FI68823C - Foerfarande foer framstaellning av nya antibakteriella 2-amino-8-cyklopropyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidin-6-karboxylsyror - Google Patents

Foerfarande foer framstaellning av nya antibakteriella 2-amino-8-cyklopropyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidin-6-karboxylsyror Download PDF

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Publication number
FI68823C
FI68823C FI800266A FI800266A FI68823C FI 68823 C FI68823 C FI 68823C FI 800266 A FI800266 A FI 800266A FI 800266 A FI800266 A FI 800266A FI 68823 C FI68823 C FI 68823C
Authority
FI
Finland
Prior art keywords
alkyl
pyrimidine
cyclopropyl
carboxylic acid
oxo
Prior art date
Application number
FI800266A
Other languages
English (en)
Finnish (fi)
Other versions
FI68823B (fi
FI800266A (fi
Inventor
Klaus Grohe
Hans-Joachim Zeiler
Karl Georg Metzger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI800266A publication Critical patent/FI800266A/fi
Priority to FI834051A priority Critical patent/FI834051A0/fi
Publication of FI68823B publication Critical patent/FI68823B/fi
Application granted granted Critical
Publication of FI68823C publication Critical patent/FI68823C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fodder In General (AREA)
FI800266A 1979-02-01 1980-01-30 Foerfarande foer framstaellning av nya antibakteriella 2-amino-8-cyklopropyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidin-6-karboxylsyror FI68823C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI834051A FI834051A0 (fi) 1979-02-01 1983-11-03 Saosom fodertillsats anvaendbara 2-amino-8-cyklopropyl-5-oxo-5,8-dihydro-pyrido/2,3-d/pyrimidin-6-karboxylsyror och foerfarande foer deras framstaellning

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2903850 1979-02-01
DE19792903850 DE2903850A1 (de) 1979-02-01 1979-02-01 2-amino-8-cyclopropyl-5-oxo-5,8- dihydro-pyrido eckige klammer auf 2,3-d eckige klammer zu -pyrimidin-6-carnonsaeuren, verfahren zu ihrer herstellung sowie ihrer verwendung als antibakterielle mittel

Publications (3)

Publication Number Publication Date
FI800266A FI800266A (fi) 1980-08-02
FI68823B FI68823B (fi) 1985-07-31
FI68823C true FI68823C (fi) 1985-11-11

Family

ID=6061940

Family Applications (1)

Application Number Title Priority Date Filing Date
FI800266A FI68823C (fi) 1979-02-01 1980-01-30 Foerfarande foer framstaellning av nya antibakteriella 2-amino-8-cyklopropyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidin-6-karboxylsyror

Country Status (12)

Country Link
US (1) US4556709A (cs)
EP (1) EP0014390B1 (cs)
JP (2) JPS5817758B2 (cs)
AT (1) ATE647T1 (cs)
AU (1) AU537475B2 (cs)
CA (1) CA1142923A (cs)
DE (2) DE2903850A1 (cs)
DK (1) DK152499C (cs)
ES (1) ES488186A1 (cs)
FI (1) FI68823C (cs)
IL (1) IL59253A (cs)
ZA (1) ZA80578B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4670444B1 (en) * 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
IT1200470B (it) * 1985-05-10 1989-01-18 Schering Spa Composti ad attivita' antibatterica,loro preparazione e composizioni farmaceutiche relative
ATE90673T1 (de) * 1986-12-02 1993-07-15 British Tech Group Antifolat-mittel.
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
WO2009139834A1 (en) * 2008-05-13 2009-11-19 Poniard Pharmaceuticals, Inc. Bioactive compounds for treatment of cancer and neurodegenerative diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4837279B1 (cs) * 1970-08-29 1973-11-09
US3673184A (en) * 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
FR2194420B1 (cs) * 1972-08-02 1975-10-17 Bellon Labor Sa Roger
JPS5336478B2 (cs) * 1972-08-14 1978-10-03
GB1451911A (en) * 1972-08-14 1976-10-06 Dainippon Pharmaceutical Co 2-1-piperazino-5-oxopyrido-2,3,d-pyrimidine-6-carboxylic acids their preparation and pharmaceutical compositions thereof
US4017622A (en) * 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
US3992380A (en) * 1975-03-03 1976-11-16 Sterling Drug Inc. 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters
JPS5312889A (en) * 1976-07-22 1978-02-04 Dainippon Pharmaceut Co Ltd P-aminobenzylpiperazine dervatives

Also Published As

Publication number Publication date
DE2903850A1 (de) 1980-08-07
EP0014390B1 (de) 1982-02-03
ATE647T1 (de) 1982-02-15
FI68823B (fi) 1985-07-31
AU5502380A (en) 1980-08-07
ZA80578B (en) 1981-01-28
JPS6246523B2 (cs) 1987-10-02
AU537475B2 (en) 1984-06-28
US4556709A (en) 1985-12-03
DK41880A (da) 1980-08-02
CA1142923A (en) 1983-03-15
JPS5817758B2 (ja) 1983-04-09
JPS55104281A (en) 1980-08-09
DE3060162D1 (en) 1982-03-11
FI800266A (fi) 1980-08-02
JPS5877816A (ja) 1983-05-11
DK152499B (da) 1988-03-07
IL59253A (en) 1983-07-31
DK152499C (da) 1988-07-25
IL59253A0 (en) 1980-05-30
ES488186A1 (es) 1980-09-16
EP0014390A1 (de) 1980-08-20

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Owner name: BAYER AKTIENGESELLSCHAFT