FI942422A0 - Menetelmä fysostigmiinin valmistuksessa käytettyjen välituotteiden enantioselektiivistä synteesiä varten - Google Patents

Menetelmä fysostigmiinin valmistuksessa käytettyjen välituotteiden enantioselektiivistä synteesiä varten

Info

Publication number
FI942422A0
FI942422A0 FI942422A FI942422A FI942422A0 FI 942422 A0 FI942422 A0 FI 942422A0 FI 942422 A FI942422 A FI 942422A FI 942422 A FI942422 A FI 942422A FI 942422 A0 FI942422 A0 FI 942422A0
Authority
FI
Finland
Prior art keywords
physostigmine
preparation
intermediates used
enantioselective synthesis
enantioselective
Prior art date
Application number
FI942422A
Other languages
English (en)
Swedish (sv)
Other versions
FI942422A (fi
Inventor
Thomas Bing Kin Lee
George Seung-Kit Wong
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI942422A0 publication Critical patent/FI942422A0/fi
Publication of FI942422A publication Critical patent/FI942422A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI942422A 1993-05-27 1994-05-25 Menetelmä fysostigmiinin valmistuksessa käytettyjen välituotteiden enantioselektiivistä synteesiä varten FI942422A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/067,892 US5521320A (en) 1990-01-22 1993-05-27 Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine

Publications (2)

Publication Number Publication Date
FI942422A0 true FI942422A0 (fi) 1994-05-25
FI942422A FI942422A (fi) 1994-11-28

Family

ID=22079102

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942422A FI942422A (fi) 1993-05-27 1994-05-25 Menetelmä fysostigmiinin valmistuksessa käytettyjen välituotteiden enantioselektiivistä synteesiä varten

Country Status (17)

Country Link
US (1) US5521320A (fi)
EP (1) EP0700381A4 (fi)
JP (1) JP2843759B2 (fi)
KR (1) KR100220766B1 (fi)
CN (1) CN1047167C (fi)
AU (1) AU683052B2 (fi)
CA (1) CA2124430A1 (fi)
CZ (1) CZ127894A3 (fi)
FI (1) FI942422A (fi)
HU (1) HUT72886A (fi)
IL (1) IL109796A (fi)
NO (1) NO941967L (fi)
NZ (1) NZ260587A (fi)
RU (1) RU2109013C1 (fi)
SG (1) SG55156A1 (fi)
WO (1) WO1994027963A1 (fi)
ZA (1) ZA943684B (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840915A (en) * 1990-01-22 1998-11-24 Hoechst Marion Roussel, Inc. Process for the enatioselective synthesis of intermediates used
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
JP2004529110A (ja) * 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
US8399546B2 (en) * 2004-08-05 2013-03-19 Sabic Innovative Plastics Ip B.V. Flame retardant thermoplastic compositions having EMI shielding
CN101121717B (zh) * 2007-05-17 2010-07-28 四川大学 抗老年痴呆疾病的天然药物毒扁豆碱及其衍生物苯胺基甲酸酯毒扁豆酚碱的合成
US9126995B2 (en) * 2011-11-08 2015-09-08 Nissan Chemical Industries, Ltd. Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
WO2017181012A1 (en) 2016-04-15 2017-10-19 Brandeis University Cinchonium betaine catalysts and methods of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404472A (en) * 1889-06-04 Steering appaeattts
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
US4578509A (en) * 1983-04-01 1986-03-25 Merck & Co., Inc. Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
JPS60169442A (ja) * 1984-02-10 1985-09-02 Mitsubishi Chem Ind Ltd 桂皮酸エステル類の製造方法
US4704472A (en) * 1985-12-18 1987-11-03 Merck & Co., Inc. Preparation of an enantiomer of a substituted fluorenyloxyacetic acid
ATE125254T1 (de) * 1989-09-19 1995-08-15 Hoechst Roussel Pharma Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen.
US5274117A (en) * 1990-01-22 1993-12-28 Hoechst-Roussel Pharmaceuticals, Inc. Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
SG52631A1 (en) * 1990-01-22 1998-09-28 Hoechst Roussel Pharma Process for the enantioselection sznthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine

Also Published As

Publication number Publication date
FI942422A (fi) 1994-11-28
CN1100094A (zh) 1995-03-15
CA2124430A1 (en) 1994-11-28
NZ260587A (en) 1996-06-25
HU9401595D0 (en) 1994-08-29
KR100220766B1 (ko) 1999-09-15
HUT72886A (en) 1996-06-28
IL109796A (en) 1999-08-17
JPH06336476A (ja) 1994-12-06
CN1047167C (zh) 1999-12-08
AU6330694A (en) 1994-12-01
ZA943684B (en) 1995-01-25
EP0700381A4 (en) 1996-05-22
RU2109013C1 (ru) 1998-04-20
NO941967L (no) 1994-11-28
JP2843759B2 (ja) 1999-01-06
US5521320A (en) 1996-05-28
IL109796A0 (en) 1994-08-26
WO1994027963A1 (en) 1994-12-08
EP0700381A1 (en) 1996-03-13
CZ127894A3 (en) 1994-12-15
NO941967D0 (no) 1994-05-26
SG55156A1 (en) 1998-12-21
AU683052B2 (en) 1997-10-30

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.