FI79411B - Foerfarande foer vaerdering av cellernas malignitet, vid foerfarandet anvaendbara antikroppar, antigener, deras framstaellning och anvaendning. - Google Patents
Foerfarande foer vaerdering av cellernas malignitet, vid foerfarandet anvaendbara antikroppar, antigener, deras framstaellning och anvaendning. Download PDFInfo
- Publication number
- FI79411B FI79411B FI833952A FI833952A FI79411B FI 79411 B FI79411 B FI 79411B FI 833952 A FI833952 A FI 833952A FI 833952 A FI833952 A FI 833952A FI 79411 B FI79411 B FI 79411B
- Authority
- FI
- Finland
- Prior art keywords
- pro
- gly
- ala
- ser
- thr
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 claims description 81
- 206010028980 Neoplasm Diseases 0.000 claims description 56
- 238000000034 method Methods 0.000 claims description 53
- 108700020796 Oncogene Proteins 0.000 claims description 42
- 230000014509 gene expression Effects 0.000 claims description 41
- 108020004999 messenger RNA Proteins 0.000 claims description 36
- 230000003211 malignant effect Effects 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 26
- 230000036210 malignancy Effects 0.000 claims description 26
- 108010038807 Oligopeptides Proteins 0.000 claims description 25
- 102000015636 Oligopeptides Human genes 0.000 claims description 25
- 108090000623 proteins and genes Proteins 0.000 claims description 25
- 102000043276 Oncogene Human genes 0.000 claims description 18
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 15
- 230000000890 antigenic effect Effects 0.000 claims description 15
- 150000001413 amino acids Chemical group 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 10
- 230000001413 cellular effect Effects 0.000 claims description 9
- 125000003729 nucleotide group Chemical group 0.000 claims description 8
- 239000002773 nucleotide Substances 0.000 claims description 7
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 6
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims description 6
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 230000001131 transforming effect Effects 0.000 claims description 6
- 102000053602 DNA Human genes 0.000 claims description 5
- 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 claims description 5
- 102000007568 Proto-Oncogene Proteins c-fos Human genes 0.000 claims description 5
- 238000003745 diagnosis Methods 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 230000001177 retroviral effect Effects 0.000 claims description 5
- MQIGTEQXYCRLGK-BQBZGAKWSA-N Ala-Gly-Pro Chemical compound C[C@H](N)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O MQIGTEQXYCRLGK-BQBZGAKWSA-N 0.000 claims description 4
- SITWEMZOJNKJCH-UHFFFAOYSA-N L-alanine-L-arginine Natural products CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N SITWEMZOJNKJCH-UHFFFAOYSA-N 0.000 claims description 4
- SNGZLPOXVRTNMB-LPEHRKFASA-N Pro-Ser-Pro Chemical compound C1C[C@H](NC1)C(=O)N[C@@H](CO)C(=O)N2CCC[C@@H]2C(=O)O SNGZLPOXVRTNMB-LPEHRKFASA-N 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 108010057821 leucylproline Proteins 0.000 claims description 4
- 239000003550 marker Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 108010077112 prolyl-proline Proteins 0.000 claims description 4
- 108020004414 DNA Proteins 0.000 claims description 3
- RWCOTTLHDJWHRS-YUMQZZPRSA-N Pro-Pro Chemical compound OC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 RWCOTTLHDJWHRS-YUMQZZPRSA-N 0.000 claims description 3
- 108060006706 SRC Proteins 0.000 claims description 3
- 102000001332 SRC Human genes 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 229920005990 polystyrene resin Polymers 0.000 claims description 3
- 101710147844 Myb protein Proteins 0.000 claims description 2
- 108010087776 Proto-Oncogene Proteins c-myb Proteins 0.000 claims description 2
- 102000009096 Proto-Oncogene Proteins c-myb Human genes 0.000 claims description 2
- 239000013599 cloning vector Substances 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims 3
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 210000000601 blood cell Anatomy 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- SFTZWNJFZYOLBD-ZDLURKLDSA-N Ser-Gly-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H](N)CO SFTZWNJFZYOLBD-ZDLURKLDSA-N 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 108010053725 prolylvaline Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 28
- 210000001519 tissue Anatomy 0.000 description 27
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 23
- 239000000047 product Substances 0.000 description 19
- 239000000427 antigen Substances 0.000 description 17
- 108091007433 antigens Proteins 0.000 description 17
- 102000036639 antigens Human genes 0.000 description 17
- 238000009396 hybridization Methods 0.000 description 14
- 102000004196 processed proteins & peptides Human genes 0.000 description 11
- 241000287828 Gallus gallus Species 0.000 description 9
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 9
- 235000013330 chicken meat Nutrition 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 210000001161 mammalian embryo Anatomy 0.000 description 7
- 210000002257 embryonic structure Anatomy 0.000 description 6
- 230000008175 fetal development Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 6
- 241001430294 unidentified retrovirus Species 0.000 description 6
- 108020004705 Codon Proteins 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000013518 transcription Methods 0.000 description 5
- 230000035897 transcription Effects 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 210000003754 fetus Anatomy 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 101150001535 SRC gene Proteins 0.000 description 3
- ADJDNJCSPNFFPI-FXQIFTODSA-N Ser-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO ADJDNJCSPNFFPI-FXQIFTODSA-N 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000004720 fertilization Effects 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- 210000005260 human cell Anatomy 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 210000002826 placenta Anatomy 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 108700026239 src Genes Proteins 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000212384 Bifora Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108091000080 Phosphotransferase Proteins 0.000 description 2
- BIYXEUAFGLTAEM-WUJLRWPWSA-N Thr-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)NCC(O)=O BIYXEUAFGLTAEM-WUJLRWPWSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000000246 agarose gel electrophoresis Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 230000013020 embryo development Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 208000025113 myeloid leukemia Diseases 0.000 description 2
- 102000020233 phosphotransferase Human genes 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- XWZAWHJNTHSHGD-SIDOVBMKSA-N (2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]propanoyl]amino]hexanamide Polymers CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O XWZAWHJNTHSHGD-SIDOVBMKSA-N 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241000713838 Avian myeloblastosis virus Species 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000252203 Clupea harengus Species 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 241001290006 Fissurella Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 108010020361 Oncogene Protein gp140(v-fms) Proteins 0.000 description 1
- 108010058765 Oncogene Protein pp60(v-src) Proteins 0.000 description 1
- 108010054076 Oncogene Proteins v-myb Proteins 0.000 description 1
- 241000237988 Patellidae Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 108010001859 Proto-Oncogene Proteins c-rel Proteins 0.000 description 1
