ES8707726A1 - Un procedimiento para la obtencion de compuestos de 1-oxa-1-destia-cefalos-porina - Google Patents
Un procedimiento para la obtencion de compuestos de 1-oxa-1-destia-cefalos-porinaInfo
- Publication number
- ES8707726A1 ES8707726A1 ES557155A ES557155A ES8707726A1 ES 8707726 A1 ES8707726 A1 ES 8707726A1 ES 557155 A ES557155 A ES 557155A ES 557155 A ES557155 A ES 557155A ES 8707726 A1 ES8707726 A1 ES 8707726A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- dethia
- oxa
- image
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D505/02—Preparation
- C07D505/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D505/10—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D505/12—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Abstract
METODO DE OBTENER COMPUESTOS 1-OXA-1-DESTIA-CEFALOSPORINA. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN TOLUENO, ENTRE 0 Y 80JC, PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y B) REDUCIR CATALITICAMENTE A (IV) CON HIDROGENO EN PRESENCIA DE RD Y EN ACIDO CLORHIDRICO PARA SEPARAR GRUPOS PROTECTORES CARBOXI Y AMINO Y OBTENER UN COMPUESTO DE FORMULA (I), SIENDO: R2 Y R3 H O METILO; R4 H METILO O CARBOXILO; R7 UN GRUPO PROTECTOR DE CARBOXILO Y X CL O BR. SE UTILIZAN COMO ANTIBACTERIANOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/705,799 US4645769A (en) | 1985-03-01 | 1985-03-01 | 1-oxa-1-dethia-cephalosporin compounds and antibacterial agent comprising the same |
Publications (2)
Publication Number | Publication Date |
---|---|
ES557155A0 ES557155A0 (es) | 1987-08-16 |
ES8707726A1 true ES8707726A1 (es) | 1987-08-16 |
Family
ID=24835001
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552486A Expired ES8705450A1 (es) | 1985-03-01 | 1986-02-27 | Un procedimiento para la obtencion de compuestos de 1-oxa-1-dertia cefalosporina. |
ES557155A Expired ES8707726A1 (es) | 1985-03-01 | 1986-10-30 | Un procedimiento para la obtencion de compuestos de 1-oxa-1-destia-cefalos-porina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552486A Expired ES8705450A1 (es) | 1985-03-01 | 1986-02-27 | Un procedimiento para la obtencion de compuestos de 1-oxa-1-dertia cefalosporina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4645769A (es) |
EP (1) | EP0193858B1 (es) |
JP (1) | JPH0633280B2 (es) |
KR (1) | KR900003500B1 (es) |
AT (1) | ATE69819T1 (es) |
CA (1) | CA1268177A (es) |
DE (1) | DE3682599D1 (es) |
DK (1) | DK92486A (es) |
ES (2) | ES8705450A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960002856B1 (ko) * | 1987-03-09 | 1996-02-27 | 오쓰까 세이야꾸 가부시끼가이샤 | 2-옥사-이소세펨 화합물, 이를 함유하는 조성물 및 이의 제조방법 |
DK582788A (da) * | 1987-10-22 | 1989-04-23 | Otsuka Pharma Co Ltd | 2-oxa-isocephemforbindelser, midler der indeholder dem og fremgangsmaader til fremstilling af dem |
US5525599A (en) * | 1993-07-21 | 1996-06-11 | Eli Lilly And Company | 7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids |
JP6377570B2 (ja) * | 2014-04-28 | 2018-08-22 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 2−置換セフェム化合物を含有する医薬組成物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4226866A (en) * | 1972-11-06 | 1980-10-07 | Merck & Co., Inc. | Novel antibiotic analogues of cephalosporins |
JPS5331690A (en) * | 1976-09-01 | 1978-03-25 | Shionogi & Co Ltd | Oxadithiacephalosporins |
AU514377B2 (en) * | 1977-02-15 | 1981-02-05 | Shionogi & Co., Ltd. | l-OXADETHIACEPHAM COMPOUNDS |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
DK487979A (da) * | 1978-11-17 | 1980-05-18 | Glaxo Group Ltd | Fremgangsmaade til fremstilling af cephalosporinantibiotika |
FR2474504A1 (fr) * | 1979-05-23 | 1981-07-31 | Rhone Poulenc Ind | Nouvelles thiovinyl-3 cephalosporines, leur preparation et les medicaments qui les contiennent |
HU184771B (en) * | 1979-05-23 | 1984-10-29 | Rhone Poulenc Ind | Process for producing new 3-thiovinyl-cepheme-carboxylic acid derivatives |
DE3137038A1 (de) * | 1981-09-17 | 1983-03-24 | Bayer Ag, 5090 Leverkusen | Ss-lactam antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS5849382A (ja) * | 1981-09-18 | 1983-03-23 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
JPS5874680A (ja) * | 1981-10-01 | 1983-05-06 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
FR2516515A1 (fr) * | 1981-11-16 | 1983-05-20 | Sanofi Sa | Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant |
US4534898A (en) * | 1982-07-23 | 1985-08-13 | Merck & Co., Inc. | 1-Oxa-1-dethia-cephalosporin derivatives |
-
1985
- 1985-03-01 US US06/705,799 patent/US4645769A/en not_active Expired - Fee Related
-
1986
- 1986-02-19 CA CA000502142A patent/CA1268177A/en not_active Expired - Fee Related
- 1986-02-26 AT AT86102483T patent/ATE69819T1/de not_active IP Right Cessation
- 1986-02-26 EP EP86102483A patent/EP0193858B1/en not_active Expired - Lifetime
- 1986-02-26 DE DE8686102483T patent/DE3682599D1/de not_active Expired - Fee Related
- 1986-02-27 ES ES552486A patent/ES8705450A1/es not_active Expired
- 1986-02-28 KR KR1019860001452A patent/KR900003500B1/ko not_active IP Right Cessation
- 1986-02-28 DK DK92486A patent/DK92486A/da not_active Application Discontinuation
- 1986-02-28 JP JP61041854A patent/JPH0633280B2/ja not_active Expired - Lifetime
- 1986-10-30 ES ES557155A patent/ES8707726A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
KR860007264A (ko) | 1986-10-10 |
ES557155A0 (es) | 1987-08-16 |
JPH0633280B2 (ja) | 1994-05-02 |
EP0193858A1 (en) | 1986-09-10 |
DK92486A (da) | 1986-09-02 |
DE3682599D1 (de) | 1992-01-09 |
DK92486D0 (da) | 1986-02-28 |
EP0193858B1 (en) | 1991-11-27 |
KR900003500B1 (ko) | 1990-05-21 |
JPS61251685A (ja) | 1986-11-08 |
ES8705450A1 (es) | 1987-05-01 |
US4645769A (en) | 1987-02-24 |
ES552486A0 (es) | 1987-05-01 |
CA1268177A (en) | 1990-04-24 |
ATE69819T1 (de) | 1991-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |