FI114782B - Förfarande för framställning av ett medicinplåster i form av ett laminat - Google Patents
Förfarande för framställning av ett medicinplåster i form av ett laminat Download PDFInfo
- Publication number
- FI114782B FI114782B FI954989A FI954989A FI114782B FI 114782 B FI114782 B FI 114782B FI 954989 A FI954989 A FI 954989A FI 954989 A FI954989 A FI 954989A FI 114782 B FI114782 B FI 114782B
- Authority
- FI
- Finland
- Prior art keywords
- patch
- concentration
- matrix
- skin
- active substance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Laminated Bodies (AREA)
- Materials For Medical Uses (AREA)
Claims (8)
1. Förfarande för framställning av ett medicin-pläster i form av ett laminat, kännetecknat av att 5 a) en matrix framställs, varvid i) en E-vitamin eller ett E-vitaminderivat och ii) minst ett aktivt ämne, som väljs bland östro-gen- och progestagenhormoner, iii) upplöses i en polymer, varvid polymeren är en 10 akrylatbaserad kopolymer och den akrylatbaserade polymeren bestär tili minst 50 vikt-% av en alkylakrylatmonomer, om-fattande 2-etylhexylat, och eventuellt av en akrylatmono-mer kopolymeriserad med akrylsyra, b) matrixen utbreds pä en bärare för att bilda ett 15 laminat och c) plästret bildas i form av ett laminat.
2. Förfarande enligt patentkrav 1, kännetecknat av att man använder en sädan koncentration av det aktiva ämnet eller en sädan koncentration av ätminstone 20 ett aktivt ämne att da plästret placeras pä huden, överskrids det aktiva ämnets eller ätminstone ett aktivt * ämnes mättningskoncentration.
,\· 3. Förfarande enligt patentkrav 2, känneteck- : n a t av att man använder en koncentration av det aktiva ** 25 ämnet eller ätminstone ett aktivt ämne, vilken koncentra- tion under förhällanden som räder under lagring av medi-cinplästret är närä mättningskoncentrationen.
4. Förfarande enligt patentkrav 2 eller 3, kän - . netecknat av att man använder en sädan koncentration » 3. av det aktiva ämnet eller ätminstone ett aktivt ämne att ·* mättningskoncentrationen i samband med användning av plästret överskrids 5 - 100 %, i synnerhet 20 - 80 %.
; ·· 5. Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att bäraren som använts ' 35 är i form av en film med begränsad eller ingen permeabili- tet för vatten och vattenänga. 114782
6. Förfarande enligt nägot av de föregäende pa-tentkraven, kännetecknat av att E-vitaminderivatet som använts är alfa-tokoferol, alfa-tokoferolacetat, alfa-tokoferolsuckinat och/eller alfa-tokoferolnikotinat. 5
7. Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att man använder en E-vitamin- och/eller E-vitaminderivatkoncentration, som är i omrädet 0,5 - 20 vikt-%, i synnerhet 1 - 100 vikt-% beräk-nat frän matrixen. 10
8. Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att man framställer ett pläster, vars godtagbara storlek är högst cirka 200 cm2, varvid det aktiva ämnets koncentration i blodet bringas närä en terapeutiskt önskad koncentration i blodet genom 15 regiering av E-vitamin- och/eller E-vitaminderivathalten. * * » ' * ♦
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4312818 | 1993-04-20 | ||
DE4312818 | 1993-04-20 | ||
DE19934339400 DE4339400A1 (de) | 1993-11-18 | 1993-11-18 | Wirkstoffpflaster |
DE4339400 | 1993-11-18 | ||
EP9401231 | 1994-04-20 | ||
PCT/EP1994/001231 WO1994023707A1 (de) | 1993-04-20 | 1994-04-20 | Wirkstoffplaster |
Publications (3)
Publication Number | Publication Date |
---|---|
FI954989A0 FI954989A0 (sv) | 1995-10-19 |
FI954989A FI954989A (sv) | 1995-10-19 |
FI114782B true FI114782B (sv) | 2004-12-31 |
Family
ID=25925074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI954989A FI114782B (sv) | 1993-04-20 | 1995-10-19 | Förfarande för framställning av ett medicinplåster i form av ett laminat |
Country Status (14)
Country | Link |
---|---|
US (2) | US5683711A (sv) |
EP (2) | EP0695177B1 (sv) |
JP (1) | JP3489831B2 (sv) |
AT (2) | ATE163262T1 (sv) |
AU (1) | AU678237B2 (sv) |
CA (1) | CA2161004C (sv) |
DE (2) | DE59405277D1 (sv) |
DK (2) | DK0813865T3 (sv) |
ES (2) | ES2164286T3 (sv) |
FI (1) | FI114782B (sv) |
HU (2) | HU223045B1 (sv) |
NO (1) | NO311829B1 (sv) |
PT (1) | PT813865E (sv) |
WO (1) | WO1994023707A1 (sv) |
