FI114782B - Förfarande för framställning av ett medicinplåster i form av ett laminat - Google Patents

Förfarande för framställning av ett medicinplåster i form av ett laminat Download PDF

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Publication number
FI114782B
FI114782B FI954989A FI954989A FI114782B FI 114782 B FI114782 B FI 114782B FI 954989 A FI954989 A FI 954989A FI 954989 A FI954989 A FI 954989A FI 114782 B FI114782 B FI 114782B
Authority
FI
Finland
Prior art keywords
patch
concentration
matrix
skin
active substance
Prior art date
Application number
FI954989A
Other languages
English (en)
Finnish (fi)
Other versions
FI954989A0 (sv
FI954989A (sv
Inventor
Wilfried Fischer
Karin Klokkers
Original Assignee
Hexal Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19934339400 external-priority patent/DE4339400A1/de
Application filed by Hexal Ag filed Critical Hexal Ag
Publication of FI954989A0 publication Critical patent/FI954989A0/sv
Publication of FI954989A publication Critical patent/FI954989A/sv
Application granted granted Critical
Publication of FI114782B publication Critical patent/FI114782B/sv

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Laminated Bodies (AREA)
  • Materials For Medical Uses (AREA)

Claims (8)

1. Förfarande för framställning av ett medicin-pläster i form av ett laminat, kännetecknat av att 5 a) en matrix framställs, varvid i) en E-vitamin eller ett E-vitaminderivat och ii) minst ett aktivt ämne, som väljs bland östro-gen- och progestagenhormoner, iii) upplöses i en polymer, varvid polymeren är en 10 akrylatbaserad kopolymer och den akrylatbaserade polymeren bestär tili minst 50 vikt-% av en alkylakrylatmonomer, om-fattande 2-etylhexylat, och eventuellt av en akrylatmono-mer kopolymeriserad med akrylsyra, b) matrixen utbreds pä en bärare för att bilda ett 15 laminat och c) plästret bildas i form av ett laminat.
2. Förfarande enligt patentkrav 1, kännetecknat av att man använder en sädan koncentration av det aktiva ämnet eller en sädan koncentration av ätminstone 20 ett aktivt ämne att da plästret placeras pä huden, överskrids det aktiva ämnets eller ätminstone ett aktivt * ämnes mättningskoncentration.
,\· 3. Förfarande enligt patentkrav 2, känneteck- : n a t av att man använder en koncentration av det aktiva ** 25 ämnet eller ätminstone ett aktivt ämne, vilken koncentra- tion under förhällanden som räder under lagring av medi-cinplästret är närä mättningskoncentrationen.
4. Förfarande enligt patentkrav 2 eller 3, kän - . netecknat av att man använder en sädan koncentration » 3. av det aktiva ämnet eller ätminstone ett aktivt ämne att ·* mättningskoncentrationen i samband med användning av plästret överskrids 5 - 100 %, i synnerhet 20 - 80 %.
; ·· 5. Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att bäraren som använts ' 35 är i form av en film med begränsad eller ingen permeabili- tet för vatten och vattenänga. 114782
6. Förfarande enligt nägot av de föregäende pa-tentkraven, kännetecknat av att E-vitaminderivatet som använts är alfa-tokoferol, alfa-tokoferolacetat, alfa-tokoferolsuckinat och/eller alfa-tokoferolnikotinat. 5
7. Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att man använder en E-vitamin- och/eller E-vitaminderivatkoncentration, som är i omrädet 0,5 - 20 vikt-%, i synnerhet 1 - 100 vikt-% beräk-nat frän matrixen. 10
8. Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att man framställer ett pläster, vars godtagbara storlek är högst cirka 200 cm2, varvid det aktiva ämnets koncentration i blodet bringas närä en terapeutiskt önskad koncentration i blodet genom 15 regiering av E-vitamin- och/eller E-vitaminderivathalten. * * » ' * ♦
FI954989A 1993-04-20 1995-10-19 Förfarande för framställning av ett medicinplåster i form av ett laminat FI114782B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4312818 1993-04-20
DE4312818 1993-04-20
DE19934339400 DE4339400A1 (de) 1993-11-18 1993-11-18 Wirkstoffpflaster
DE4339400 1993-11-18
EP9401231 1994-04-20
PCT/EP1994/001231 WO1994023707A1 (de) 1993-04-20 1994-04-20 Wirkstoffplaster

Publications (3)

Publication Number Publication Date
FI954989A0 FI954989A0 (sv) 1995-10-19
FI954989A FI954989A (sv) 1995-10-19
FI114782B true FI114782B (sv) 2004-12-31

Family

ID=25925074

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954989A FI114782B (sv) 1993-04-20 1995-10-19 Förfarande för framställning av ett medicinplåster i form av ett laminat

Country Status (14)

Country Link
US (2) US5683711A (sv)
EP (2) EP0695177B1 (sv)
JP (1) JP3489831B2 (sv)
AT (2) ATE163262T1 (sv)
AU (1) AU678237B2 (sv)
CA (1) CA2161004C (sv)
DE (2) DE59405277D1 (sv)
DK (2) DK0813865T3 (sv)
ES (2) ES2164286T3 (sv)
FI (1) FI114782B (sv)
HU (2) HU223045B1 (sv)
NO (1) NO311829B1 (sv)
PT (1) PT813865E (sv)
WO (1) WO1994023707A1 (sv)

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DE19533089C1 (de) 1995-09-07 1997-05-22 Hexal Ag Tacrin-Pflaster
DE19642043A1 (de) * 1995-10-23 1997-04-24 Hexal Ag Transdermales therapeutisches System (TTS) für die Verabreichung von Wirkstoffen zur Behandlung von Drogenabhängigkeit oder Drogensucht
DE19548332A1 (de) * 1995-12-22 1997-07-10 Rotta Res Bv Hormonpflaster
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US6767902B2 (en) 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
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AU1800099A (en) 1997-11-25 1999-06-15 Theratech, Inc. Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties
DE19814257A1 (de) 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
DE19828273B4 (de) * 1998-06-25 2005-02-24 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren
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Also Published As

Publication number Publication date
ATE163262T1 (de) 1998-03-15
EP0813865B1 (de) 2001-09-19
HUT73668A (en) 1996-09-30
DE59405277D1 (de) 1998-03-26
ES2164286T3 (es) 2002-02-16
HU223045B1 (hu) 2004-03-01
ATE205706T1 (de) 2001-10-15
NO954186D0 (no) 1995-10-19
EP0813865A1 (de) 1997-12-29
FI954989A0 (sv) 1995-10-19
HU0301253D0 (en) 2003-07-28
AU678237B2 (en) 1997-05-22
AU6569694A (en) 1994-11-08
DK0813865T3 (da) 2001-11-19
US5830505A (en) 1998-11-03
EP0695177B1 (de) 1998-02-18
NO954186L (no) 1995-10-19
JPH09501398A (ja) 1997-02-10
PT813865E (pt) 2002-02-28
JP3489831B2 (ja) 2004-01-26
HU223042B1 (hu) 2004-03-01
CA2161004A1 (en) 1994-10-27
DE59409873D1 (de) 2001-10-25
FI954989A (sv) 1995-10-19
ES2115231T3 (es) 1998-06-16
NO311829B1 (no) 2002-02-04
EP0695177A1 (de) 1996-02-07
CA2161004C (en) 2004-10-26
DK0695177T3 (da) 1998-09-28
WO1994023707A1 (de) 1994-10-27
HU9502994D0 (en) 1995-12-28
US5683711A (en) 1997-11-04

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