FI813034L - Foerfarande foer framstaellning av substituerade imino-disyror - Google Patents
Foerfarande foer framstaellning av substituerade imino-disyrorInfo
- Publication number
- FI813034L FI813034L FI813034A FI813034A FI813034L FI 813034 L FI813034 L FI 813034L FI 813034 A FI813034 A FI 813034A FI 813034 A FI813034 A FI 813034A FI 813034 L FI813034 L FI 813034L
- Authority
- FI
- Finland
- Prior art keywords
- immovable
- framework
- substances
- implementation
- immovable substances
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8021095A FR2491469A1 (fr) | 1980-10-02 | 1980-10-02 | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR8021095 | 1980-10-02 | ||
FR8106916 | 1981-04-07 | ||
FR8106916A FR2503155A2 (fr) | 1980-10-02 | 1981-04-07 | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
Publications (3)
Publication Number | Publication Date |
---|---|
FI813034L true FI813034L (fi) | 1982-04-03 |
FI77230B FI77230B (fi) | 1988-10-31 |
FI77230C FI77230C (fi) | 1989-02-10 |
Family
ID=26222007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI813034A FI77230C (fi) | 1980-10-02 | 1981-09-30 | Foerfarande foer framstaellning av substituerade perhydroindoliminodisyror med antihypertensiv aktivitet. |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0049658B1 (fi) |
JP (1) | JPS5791974A (fi) |
KR (1) | KR860001875B1 (fi) |
AR (1) | AR242949A1 (fi) |
AT (1) | ATE7910T1 (fi) |
AU (1) | AU542611B2 (fi) |
CA (1) | CA1341196C (fi) |
DD (1) | DD201783A5 (fi) |
DE (1) | DE3164201D1 (fi) |
DK (1) | DK157011C (fi) |
EG (1) | EG15361A (fi) |
ES (1) | ES505999A0 (fi) |
FI (1) | FI77230C (fi) |
FR (1) | FR2503155A2 (fi) |
GE (1) | GEP19970943B (fi) |
GR (1) | GR75016B (fi) |
HU (1) | HU185147B (fi) |
IE (1) | IE51821B1 (fi) |
IL (1) | IL63940A (fi) |
LU (1) | LU88262I2 (fi) |
MD (1) | MD381C2 (fi) |
NL (1) | NL930046I2 (fi) |
NO (1) | NO160780C (fi) |
NZ (1) | NZ198535A (fi) |
OA (1) | OA06914A (fi) |
PH (1) | PH17516A (fi) |
PT (1) | PT73755B (fi) |
SU (1) | SU1153827A3 (fi) |
UA (1) | UA6308A1 (fi) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4933361A (en) * | 1981-12-29 | 1990-06-12 | Hoechst Aktiengesellschaft | Derivatives of bicyclic aminoacids agents containing these compounds and their use |
US4977260A (en) * | 1986-11-21 | 1990-12-11 | Hoechst Aktiengesellschaft | Intermediates for preparing mono-, bi- and tricyclic amino acids |
US5011940A (en) * | 1987-07-03 | 1991-04-30 | Hoechst Aktiengesellschaft | Process for the preparation of bicyclic amino carboxylic acids, intermediates in this process, and their use |
US5053519A (en) * | 1981-11-05 | 1991-10-01 | Hoechst Ag | Cis, endo-2-azabicyclo-[3.3.0]-octane-5-carboxylic acids |
US5055591A (en) * | 1983-09-16 | 1991-10-08 | Hoechst Aktiengesellschaft | Process for the preparation of octahydropenta(b)pyrrole carboxylates |
US5068351A (en) * | 1983-09-16 | 1991-11-26 | Hoechst Aktiengesellschaft | Process for the preparation of n octahydropenta (6) pyrrole carboxylates |
US5098910A (en) * | 1986-10-02 | 1992-03-24 | Hoechst Aktiengesellschaft | Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
US5231080A (en) * | 1985-10-15 | 1993-07-27 | Hoechst Aktiengesellschaft | Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease |
US5403856A (en) * | 1984-04-12 | 1995-04-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors |
US5550255A (en) * | 1984-08-28 | 1996-08-27 | Hoechst Aktiengesellschaft | Cis, endo-2-azabicycloalkane-3-carboxylic acid derivatives |
US5747504A (en) * | 1984-04-12 | 1998-05-05 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0046953B1 (de) * | 1980-08-30 | 1989-12-06 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
LU88621I2 (fr) * | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
ZA817261B (en) * | 1980-10-23 | 1982-09-29 | Schering Corp | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
US4479963A (en) * | 1981-02-17 | 1984-10-30 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
US4532342A (en) * | 1981-02-20 | 1985-07-30 | Warner-Lambert Company | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
IN156096B (fi) * | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
EP0065301A1 (en) * | 1981-05-18 | 1982-11-24 | Merck & Co. Inc. | Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same |
SU1327787A3 (ru) * | 1981-11-05 | 1987-07-30 | Хехст Аг (Фирма) | Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей |
EP0170775B2 (de) * | 1981-12-29 | 1994-10-12 | Hoechst Aktiengesellschaft | Derivate bicyclischer Aminosäuren, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie neue bicyclische Aminosäuren als Zwischenstufen und Verfahren zu deren Herstellung |
DE3210496A1 (de) * | 1982-03-23 | 1983-10-06 | Hoechst Ag | Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
US5175306A (en) * | 1983-01-31 | 1992-12-29 | Hoechst Aktiengesellschaft | Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters |
HU191120B (en) * | 1983-01-31 | 1987-01-28 | Hoechts Ag,De | Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers |
DE3303344A1 (de) | 1983-02-02 | 1984-08-02 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern |
DE3408923A1 (de) * | 1984-03-12 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Carboxyalkyldipeptidderivate, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
GB8422165D0 (en) * | 1984-09-01 | 1984-10-03 | Wellcome Found | Compounds |
US4693996A (en) * | 1985-12-23 | 1987-09-15 | Warner-Lambert Company | Method of treating heart failure and medicaments therefor |
FR2620700B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
FR2620703B1 (fr) * | 1987-09-17 | 1991-10-04 | Adir | Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides |
FR2620699B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
TW197945B (fi) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
LT3872B (en) | 1993-12-06 | 1996-04-25 | Hoechst Ag | Novel peptides and pharmaceutical compositions containing them |
EP0796855B1 (de) | 1996-03-20 | 2002-02-06 | Hoechst Aktiengesellschaft | Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
FR2746394B1 (fr) | 1996-03-20 | 1998-05-29 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
FR2807430B1 (fr) * | 2000-04-11 | 2002-05-17 | Adir | Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril |
AU2007203451B2 (en) * | 2000-07-06 | 2010-09-02 | Les Laboratoires Servier | Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt |
FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
ES2289060T3 (es) * | 2002-01-30 | 2008-02-01 | Les Laboratoires Servier | Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis. |
FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
GB2395195A (en) * | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
PL1636185T3 (pl) | 2003-06-24 | 2012-12-31 | Servier Lab | Nowe formy krystaliczne peryndoprylu erbuminy |
EP1367061B1 (fr) * | 2003-06-30 | 2006-01-04 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
SI1380590T1 (sl) * | 2003-08-29 | 2006-12-31 | Servier Lab | Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli |
ES2334900T3 (es) * | 2003-09-01 | 2010-03-17 | Les Laboratoires Servier | Nuevo procedimiento de sintesis de esteres de n-((s)-1-carboxibutil)-(s)-alanina y su aplicacion a la sintesis de perindopril. |
SI21703A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia |
GB2413128A (en) * | 2004-04-13 | 2005-10-19 | Neopharma Ltd | Process for the preparation of perindopril |
SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
PT1679072E (pt) | 2005-01-06 | 2008-12-22 | Ipca Lab Ltd | Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril |
EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
FR2897866B1 (fr) * | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
SI22543A (sl) | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
GB0910692D0 (en) | 2009-06-20 | 2009-08-05 | Teva Pharma | Compound |
PT105315B (pt) | 2010-09-29 | 2013-01-16 | Inst Superior Tecnico | Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas |
FR2985511B1 (fr) | 2012-01-05 | 2014-01-03 | Servier Lab | Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2985512B1 (fr) * | 2012-01-05 | 2014-06-20 | Servier Lab | Procede de preparation du sel de l-arginine du perindopril |
WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
EP3842035A1 (en) | 2019-12-23 | 2021-06-30 | KRKA, d.d., Novo mesto | Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5572169A (en) * | 1978-11-27 | 1980-05-30 | Tanabe Seiyaku Co Ltd | Isoquinoline derivative and its preparation |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4461896A (en) * | 1979-02-07 | 1984-07-24 | Norwich Eaton Pharmaceuticals, Inc. | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids |
DE3063420D1 (en) * | 1979-03-26 | 1983-07-07 | Takeda Chemical Industries Ltd | Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension |
US4294832A (en) * | 1979-04-28 | 1981-10-13 | Tanabe Seiyaku Co., Ltd. | Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof |
GB2048863B (en) * | 1979-05-16 | 1983-06-15 | Morton Norwich Products Inc | Tetrahydroisoquinoline-3-carboxylic acids |
US4303583A (en) * | 1979-08-13 | 1981-12-01 | American Home Products Corporation | 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones |
FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR2470767A1 (fr) * | 1979-12-07 | 1981-06-12 | Science Union & Cie | Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes |
ZA811493B (en) * | 1980-04-02 | 1982-03-31 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
US4251444A (en) * | 1980-04-07 | 1981-02-17 | American Home Products Corporation | Thiazepino-[4,3-b]-isoquinoline-1,5-dione derivatives and precursors |
EP0046953B1 (de) * | 1980-08-30 | 1989-12-06 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
-
1981
- 1981-04-07 FR FR8106916A patent/FR2503155A2/fr active Granted
- 1981-09-25 IL IL63940A patent/IL63940A/xx not_active IP Right Cessation
- 1981-09-29 EP EP81401501A patent/EP0049658B1/fr not_active Expired
- 1981-09-29 LU LU88262C patent/LU88262I2/xx unknown
- 1981-09-29 DE DE8181401501T patent/DE3164201D1/de not_active Expired
- 1981-09-29 AT AT81401501T patent/ATE7910T1/de active
- 1981-09-29 IE IE2257/81A patent/IE51821B1/en active Protection Beyond IP Right Term
- 1981-09-30 FI FI813034A patent/FI77230C/fi not_active IP Right Cessation
- 1981-09-30 EG EG556/81A patent/EG15361A/xx active
- 1981-09-30 AR AR81286934A patent/AR242949A1/es active
- 1981-10-01 UA UA3344196A patent/UA6308A1/uk unknown
- 1981-10-01 NO NO813339A patent/NO160780C/no not_active IP Right Cessation
- 1981-10-01 SU SU813344196A patent/SU1153827A3/ru active
- 1981-10-01 PH PH26297A patent/PH17516A/en unknown
- 1981-10-01 DD DD81233794A patent/DD201783A5/de unknown
- 1981-10-01 DK DK434381A patent/DK157011C/da not_active IP Right Cessation
- 1981-10-01 PT PT73755A patent/PT73755B/pt unknown
- 1981-10-01 HU HU812838A patent/HU185147B/hu not_active IP Right Cessation
- 1981-10-01 OA OA57509A patent/OA06914A/xx unknown
- 1981-10-01 GR GR66179A patent/GR75016B/el unknown
- 1981-10-01 AU AU75949/81A patent/AU542611B2/en not_active Expired
- 1981-10-01 CA CA000387093A patent/CA1341196C/fr not_active Expired - Lifetime
- 1981-10-02 NZ NZ198535A patent/NZ198535A/en unknown
- 1981-10-02 JP JP56157367A patent/JPS5791974A/ja active Granted
- 1981-10-02 ES ES505999A patent/ES505999A0/es active Granted
- 1981-10-02 KR KR1019810003709A patent/KR860001875B1/ko not_active IP Right Cessation
-
1993
- 1993-06-01 NL NL930046C patent/NL930046I2/nl unknown
-
1994
- 1994-05-16 GE GEAP19941926A patent/GEP19970943B/en unknown
- 1994-12-29 MD MD95-0107A patent/MD381C2/ro unknown
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5053519A (en) * | 1981-11-05 | 1991-10-01 | Hoechst Ag | Cis, endo-2-azabicyclo-[3.3.0]-octane-5-carboxylic acids |
US5061722A (en) * | 1981-11-05 | 1991-10-29 | Hoechst Ag | Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a process for their preparation, agents containing these compounds and their use |
US4933361A (en) * | 1981-12-29 | 1990-06-12 | Hoechst Aktiengesellschaft | Derivatives of bicyclic aminoacids agents containing these compounds and their use |
US5068351A (en) * | 1983-09-16 | 1991-11-26 | Hoechst Aktiengesellschaft | Process for the preparation of n octahydropenta (6) pyrrole carboxylates |
US5055591A (en) * | 1983-09-16 | 1991-10-08 | Hoechst Aktiengesellschaft | Process for the preparation of octahydropenta(b)pyrrole carboxylates |
US5403856A (en) * | 1984-04-12 | 1995-04-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors |
US5747504A (en) * | 1984-04-12 | 1998-05-05 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors |
US5550255A (en) * | 1984-08-28 | 1996-08-27 | Hoechst Aktiengesellschaft | Cis, endo-2-azabicycloalkane-3-carboxylic acid derivatives |
US5231080A (en) * | 1985-10-15 | 1993-07-27 | Hoechst Aktiengesellschaft | Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
US5098910A (en) * | 1986-10-02 | 1992-03-24 | Hoechst Aktiengesellschaft | Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs |
US5500434A (en) * | 1986-10-02 | 1996-03-19 | Hoechst Aktiengesellschaft | Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs |
US5721244A (en) * | 1986-10-02 | 1998-02-24 | Hoechst Aktiengesellschaft | Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs |
US4977260A (en) * | 1986-11-21 | 1990-12-11 | Hoechst Aktiengesellschaft | Intermediates for preparing mono-, bi- and tricyclic amino acids |
US5011940A (en) * | 1987-07-03 | 1991-04-30 | Hoechst Aktiengesellschaft | Process for the preparation of bicyclic amino carboxylic acids, intermediates in this process, and their use |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ND | Supplementary protection certificate (spc) granted | ||
SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L26 Extension date: 20030622 |
|
MA | Patent expired |
Owner name: ADIR |