Families Citing this family (41)
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DE4429667C2 (de) * | 1994-08-20 | 1996-07-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
DE19517145C2 (de) * | 1995-05-10 | 2000-02-24 | Hexal Pharmaforschung Gmbh | Transdermales therapeutisches System (TTS) zur Verabreichung von Testosteron |
NZ309980A (en) * | 1995-06-07 | 2001-06-29 | Noven Pharma | Transdermal composition containing a blend of one or more polymers, one or more drugs that has a low molecular weight and is liquid at room temperature |
US6316022B1 (en) | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
DE19533089C1 (de) | 1995-09-07 | 1997-05-22 | Hexal Ag | Tacrin-Pflaster |
DE19642043A1 (de) * | 1995-10-23 | 1997-04-24 | Hexal Ag | Transdermales therapeutisches System (TTS) für die Verabreichung von Wirkstoffen zur Behandlung von Drogenabhängigkeit oder Drogensucht |
DE19548332A1 (de) * | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
US6767902B2 (en) | 1997-09-17 | 2004-07-27 | The Population Council, Inc. | Androgen as a male contraceptive and non-contraceptive androgen replacement |
US20020012694A1 (en) * | 1997-09-17 | 2002-01-31 | Alfred J. Moo-Young | Transdermal administration of ment |
AU1800099A (en) | 1997-11-25 | 1999-06-15 | Theratech, Inc. | Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties |
DE19814257A1 (de) | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
DE19828273B4 (de) * | 1998-06-25 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren |
US6475514B1 (en) * | 1998-12-03 | 2002-11-05 | Andrew Blitzer | Athletic patch |
DE19859910C2 (de) * | 1998-12-23 | 2001-03-22 | Ratiopharm Gmbh | Orales Arzneimittel |
IL143604A0 (en) | 1998-12-30 | 2002-04-21 | Dexcel Ltd | Dispersable concentrate for the delivery of cyclosporin |
US6417227B1 (en) | 1999-04-28 | 2002-07-09 | Cg And Associates | Methods of delivery of cetyl myristoleate |
US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US7235397B1 (en) | 2000-04-14 | 2007-06-26 | Gensys, Inc. | Methods and compositions for culturing spirochete and treating spirochetal diseases |
DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
US20020198215A1 (en) * | 2000-10-23 | 2002-12-26 | Lino Tavares | Terazosin transdermal device and methods |
DE10141651B4 (de) * | 2001-08-24 | 2007-02-15 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung |
DE10141652B4 (de) * | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
US20040258739A1 (en) * | 2001-09-04 | 2004-12-23 | Rudy Susilo | Plaster for the treatment of dysfunctions and disorders of nails |
DE60312160T2 (de) * | 2002-06-10 | 2007-10-31 | Euro-Celtique S.A. | Entsorgungssysteme für transdermale abgabevorrichtungen zur verhinderung des missbrauchs von darin enthaltenen wirkstoffen |
MXPA05008366A (es) * | 2003-02-07 | 2005-11-04 | Lohmann Therapie Syst Lts | Sistema terapeutico transdermico adecuado para la aplicacion de calor para promover la penetracion de sustancias activas y el uso del mismo. |
CZ295826B6 (cs) * | 2003-04-28 | 2005-11-16 | Ústav Makromolekulární Chemie Av Čr | Materiál pro krytí ran obsahující lapače radikálů |
CN100457064C (zh) * | 2003-10-28 | 2009-02-04 | 诺芬药品公司 | 透皮递药装置 |
US20050096311A1 (en) * | 2003-10-30 | 2005-05-05 | Cns Response | Compositions and methods for treatment of nervous system disorders |
DE102004059880A1 (de) * | 2004-12-10 | 2006-06-14 | Grünenthal GmbH | Stabiles, hormonhaltiges (Zwischen-)Produkt |
JP5084496B2 (ja) * | 2005-02-04 | 2012-11-28 | 久光製薬株式会社 | 経皮吸収貼付剤 |
US20070018059A1 (en) * | 2005-07-25 | 2007-01-25 | Woodcock John E | Apparatus for holding a container at an angle |
BRPI0806462A2 (pt) * | 2007-01-11 | 2011-09-06 | Drossapharm Ag | emplastro médico para liberar compostos farmaceuticamente ativos na pele, e, processo para a preparação da dispersão |
US8513323B2 (en) * | 2007-06-22 | 2013-08-20 | Kimbery-Clark Worldwide, Inc. | Multifunctional silicone blends |
ES2528650T3 (es) | 2010-11-17 | 2015-02-11 | Hexal Ag | Sistema terapéutico transdérmico que comprende buprenorfina |
EP2968652B1 (en) | 2013-03-13 | 2020-07-22 | Avery Dennison Corporation | Improving adhesive properties |
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NL7711916A (nl) * | 1977-10-29 | 1979-05-02 | Akzo Nv | Werkwijze ter bereiding van sterk geconcen- treerde farmaceutische preparaten van steroiden. |
US4439432A (en) * | 1982-03-22 | 1984-03-27 | Peat Raymond F | Treatment of progesterone deficiency and related conditions with a stable composition of progesterone and tocopherols |
JPS59184121A (ja) * | 1983-03-31 | 1984-10-19 | Nitto Electric Ind Co Ltd | アクリル系膏体 |
US5023084A (en) * | 1986-12-29 | 1991-06-11 | Rutgers, The State University Of New Jersey | Transdermal estrogen/progestin dosage unit, system and process |
CH674618A5 (sv) * | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
US5300291A (en) * | 1988-03-04 | 1994-04-05 | Noven Pharmaceuticals, Inc. | Method and device for the release of drugs to the skin |
GB8807504D0 (en) * | 1988-03-29 | 1988-05-05 | Sandoz Ltd | Improvements in/relating to organic compounds |
JP2857882B2 (ja) * | 1988-11-02 | 1999-02-17 | 富山化学工業株式会社 | ピロキシカムのプラスター剤 |
DE3902013A1 (de) * | 1989-01-25 | 1990-09-20 | Knoll Ag | Pflaster zur transdermalen anwendung |
JP2875611B2 (ja) * | 1990-08-29 | 1999-03-31 | エーザイ株式会社 | ケイ酸カルシウム含有外用剤 |
GB9021674D0 (en) * | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
DE4116912A1 (de) * | 1991-05-18 | 1992-11-26 | Schering Ag | Mittel zur transdermalen applikation enthaltend ergolin-derivate |
AU658681B2 (en) * | 1991-10-23 | 1995-04-27 | Block Drug Company Inc., The | Penetration enhancement of topically applied formulations |
DE4237453C1 (sv) * | 1992-11-06 | 1993-08-19 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De |
-
1994
- 1994-04-20 DK DK97113342T patent/DK0813865T3/da active
- 1994-04-20 JP JP52278494A patent/JP3489831B2/ja not_active Expired - Fee Related
- 1994-04-20 US US08/535,038 patent/US5683711A/en not_active Expired - Lifetime
- 1994-04-20 PT PT97113342T patent/PT813865E/pt unknown
- 1994-04-20 EP EP94913616A patent/EP0695177B1/de not_active Expired - Lifetime
- 1994-04-20 ES ES97113342T patent/ES2164286T3/es not_active Expired - Lifetime
- 1994-04-20 AT AT94913616T patent/ATE163262T1/de active
- 1994-04-20 CA CA002161004A patent/CA2161004C/en not_active Expired - Fee Related
- 1994-04-20 EP EP97113342A patent/EP0813865B1/de not_active Expired - Lifetime
- 1994-04-20 DK DK94913616T patent/DK0695177T3/da active
- 1994-04-20 DE DE59405277T patent/DE59405277D1/de not_active Expired - Lifetime
- 1994-04-20 HU HU9502994A patent/HU223045B1/hu active IP Right Revival
- 1994-04-20 DE DE59409873T patent/DE59409873D1/de not_active Expired - Lifetime
- 1994-04-20 ES ES94913616T patent/ES2115231T3/es not_active Expired - Lifetime
- 1994-04-20 AT AT97113342T patent/ATE205706T1/de active
- 1994-04-20 AU AU65696/94A patent/AU678237B2/en not_active Expired
- 1994-04-20 HU HU0301253A patent/HU223042B1/hu active IP Right Grant
- 1994-04-20 WO PCT/EP1994/001231 patent/WO1994023707A1/de active IP Right Grant
-
1995
- 1995-10-19 FI FI954989A patent/FI114782B/sv not_active IP Right Cessation
- 1995-10-19 NO NO19954186A patent/NO311829B1/no not_active IP Right Cessation
-
1997
- 1997-04-01 US US08/829,858 patent/US5830505A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE163262T1 (de) | 1998-03-15 |
EP0813865B1 (de) | 2001-09-19 |
HUT73668A (en) | 1996-09-30 |
DE59405277D1 (de) | 1998-03-26 |
ES2164286T3 (es) | 2002-02-16 |
HU223045B1 (hu) | 2004-03-01 |
ATE205706T1 (de) | 2001-10-15 |
NO954186D0 (no) | 1995-10-19 |
EP0813865A1 (de) | 1997-12-29 |
FI954989A0 (sv) | 1995-10-19 |
HU0301253D0 (en) | 2003-07-28 |
AU678237B2 (en) | 1997-05-22 |
AU6569694A (en) | 1994-11-08 |
DK0813865T3 (da) | 2001-11-19 |
US5830505A (en) | 1998-11-03 |
EP0695177B1 (de) | 1998-02-18 |
NO954186L (no) | 1995-10-19 |
JPH09501398A (ja) | 1997-02-10 |
PT813865E (pt) | 2002-02-28 |
JP3489831B2 (ja) | 2004-01-26 |
HU223042B1 (hu) | 2004-03-01 |
CA2161004A1 (en) | 1994-10-27 |
DE59409873D1 (de) | 2001-10-25 |
FI954989A (sv) | 1995-10-19 |
ES2115231T3 (es) | 1998-06-16 |
NO311829B1 (no) | 2002-02-04 |
EP0695177A1 (de) | 1996-02-07 |
CA2161004C (en) | 2004-10-26 |
DK0695177T3 (da) | 1998-09-28 |
WO1994023707A1 (de) | 1994-10-27 |
HU9502994D0 (en) | 1995-12-28 |
US5683711A (en) | 1997-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |