ZA943684B - Process for the enantioselective systhesis of alkylated oxindoles used as intermediates in the preparation of physostigmine - Google Patents

Process for the enantioselective systhesis of alkylated oxindoles used as intermediates in the preparation of physostigmine

Info

Publication number
ZA943684B
ZA943684B ZA943684A ZA943684A ZA943684B ZA 943684 B ZA943684 B ZA 943684B ZA 943684 A ZA943684 A ZA 943684A ZA 943684 A ZA943684 A ZA 943684A ZA 943684 B ZA943684 B ZA 943684B
Authority
ZA
South Africa
Prior art keywords
systhesis
physostigmine
enantioselective
intermediates
preparation
Prior art date
Application number
ZA943684A
Other languages
English (en)
Inventor
Thomas Bing Kin Lee
George Seung-Kit Wong
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA943684B publication Critical patent/ZA943684B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA943684A 1993-05-27 1994-05-26 Process for the enantioselective systhesis of alkylated oxindoles used as intermediates in the preparation of physostigmine ZA943684B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/067,892 US5521320A (en) 1990-01-22 1993-05-27 Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine

Publications (1)

Publication Number Publication Date
ZA943684B true ZA943684B (en) 1995-01-25

Family

ID=22079102

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA943684A ZA943684B (en) 1993-05-27 1994-05-26 Process for the enantioselective systhesis of alkylated oxindoles used as intermediates in the preparation of physostigmine

Country Status (17)

Country Link
US (1) US5521320A (xx)
EP (1) EP0700381A4 (xx)
JP (1) JP2843759B2 (xx)
KR (1) KR100220766B1 (xx)
CN (1) CN1047167C (xx)
AU (1) AU683052B2 (xx)
CA (1) CA2124430A1 (xx)
CZ (1) CZ127894A3 (xx)
FI (1) FI942422A (xx)
HU (1) HUT72886A (xx)
IL (1) IL109796A (xx)
NO (1) NO941967L (xx)
NZ (1) NZ260587A (xx)
RU (1) RU2109013C1 (xx)
SG (1) SG55156A1 (xx)
WO (1) WO1994027963A1 (xx)
ZA (1) ZA943684B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840915A (en) * 1990-01-22 1998-11-24 Hoechst Marion Roussel, Inc. Process for the enatioselective synthesis of intermediates used
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
WO2002070478A1 (en) * 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
US8399546B2 (en) * 2004-08-05 2013-03-19 Sabic Innovative Plastics Ip B.V. Flame retardant thermoplastic compositions having EMI shielding
CN101121717B (zh) * 2007-05-17 2010-07-28 四川大学 抗老年痴呆疾病的天然药物毒扁豆碱及其衍生物苯胺基甲酸酯毒扁豆酚碱的合成
US9126995B2 (en) * 2011-11-08 2015-09-08 Nissan Chemical Industries, Ltd. Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
WO2017181012A1 (en) * 2016-04-15 2017-10-19 Brandeis University Cinchonium betaine catalysts and methods of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404472A (en) * 1889-06-04 Steering appaeattts
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
US4578509A (en) * 1983-04-01 1986-03-25 Merck & Co., Inc. Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
JPS60169442A (ja) * 1984-02-10 1985-09-02 Mitsubishi Chem Ind Ltd 桂皮酸エステル類の製造方法
US4704472A (en) * 1985-12-18 1987-11-03 Merck & Co., Inc. Preparation of an enantiomer of a substituted fluorenyloxyacetic acid
DE69020989T2 (de) * 1989-09-19 1996-02-08 Hoechst Roussel Pharma Verfahren zur Racematspaltung von 5-alkoxy-substituierten (+/-)-1,3-dimethyloxindolylethylaminen.
ES2120407T3 (es) * 1990-01-22 1998-11-01 Hoechst Marion Roussel Inc Procedimiento para la sintesis enantioselectiva de oxindoles alquilados, utilizados como productos intermedios en la preparacion de fisostigmina.
US5274117A (en) * 1990-01-22 1993-12-28 Hoechst-Roussel Pharmaceuticals, Inc. Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine

Also Published As

Publication number Publication date
HUT72886A (en) 1996-06-28
AU683052B2 (en) 1997-10-30
CN1047167C (zh) 1999-12-08
KR100220766B1 (ko) 1999-09-15
IL109796A0 (en) 1994-08-26
JPH06336476A (ja) 1994-12-06
JP2843759B2 (ja) 1999-01-06
WO1994027963A1 (en) 1994-12-08
SG55156A1 (en) 1998-12-21
NZ260587A (en) 1996-06-25
EP0700381A4 (en) 1996-05-22
FI942422A (fi) 1994-11-28
CN1100094A (zh) 1995-03-15
NO941967L (no) 1994-11-28
NO941967D0 (no) 1994-05-26
RU2109013C1 (ru) 1998-04-20
CZ127894A3 (en) 1994-12-15
HU9401595D0 (en) 1994-08-29
AU6330694A (en) 1994-12-01
US5521320A (en) 1996-05-28
IL109796A (en) 1999-08-17
CA2124430A1 (en) 1994-11-28
FI942422A0 (fi) 1994-05-25
EP0700381A1 (en) 1996-03-13

Similar Documents

Publication Publication Date Title
AU3217897A (en) Analogs of cc-1065 and the duocarmycins
AU3164493A (en) Improvements in or relating to the lining of passageways
AU4525396A (en) Process for the preparation of perfluorocarbons
IL129759A0 (en) Process for the preparation of benzyl-ethers
GR3036917T3 (en) Process for the preparation of pyrimidine compounds
AU8758298A (en) Process for the preparation of 2'-fluoro-5-methyl-beta -l-arabinofuranosyluridine
AU646771B2 (en) Intermediates useful in the preparation of substituted indolone derivatives
ZA943684B (en) Process for the enantioselective systhesis of alkylated oxindoles used as intermediates in the preparation of physostigmine
GB9323088D0 (en) Novel process for the preparation of benzylformimidate
AU2173597A (en) Process for the preparation of tenidap
EP0887342A3 (en) Process for preparing 4-substituted-1H-indole-3-glyoxamides
GB9611041D0 (en) Process for the preparation of optically active methadones in high enantiomeric purity
IL128026A0 (en) Process for the preparation of hexanitrohexa-azaisowurtzitanes
GR3035436T3 (en) Process for the preparation of 2-H-heptafluoropropane
AU2788297A (en) Process for the preparation of 3-hydroxypyrrolidine
ZA944487B (en) Process for the preparation of indoles
EP0945433A4 (en) METHOD FOR PRODUCING ACYLOXYALKANESULPHONIC ACID
AU6545790A (en) Process for applying pictorial designs to the surfaces of articles
GB9302184D0 (en) Improvements relating to the formation of cartosn
IL116759A0 (en) Process for the preparation of para-fluorophenol
EP0831156A4 (en) 3-ALCOXYMETHYLCEPHEMS PREPARATION PROCESS
GB9200653D0 (en) Novel process for the preparation of 3-unsubstituted indoles
AU640818B2 (en) Process for the preparation of aminopyrimidines
EP0486900A3 (en) Process for the preparation of indoles
AU5120798A (en) Process for the preparation of phtalides