FI900577A0 - 1-bentzyl-3-hydroximetyl-indazoletrar med alifatiska 2-hydroxisyror. - Google Patents

1-bentzyl-3-hydroximetyl-indazoletrar med alifatiska 2-hydroxisyror.

Info

Publication number: FI900577A0
Authority: FI; Finland
Prior art keywords: indazoletrar; hydroxisyror; bentzyl; alifatiska; hydroximethyl
Prior art date: 1989-02-07

Application number

FI900577A

Other languages

English (en)

Other versions

FI102678B (fi

FI102678B1 (fi

Inventor

Bruno Silvestrini

Leandro Baiocchi

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-07

Filing date

1990-02-06

Publication date

1990-02-06

1990-02-06 Application filed by Acraf filed Critical Acraf

1990-02-06 Publication of FI900577A0 publication Critical patent/FI900577A0/fi

1999-01-29 Application granted granted Critical

1999-01-29 Publication of FI102678B publication Critical patent/FI102678B/fi

1999-01-29 Publication of FI102678B1 publication Critical patent/FI102678B1/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Thiazole And Isothizaole Compounds (AREA)

FI900577A 1989-02-07 1990-02-06 Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste FI102678B1 (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8947620A IT1230441B (it)	1989-02-07	1989-02-07	Eteri della serie dell'indazolo

Publications (3)

Publication Number	Publication Date
FI900577A0 true FI900577A0 (fi)	1990-02-06
FI102678B FI102678B (fi)	1999-01-29
FI102678B1 FI102678B1 (fi)	1999-01-29

Family

ID=11261479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI900577A FI102678B1 (fi)	1989-02-07	1990-02-06	Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste

Country Status (36)

Country	Link
US (2)	US4999367A (fi)
EP (1)	EP0382276B1 (fi)
JP (1)	JP2870925B2 (fi)
KR (1)	KR0145525B1 (fi)
CN (2)	CN1046505C (fi)
AR (1)	AR247386A1 (fi)
AT (1)	ATE127115T1 (fi)
AU (1)	AU624895B2 (fi)
BG (1)	BG50273A3 (fi)
CA (1)	CA2009503C (fi)
CZ (1)	CZ280121B6 (fi)
DD (2)	DD291995A5 (fi)
DE (2)	DE69021902T2 (fi)
DK (1)	DK0382276T3 (fi)
EG (1)	EG19170A (fi)
ES (1)	ES2020171T3 (fi)
FI (1)	FI102678B1 (fi)
GE (1)	GEP19971030B (fi)
GR (2)	GR910300073T1 (fi)
HU (1)	HU204793B (fi)
IL (1)	IL93132A (fi)
IN (1)	IN170957B (fi)
IT (1)	IT1230441B (fi)
LT (1)	LT3604B (fi)
LV (1)	LV10612B (fi)
NZ (1)	NZ232258A (fi)
PE (1)	PE25091A1 (fi)
PH (1)	PH26552A (fi)
PL (2)	PL163730B1 (fi)
PT (1)	PT93067B (fi)
RO (1)	RO106252B1 (fi)
RU (3)	RU2066318C1 (fi)
SK (1)	SK278441B6 (fi)
UA (1)	UA26852C2 (fi)
YU (1)	YU47943B (fi)
ZA (1)	ZA90644B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1253703B (it) *	1991-04-22	1995-08-23	Angelini Francesco Ist Ricerca	Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it)	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) *	1997-11-26	1999-08-24	Intel Corporation	Two-transistor DRAM cell for logic process technology
US7514463B2 (en) *	2004-08-20	2009-04-07	University Of Kansas	Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it)	2006-11-24	2008-05-25	Acraf	Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
LT2254869T (lt)	2008-03-07	2017-08-10	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Nauji 1-benzil-3-hidroksimetilindazolo dariniai ir jų panaudojimas gydyme ligų, susijusių su cx3cr1 ir p40 raiška
AU2009221063B2 (en)	2008-03-07	2013-03-21	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
US8461194B2 (en)	2008-03-07	2013-06-11	Aziende Chimiche Riunite Angelini Francesco A. C. R. A. F. S. P. A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40
MX2012001520A (es) *	2009-08-03	2012-06-01	Acraf	Proceso para la preparacion de 1-bencil-3-hidroximetil-1h-indazol y sus derivados e intermediarios de magnesio requeridos.
UA108742C2 (uk) *	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
CA2911041C (en)	2012-05-01	2020-12-15	Shelley Romayne BOYD	Methods for treating and diagnosing blinding eye diseases
US8999292B2 (en)	2012-05-01	2015-04-07	Translatum Medicus Inc.	Methods for treating and diagnosing blinding eye diseases
JP2015521183A (ja)	2012-05-18	2015-07-27	サノフイ	ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用
SI2882715T1 (sl)	2012-05-18	2017-03-31	Sanofi	Derivati pirazola in njihova uporaba kot antagonisti LPAR5
CN108047136B (zh) *	2017-12-20	2021-07-09	长春普华制药股份有限公司	一种苄达酸的精制方法
WO2020261158A1 (en) *	2019-06-25	2020-12-30	Translatum Medicus Inc.	Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) *	2021-10-19	2022-01-14	吕梁学院	一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL28032A (en) *	1966-08-29	1971-08-25	Acraf	Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) *	1969-01-29	1969-09-30	Acraf	Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it)	1980-07-29	1986-06-25	Acraf	Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it)	1981-11-27	1988-01-28	Acraf	Trattamento della cataratta
IT1194564B (it)	1983-04-18	1988-09-22	Acraf	Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it)	1986-08-01	1988-12-06	Acraf	Metodo per il tratamento di lenti a contatto

1989
- 1989-02-07 IT IT8947620A patent/IT1230441B/it active
1990
- 1990-01-22 IL IL9313290A patent/IL93132A/en not_active IP Right Cessation
- 1990-01-23 AT AT90200167T patent/ATE127115T1/de not_active IP Right Cessation
- 1990-01-23 DK DK90200167.6T patent/DK0382276T3/da active
- 1990-01-23 ES ES90200167T patent/ES2020171T3/es not_active Expired - Lifetime
- 1990-01-23 DE DE69021902T patent/DE69021902T2/de not_active Expired - Lifetime
- 1990-01-23 DE DE199090200167T patent/DE382276T1/de active Pending
- 1990-01-23 EP EP90200167A patent/EP0382276B1/en not_active Expired - Lifetime
- 1990-01-24 US US07/470,118 patent/US4999367A/en not_active Expired - Lifetime
- 1990-01-26 NZ NZ232258A patent/NZ232258A/en unknown
- 1990-01-29 ZA ZA90644A patent/ZA90644B/xx unknown
- 1990-01-30 IN IN81/CAL/90A patent/IN170957B/en unknown
- 1990-01-30 PE PE1990164654A patent/PE25091A1/es unknown
- 1990-02-02 AU AU49066/90A patent/AU624895B2/en not_active Expired
- 1990-02-05 PL PL90285287A patent/PL163730B1/pl unknown
- 1990-02-05 RO RO144074A patent/RO106252B1/ro unknown
- 1990-02-05 YU YU20690A patent/YU47943B/sh unknown
- 1990-02-05 PL PL90283638A patent/PL163720B1/pl unknown
- 1990-02-06 HU HU90689A patent/HU204793B/hu unknown
- 1990-02-06 EG EG6290A patent/EG19170A/xx active
- 1990-02-06 SK SK563-90A patent/SK278441B6/sk not_active IP Right Cessation
- 1990-02-06 UA UA4743128A patent/UA26852C2/uk unknown
- 1990-02-06 PH PH40002A patent/PH26552A/en unknown
- 1990-02-06 AR AR90316095A patent/AR247386A1/es active
- 1990-02-06 CZ CS90563A patent/CZ280121B6/cs not_active IP Right Cessation
- 1990-02-06 PT PT93067A patent/PT93067B/pt active IP Right Grant
- 1990-02-06 JP JP2027007A patent/JP2870925B2/ja not_active Expired - Lifetime
- 1990-02-06 BG BG91122A patent/BG50273A3/xx unknown
- 1990-02-06 RU SU904743128A patent/RU2066318C1/ru active
- 1990-02-06 FI FI900577A patent/FI102678B1/fi active IP Right Grant
- 1990-02-07 CN CN90100599A patent/CN1046505C/zh not_active Expired - Fee Related
- 1990-02-07 DD DD90337657A patent/DD291995A5/de unknown
- 1990-02-07 KR KR1019900001453A patent/KR0145525B1/ko not_active IP Right Cessation
- 1990-02-07 DD DD90342349A patent/DD295363A5/de unknown
- 1990-02-07 CA CA002009503A patent/CA2009503C/en not_active Expired - Lifetime
- 1990-12-20 US US07/632,117 patent/US5112986A/en not_active Expired - Lifetime
1991
- 1991-06-05 RU SU914895526A patent/RU2055071C1/ru active
- 1991-06-05 RU SU914895540A patent/RU2044729C1/ru active
- 1991-11-15 GR GR91300073T patent/GR910300073T1/el unknown
1993
- 1993-06-22 LV LVP-93-647A patent/LV10612B/lv unknown
- 1993-07-26 GE GEAP19931214A patent/GEP19971030B/en unknown
- 1993-08-17 LT LTIP872A patent/LT3604B/lt not_active IP Right Cessation
- 1993-09-15 CN CN93117740A patent/CN1034016C/zh not_active Expired - Fee Related
1995
- 1995-11-22 GR GR950403284T patent/GR3018165T3/el unknown

