9988595A BG99885A BG 99885 A BG99885 A BG 99885A BG 99885 A BG99885 A BG 99885A BG 9988595 A BG9988595 A BG 9988595A BG 99885 A BG99885 A BG 99885A
Authority
BG
Bulgaria
Prior art keywords
pyridine derivatives
dopamine
pyrene
substituted
receptor
Prior art date
Application number
BG99885A
Other languages
Bulgarian (bg)
English (en)
Inventor
Raymond Baker
Neil CURTIS
Janusz Kulagowski
Paul Leeson
Mark Ridgill
Adrian Smith
Original Assignee
Raymond Baker
Neil CURTIS
Janusz Kulagowski
Paul Leeson
Mark Ridgill
Adrian Smith
Merck Sharp & Dohme Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304111A external-priority patent/GB9304111D0/en
Priority claimed from GB939316275A external-priority patent/GB9316275D0/en
Application filed by Raymond Baker, Neil CURTIS, Janusz Kulagowski, Paul Leeson, Mark Ridgill, Adrian Smith, Merck Sharp & Dohme Limited filed Critical Raymond Baker
Publication of BG99885A publication Critical patent/BG99885A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG99885A 1993-03-01 1995-08-24 Pyrene-pyridine derivatives BG99885A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939304111A GB9304111D0 (en) 1993-03-01 1993-03-01 Therapeutic agents
GB939316275A GB9316275D0 (en) 1993-08-05 1993-08-05 Therapeutic agents
PCT/GB1994/000337 WO1994020497A1 (en) 1993-03-01 1994-02-21 Pyrrolo-pyridine derivatives

Publications (1)

Publication Number Publication Date
BG99885A true BG99885A (en) 1996-02-29

Family

ID=26302519

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99885A BG99885A (en) 1993-03-01 1995-08-24 Pyrene-pyridine derivatives

Country Status (20)

Country Link
US (1) US5432177A (fi)
EP (1) EP0623618A3 (fi)
JP (1) JP2710751B2 (fi)
KR (1) KR960701052A (fi)
CN (1) CN1118598A (fi)
AU (1) AU674373B2 (fi)
BG (1) BG99885A (fi)
BR (1) BR9406128A (fi)
CA (1) CA2116213A1 (fi)
CZ (1) CZ224195A3 (fi)
FI (1) FI954088A (fi)
HU (1) HUT71799A (fi)
IL (1) IL108729A0 (fi)
NO (1) NO953406L (fi)
NZ (1) NZ261593A (fi)
PL (1) PL310443A1 (fi)
SI (1) SI9400091A (fi)
SK (1) SK106395A3 (fi)
WO (1) WO1994020497A1 (fi)
YU (1) YU9194A (fi)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622950A (en) * 1993-03-01 1997-04-22 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
ES2134929T3 (es) * 1993-03-01 1999-10-16 Merck Sharp & Dohme Derivados de pirrolo-piridina como ligandos para receptores de dopamina.
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
AU6435594A (en) * 1993-04-15 1994-11-08 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
AU701227B2 (en) * 1993-09-10 1999-01-21 Cytomed, Inc Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
CA2190501A1 (en) * 1994-05-19 1995-11-30 Jose Luis Castro Pineiro Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
CZ285090B6 (cs) * 1994-09-30 1999-05-12 Pfizer Inc. 2,7-Disubstituovaný oktahydro-1H-pyrido-[1,2-a]pyrazinové deriváty a farmaceutické prostředky na jejich bázi
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
WO1996025414A1 (en) * 1995-02-15 1996-08-22 Pharmacia & Upjohn Company Imidazo[1,2-a]pyridines for the treatment of cns and cardiac diseases
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
GB9507291D0 (en) * 1995-04-07 1995-05-31 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
US5725838A (en) * 1996-05-31 1998-03-10 Resolution Pharmaceuticals, Inc. Radiolabeled D4 receptor ligands
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands
AU8096798A (en) * 1997-06-27 1999-01-19 Resolution Pharmaceuticals Inc. Dopamine d4 receptor ligands
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
ES2222219T3 (es) * 1999-08-12 2005-02-01 Nps Allelix Corp. Azaindoles que tienen actividad con el receptor de serotonina.
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
EA200300084A1 (ru) * 2000-06-29 2003-06-26 Х.Лундбекк А/С Производные индола, пригодные для лечения расстройств цнс
JP4180365B2 (ja) * 2000-07-31 2008-11-12 エフ．ホフマン−ラ ロシュ アーゲー ピペラジン誘導体
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
EP1406631A4 (en) * 2001-06-13 2005-03-23 Univ Michigan DOPAMINE RECEPTOR LIGANDS AND CORRESPONDING THERAPEUTIC METHODS
WO2003038060A2 (en) 2001-11-01 2003-05-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
CN100347171C (zh) * 2002-02-08 2007-11-07 中国科学院上海原子核研究所 一种吡啶类化合物及其制备方法和作为多巴胺d4受体拮抗剂的应用
CN1305873C (zh) * 2002-07-12 2007-03-21 中国科学院上海原子核研究所 [18f]氟标记的吡啶类化合物及其制备方法和作为多巴胺d4受体显像剂的应用
JP2004123562A (ja) * 2002-09-30 2004-04-22 Japan Science & Technology Corp 神経細胞死抑制作用を有する化合物を用いた医薬
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
CA2550361C (en) 2003-12-19 2014-04-29 Prabha Ibrahim Compounds and methods for development of ret modulators
EA011218B1 (ru) 2004-03-25 2009-02-27 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Сокристаллы госсипола и их применение
EP1755597A2 (en) * 2004-06-17 2007-02-28 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
EP1885723A2 (en) * 2005-05-17 2008-02-13 Plexxikon, Inc. Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
TWI432193B (zh) * 2005-06-22 2014-04-01 Plexxikon Inc 用於激酶調節的化合物及方法及其適應症
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
MX2008010481A (es) 2006-02-17 2008-12-19 Memory Pharm Corp Compuestos que tienen afinado para el receptor f-ht6.
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
AR078033A1 (es) 2009-04-03 2011-10-12 Plexxikon Inc Una dispersion solida, que contiene al compuesto {3-[5-(4-(cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico, composiciones y formulaciones que comprenden a dicha dispersion solida; metodos para fabricar dicha dispersion solida, formas 1 y 2 de
US8546377B2 (en) * 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2012074769A1 (en) * 2010-12-02 2012-06-07 Eli Lilly And Company 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds
US9624213B2 (en) 2011-02-07 2017-04-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
ES2649144T3 (es) * 2012-11-08 2018-01-10 Pfizer Inc. Compuestos heteroaromáticos y su uso como ligandos de dopamina D1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3511841A (en) * 1967-05-29 1970-05-12 Sterling Drug Inc 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines
US5422265A (en) * 1990-12-07 1995-06-06 State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The Oregon Health Sciences University DNA sequence for the human dopamine receptor D4 and expression thereof in mammalian cells

