ES8801247A1 - 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives - Google Patents

3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Info

Publication number
ES8801247A1
ES8801247A1 ES556101A ES556101A ES8801247A1 ES 8801247 A1 ES8801247 A1 ES 8801247A1 ES 556101 A ES556101 A ES 556101A ES 556101 A ES556101 A ES 556101A ES 8801247 A1 ES8801247 A1 ES 8801247A1
Authority
ES
Spain
Prior art keywords
phenyl
hydrogen
imidazolylmethyl
carbazol
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556101A
Other languages
Spanish (es)
Other versions
ES556101A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8801247A1 publication Critical patent/ES8801247A1/en
Publication of ES556101A0 publication Critical patent/ES556101A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of formula (I). < IMAGE > [wherein R<1> is hydrogen C1-10 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenyl-C1-3alkyl, and one of the groups represented by R<2>, R<3> and R<4> is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-C1-3alkyl and each of the other two groups, which may be the same or different, is hydrogen or C1-6alkyl and physiologically acceptable salts and solvates, e.g. hydrates, thereof] are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia.
ES556101A 1984-01-25 1986-06-16 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives Expired ES8801247A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
ES8801247A1 true ES8801247A1 (en) 1987-12-16
ES556101A0 ES556101A0 (en) 1987-12-16

Family

ID=26287221

Family Applications (3)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES548430A Expired ES8708224A1 (en) 1984-01-25 1985-10-31 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES556101A Expired ES8801247A1 (en) 1984-01-25 1986-06-16 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES548430A Expired ES8708224A1 (en) 1984-01-25 1985-10-31 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE3502508A1 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU88268I2 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK404391A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2043535A1 (en) * 1992-03-13 1993-12-16 Vita Invest Sa Procedure for the obtaining of 1,2,3,9-tetrahydro-9-methyl-3- (2-methyl-1H-imidazol-1-il) methyl-4h-carbazol-4-ona. (Machine-translation by Google Translate, not legally binding)

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GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
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CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
ATE97803T1 (en) * 1989-04-21 1993-12-15 Sandoz Ag THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2043535A1 (en) * 1992-03-13 1993-12-16 Vita Invest Sa Procedure for the obtaining of 1,2,3,9-tetrahydro-9-methyl-3- (2-methyl-1H-imidazol-1-il) methyl-4h-carbazol-4-ona. (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
SE8500368D0 (en) 1985-01-25
SE8500368L (en) 1985-07-26
DK35785A (en) 1985-07-26
ES8708224A1 (en) 1987-10-01
GB8501889D0 (en) 1985-02-27
FI84349C (en) 1991-11-25
SG7089G (en) 1989-06-09
IL74165A (en) 1988-11-15
KR850005439A (en) 1985-08-26
NL940009I1 (en) 1994-07-18
ATA20485A (en) 1990-08-15
FI850323A0 (en) 1985-01-25
IT8547600A0 (en) 1985-01-25
GB2153821A (en) 1985-08-29
NZ210940A (en) 1989-08-29
ES539852A0 (en) 1986-07-16
DE3502508C2 (en) 1990-05-03
PT79890A (en) 1985-02-01
BE901576A (en) 1985-07-25
CY1479A (en) 1989-07-21
PT79890B (en) 1987-02-03
SE460359B (en) 1989-10-02
AU3809785A (en) 1985-08-01
NO164025C (en) 1990-08-22
HU193592B (en) 1987-11-30
KR920003064B1 (en) 1992-04-13
LU88268I2 (en) 1994-02-03
FI84349B (en) 1991-08-15
GR850219B (en) 1985-05-23
NO850300L (en) 1985-07-26
FR2561244A1 (en) 1985-09-20
NO1994022I1 (en) 1994-11-09
DK35785D0 (en) 1985-01-25
CH664152A5 (en) 1988-02-15
FR2561244B1 (en) 1988-03-04
NL190373B (en) 1993-09-01
NL190373C (en) 1994-02-01
LU85743A1 (en) 1986-08-04
IE57809B1 (en) 1993-04-21
ES548430A0 (en) 1987-10-01
CZ404391A3 (en) 1993-04-14
AT392276B (en) 1991-02-25
HK33189A (en) 1989-04-28
HUT37784A (en) 1986-02-28
DK169521B1 (en) 1994-11-21
PH22672A (en) 1988-11-14
CA1252793A (en) 1989-04-18
NL940009I2 (en) 1999-05-03
NL8500202A (en) 1985-08-16
DE3502508A1 (en) 1985-08-14
NO164025B (en) 1990-05-14
AU579132B2 (en) 1988-11-17
ES8609309A1 (en) 1986-07-16
IT1182150B (en) 1987-09-30
DE19375046I2 (en) 2002-10-10
GB2153821B (en) 1988-01-20
SK277923B6 (en) 1995-08-09
ES556101A0 (en) 1987-12-16
IE850187L (en) 1985-07-25
FI850323L (en) 1985-07-26
SK404391A3 (en) 1995-08-09

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Legal Events

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FD1A Patent lapsed

Effective date: 20071029