ES8802030A1 - Procedimiento para preparar dihidropiridinas. - Google Patents
Procedimiento para preparar dihidropiridinas.Info
- Publication number
- ES8802030A1 ES8802030A1 ES551847A ES551847A ES8802030A1 ES 8802030 A1 ES8802030 A1 ES 8802030A1 ES 551847 A ES551847 A ES 551847A ES 551847 A ES551847 A ES 551847A ES 8802030 A1 ES8802030 A1 ES 8802030A1
- Authority
- ES
- Spain
- Prior art keywords
- bears
- alkyl
- substituents
- ring
- dihydropyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DIHIDROPIRIDINAS, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UNA AMINA DE FORMULA GENERAL (II), EN LA QUE A ES UN ANILLO BENCENICO QUE LLEVA UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE HALOGENO, CIANO, NITRO O ALQUILO; R1 Y R2 REPRESENTAN CADA UNO DE ELLOS ALQUILO O ALCOXIALQUILO; R3 ES ALQUILO DE HASTA 6 ATOMOS DE CARBONO; AR ES FENILENO O NAFTILO; X ES OXIGENO O NH; Q ES 1, 2, 3 O 4; E Y ES ALQUILENO DE CADENA RECTA O RAMIFICADA DE 1 A 12 ATOMOS DE CARBONO, CON UN EPOXIDO DE FORMULA GENERAL (III). DE APLICACION EN MEDICINA POR SUS PROPIEDADES ANTIHIPERTENSIVAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858503428A GB8503428D0 (en) | 1985-02-11 | 1985-02-11 | Nitrogen-containing compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES551847A0 ES551847A0 (es) | 1988-03-16 |
ES8802030A1 true ES8802030A1 (es) | 1988-03-16 |
Family
ID=10574273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES551847A Expired ES8802030A1 (es) | 1985-02-11 | 1986-02-11 | Procedimiento para preparar dihidropiridinas. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0194752A1 (es) |
JP (1) | JPS61233667A (es) |
AU (1) | AU5326386A (es) |
DK (1) | DK65686A (es) |
ES (1) | ES8802030A1 (es) |
FI (1) | FI860618A (es) |
GB (1) | GB8503428D0 (es) |
GR (1) | GR860366B (es) |
HU (1) | HUT40412A (es) |
IL (1) | IL77799A0 (es) |
NO (1) | NO860462L (es) |
PT (1) | PT82010B (es) |
ZA (1) | ZA86814B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0254682A1 (de) * | 1986-07-22 | 1988-01-27 | Ciba-Geigy Ag | Neue Phenoxyaliphatylphenylenoxyalkylester und -amide |
US5468746A (en) * | 1988-07-29 | 1995-11-21 | Zambon Group S.P.A. | Compounds active on the cardiovascular system |
IT1229118B (it) * | 1988-07-29 | 1991-07-22 | Simes | Composti attivi sul sistema cardiovascolare che presentano sia la struttura dei beta-bloccanti sia una porzione calcio-antagonista |
EP0352863A3 (en) * | 1988-07-29 | 1990-08-22 | ZAMBON GROUP S.p.A. | 1,4-dihydropyridine dicarboxylic acid derivatives |
FR2700541B1 (fr) * | 1993-01-21 | 1995-03-03 | Adir | Nouveaux composés de 1,4-dihydropyridine, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2228363A1 (de) * | 1972-06-10 | 1974-01-03 | Bayer Ag | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
DE2753946A1 (de) * | 1977-12-03 | 1979-06-13 | Bayer Ag | 1-n-aryl-1,4-dihydropyridine und ihre verwendung als arzneimittel |
-
1985
- 1985-02-11 GB GB858503428A patent/GB8503428D0/en active Pending
-
1986
- 1986-02-04 ZA ZA86814A patent/ZA86814B/xx unknown
- 1986-02-05 IL IL77799A patent/IL77799A0/xx unknown
- 1986-02-06 AU AU53263/86A patent/AU5326386A/en not_active Abandoned
- 1986-02-07 GR GR860366A patent/GR860366B/el unknown
- 1986-02-10 NO NO860462A patent/NO860462L/no unknown
- 1986-02-10 EP EP86300887A patent/EP0194752A1/en not_active Withdrawn
- 1986-02-10 PT PT82010A patent/PT82010B/pt unknown
- 1986-02-10 HU HU86532A patent/HUT40412A/hu unknown
- 1986-02-11 ES ES551847A patent/ES8802030A1/es not_active Expired
- 1986-02-11 FI FI860618A patent/FI860618A/fi not_active Application Discontinuation
- 1986-02-11 DK DK65686A patent/DK65686A/da not_active Application Discontinuation
- 1986-02-12 JP JP61028758A patent/JPS61233667A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FI860618A0 (fi) | 1986-02-11 |
GR860366B (en) | 1986-06-03 |
IL77799A0 (en) | 1986-08-31 |
NO860462L (no) | 1986-08-12 |
GB8503428D0 (en) | 1985-03-13 |
HUT40412A (en) | 1986-12-28 |
ZA86814B (en) | 1986-11-26 |
EP0194752A1 (en) | 1986-09-17 |
JPS61233667A (ja) | 1986-10-17 |
DK65686D0 (da) | 1986-02-11 |
PT82010B (en) | 1987-12-16 |
ES551847A0 (es) | 1988-03-16 |
PT82010A (en) | 1986-03-01 |
DK65686A (da) | 1986-08-12 |
AU5326386A (en) | 1986-08-14 |
FI860618A (fi) | 1986-08-12 |
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