Also Published As

Publication number Publication date
JP2710751B2 (ja) 1998-02-10
FI954088A0 (fi) 1995-08-31
EP0623618A2 (en) 1994-11-09
WO1994020497A1 (en) 1994-09-15
US5432177A (en) 1995-07-11
AU5647094A (en) 1994-09-08
NO953406L (no) 1995-10-31
FI954088A (fi) 1995-08-31
HU9501871D0 (en) 1995-08-28
NZ261593A (en) 1996-09-25
CN1118598A (zh) 1996-03-13
CZ224195A3 (en) 1996-03-13
NO953406D0 (no) 1995-08-30
PL310443A1 (en) 1995-12-11
HUT71799A (en) 1996-02-28
SK106395A3 (en) 1995-12-06
SI9400091A (en) 1994-12-31
IL108729A0 (en) 1994-05-30
BR9406128A (pt) 1996-02-27
AU674373B2 (en) 1996-12-19
CA2116213A1 (en) 1994-09-02
KR960701052A (ko) 1996-02-24
JPH06279442A (ja) 1994-10-04
EP0623618A3 (en) 1997-04-02
YU9194A (sh) 1997-08-22

Similar Documents

Publication Publication Date Title
BG99885A (en) Pyrene-pyridine derivatives
IT1271352B (it) Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
DE69407176D1 (de) Antipsychotische benzimidazolderivate
MY126973A (en) Derivatives of 4-aminopiperidine and their use as a medicament
ZA952382B (en) Naphthalamides as central nervous system agents
EA199800340A1 (ru) Производные пиримидина как антагонисты 5нт2с
ES2123810T3 (es) Heterociclos utiles como antagonistas de neuroquinina.
CA2129995A1 (en) Piperidinyl thiacyclic derivatives
KR900000092A (ko) 신경 장애의 치료에 있어서 유리딘의 약리학적 용도
GR3019782T3 (en) Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
NZ504040A (en) Cyclopentene derivatives useful as antagonists of the motilin receptor
WO1992007832A3 (en) Substituted piperazines as central nervous system agents
FI945807A0 (fi) 2,5-diokso-2,5-dihydro-1H-bents/b/atsepiinit NMDA-reseptorin antagonisteina
EE04905B1 (et) Pridasino[4,5-b]indool-1-atseetamiidi derivaatide kasutamine ravimite valmistamiseks perifeersete bensodiasepiiniretseptorite dsfunktsioneerimisegaseotud haiguste raviks
ES2080736T3 (es) Uso de 2,3,4,5-tetrahidro-1h-3-benzazepinas en el tratamiento de trastornos neurologicos.
BR9406034A (pt) Derivados de imidazoloquinoxalinonas como antagonistas de eaa.
MY105555A (en) Heterocyclicguanidines as 5ht 3 antagonists.
PT935598E (pt) Derivados de 3-oxo-pirido (1,2-a)benzimidazole-4-carboxamida alquilo substituidos contendo 5 heteroatomos uteis no tratamento de disturbios do sistema nervoso central
DE3780542D1 (en) Substituierte hexahydroarylchinolizine.
DK0789701T3 (da) Substituerede tetracykliske azepinderivater med 5-HT2-receptoraffinitet
BR9914397A (pt) Derivados da ureidopiperidina como antagonistas seletivos dos receptores nk3 humanos
JPS5572193A (en) 9*100dihydroo4hhbenzo*4*5*cycloheptaa *1*22b*thiophenee4*99imine
MX9706967A (es) Indazolcarboxamidas.