FI120641B - Fettemulsioner för parenteral administrering, vilka innehåller edetat som konserveringsmedel - Google Patents

Fettemulsioner för parenteral administrering, vilka innehåller edetat som konserveringsmedel Download PDF

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Publication number
FI120641B
FI120641B FI20085586A FI20085586A FI120641B FI 120641 B FI120641 B FI 120641B FI 20085586 A FI20085586 A FI 20085586A FI 20085586 A FI20085586 A FI 20085586A FI 120641 B FI120641 B FI 120641B
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FI
Finland
Prior art keywords
water
oil
propofol
agent
emulsion
Prior art date
Application number
FI20085586A
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English (en)
Finnish (fi)
Other versions
FI20085586A (sv
Inventor
Christopher Jones
John Platt
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48793621&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI120641(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to GB9405593A priority Critical patent/GB9405593D0/en
Priority to PCT/GB1995/000579 priority patent/WO1996029064A1/en
Priority to IT95MI000529A priority patent/IT1281193B1/it
Priority to DE69528714T priority patent/DE69528714T2/de
Priority to EP95911412A priority patent/EP0814787B1/en
Priority to SI9530628T priority patent/SI0814787T1/xx
Priority to AU18988/95A priority patent/AU710143B2/en
Priority to AT02009330T priority patent/ATE312625T1/de
Priority to PL95322278A priority patent/PL186354B1/pl
Priority to CZ0290497A priority patent/CZ297549B6/cs
Priority to ZA952239A priority patent/ZA952239B/xx
Priority to DK95911412T priority patent/DK0814787T3/da
Priority to AT95911412T priority patent/ATE226817T1/de
Priority to BR9510452A priority patent/BR9510452A/pt
Priority to NZ282005A priority patent/NZ282005A/xx
Priority to IL11302195A priority patent/IL113021A/en
Priority to CA002212794A priority patent/CA2212794C/en
Priority to TW084102594A priority patent/TW458781B/zh
Priority to BE9500241A priority patent/BE1009198A5/fr
Priority to EP02009330A priority patent/EP1238677B1/en
Priority to CH01282/04A priority patent/CH694423A5/de
Priority to CH02011/97A priority patent/CH693764A5/de
Priority to NZ500588A priority patent/NZ500588A/en
Priority to CH00393/03A priority patent/CH693762A5/de
Priority to PT95911412T priority patent/PT814787E/pt
Priority to SK1247-97A priority patent/SK286375B6/sk
Priority to DE19509828A priority patent/DE19509828A1/de
Priority to ES95911412T priority patent/ES2183869T3/es
Priority to HU9702180A priority patent/HU227951B1/hu
Priority to CH02053/03A priority patent/CH694396A5/de
Priority to FR9503128A priority patent/FR2731617B1/fr
Priority to ES02009330T priority patent/ES2253469T3/es
Priority to GB9505405A priority patent/GB2298789B/en
Priority to RU97117100A priority patent/RU2147432C1/ru
Priority to MX9707005A priority patent/MX9707005A/es
Priority to DK02009330T priority patent/DK1238677T3/da
Priority to JP08528148A priority patent/JP3067806B2/ja
Priority to US08/408,707 priority patent/US5714520A/en
Priority to SE9703274A priority patent/SE523909C2/sv
Priority to LU90136A priority patent/LU90136B1/de
Priority to NO19974278A priority patent/NO320007B1/no
Priority to FI973702A priority patent/FI120640B/sv
Priority to DK106697A priority patent/DK106697A/da
Priority to HK98109677A priority patent/HK1008927A1/xx
Priority to JP00624199A priority patent/JP4012328B2/ja
Priority to SE0400115A priority patent/SE527123C2/sv
Priority to NO20041838A priority patent/NO334956B1/no
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to FI20085586A priority patent/FI120641B/sv
Publication of FI20085586A publication Critical patent/FI20085586A/sv
Application granted granted Critical
Publication of FI120641B publication Critical patent/FI120641B/sv

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)

Claims (3)

