FI102678B1 - Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste

Info

Publication number: FI102678B1
Authority: FI; Finland
Prior art keywords: hydroxymethylindazole; benzyl; preparation; intermediate compound; therapeutically useful
Prior art date: 1989-02-07

Application number

FI900577A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI900577A0 (fi

FI102678B (fi

Inventor

Bruno Silvestrini

Leandro Baiocchi

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-07

Filing date

1990-02-06

Publication date

1999-01-29

1990-02-06 Application filed by Acraf filed Critical Acraf

1990-02-06 Publication of FI900577A0 publication Critical patent/FI900577A0/fi

1999-01-29 Application granted granted Critical

1999-01-29 Publication of FI102678B publication Critical patent/FI102678B/fi

1999-01-29 Publication of FI102678B1 publication Critical patent/FI102678B1/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

FI900577A 1989-02-07 1990-02-06 Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste FI102678B1 (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8947620A IT1230441B (it)	1989-02-07	1989-02-07	Eteri della serie dell'indazolo

Publications (3)

Publication Number	Publication Date
FI900577A0 FI900577A0 (fi)	1990-02-06
FI102678B FI102678B (fi)	1999-01-29
FI102678B1 true FI102678B1 (fi)	1999-01-29

Family

ID=11261479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI900577A FI102678B1 (fi)	1989-02-07	1990-02-06	Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste

Country Status (36)

Country	Link
US (2)	US4999367A (it)
EP (1)	EP0382276B1 (it)
JP (1)	JP2870925B2 (it)
KR (1)	KR0145525B1 (it)
CN (2)	CN1046505C (it)
AR (1)	AR247386A1 (it)
AT (1)	ATE127115T1 (it)
AU (1)	AU624895B2 (it)
BG (1)	BG50273A3 (it)
CA (1)	CA2009503C (it)
CZ (1)	CZ280121B6 (it)
DD (2)	DD291995A5 (it)
DE (2)	DE69021902T2 (it)
DK (1)	DK0382276T3 (it)
EG (1)	EG19170A (it)
ES (1)	ES2020171T3 (it)
FI (1)	FI102678B1 (it)
GE (1)	GEP19971030B (it)
GR (2)	GR910300073T1 (it)
HU (1)	HU204793B (it)
IL (1)	IL93132A (it)
IN (1)	IN170957B (it)
IT (1)	IT1230441B (it)
LT (1)	LT3604B (it)
LV (1)	LV10612B (it)
NZ (1)	NZ232258A (it)
PE (1)	PE25091A1 (it)
PH (1)	PH26552A (it)
PL (2)	PL163730B1 (it)
PT (1)	PT93067B (it)
RO (1)	RO106252B1 (it)
RU (3)	RU2066318C1 (it)
SK (1)	SK278441B6 (it)
UA (1)	UA26852C2 (it)
YU (1)	YU47943B (it)
ZA (1)	ZA90644B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1253703B (it) *	1991-04-22	1995-08-23	Angelini Francesco Ist Ricerca	Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it)	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) *	1997-11-26	1999-08-24	Intel Corporation	Two-transistor DRAM cell for logic process technology
US7514463B2 (en) *	2004-08-20	2009-04-07	University Of Kansas	Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it)	2006-11-24	2008-05-25	Acraf	Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
CN101959866B (zh)	2008-03-07	2013-10-02	方济各安吉利克化学联合股份有限公司	1-苄基-3-羟基甲基吲唑衍生物及其在治疗基于mcp-1和cx3cr1表达的疾病中的用途
WO2009109618A2 (en) *	2008-03-07	2009-09-11	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
CA2714436C (en)	2008-03-07	2017-06-27	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
MX2012001520A (es) *	2009-08-03	2012-06-01	Acraf	Proceso para la preparacion de 1-bencil-3-hidroximetil-1h-indazol y sus derivados e intermediarios de magnesio requeridos.
UA108742C2 (uk) *	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
DK2844250T3 (en)	2012-05-01	2018-01-08	Translatum Medicus Inc	METHODS OF TREATMENT AND DIAGNOSTICATION OF EYE DISEASES CONCERNING BLINDNESS
US8999292B2 (en)	2012-05-01	2015-04-07	Translatum Medicus Inc.	Methods for treating and diagnosing blinding eye diseases
PT2882715T (pt)	2012-05-18	2016-12-30	Sanofi Sa	Derivados de pirazol e seu uso como antagonistas de lpar5
US9346757B2 (en)	2012-05-18	2016-05-24	Sanofi	Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
CN108047136B (zh) *	2017-12-20	2021-07-09	长春普华制药股份有限公司	一种苄达酸的精制方法
EP3990433A4 (en) *	2019-06-25	2023-07-26	Translatum Medicus Inc.	METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
CN113929627A (zh) *	2021-10-19	2022-01-14	吕梁学院	一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL28032A (en) *	1966-08-29	1971-08-25	Acraf	Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) *	1969-01-29	1969-09-30	Acraf	Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it)	1980-07-29	1986-06-25	Acraf	Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it)	1981-11-27	1988-01-28	Acraf	Trattamento della cataratta
IT1194564B (it)	1983-04-18	1988-09-22	Acraf	Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it)	1986-08-01	1988-12-06	Acraf	Metodo per il tratamento di lenti a contatto