- 102000000850 Proto-Oncogene Proteins c-rel Human genes 0.000 description 1
- 108010021833 Proto-Oncogene Proteins c-yes Proteins 0.000 description 1
- 102000007696 Proto-Oncogene Proteins c-yes Human genes 0.000 description 1
- 108091008109 Pseudogenes Proteins 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 241000714474 Rous sarcoma virus Species 0.000 description 1
- 101900269587 Rous sarcoma virus Tyrosine-protein kinase transforming protein Src Proteins 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 101710101493 Viral myc transforming protein Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 108010087924 alanylproline Proteins 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- -1 c-mos Proteins 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 210000002308 embryonic cell Anatomy 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000013569 fruit product Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 235000019514 herring Nutrition 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108700021654 myb Genes Proteins 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/82—Translation products from oncogenes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43925282A | 1982-11-04 | 1982-11-04 | |
US43925282 | 1982-11-04 | ||
US49602783A | 1983-05-19 | 1983-05-19 | |
US49602783 | 1983-05-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI833952A0 FI833952A0 (fi) | 1983-10-28 |
FI833952A FI833952A (fi) | 1984-05-05 |
FI79411B true FI79411B (fi) | 1989-08-31 |
Family
ID=27031979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI833952A FI79411B (fi) | 1982-11-04 | 1983-10-28 | Foerfarande foer vaerdering av cellernas malignitet, vid foerfarandet anvaendbara antikroppar, antigener, deras framstaellning och anvaendning. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0108564B1 (no) |
JP (3) | JPH0728759B2 (no) |
AU (1) | AU559912B2 (no) |
BR (1) | BR8306175A (no) |
CA (1) | CA1252046A (no) |
DE (1) | DE3376507D1 (no) |
DK (1) | DK498083A (no) |
ES (2) | ES8704005A1 (no) |
FI (1) | FI79411B (no) |
GR (1) | GR78948B (no) |
IE (1) | IE56509B1 (no) |
IL (1) | IL70067A (no) |
NO (1) | NO163986C (no) |
NZ (1) | NZ206096A (no) |
PH (1) | PH20994A (no) |
PT (1) | PT77605B (no) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6713619B1 (en) | 1980-08-29 | 2004-03-30 | Massachusetts Institute Of Technology | Oncogenes and methods for their detection |
US4935341A (en) * | 1986-06-04 | 1990-06-19 | Whitehead Institute For Biomedical Research | Detection of point mutations in neu genes |
ZA84617B (en) * | 1983-02-14 | 1984-09-26 | Arup Sen | Synthetic polypeptides from viryl oncogenes |
CA1219232A (en) * | 1983-08-17 | 1987-03-17 | Richard A. Lerner | Polypeptide-induced monoclonal receptors to protein ligands |
US5733738A (en) * | 1983-08-17 | 1998-03-31 | Ligand Pharmaceuticals | Polypeptide-induced monoclonal receptors to protein ligands |
EP0177814A3 (en) * | 1984-09-19 | 1987-12-02 | Cetus Corporation | Peptide antibodies and their use in detecting oncogene products |
US4798787A (en) * | 1984-09-19 | 1989-01-17 | Cetus Corporation | Peptide antibodies and their use in detecting oncogene products |
US4762706A (en) * | 1984-10-17 | 1988-08-09 | Cetus Corporation | Peptide antibodies and their use in detecting oncogene products |
IL76997A0 (en) * | 1984-11-14 | 1986-04-29 | Oncogene Science Inc | Probes and methods useful for detecting chromosomal translocation |
US5028527A (en) * | 1988-02-22 | 1991-07-02 | Applied Bio Technology | Monoclonal antibodies against activated ras proteins with amino acid mutations at position 13 of the protein |
US5081230A (en) * | 1987-07-08 | 1992-01-14 | E. I. Dupont Denemours And Company | Monoclonal antibodies reactive with normal and oncogenic forms of the ras p21 protein |
US5443956A (en) * | 1985-01-29 | 1995-08-22 | Oncogene Science, Inc. | Detection, quantitation and classification of RAS proteins in body fluids and tissues |
US6200764B1 (en) | 1985-01-29 | 2001-03-13 | Bayer Corporation | Detection, quantitation and classification of ras proteins in body fluids and tissues |
CA1296660C (en) * | 1985-01-29 | 1992-03-03 | Walter P. Carney | Monoclonal antibody against a ras oncogene p21 related dodecapeptide |
US5084380A (en) * | 1985-01-29 | 1992-01-28 | Applied Biotechnology | Monoclonal antibodies reactive with activated and oncogenic ras p21 proteins |
US4898932A (en) * | 1985-01-29 | 1990-02-06 | E. I. Du Pont De Nemours And Company | Monoclonal antibodies reactive with activated and oncogenic ras p21 proteins |
DE3686304T2 (de) * | 1985-04-04 | 1993-02-11 | Univ Georgetown | Typenspezifische papillomavirus-dns-sequenzen und peptide. |
EP0203587A3 (en) * | 1985-05-30 | 1989-08-09 | F. Hoffmann-La Roche Ag | Ras oncogene peptides and antibodies |
EP0206065A3 (en) * | 1985-06-27 | 1989-04-19 | James R. Feramisco | Method of detecting oncogene and proto-oncogene related proteins in extracellular biological fluids |
US6083709A (en) * | 1985-08-21 | 2000-07-04 | Osi Pharmaceuticals, Inc. | Immunoassay for detection of mutant P53 polypeptide in serum |
IL79755A0 (en) * | 1985-08-21 | 1986-11-30 | Oncogene Science Inc | Immunoassay for detection of ras encoded protein |
FR2594833B1 (fr) * | 1986-02-26 | 1989-04-28 | Centre Nat Rech Scient | Proteines homologues de celles codees par des oncogenes humains, procede d'obtention de ces proteines et leurs applications immunologiques, physiopathologiques et therapeutiques |
FI76119C (fi) * | 1986-02-27 | 1988-09-09 | Orion Yhtymae Oy | Kvantitativ bestaemning av nukleinsyramolekyler och reagensfoerpackning som anvaends vid foerfarandet. |
EP0246709A1 (en) * | 1986-05-20 | 1987-11-25 | Stichting Katholieke Universiteit | Recombinant DNA and cDNA, mRNA, protein, antibodies, and a method of detecting tumor cells |
US5320941A (en) * | 1986-06-06 | 1994-06-14 | Dallan Young | DNA sequence encoding mas onhcogene, polypeptides encoded therefrom and diagnostic and other methods based therefrom |
JPS6374492A (ja) * | 1986-09-18 | 1988-04-04 | Hiroshi Shiyuku | モノクロ−ナル抗体 |
NO881560L (no) * | 1987-05-05 | 1988-11-07 | Hope City | Fremgangsmaate for detektering av begynnende resistens motterapeutiske midler i kreftpasienter. |
US5085983A (en) * | 1988-08-19 | 1992-02-04 | City Of Hope | Detection of human tumor progression and drug resistance |
EP0304845A3 (en) * | 1987-08-28 | 1991-03-06 | Profile Diagnostic Sciences Inc. | Method and kit for assaying gene expressions |
CA1341191C (en) * | 1988-04-18 | 2001-02-27 | Robert Allan Weinberg | Detection of neu gene expression and products |
AU3533089A (en) * | 1988-04-22 | 1989-11-24 | E.I. Du Pont De Nemours And Company | Monoclonal antibodies specific for the harvey, kirsten, and n ras proteins and their use as diagnostic reagents |
US5763573A (en) * | 1988-08-10 | 1998-06-09 | Chiron Corporation | GTPase activating protein fragments |
US5760203A (en) * | 1988-08-10 | 1998-06-02 | Chiron Corporation | Gap gene sequences |
JPH04500122A (ja) * | 1988-08-12 | 1992-01-09 | プロジェンクス・インコーポレイテッド | 蛋白リガンドに対するポリペプチド誘発モノクローナル受容体 |
FR2637600B1 (fr) * | 1988-10-11 | 1992-03-06 | Pasteur Institut | Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques |
GB9103974D0 (en) * | 1991-02-26 | 1991-04-10 | Norsk Hydro As | Therapeutically useful peptides or peptide fragments |
NZ592340A (en) | 2001-03-27 | 2012-12-21 | Elenore S Bogoch | A method for making a virus vaccine compising Replikin peptides |
US7774144B2 (en) | 2001-10-26 | 2010-08-10 | Samuel Bogoch | System and method for identifying complex patterns of amino acids |
US7189800B2 (en) | 2001-03-27 | 2007-03-13 | Samuel Bogoch | Replikin peptides in rapid replication of glioma cells and in influenza epidemics |
US7452963B2 (en) | 2001-03-27 | 2008-11-18 | Samuel Bogoch | Replikin peptides and antibodies therefore |
US7420028B2 (en) | 2001-03-27 | 2008-09-02 | Samuel Bogoch | Replikins and methods of identifying replikin-containing sequences |
US7894999B2 (en) | 2001-03-27 | 2011-02-22 | Samuel Bogoch | Systems and methods for identifying Replikin Scaffolds and uses of said Replikin Scaffolds |
US7442761B2 (en) * | 2003-06-06 | 2008-10-28 | Samuel Bogoch | Replikin peptides and uses thereof |
EP2261368A1 (en) | 2002-03-13 | 2010-12-15 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
JP4606879B2 (ja) | 2002-11-15 | 2011-01-05 | ジェノミック ヘルス, インコーポレイテッド | Egfr陽性癌の遺伝子発現プロファイリング |
US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
EP1597391B1 (en) | 2003-02-20 | 2008-10-29 | Genomic Health, Inc. | Use of intronic rna to measure gene expression |
US8494781B2 (en) | 2003-06-06 | 2013-07-23 | Samuel Bogoch | Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds |
DK1641810T4 (en) | 2003-06-24 | 2017-07-03 | Genomic Health Inc | Predicting the likelihood of cancer recurrence |
ES2905579T3 (es) | 2003-07-10 | 2022-04-11 | Genomic Health Inc | Algoritmo del perfil de expresión y prueba para el pronóstico de la recaída del cáncer de mama |
EP1699936B1 (en) | 2003-12-23 | 2011-02-09 | Genomic Health, Inc. | Universal amplification of fragmented rna |
ITPD20040065A1 (it) * | 2004-03-15 | 2004-06-15 | Univ Padova | Peptidi della vitronectina e loro impiego terapeutico nella adesione degli osteoblasti |
ES2636470T3 (es) | 2004-04-09 | 2017-10-05 | Genomic Health, Inc. | Marcadores de expresión génica para predecir la respuesta a la quimioterapia |
US9254315B2 (en) | 2004-04-28 | 2016-02-09 | Samuel Bogoch | Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds |
ATE550440T1 (de) | 2004-11-05 | 2012-04-15 | Genomic Health Inc | Molekulare indikatoren für brustkrebsprognose und vorhersage des ansprechens auf eine behandlung |
JP5020088B2 (ja) | 2004-11-05 | 2012-09-05 | ジェノミック ヘルス, インコーポレイテッド | 遺伝子発現マーカーを使用する、化学療法に対する反応の予測 |
WO2008140557A2 (en) | 2006-10-24 | 2008-11-20 | Samuel Bogoch | A method of predicting influenza outbreaks |
WO2008156914A2 (en) | 2007-05-30 | 2008-12-24 | Samuel Bogoch | Synthetic replikin peptides against pathogenic infection of invertebrates in aquaculture |
US9233148B2 (en) | 2009-01-09 | 2016-01-12 | Samuel Bogoch | Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza |
US9328142B2 (en) | 2011-05-25 | 2016-05-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lipopeptide inhibitors of RAS oncoproteins |
CA2842345A1 (en) | 2011-07-20 | 2013-01-24 | Samuel Bogoch | Peptides shared among lethal cancers and therapeutic compositions comprising said peptides |
CA3036352C (en) | 2016-09-09 | 2020-09-15 | De Nora Permelec Ltd | Method for producing anode for alkaline water electrolysis, and anode for alkaline water electrolysis |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1598686A (en) * | 1977-04-29 | 1981-09-23 | Dia Prosim | Enzymes immobilised on a resin via chelation with a metal |
IT1207172B (it) * | 1979-02-15 | 1989-05-17 | Anic Spa | Processo per la preparazione dicorpi microporosi inglobanti uno o piu' agenti attivi. |
ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
ES506955A0 (es) * | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
GB2108510B (en) * | 1981-10-03 | 1984-12-12 | Ciba Geigy Ag | Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof |
-
1983
- 1983-10-25 CA CA000439666A patent/CA1252046A/en not_active Expired
- 1983-10-25 IE IE2493/83A patent/IE56509B1/en not_active IP Right Cessation
- 1983-10-27 IL IL70067A patent/IL70067A/xx not_active IP Right Cessation
- 1983-10-27 DE DE8383306548T patent/DE3376507D1/de not_active Expired
- 1983-10-27 AU AU20650/83A patent/AU559912B2/en not_active Expired
- 1983-10-27 EP EP83306548A patent/EP0108564B1/en not_active Expired
- 1983-10-28 NZ NZ206096A patent/NZ206096A/en unknown
- 1983-10-28 FI FI833952A patent/FI79411B/fi not_active Application Discontinuation
- 1983-10-31 DK DK498083A patent/DK498083A/da not_active Application Discontinuation
- 1983-11-01 GR GR72841A patent/GR78948B/el unknown
- 1983-11-03 ES ES526991A patent/ES8704005A1/es not_active Expired
- 1983-11-03 NO NO834014A patent/NO163986C/no not_active IP Right Cessation
- 1983-11-03 PH PH29782A patent/PH20994A/en unknown
- 1983-11-04 PT PT77605A patent/PT77605B/pt not_active IP Right Cessation
- 1983-11-04 BR BR8306175A patent/BR8306175A/pt unknown
- 1983-11-04 JP JP58207345A patent/JPH0728759B2/ja not_active Expired - Lifetime
-
1984
- 1984-06-04 ES ES533105A patent/ES533105A0/es active Granted
-
1992
- 1992-04-24 JP JP4131686A patent/JPH0759188B2/ja not_active Expired - Lifetime
-
1994
- 1994-11-29 JP JP6319042A patent/JP2716670B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK498083D0 (da) | 1983-10-31 |
EP0108564A1 (en) | 1984-05-16 |
PH20994A (en) | 1987-06-18 |
NO163986B (no) | 1990-05-07 |
EP0108564B1 (en) | 1988-05-04 |
JPH0759188B2 (ja) | 1995-06-28 |
BR8306175A (pt) | 1984-06-12 |
JPS59113898A (ja) | 1984-06-30 |
NO834014L (no) | 1984-05-07 |
DE3376507D1 (en) | 1988-06-09 |
ES526991A0 (es) | 1987-03-01 |
IL70067A0 (en) | 1984-01-31 |
PT77605B (en) | 1986-05-05 |
PT77605A (en) | 1983-12-01 |
ES8704005A1 (es) | 1987-03-01 |
CA1252046A (en) | 1989-04-04 |
AU2065083A (en) | 1984-05-10 |
GR78948B (no) | 1984-10-02 |
JP2716670B2 (ja) | 1998-02-18 |
IE832493L (en) | 1984-05-04 |
ES8600215A1 (es) | 1985-10-01 |
ES533105A0 (es) | 1985-10-01 |
NO163986C (no) | 1990-08-15 |
IL70067A (en) | 1989-08-15 |
IE56509B1 (en) | 1991-08-28 |
FI833952A (fi) | 1984-05-05 |
JPH0728759B2 (ja) | 1995-04-05 |
AU559912B2 (en) | 1987-03-26 |
JPH05328965A (ja) | 1993-12-14 |
DK498083A (da) | 1984-05-05 |
NZ206096A (en) | 1986-09-10 |
FI833952A0 (fi) | 1983-10-28 |
JPH07215995A (ja) | 1995-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI79411B (fi) | Foerfarande foer vaerdering av cellernas malignitet, vid foerfarandet anvaendbara antikroppar, antigener, deras framstaellning och anvaendning. | |
US4699877A (en) | Methods and compositions for detecting human tumors | |
USRE35491E (en) | Methods and compositions for detecting human tumors | |
JP3989528B2 (ja) | Dna配列及びエンコードされた***に特異的な乳癌たんぱく質 | |
US6222020B1 (en) | Antigens derived from the core protein of the human mammary epithelial mucin | |
EP1626084B1 (en) | Compositions and methods for the diagnosis of tumours | |
EP1103623A1 (en) | Human mucin core protein: nucleic acid probes, peptide fragments and antibodies thereto, and uses thereof in diagnostic and therapeutic methods | |
AU2003201315C1 (en) | WNT-1 Induced secreted polypeptides; WISP-1, -2 and -3 | |
US20060275783A1 (en) | Gene markers for lung cancer | |
Nanus et al. | Infrequent ras oncogene point mutations in renal cell carcinoma | |
Monnat et al. | Prognostic implications of expression of the cellular genes myc, fos, Ha‐ras and Ki‐ras in colon carcinoma | |
US5182205A (en) | Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor | |
EP0269127B1 (en) | Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor | |
KR100948808B1 (ko) | 간암 마커로서의 lcn2 유전자, 단백질 및 간암 진단키트 | |
JP2008507261A (ja) | 肺癌診断のための新規のヌクレオチド配列およびアミノ酸配列、ならびにそのアッセイおよび使用方法 | |
JP4782378B2 (ja) | リンパ球異常増殖疾患の診断方法 | |
JP4227881B2 (ja) | 成人t細胞白血病診断薬 | |
DK174459B1 (da) | Fremgangsmåde til fremstilling af et antigenisk oligopeptid | |
DK174458B1 (da) | Fremgangsmåde til fremstilling af et antigenisk oligopeptid | |
US5171850A (en) | Intestinal oncofetal gene | |
KR100861465B1 (ko) | 위암 유발 유전자 ZNF312b와 이에 의해 코드되는단백질 및 이를 이용한 위암 진단 키트 | |
KR102110338B1 (ko) | 대장암 진단 마커로서의 신규 folr2 융합유전자 및 이의 용도 | |
US20020071830A1 (en) | Probe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |
Owner name: THE REGENTS OF THE UNIVERSITY OF |