FI863564A - Foerfarande foer framstaellning av heterocykliskt substituerade indoler. - Google Patents

Foerfarande foer framstaellning av heterocykliskt substituerade indoler. Download PDF

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Publication number
FI863564A
FI863564A FI863564A FI863564A FI863564A FI 863564 A FI863564 A FI 863564A FI 863564 A FI863564 A FI 863564A FI 863564 A FI863564 A FI 863564A FI 863564 A FI863564 A FI 863564A
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FI
Finland
Prior art keywords
heteroatoms
alkyl
image
cyano
present
Prior art date
Application number
FI863564A
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English (en)
Other versions
FI863564A0 (fi
Inventor
Alfred Mertens
Der Saal Wolfgang Von
Walter-Gunar Friebe
Bernd Mueller-Beckmann
Gisbert Sponer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI863564A0 publication Critical patent/FI863564A0/fi
Publication of FI863564A publication Critical patent/FI863564A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI863564A 1985-09-05 1986-09-04 Foerfarande foer framstaellning av heterocykliskt substituerade indoler. FI863564A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853531658 DE3531658A1 (de) 1985-09-05 1985-09-05 Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel

Publications (2)

Publication Number Publication Date
FI863564A0 FI863564A0 (fi) 1986-09-04
FI863564A true FI863564A (fi) 1987-03-06

Family

ID=6280166

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863564A FI863564A (fi) 1985-09-05 1986-09-04 Foerfarande foer framstaellning av heterocykliskt substituerade indoler.

Country Status (17)

Country Link
US (1) US4851406A (fi)
EP (1) EP0223937B1 (fi)
JP (1) JPS6256486A (fi)
KR (1) KR870003099A (fi)
AT (1) ATE73797T1 (fi)
AU (1) AU572405B2 (fi)
DD (1) DD258229A5 (fi)
DE (2) DE3531658A1 (fi)
DK (1) DK419086A (fi)
ES (1) ES2001936A6 (fi)
FI (1) FI863564A (fi)
GR (1) GR862248B (fi)
HU (1) HU197000B (fi)
IL (1) IL79911A (fi)
NZ (1) NZ217419A (fi)
PT (1) PT83310B (fi)
ZA (1) ZA866705B (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3769B (en) 1989-02-11 1996-03-25 Orion Yhtymae Oy Heterocyclic compounds

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DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JP2597893B2 (ja) * 1988-07-21 1997-04-09 自動車機器株式会社 流体給排用接続筒を備えたシリンダとその製造方法および製造装置
DE3826855A1 (de) * 1988-08-06 1990-02-15 Cassella Ag 4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung
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US5185332A (en) * 1989-02-11 1993-02-09 Orion-Yhtyma Oy Thiadiazines and pharmaceutical compositions thereof as well as method of use
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HU219974B (hu) * 1990-06-07 2001-10-28 Astrazeneca Ab, Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
US5317103A (en) * 1991-01-15 1994-05-31 Merck Sharp & Dohme Limited Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
US5183825A (en) * 1992-04-07 1993-02-02 American Home Products Corporation 4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use
US5194435A (en) * 1992-04-07 1993-03-16 American Home Products Corporation 4-arylmethyl-5-alkyl-3h-pyrazol-3-ones
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
AU699272B2 (en) * 1994-08-02 1998-11-26 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives
US5523312A (en) * 1994-09-27 1996-06-04 Sterling Winthrop Inc. Antipicornaviral agents
EP1060166A1 (de) * 1998-02-03 2000-12-20 Boehringer Ingelheim Pharma KG 5-gliedrige benzokondensierte heterocyclen als antithrombotika
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
FI20000577A0 (fi) * 2000-03-13 2000-03-13 Orion Yhtymae Oy Pyridatsinyylifenyylihydratsoneja
TWI224101B (en) * 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
DK1397130T3 (da) * 2001-06-20 2007-11-12 Wyeth Corp Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1)
UA80453C2 (en) * 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
AU2003296324A1 (en) * 2002-12-10 2004-06-30 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DE60306548T2 (de) * 2002-12-10 2007-06-21 Wyeth Substituierte 3-carbonyl-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren
AU2003296323A1 (en) * 2002-12-10 2004-06-30 Wyeth Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CN1723197A (zh) * 2002-12-10 2006-01-18 惠氏公司 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－烷基和3－芳基烷基1h－吲哚－1－基乙酸衍生物
US7420083B2 (en) * 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7332521B2 (en) * 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7582773B2 (en) * 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US20050215626A1 (en) * 2003-09-25 2005-09-29 Wyeth Substituted benzofuran oximes
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7351726B2 (en) * 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7534894B2 (en) * 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7342039B2 (en) * 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7411083B2 (en) * 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
MX2007002178A (es) * 2004-08-23 2007-04-02 Wyeth Corp Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.
WO2006023864A1 (en) * 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as pai-1 inhibitors
JP2008510816A (ja) 2004-08-23 2008-04-10 ワイス チアゾロ−ナフチル酸
AU2006279496A1 (en) * 2005-08-17 2007-02-22 Wyeth Substituted indoles and use thereof
WO2014164704A2 (en) 2013-03-11 2014-10-09 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer

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US3322786A (en) * 1965-10-07 1967-05-30 Merck & Co Inc 3-indolyl aliphatic acids
US3928380A (en) * 1973-03-29 1975-12-23 Sterling Drug Inc 1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles)
DE2557341A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
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DE2845220A1 (de) * 1978-10-17 1980-04-30 Yoshitomi Pharmaceutical Pyridazinon-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und ihre verwendung bei der behandlung von thrombosen und hypertonie
DE3172252D1 (en) * 1980-11-14 1985-10-17 Ici Plc Heterocyclic compounds
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CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
FR2530246B1 (fr) * 1982-07-16 1985-06-14 Delalande Sa Nouveaux derives pyrido indoliniques et pirido indoliques et leurs sels, ainsi que le procede de preparation et l'application en therapeutique de ces derives et sels
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3769B (en) 1989-02-11 1996-03-25 Orion Yhtymae Oy Heterocyclic compounds

Also Published As

Publication number Publication date
US4851406A (en) 1989-07-25
ATE73797T1 (de) 1992-04-15
IL79911A0 (en) 1986-12-31
AU572405B2 (en) 1988-05-05
NZ217419A (en) 1989-03-29
ES2001936A6 (es) 1988-07-01
JPS6256486A (ja) 1987-03-12
EP0223937B1 (de) 1992-03-18
DE3531658A1 (de) 1987-03-12
AU6216686A (en) 1987-03-12
DE3684415D1 (de) 1992-04-23
IL79911A (en) 1991-04-15
HU197000B (en) 1989-02-28
PT83310A (de) 1986-10-01
EP0223937A1 (de) 1987-06-03
ZA866705B (en) 1987-04-29
KR870003099A (ko) 1987-04-15
PT83310B (pt) 1989-01-17
GR862248B (en) 1986-12-31
DK419086A (da) 1987-03-06
DK419086D0 (da) 1986-09-02
FI863564A0 (fi) 1986-09-04
DD258229A5 (de) 1988-07-13
HUT41770A (en) 1987-05-28

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Owner name: BOEHRINGER MANNHEIM GMBH