FI62668C - Foerfarande foer framstaellning av h1- och h2-histaminantagonistiska 2-amino-4-pyrimidonderivat - Google Patents

Foerfarande foer framstaellning av h1- och h2-histaminantagonistiska 2-amino-4-pyrimidonderivat Download PDF

Info

Publication number
FI62668C
FI62668C FI763664A FI763664A FI62668C FI 62668 C FI62668 C FI 62668C FI 763664 A FI763664 A FI 763664A FI 763664 A FI763664 A FI 763664A FI 62668 C FI62668 C FI 62668C
Authority
FI
Finland
Prior art keywords
pyrimidone
het
pyridylmethyl
mixture
pyridyl
Prior art date
Application number
FI763664A
Other languages
English (en)
Finnish (fi)
Other versions
FI763664A (pt
FI62668B (fi
Inventor
Thomas Henry Brown
Graham John Durant
Charon Robin Ganellin
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of FI763664A publication Critical patent/FI763664A/fi
Application granted granted Critical
Publication of FI62668B publication Critical patent/FI62668B/fi
Publication of FI62668C publication Critical patent/FI62668C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI763664A 1975-12-29 1976-12-21 Foerfarande foer framstaellning av h1- och h2-histaminantagonistiska 2-amino-4-pyrimidonderivat FI62668C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5300175 1975-12-29
GB5300175 1975-12-29

Publications (3)

Publication Number Publication Date
FI763664A FI763664A (pt) 1977-06-30
FI62668B FI62668B (fi) 1982-10-29
FI62668C true FI62668C (fi) 1983-02-10

Family

ID=10466233

Family Applications (1)

Application Number Title Priority Date Filing Date
FI763664A FI62668C (fi) 1975-12-29 1976-12-21 Foerfarande foer framstaellning av h1- och h2-histaminantagonistiska 2-amino-4-pyrimidonderivat

Country Status (37)

Country Link
JP (1) JPS5283388A (pt)
AR (1) AR222290A1 (pt)
AT (1) AT360024B (pt)
AU (1) AU508123B2 (pt)
BE (1) BE849810A (pt)
BG (1) BG29722A3 (pt)
CA (1) CA1073458A (pt)
CH (1) CH631981A5 (pt)
CS (1) CS203995B2 (pt)
DD (1) DD128588A5 (pt)
DE (1) DE2658267A1 (pt)
DK (1) DK587076A (pt)
EG (1) EG12439A (pt)
ES (1) ES454656A1 (pt)
FI (1) FI62668C (pt)
FR (1) FR2336935A1 (pt)
GR (1) GR62441B (pt)
HU (1) HU175171B (pt)
IE (1) IE45082B1 (pt)
IL (1) IL51040A (pt)
IT (2) IT1124740B (pt)
LU (1) LU76481A1 (pt)
MW (1) MW5076A1 (pt)
MX (1) MX5119E (pt)
NL (1) NL7614538A (pt)
NO (1) NO146396C (pt)
NZ (1) NZ182759A (pt)
OA (1) OA05526A (pt)
PH (1) PH14723A (pt)
PL (1) PL104376B1 (pt)
PT (1) PT65949B (pt)
RO (1) RO72475A (pt)
SE (1) SE431544B (pt)
SU (1) SU791235A3 (pt)
YU (1) YU311676A (pt)
ZA (1) ZA767198B (pt)
ZM (1) ZM14376A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186511A (en) 1977-03-19 1980-11-14 Smith Kline French Lab 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
IL56265A (en) * 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor
US4539207A (en) * 1978-02-13 1985-09-03 Smith Kline & French Laboratories Limited Pyrimidine compounds
IN151188B (pt) * 1978-02-13 1983-03-05 Smith Kline French Lab
IL57005A (en) * 1978-04-11 1983-11-30 Smith Kline French Lab Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
ZA792607B (en) * 1978-05-30 1980-07-30 Smith Kline French Lab Nitro compounds
ZA793392B (en) * 1978-07-15 1980-08-27 Smith Kline French Lab Isoureas and isothioureas
US4374836A (en) 1978-10-16 1983-02-22 Imperial Chemical Industries Ltd. Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
US4255428A (en) 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55133379A (en) * 1979-04-05 1980-10-17 Smith Kline French Lab Pyrimidone compound
EP0017680B1 (en) * 1979-04-11 1982-04-21 Smith Kline & French Laboratories Limited Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative
CA1155842A (en) * 1980-03-29 1983-10-25 Thomas H. Brown Compounds
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
IN146736B (pt) * 1975-10-02 1979-08-25 Smith Kline French Lab

