ES8802028A1 - Procedimiento para preparar dihidropiridinas. - Google Patents
Procedimiento para preparar dihidropiridinas.Info
- Publication number
- ES8802028A1 ES8802028A1 ES551845A ES551845A ES8802028A1 ES 8802028 A1 ES8802028 A1 ES 8802028A1 ES 551845 A ES551845 A ES 551845A ES 551845 A ES551845 A ES 551845A ES 8802028 A1 ES8802028 A1 ES 8802028A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- bears
- phenylene
- dihydropyridine
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DIHIDROPIRIDINAS, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN EPOXIDO DE FORMULA GENERAL (II), EN LA QUE R1 ES ALQUILO O ALCOXIALQUILO/ R2 Y R3, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN CADA UNO DE ELLOS UN GRUPO ACIDO DE HASTA 6 ATOMOS DE CARBONO; R4 ES ACIDO O HIDROXIALQUILO; EL ANILLO BENCENO A LLEVA UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE HALOGENO, CIANO O NITRO; Y AR ES FENILENO, NAFTILENO O TETRAHIDRONAFTILENO; X ES OXIGENO O NH; E Y ES ALQUILENO DE CADENA RECTA O RAMIFICADA, CON UNA AMINA DE FORMULA GENERAL (III). DE APLICACION EN MEDICINA POR SUS PROPIEDADES ANTIHIPERTENSIVAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858503426A GB8503426D0 (en) | 1985-02-11 | 1985-02-11 | Pyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES551845A0 ES551845A0 (es) | 1988-03-16 |
ES8802028A1 true ES8802028A1 (es) | 1988-03-16 |
Family
ID=10574271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES551845A Expired ES8802028A1 (es) | 1985-02-11 | 1986-02-11 | Procedimiento para preparar dihidropiridinas. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0194046A1 (es) |
JP (1) | JPS61233668A (es) |
AU (1) | AU5326186A (es) |
DK (1) | DK65986A (es) |
ES (1) | ES8802028A1 (es) |
FI (1) | FI860620A (es) |
GB (1) | GB8503426D0 (es) |
GR (1) | GR860368B (es) |
HU (1) | HUT40413A (es) |
NO (1) | NO860464L (es) |
PT (1) | PT82007B (es) |
ZA (1) | ZA86815B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994476A (en) * | 1984-10-31 | 1991-02-19 | Bristol-Myers Company | Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties |
IL77843A (en) * | 1985-02-11 | 1989-07-31 | Syntex Inc | Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them |
EP0254682A1 (de) * | 1986-07-22 | 1988-01-27 | Ciba-Geigy Ag | Neue Phenoxyaliphatylphenylenoxyalkylester und -amide |
WO1992006087A1 (fr) * | 1990-10-02 | 1992-04-16 | Kaken Pharmaceutical Co., Ltd. | Derive d'ethynylphenyle a substitution pyridazinone et medicament contre les affections des organes circulatoires contenant ce derive en tant qu'ingredient actif |
GB9117340D0 (en) * | 1991-08-10 | 1991-09-25 | Fujisawa Pharmaceutical Co | Dihydropyridine compounds,and process for their preparation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
JPS60156671A (ja) * | 1984-01-25 | 1985-08-16 | Yamanouchi Pharmaceut Co Ltd | ジヒドロピリジン誘導体およびその製造法 |
-
1985
- 1985-02-11 GB GB858503426A patent/GB8503426D0/en active Pending
-
1986
- 1986-02-04 ZA ZA86815A patent/ZA86815B/xx unknown
- 1986-02-06 AU AU53261/86A patent/AU5326186A/en not_active Abandoned
- 1986-02-07 GR GR860368A patent/GR860368B/el unknown
- 1986-02-10 EP EP86300885A patent/EP0194046A1/en not_active Withdrawn
- 1986-02-10 HU HU86533A patent/HUT40413A/hu unknown
- 1986-02-10 NO NO860464A patent/NO860464L/no unknown
- 1986-02-10 PT PT82007A patent/PT82007B/pt unknown
- 1986-02-11 FI FI860620A patent/FI860620A/fi not_active Application Discontinuation
- 1986-02-11 ES ES551845A patent/ES8802028A1/es not_active Expired
- 1986-02-11 DK DK65986A patent/DK65986A/da not_active Application Discontinuation
- 1986-02-12 JP JP61028759A patent/JPS61233668A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NO860464L (no) | 1986-08-12 |
PT82007B (en) | 1987-12-22 |
FI860620A0 (fi) | 1986-02-11 |
ES551845A0 (es) | 1988-03-16 |
HUT40413A (en) | 1986-12-28 |
EP0194046A1 (en) | 1986-09-10 |
FI860620A (fi) | 1986-08-12 |
GR860368B (en) | 1986-05-29 |
DK65986D0 (da) | 1986-02-11 |
GB8503426D0 (en) | 1985-03-13 |
ZA86815B (en) | 1986-11-26 |
DK65986A (da) | 1986-08-12 |
PT82007A (en) | 1986-03-01 |
AU5326186A (en) | 1986-08-14 |
JPS61233668A (ja) | 1986-10-17 |
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