1989
- 1989-02-07 IT IT8947620A patent/IT1230441B/it active
1990
- 1990-01-22 IL IL9313290A patent/IL93132A/en not_active IP Right Cessation
- 1990-01-23 DE DE69021902T patent/DE69021902T2/de not_active Expired - Lifetime
- 1990-01-23 AT AT90200167T patent/ATE127115T1/de not_active IP Right Cessation
- 1990-01-23 ES ES90200167T patent/ES2020171T3/es not_active Expired - Lifetime
- 1990-01-23 EP EP90200167A patent/EP0382276B1/en not_active Expired - Lifetime
- 1990-01-23 DE DE199090200167T patent/DE382276T1/de active Pending
- 1990-01-23 DK DK90200167.6T patent/DK0382276T3/da active
- 1990-01-24 US US07/470,118 patent/US4999367A/en not_active Expired - Lifetime
- 1990-01-26 NZ NZ232258A patent/NZ232258A/en unknown
- 1990-01-29 ZA ZA90644A patent/ZA90644B/xx unknown
- 1990-01-30 PE PE1990164654A patent/PE25091A1/es unknown
- 1990-01-30 IN IN81/CAL/90A patent/IN170957B/en unknown
- 1990-02-02 AU AU49066/90A patent/AU624895B2/en not_active Expired
- 1990-02-05 YU YU20690A patent/YU47943B/sh unknown
- 1990-02-05 PL PL90285287A patent/PL163730B1/pl unknown
- 1990-02-05 PL PL90283638A patent/PL163720B1/pl unknown
- 1990-02-05 RO RO144074A patent/RO106252B1/ro unknown
- 1990-02-06 UA UA4743128A patent/UA26852C2/uk unknown
- 1990-02-06 PT PT93067A patent/PT93067B/pt active IP Right Grant
- 1990-02-06 RU SU904743128A patent/RU2066318C1/ru active
- 1990-02-06 CZ CS90563A patent/CZ280121B6/cs not_active IP Right Cessation
- 1990-02-06 BG BG91122A patent/BG50273A3/xx unknown
- 1990-02-06 JP JP2027007A patent/JP2870925B2/ja not_active Expired - Lifetime
- 1990-02-06 FI FI900577A patent/FI102678B1/fi active IP Right Grant
- 1990-02-06 EG EG6290A patent/EG19170A/xx active
- 1990-02-06 PH PH40002A patent/PH26552A/en unknown
- 1990-02-06 AR AR90316095A patent/AR247386A1/es active
- 1990-02-06 SK SK563-90A patent/SK278441B6/sk not_active IP Right Cessation
- 1990-02-06 HU HU90689A patent/HU204793B/hu unknown
- 1990-02-07 DD DD90337657A patent/DD291995A5/de unknown
- 1990-02-07 CA CA002009503A patent/CA2009503C/en not_active Expired - Lifetime
- 1990-02-07 KR KR1019900001453A patent/KR0145525B1/ko not_active IP Right Cessation
- 1990-02-07 CN CN90100599A patent/CN1046505C/zh not_active Expired - Fee Related
- 1990-02-07 DD DD90342349A patent/DD295363A5/de unknown
- 1990-12-20 US US07/632,117 patent/US5112986A/en not_active Expired - Lifetime
1991
- 1991-06-05 RU SU914895526A patent/RU2055071C1/ru active
- 1991-06-05 RU SU914895540A patent/RU2044729C1/ru active
- 1991-11-15 GR GR91300073T patent/GR910300073T1/el unknown
1993
- 1993-06-22 LV LVP-93-647A patent/LV10612B/lv unknown
- 1993-07-26 GE GEAP19931214A patent/GEP19971030B/en unknown
- 1993-08-17 LT LTIP872A patent/LT3604B/lt not_active IP Right Cessation
- 1993-09-15 CN CN93117740A patent/CN1034016C/zh not_active Expired - Fee Related
1995
- 1995-11-22 GR GR950403284T patent/GR3018165T3/el unknown

Also Published As

Publication number	Publication date
EP0382276B1 (en)	1995-08-30
IL93132A0 (en)	1990-11-05
PE25091A1 (es)	1991-08-17
YU47943B (sh)	1996-07-24
LTIP872A (en)	1995-03-27
LT3604B (en)	1995-12-27
CZ280121B6 (cs)	1995-11-15
FI900577A0 (fi)	1990-02-06
DE69021902T2 (de)	1996-05-23
PT93067A (pt)	1990-08-31
DD295363A5 (de)	1991-10-31
JP2870925B2 (ja)	1999-03-17
ATE127115T1 (de)	1995-09-15
US5112986A (en)	1992-05-12
SK56390A3 (en)	1997-05-07
RU2066318C1 (ru)	1996-09-10
ES2020171A4 (es)	1991-08-01
HUT53088A (en)	1990-09-28
EG19170A (en)	1994-11-30
GR3018165T3 (en)	1996-02-29
KR900012913A (ko)	1990-09-03
IN170957B (it)	1992-06-20
AU4906690A (en)	1990-08-16
RU2044729C1 (ru)	1995-09-27
CN1046505C (zh)	1999-11-17
PH26552A (en)	1992-08-19
YU20690A (sh)	1992-07-20
CN1088201A (zh)	1994-06-22
PL163720B1 (pl)	1994-04-29
JPH02240065A (ja)	1990-09-25
NZ232258A (en)	1991-06-25
RO106252B1 (ro)	1993-03-31
DD291995A5 (de)	1991-07-18
US4999367A (en)	1991-03-12
DK0382276T3 (da)	1996-01-15
KR0145525B1 (ko)	1998-08-17
HU204793B (en)	1992-02-28
CA2009503C (en)	2000-04-11
GR910300073T1 (en)	1991-11-15
FI102678B (fi)	1999-01-29
DE382276T1 (de)	1991-11-28
DE69021902D1 (de)	1995-10-05
AU624895B2 (en)	1992-06-25
PL163730B1 (pl)	1994-04-29
PT93067B (pt)	1995-12-29
GEP19971030B (en)	1997-06-13
ES2020171T3 (es)	1995-12-01
IL93132A (en)	1994-05-30
CN1034016C (zh)	1997-02-12
HU900689D0 (en)	1990-04-28
EP0382276A3 (en)	1990-12-12
IT1230441B (it)	1991-10-23
UA26852C2 (uk)	1999-12-29
SK278441B6 (en)	1997-05-07
ZA90644B (en)	1991-01-30
AR247386A1 (es)	1994-12-29
CA2009503A1 (en)	1990-08-07
EP0382276A2 (en)	1990-08-16
BG50273A3 (en)	1992-06-15
RU2055071C1 (ru)	1996-02-27
IT8947620A0 (it)	1989-02-07
LV10612B (en)	1995-08-20
LV10612A (lv)	1995-04-20
CN1044810A (zh)	1990-08-22
CZ56390A3 (en)	1995-06-14

Legal Events

Date	Code	Title	Description
1990-02-06	FG	Patent granted	Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI
2004-08-31	FG	Patent granted	Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI

Publication	Publication Date	Title
FI104170B1 (fi)	1999-11-30	Menetelmä terapeuttisesti käyttökelpoisten 3-amidopyratsolijohdannaisten valmistamiseksi
NO179584C (no)	1996-11-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
FI885943A (fi)	1989-06-24	Menetelmä uusien terapeuttisesti käyttökelpoisten adenosiinijohdannaisten valmistamiseksi ja välituotteita
FI94250B (fi)	1995-04-28	Menetelmä uusien, terapeuttisesti käyttökelpoisten eetterien valmistamiseksi
FI881223A0 (fi)	1988-03-15	Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi
FI102678B1 (fi)	1999-01-29	Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste
IS3529A7 (is)	1990-07-24	Hliðstæð aðferð við framleiðslu á meðferðarvirkum bis-aza-bísýklískum efnasamböndum
FI895757A0 (fi)	1989-12-01	Menetelmä terapeuttisesti käyttökelpoisten propenonioksiimieettereiden valmistamiseksi
FI850654L (fi)	1985-08-18	Menetelmä terapeuttisesti käyttökelpoisten pleuromutilinijohdannaisten valmistamiseksi
FI895417A0 (fi)	1989-11-14	Menetelmä uusien terapeuttisesti käyttökelpoisten 2'-halometylideeninukleosidien valmistamiseksi
FI92696C (fi)	1994-12-27	Menetelmä terapeuttisesti käyttökelpoisten tiatsolidiinidionijohdannaisten valmistamiseksi
FI895393A0 (fi)	1989-11-13	Menetelmä terapeuttisesti käyttökelpoisten alkyylisubstituoitujen 2-alkyyliamiinibentsopyran-6-olien valmistamiseksi
FI883672A (fi)	1989-02-08	Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi
FI95701C (fi)	1996-03-11	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI892948A0 (fi)	1989-06-15	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI893003A (fi)	1989-12-21	Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
FI911420A0 (fi)	1991-03-25	Menetelmä terapeuttisesti käyttökelpoisten yhdisteiden valmistamiseksi
FI92064C (fi)	1994-09-26	Menetelmä terapeuttisesti käyttökelpoisten N-bentsopyranyylilaktaamien valmistamiseksi
FI92825C (fi)	1995-01-10	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
NO174203C (no)	1994-04-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive
FI884473A (fi)	1989-04-02	Menetelmä terapeuttisesti käyttökelpoisten fenoksialkyylipyrokatekolijohdannaisten valmistamiseksi
PT86938A (pt)	1988-04-01	Process for the preparation of a macrocyclic compound
FI892420A0 (fi)	1989-05-19	Menetelmä terapeuttisesti käyttökelpoisten 2-aminoetanolijohdannaisten valmistamiseksi
FI893434A (fi)	1990-01-16	Menetelmä uusien terapeuttisesti käyttökelpoisten sykloalkyylitiatsolijohdannaisten valmistamiseksi
NO175780C (no)	1994-12-07	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte dibenzofuraner