Also Published As

Publication number Publication date
CH631981A5 (en) 1982-09-15
DD128588A5 (de) 1977-11-30
LU76481A1 (pt) 1977-06-15
MX5119E (es) 1983-03-24
PT65949B (pt) 1978-06-15
NL7614538A (nl) 1977-07-01
IT7919107A0 (it) 1979-01-05
ES454656A1 (es) 1977-11-16
DE2658267A1 (de) 1977-07-07
YU311676A (en) 1983-01-21
NO146396B (no) 1982-06-14
AU508123B2 (en) 1980-03-13
SE431544B (sv) 1984-02-13
FI763664A (pt) 1977-06-30
CS203995B2 (en) 1981-03-31
CA1073458A (en) 1980-03-11
JPS6129355B2 (pt) 1986-07-05
FI62668B (fi) 1982-10-29
PL104376B1 (pl) 1979-08-31
BE849810A (fr) 1977-06-23
FR2336935B1 (pt) 1980-03-21
ZM14376A1 (en) 1977-08-22
ATA960876A (de) 1980-05-15
GR62441B (en) 1979-04-12
IT1124740B (it) 1986-05-14
AR222290A1 (es) 1981-05-15
JPS5283388A (en) 1977-07-12
BG29722A3 (en) 1981-01-15
AU2097676A (en) 1978-07-06
NO146396C (no) 1982-09-22
IE45082B1 (en) 1982-06-16
DK587076A (da) 1977-06-30
PT65949A (pt) 1977-01-01
FR2336935A1 (fr) 1977-07-29
IL51040A0 (en) 1977-02-28
HU175171B (hu) 1980-05-28
NO764370L (pt) 1977-06-30
PH14723A (en) 1981-11-13
NZ182759A (en) 1978-06-02
IE45082L (en) 1977-06-29
MW5076A1 (en) 1978-02-08
RO72475A (ro) 1982-10-26
EG12439A (en) 1979-09-30
IL51040A (en) 1980-12-31
OA05526A (fr) 1981-04-30
SE7614620L (sv) 1977-06-30
SU791235A3 (ru) 1980-12-23
ZA767198B (en) 1977-11-30
AT360024B (de) 1980-12-10

Similar Documents

Publication Publication Date Title
FI62668C (fi) Foerfarande foer framstaellning av h1- och h2-histaminantagonistiska 2-amino-4-pyrimidonderivat
US4154834A (en) Substituted isocytosines having histamine H2 -antagonist activity
FI66000C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva 2-amino-4-pyrimidonderivat
TW434227B (en) Novel N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immune modulating effect
US4216318A (en) Heterocyclic alkyl 4-pyrimidones
IL105806A (en) History of aminoquinoline and pharmaceuticals containing them
FI61701B (fi) Foerfarande foer framstaellning av h2-histaminantagonistiska 2-amino-4-pyrimidonderivat
US4523015A (en) Process and nitroaminopyrimidone intermediates for histamine H2 -antagonists
US4227000A (en) Intermediates in the process for making histamine antagonists
EP0068834B1 (en) Pyrimidinone derivatives and pharmaceutical compositions containing them
US4413127A (en) Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles
CA1208215A (en) Pyrimidinone derivatives as histamine antagonists
SU1033003A3 (ru) Способ получени производных 4-пиримидона или их фармацевтически приемлемых кислотно-аддитивных солей
CA1188303A (en) 5-(pyridinyl)-1h-benzimidazoles and 1-hydroxy-6- (pyridinyl)-1h-benzimidazoles, their preparation and use as cardiotonics
NO851113L (no) ((pyridinyl)-2-pyrimidinyl)ureaforbindelser egnet som kardiotoniske midler og fremgangsmaate for deres fremstilling
HU192951B (en) Process for producing pyrimidine derivatives of anti-ulcer activity
CA1166253A (en) 4-amino-6-(pyridinyl)-3(2h)-pyridazinones, preparation and cardiotonic use
SU1020003A3 (ru) Способ получени производных пиримидона
CA1133481A (en) Process for making histamine antagonists
KR830000313B1 (ko) 피리미돈의 제조방법
SU1728241A1 (ru) Способ получени 3,6-дихлор-2-цианопиридина
SU858564A3 (ru) Способ получени производных пиримидона
KR820002137B1 (ko) 피리딜 화합물의 제조방법
AU609229B2 (en) Pyrimidone compound and pharmaceutically acceptable salts thereof
GB1582527A (en) Pyrimidone and thiopyrimidone derivatives

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: SMITH KLINE & FRENCH LABORATORIES LTD