ES8900050A1 - Procedimiento para aislar (oxi)hemoglobina de soluciones o mezclas a base de la misma - Google Patents
Procedimiento para aislar (oxi)hemoglobina de soluciones o mezclas a base de la mismaInfo
- Publication number
- ES8900050A1 ES8900050A1 ES556778A ES556778A ES8900050A1 ES 8900050 A1 ES8900050 A1 ES 8900050A1 ES 556778 A ES556778 A ES 556778A ES 556778 A ES556778 A ES 556778A ES 8900050 A1 ES8900050 A1 ES 8900050A1
- Authority
- ES
- Spain
- Prior art keywords
- hemoglobin
- gel
- purification
- affinity chromatography
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
COMPRENDE LAS ETAPAS DE: A). TRATAMIENTO DE LA SOLUCION O MEZCLA QUE CONTIENE AL OXI(HEMOGLOBINA) EN FASE LIQUIDA, A TEMPERATURAS DE 0 A 37GC Y A UN PH DE 6-10, CON UN GEL CROMOTOGRAFICO DE AFINIDAD EN FASE SOLIDA, INSOLUBLE EN LA SOLUCION O MEZCLA EN FASE LIQUIDA, TENIENDO ENLAZADO QUIMICAMENTE UN POLIANION QUE SE ENLAZA ESPECIFICAMENTE CON HEMOGLOBINA POR MEDIO DE SU PUNTO DE ENLACE POLIANIONICO, SIENDO SELECCIONADO DICHO POLIANION ENTRE TRIFOSFATOS DE NUCLEOSICOS, DIFOSFOGLICERATOS, FOSFATOS DE MOSITOL Y SULFATOS DE MOSITOL. B). SEPARACION DEL GEL, RETENIENDO SOBRE EL MISMO LA OXI(HEMOGLOBINA), DE LOS OTROS COMPONENTES DE LA SOLUCION O MEZCLA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000485392A CA1244349A (en) | 1985-06-26 | 1985-06-26 | Purification of hemoglobin and modified hemoglobin by affinity chromatography |
Publications (2)
Publication Number | Publication Date |
---|---|
ES556778A0 ES556778A0 (es) | 1988-11-16 |
ES8900050A1 true ES8900050A1 (es) | 1988-11-16 |
Family
ID=4130840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES556778A Expired ES8900050A1 (es) | 1985-06-26 | 1986-06-25 | Procedimiento para aislar (oxi)hemoglobina de soluciones o mezclas a base de la misma |
Country Status (17)
Country | Link |
---|---|
US (1) | US4925574A (es) |
EP (1) | EP0231236B1 (es) |
JP (1) | JPS63500305A (es) |
CN (1) | CN86104458A (es) |
AR (1) | AR241140A1 (es) |
AT (1) | ATE68189T1 (es) |
AU (1) | AU595819B2 (es) |
CA (1) | CA1244349A (es) |
DE (1) | DE3681909D1 (es) |
DK (1) | DK95987D0 (es) |
ES (1) | ES8900050A1 (es) |
GB (1) | GB2178742B (es) |
IL (1) | IL79147A0 (es) |
MX (1) | MX168403B (es) |
NZ (1) | NZ216639A (es) |
WO (1) | WO1987000177A1 (es) |
ZA (1) | ZA864697B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753616A (en) * | 1986-11-10 | 1998-05-19 | Biopure Corporation | Method for producing a stable polymerized hemoglobin blood-substitute |
US5955581A (en) * | 1986-11-10 | 1999-09-21 | Biopure Corporation | Method for producing a stable polymerized hemoglobin blood-substitute |
JP2732252B2 (ja) * | 1987-12-07 | 1998-03-25 | 株式会社ジェイ・エム・エス | ヘモグロビン選択吸着剤 |
CA1338244C (en) * | 1988-08-17 | 1996-04-09 | Xiang-Fu Wu | Purification of hemoglobin and methemoglobin by bioselective elution |
DE69222317T2 (de) * | 1991-11-25 | 1998-02-12 | Exxon Chemical Patents, Inc., Baytown, Tex. | Polyionische, uebergangsmetall enthaltende katalysatorzusammensetzung |
US6187744B1 (en) | 1992-03-11 | 2001-02-13 | Michael W. Rooney | Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject |
US5739037A (en) * | 1992-09-29 | 1998-04-14 | Drew Scientific Limited | Process for eliminating labile glycohaemoglobin from a sample |
US5578564A (en) * | 1993-07-23 | 1996-11-26 | Somatogen, Inc. | Nickel-free hemoglobin and methods for producing such hemoglobin |
US5840851A (en) * | 1993-07-23 | 1998-11-24 | Plomer; J. Jeffrey | Purification of hemoglobin |
US5741893A (en) * | 1993-08-16 | 1998-04-21 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5840701A (en) * | 1993-08-16 | 1998-11-24 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
TW381022B (en) * | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
US5767089A (en) * | 1993-08-16 | 1998-06-16 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5804561A (en) * | 1993-08-16 | 1998-09-08 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5824781A (en) * | 1993-08-16 | 1998-10-20 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5817632A (en) * | 1993-08-16 | 1998-10-06 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5807831A (en) * | 1993-08-16 | 1998-09-15 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5725839A (en) * | 1993-08-16 | 1998-03-10 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI |
CA2106612C (en) * | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
US5456835A (en) * | 1993-11-08 | 1995-10-10 | Hemasure, Inc. | Device and process for removing free hemoglobin from blood |