1. Steril, vattenhaltig komposition för parenteral administrering, k ä n n e t e c k n a d av att den ornfattar en olja-i-vatien-emulsion, där ett med 5 vatien oblandbart lösmngsmede! är emulgerat med varten ooh stabiliserat med ett ytaktivt medel, och vilken emulsion ytterligare ornfattar dinatriurnedetat i en molar koncentration av 3 x 10'5 - 9 x 10-4 (beräknat pä fri EDTA-syra).
2, Steril, farmaceutisk komposition för parenteral administrering, kännetecknad av att den ornfattar en olja-i-vatten-emulsion, som inne- 10 halier ett terapeutiskt eiler farmaceutiskt medei, som är emulgerat, antingen ensamt eiler lost i ett med varten oblandbart losningsmedel, med vatien och stabiliserat med ett ytaktivt medel, och vilken emulsion ytterligare ornfattar di-natriumedefat i en molar koncentration av 3 x 1Ö"5 - 9 x 10'4 {beräknat pä fri EDTA-syra), 15
3, Komposition enligt patentkrav 2, kän netecknad av art det ornfattar ett antifungait medel, anestetiskt medel, antibakteriellt medel, anti-cancermedei, antiemetiskt medel, medel som verkar pä det centrala nervsys-temet, en steroid, ett barbiturat eiler ett vitaminpreparat
FI20085586A 1994-03-22 2008-06-13 Fettemulsioner för parenteral administrering, vilka innehåller edetat som konserveringsmedel FI120641B (sv)

Priority Applications (48)

Application Number Priority Date Filing Date Title
GB9405593A GB9405593D0 (en) 1994-03-22 1994-03-22 Pharmaceutical compositions
PCT/GB1995/000579 WO1996029064A1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate
IT95MI000529A IT1281193B1 (it) 1994-03-22 1995-03-17 Composizioni farmaceutiche contenenti 2,6 diisopropilfenolo (propofol) e metodo per la loro preparazione
DE69528714T DE69528714T2 (de) 1994-03-22 1995-03-17 Propofol und disodium edta enthaltende öl-in-wasser emulsionen
EP95911412A EP0814787B1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
SI9530628T SI0814787T1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
AU18988/95A AU710143B2 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate
AT02009330T ATE312625T1 (de) 1994-03-22 1995-03-17 Parenterale fettemulsionen, die edta als konservierungsmittel enthalten
PL95322278A PL186354B1 (pl) 1994-03-22 1995-03-17 Jałowe kompozycje farmaceutyczne oraz sposoby ograniczania potencjału wzrostowego drobnoustrojów i poprawiania czasu stosowania emulsji
CZ0290497A CZ297549B6 (cs) 1994-03-22 1995-03-17 Sterilní farmaceutický prostredek pro parenterální podání, obsahující propofol a edetát
ZA952239A ZA952239B (en) 1994-03-22 1995-03-17 Pharmaceutical compositions
DK95911412T DK0814787T3 (da) 1994-03-22 1995-03-17 Olie-i-vand emulsioner indeholdende propofol og dinatrium-edetat
AT95911412T ATE226817T1 (de) 1994-03-22 1995-03-17 Propofol und disodium edta enthaltende öl-in- wasser emulsionen
BR9510452A BR9510452A (pt) 1994-03-22 1995-03-17 Composição farmacêutica e aquosa estéril para a administração parenteral processos para limitar o potencial de crescimento microbiano em composição farmacêutica estéril para a administração parenteral para produzir anestesia em um animal de sangue quente e para aperfeiçoar o tempo de administração e/ou o tempo entre as trocas de conjuntos
NZ282005A NZ282005A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol (2,6 diisopropylphenol) and edetate
IL11302195A IL113021A (en) 1994-03-22 1995-03-17 Oil in water emulsion compositions containing edetate
CA002212794A CA2212794C (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate
TW084102594A TW458781B (en) 1994-03-22 1995-03-17 Sterile pharmaceutical compositions for parenteral administration and their uses
BE9500241A BE1009198A5 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol.
EP02009330A EP1238677B1 (en) 1994-03-22 1995-03-17 Parenteral fat emulsions comprising edetate as preservative
CH01282/04A CH694423A5 (de) 1994-03-22 1995-03-17 Verwendung von Edetat zur Stabilisierung von pharmzeutischen Zusammensetzungen.
CH02011/97A CH693764A5 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzung enthaltend Propofol und Edetat.
NZ500588A NZ500588A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate for producing anaesthesia
CH00393/03A CH693762A5 (de) 1994-03-22 1995-03-17 Wässrige Zusammensetzungen enthaltend eine Öl-in-Wasser-Emulsion
PT95911412T PT814787E (pt) 1994-03-22 1995-03-17 Emulsoes de oleo em agua que contem propofol e edetato
SK1247-97A SK286375B6 (sk) 1994-03-22 1995-03-17 Sterilná farmaceutická kompozícia na parenterálnepoužitie
DE19509828A DE19509828A1 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzungen
ES95911412T ES2183869T3 (es) 1994-03-22 1995-03-17 Emulsiones de aceite en agua que contienen propofol y edetato.
HU9702180A HU227951B1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
CH02053/03A CH694396A5 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzung mit therapeutischem oder pharmazeutischem Mittel und Edetat.
FR9503128A FR2731617B1 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol
ES02009330T ES2253469T3 (es) 1994-03-22 1995-03-17 Emulsiones grasas parenterales que comprenden edetato como conservante.
GB9505405A GB2298789B (en) 1994-03-22 1995-03-17 Pharmaceutical compositions
RU97117100A RU2147432C1 (ru) 1994-03-22 1995-03-17 Эмульсии типа масло в воде, содержащие пропофол и эдетат
MX9707005A MX9707005A (es) 1994-03-22 1995-03-17 Composiciones farmaceuticas que contienen 2,6-diisopropilfenol (propofol).
DK02009330T DK1238677T3 (da) 1994-03-22 1995-03-17 Parenterale fedtemulsioner, der omfatter edetat som konserveringsmiddel
JP08528148A JP3067806B2 (ja) 1994-03-22 1995-03-17 プロポフォールとエデテートとを含有する水中油滴エマルジョン
US08/408,707 US5714520A (en) 1994-03-22 1995-03-22 Propofol compostion containing edetate
SE9703274A SE523909C2 (sv) 1994-03-22 1997-09-10 Olja-i-vattenemulsioner innehållande propofol och edetat
LU90136A LU90136B1 (de) 1994-03-22 1997-09-10 Oel-in-Wasser-Emulsionen die Propofol und Edetat enthalten
NO19974278A NO320007B1 (no) 1994-03-22 1997-09-16 Steril farmasoytisk blanding inneholdende propofol og edetat for parenteral administrering, fremgangsmate for a begrense potensialet for mikrobevekst i blandingen, samt anvendelse derav.
FI973702A FI120640B (sv) 1994-03-22 1997-09-16 Olja-i-vattenemulsioner innehållande propofol och edetat
DK106697A DK106697A (da) 1994-03-22 1997-09-17 Emulsioner af typen olie-i-vand indeholdende propofol og edetat
HK98109677A HK1008927A1 (en) 1994-03-22 1998-08-04 Oil in water emulsions containing propofol and edetate
JP00624199A JP4012328B2 (ja) 1994-03-22 1999-01-13 エデテートを含有する水中油滴エマルジョン
SE0400115A SE527123C2 (sv) 1994-03-22 2004-01-21 Olja-I-vattenemulsioner innehållande propofol och edetat
NO20041838A NO334956B1 (no) 1994-03-22 2004-05-04 Sterilt, vandig propofolpreparat som omfatter en olje-i-vann-emulsjon og som videre omfatter en mengde av dinatriumedetat.
FI20085586A FI120641B (sv) 1994-03-22 2008-06-13 Fettemulsioner för parenteral administrering, vilka innehåller edetat som konserveringsmedel

Applications Claiming Priority (38)

Application Number Priority Date Filing Date Title
GB9405593A GB9405593D0 (en) 1994-03-22 1994-03-22 Pharmaceutical compositions
GB9405593 1994-03-22
GB9500579 1995-01-12
DE19509828A DE19509828A1 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzungen
ZA952239A ZA952239B (en) 1994-03-22 1995-03-17 Pharmaceutical compositions
HU9702180 1995-03-17
PL32227895 1995-03-17
CH12822004 1995-03-17
ZA9502239 1995-03-17
NZ282005A NZ282005A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol (2,6 diisopropylphenol) and edetate
NZ28200595 1995-03-17
CA002212794A CA2212794C (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate
BE9500241A BE1009198A5 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol.
CH01282/04A CH694423A5 (de) 1994-03-22 1995-03-17 Verwendung von Edetat zur Stabilisierung von pharmzeutischen Zusammensetzungen.
NZ500588A NZ500588A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate for producing anaesthesia
CH02011/97A CH693764A5 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzung enthaltend Propofol und Edetat.
CH00393/03A CH693762A5 (de) 1994-03-22 1995-03-17 Wässrige Zusammensetzungen enthaltend eine Öl-in-Wasser-Emulsion
EP95911412 1995-03-17
DE19509828 1995-03-17
BR9510452A BR9510452A (pt) 1994-03-22 1995-03-17 Composição farmacêutica e aquosa estéril para a administração parenteral processos para limitar o potencial de crescimento microbiano em composição farmacêutica estéril para a administração parenteral para produzir anestesia em um animal de sangue quente e para aperfeiçoar o tempo de administração e/ou o tempo entre as trocas de conjuntos
BR9510452 1995-03-17
BE9500241 1995-03-17
NZ50058895 1995-03-17
CA2212794 1995-03-17
CH3932003 1995-03-17
FR9503128 1995-03-17
CH201197 1995-03-17
PL95322278A PL186354B1 (pl) 1994-03-22 1995-03-17 Jałowe kompozycje farmaceutyczne oraz sposoby ograniczania potencjału wzrostowego drobnoustrojów i poprawiania czasu stosowania emulsji
FR9503128A FR2731617B1 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol
HU9702180A HU227951B1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
PCT/GB1995/000579 WO1996029064A1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate
EP95911412A EP0814787B1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
NO19974278A NO320007B1 (no) 1994-03-22 1997-09-16 Steril farmasoytisk blanding inneholdende propofol og edetat for parenteral administrering, fremgangsmate for a begrense potensialet for mikrobevekst i blandingen, samt anvendelse derav.
NO974278 1997-09-16
JP00624199A JP4012328B2 (ja) 1994-03-22 1999-01-13 エデテートを含有する水中油滴エマルジョン
JP624199 1999-01-13
FI20085586 2008-06-13
FI20085586A FI120641B (sv) 1994-03-22 2008-06-13 Fettemulsioner för parenteral administrering, vilka innehåller edetat som konserveringsmedel

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FI973702A FI120640B (sv) 1994-03-22 1997-09-16 Olja-i-vattenemulsioner innehållande propofol och edetat
FI20085586A FI120641B (sv) 1994-03-22 2008-06-13 Fettemulsioner för parenteral administrering, vilka innehåller edetat som konserveringsmedel

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US5714520A (en) 1998-02-03
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GB2298789B (en) 1999-12-08
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SE0400115D0 (sv) 2004-01-21
GB9505405D0 (en) 1995-05-03
JPH11500737A (ja) 1999-01-19
IL113021A0 (en) 1995-12-08
HK1008927A1 (en) 1999-07-16
GB9405593D0 (en) 1994-05-11
WO1996029064A1 (en) 1996-09-26
FI20085586A (sv) 2008-06-13
BR9510452A (pt) 1998-05-19
ES2183869T3 (es) 2003-04-01
SE0400115L (sv) 2004-01-21
NO974278D0 (no) 1997-09-16
DK1238677T3 (da) 2006-03-06
FR2731617B1 (fr) 1997-05-30
JPH11263725A (ja) 1999-09-28
FI973702A (sv) 1997-09-16
SE523909C2 (sv) 2004-06-01
ZA952239B (en) 1996-09-17
EP0814787B1 (en) 2002-10-30
HUT77358A (hu) 1998-03-30
SI0814787T1 (en) 2003-04-30
EP1238677A3 (en) 2003-01-22
ATE312625T1 (de) 2005-12-15
TW458781B (en) 2001-10-11
SK124797A3 (en) 1998-01-14
ATE226817T1 (de) 2002-11-15
SE527123C2 (sv) 2005-12-27
DK106697A (da) 1997-09-17
CH693762A5 (de) 2004-01-30
EP1238677B1 (en) 2005-12-14
EP1238677A2 (en) 2002-09-11
GB2298789A (en) 1996-09-18
NO320007B1 (no) 2005-10-10
CH694423A5 (de) 2005-01-14
IT1281193B1 (it) 1998-02-17
SE9703274D0 (sv) 1997-09-10
CZ290497A3 (en) 1997-12-17
ITMI950529A0 (it) 1995-03-17
LU90136B1 (de) 1997-11-27
RU2147432C1 (ru) 2000-04-20
JP4012328B2 (ja) 2007-11-21
MX9707005A (es) 1997-11-29
SK286375B6 (sk) 2008-08-05
CH693764A5 (de) 2004-01-30
CA2212794C (en) 2000-09-12
IL113021A (en) 2001-04-30
DK0814787T3 (da) 2003-01-06
SE9703274L (sv) 1997-09-10
PL186354B1 (pl) 2003-12-31
CZ297549B6 (cs) 2007-02-07
AU710143B2 (en) 1999-09-16
CA2212794A1 (en) 1996-09-26
CH694396A5 (de) 2004-12-31
FR2731617A1 (fr) 1996-09-20
DE69528714D1 (de) 2002-12-05
BE1009198A5 (fr) 1996-12-03
DE19509828A1 (de) 1996-09-19
NZ500588A (en) 2001-04-27
NO974278L (no) 1997-09-16
FI120640B (sv) 2010-01-15
PL322278A1 (en) 1998-01-19
PT814787E (pt) 2003-02-28
ITMI950529A1 (it) 1996-09-17
HU227951B1 (en) 2012-07-30
EP0814787A1 (en) 1998-01-07
NZ282005A (en) 2000-01-28
AU1898895A (en) 1996-10-08
FI973702A0 (sv) 1997-09-16
DE69528714T2 (de) 2003-06-12
ES2253469T3 (es) 2006-06-01
JP3067806B2 (ja) 2000-07-24

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