Also Published As

Publication number	Publication date
AU4906690A (en)	1990-08-16
UA26852C2 (uk)	1999-12-29
EG19170A (en)	1994-11-30
IL93132A (en)	1994-05-30
CZ280121B6 (cs)	1995-11-15
LV10612B (en)	1995-08-20
PH26552A (en)	1992-08-19
ATE127115T1 (de)	1995-09-15
CN1044810A (zh)	1990-08-22
GR910300073T1 (en)	1991-11-15
CN1046505C (zh)	1999-11-17
US4999367A (en)	1991-03-12
IL93132A0 (en)	1990-11-05
EP0382276A2 (en)	1990-08-16
JPH02240065A (ja)	1990-09-25
CZ56390A3 (en)	1995-06-14
GR3018165T3 (en)	1996-02-29
LT3604B (en)	1995-12-27
DK0382276T3 (da)	1996-01-15
DE69021902D1 (de)	1995-10-05
JP2870925B2 (ja)	1999-03-17
EP0382276B1 (en)	1995-08-30
CN1088201A (zh)	1994-06-22
RO106252B1 (ro)	1993-03-31
US5112986A (en)	1992-05-12
AU624895B2 (en)	1992-06-25
DE69021902T2 (de)	1996-05-23
RU2044729C1 (ru)	1995-09-27
PT93067A (pt)	1990-08-31
IT8947620A0 (it)	1989-02-07
SK56390A3 (en)	1997-05-07
IN170957B (fi)	1992-06-20
HU900689D0 (en)	1990-04-28
FI102678B (fi)	1999-01-29
LV10612A (lv)	1995-04-20
DE382276T1 (de)	1991-11-28
DD295363A5 (de)	1991-10-31
DD291995A5 (de)	1991-07-18
HU204793B (en)	1992-02-28
SK278441B6 (en)	1997-05-07
HUT53088A (en)	1990-09-28
KR900012913A (ko)	1990-09-03
PL163720B1 (pl)	1994-04-29
IT1230441B (it)	1991-10-23
NZ232258A (en)	1991-06-25
ZA90644B (en)	1991-01-30
PL163730B1 (pl)	1994-04-29
CA2009503A1 (en)	1990-08-07
RU2066318C1 (ru)	1996-09-10
LTIP872A (en)	1995-03-27
BG50273A3 (en)	1992-06-15
ES2020171A4 (es)	1991-08-01
FI102678B1 (fi)	1999-01-29
GEP19971030B (en)	1997-06-13
PE25091A1 (es)	1991-08-17
RU2055071C1 (ru)	1996-02-27
PT93067B (pt)	1995-12-29
EP0382276A3 (en)	1990-12-12
YU47943B (sh)	1996-07-24
YU20690A (sh)	1992-07-20
CA2009503C (en)	2000-04-11
ES2020171T3 (es)	1995-12-01
KR0145525B1 (ko)	1998-08-17
AR247386A1 (es)	1994-12-29
CN1034016C (zh)	1997-02-12

Legal Events

Date	Code	Title	Description
1990-02-06	FG	Patent granted	Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI
2004-08-31	FG	Patent granted	Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI

Publication	Publication Date	Title
FI904418A0 (fi)	1990-09-07	Ljusskyddskompositioner med minskad hudirriterande effekt.
FI901243A0 (fi)	1990-03-13	Antiperspirantcremer med laog aoterstod.
FI901789A0 (fi)	1990-04-09	Med naolskydd foersedd kateter.
FI901913A0 (fi)	1990-04-17	Tillaeggsanordning foer anvaendning med aerosolbehaollare.
FI901665A0 (fi)	1990-04-02	Tillverkningsanlaeggning med parallell- och sidotransportbanor.
FI903461A0 (fi)	1990-07-09	Kateter med naoltaetning.
FI904520A0 (fi)	1990-09-13	Med haeftningsperforering foersedd stoetdaempande stoppningsprodukt.
FI904416A0 (fi)	1990-09-07	Plasmabaogskaerbraennare med foerlaengd nedre munstycksdel.
FI901356A0 (fi)	1990-03-19	Med luktkontrollmaterial foersedda absorberande strukturer.
FI903619A0 (fi)	1990-07-18	Formningsduk med tvaerriktade mellantraodar.
FI902429A0 (fi)	1990-05-16	Kateter med aoterstroemningsstrypning.
FI901639A0 (fi)	1990-04-02	Golvreningsmaskin med foerbaettrad kontroll foer borsttrycket.
FI901321A0 (fi)	1990-03-16	Med bindemedel oeverdragen kapillaer transportzon.
FI900741A0 (fi)	1990-02-14	Med ultraviolett straolning haerdbart epoxisilikon-/polyolsystem.
FI900577A0 (fi)	1990-02-06	1-bentzyl-3-hydroximetyl-indazoletrar med alifatiska 2-hydroxisyror.
FI900237A0 (fi)	1990-01-16	Agglomerat med laog taethet.
FI901808A0 (fi)	1990-04-10	Sluten slaepvagn-baot med indragbara hjul.
FI901402A0 (fi)	1990-03-20	Oeverledningsanordning foer flaskor fyllda med medicinskt verksam vaetska.
FI901944A0 (fi)	1990-04-18	Hartsbindemedel med foerbaettrad utspaedbarhet.
FI895186A0 (fi)	1989-11-01	Dubbeldiffusoer med aoterspolningskolvar.
FI900859A0 (fi)	1990-02-21	Aminohartsloesningar med liten elektrisk ledningsfoermaoga.
FI901735A0 (fi)	1990-04-05	Tandborste med doseringsanordning foer tandkraem.
FI900489A0 (fi)	1990-01-31	Kontnaerers sektional spaennram med en kanfas.
FI901831A0 (fi)	1990-04-11	Glaskanna med plastlock foer kaffe- och tekokare.
FI903517A0 (fi)	1990-07-11	Foerkortat faergverk med felfri faergzon.