US5665869A (en) * | 1993-11-15 | 1997-09-09 | Somatogen, Inc. | Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin |
US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
US6150507A (en) * | 1995-03-23 | 2000-11-21 | Biopure Corporation | Method for producing a purified hemoglobin product |
US5691453A (en) * | 1995-06-07 | 1997-11-25 | Biopure Corporation | Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC |
JPH0912598A (ja) * | 1995-06-29 | 1997-01-14 | Sekisui Chem Co Ltd | ヘモグロビンの分離精製方法 |
US5741894A (en) * | 1995-09-22 | 1998-04-21 | Baxter International, Inc. | Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form |
WO1997019956A1 (en) * | 1995-11-30 | 1997-06-05 | Somatogen, Inc. | Method for control of functionality during cross-linking of hemoglobins |
US7531632B2 (en) | 2006-02-16 | 2009-05-12 | Gtc Biotherapeutics, Inc. | Clarification of transgenic milk using depth filtration |
US8273857B2 (en) * | 2009-09-22 | 2012-09-25 | Jen-Chang Hsia | Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine |
KR20160029840A (ko) | 2013-07-05 | 2016-03-15 | 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 | 친화성 크로마토그래피 매트릭스 |
TWI603772B (zh) * | 2016-05-25 | 2017-11-01 | 中華醫事科技大學 | 血紅素之純化方法及其設備 |
TWI626248B (zh) * | 2016-12-09 | 2018-06-11 | 中華醫事科技大學 | 血紅素及肌紅素之分離方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US32011A (en) * | 1861-04-09 | Coffee-pot | ||
US3350174A (en) * | 1964-01-08 | 1967-10-31 | Miles Lab | Process of determining hemoglobin separated from peroxidase inhibitors in urine |
US4011377A (en) * | 1971-02-11 | 1977-03-08 | Peter Duncan Goodearl Dean | Enzyme separation |
DE2319495C2 (de) * | 1973-04-17 | 1985-01-10 | Yeda Research And Development Co., Ltd., Rehovot | Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule |
US3873514A (en) * | 1974-05-17 | 1975-03-25 | Bio Rad Laboratories | Preparation of gel for affinity chromatography |
IL49752A (en) * | 1975-07-09 | 1979-07-25 | Kabi Ab | Compositions having affinity for hepatitis virus and method for hepatitis virus removal or concentration |
US4143203A (en) * | 1976-03-19 | 1979-03-06 | Amicon Corporation | Particulate support material |
DD149861A3 (de) * | 1976-08-12 | 1981-08-05 | Klaus Pommerening | Verfahren zur trennung bzw.reinigung von proteinen |
DE2652636A1 (de) * | 1976-11-19 | 1978-05-24 | Hans Uwe Dr Rer Nat Wolf | Verfahren zur stabilisierung von proteinen und verwandten verbindungen waehrend ihrer reinigung, isolierung und lagerung |
US4330440A (en) * | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
JPS5564599A (en) * | 1978-11-08 | 1980-05-15 | Unitika Ltd | Adenosine triphosphate derivative |
-
1985
- 1985-06-26 CA CA000485392A patent/CA1244349A/en not_active Expired
-
1986
- 1986-03-14 US US06/839,539 patent/US4925574A/en not_active Expired - Fee Related
- 1986-06-18 IL IL79147A patent/IL79147A0/xx not_active IP Right Cessation
- 1986-06-24 ZA ZA864697A patent/ZA864697B/xx unknown
- 1986-06-24 NZ NZ216639A patent/NZ216639A/xx unknown
- 1986-06-25 ES ES556778A patent/ES8900050A1/es not_active Expired
- 1986-06-25 AR AR304365A patent/AR241140A1/es active
- 1986-06-26 EP EP86904259A patent/EP0231236B1/en not_active Expired - Lifetime
- 1986-06-26 CN CN198686104458A patent/CN86104458A/zh active Pending
- 1986-06-26 GB GB8615675A patent/GB2178742B/en not_active Expired
- 1986-06-26 DE DE8686904259T patent/DE3681909D1/de not_active Expired - Fee Related
- 1986-06-26 AT AT86904259T patent/ATE68189T1/de not_active IP Right Cessation
- 1986-06-26 MX MX026907A patent/MX168403B/es unknown
- 1986-06-26 WO PCT/GB1986/000374 patent/WO1987000177A1/en active IP Right Grant
- 1986-06-26 AU AU61281/86A patent/AU595819B2/en not_active Ceased
- 1986-06-26 JP JP61503764A patent/JPS63500305A/ja active Pending
-
1987
- 1987-02-25 DK DK095987A patent/DK95987D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES556778A0 (es) | 1988-11-16 |
GB2178742B (en) | 1989-07-12 |
DE3681909D1 (de) | 1991-11-14 |
EP0231236B1 (en) | 1991-10-09 |
GB2178742A (en) | 1987-02-18 |
EP0231236A1 (en) | 1987-08-12 |
JPS63500305A (ja) | 1988-02-04 |
IL79147A0 (en) | 1986-09-30 |
WO1987000177A1 (en) | 1987-01-15 |
DK95987A (da) | 1987-02-25 |
GB8615675D0 (en) | 1986-07-30 |
AU595819B2 (en) | 1990-04-12 |
US4925574A (en) | 1990-05-15 |
ZA864697B (en) | 1987-04-29 |
AR241140A1 (es) | 1991-11-29 |
MX168403B (es) | 1993-05-24 |
ATE68189T1 (de) | 1991-10-15 |
NZ216639A (en) | 1988-09-29 |
AR241140A2 (es) | 1991-11-29 |
CA1244349A (en) | 1988-11-08 |
DK95987D0 (da) | 1987-02-25 |
AU6128186A (en) | 1987-01-30 |
CN86104458A (zh) | 1987-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |