ES8707507A1 - Un procedimiento para preparar derivados de pirazinona - Google Patents
Un procedimiento para preparar derivados de pirazinonaInfo
- Publication number
- ES8707507A1 ES8707507A1 ES530024A ES530024A ES8707507A1 ES 8707507 A1 ES8707507 A1 ES 8707507A1 ES 530024 A ES530024 A ES 530024A ES 530024 A ES530024 A ES 530024A ES 8707507 A1 ES8707507 A1 ES 8707507A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen
- formula
- alcohyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Aryl pyrazinones Chemical class 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 230000001681 protective effect Effects 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIRAZINONA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) EN DONDE R2 Y R3 SON INDEPENDIENTEMENTE HIDROGENO O ALCOHILO C1-4 Y R12 ES NITRO O UN GRUPO R10NH- SIENDO R10 UN GRUPO PROTECTOR, CON UN COMPUESTO DE FORMULA (III), DONDE R1 ES HIDROGENO O ALCOHILO C1-4; DESPUES DE ELLO, SI ES NECESARIO, SE REDUCEN LOS GRUPOS NITRO Y SE ELIMINAN LOS GRUPOS PROTECTORES. DEPENDIENDO DE LAS CONDICIONES DE REACCION SE PUEDEN OBTENER UNA VARIEDAD DE COMPUESTOS DE FORMULA GENERAL (I), DONDE R1, R2 Y R3 TIENEN LOS MISMOS SIGNIFICADOS ANTERIORES Y R4 ES HIDROGENO, UN GRUPO ALCOXI C1-6 CARBONILO, ALCOXI C1-4 O CARBOXI, O UN GRUPO -CO-(NR5)N-R6. SON AGENTES CARDIOTONICOS Y VASODILATADORES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8216437 | 1982-06-05 | ||
GB838300476A GB8300476D0 (en) | 1983-01-08 | 1983-01-08 | Heterocyclic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8707507A1 true ES8707507A1 (es) | 1985-12-01 |
ES530024A0 ES530024A0 (es) | 1985-12-01 |
Family
ID=26283037
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522962A Expired ES8500244A1 (es) | 1982-06-05 | 1983-06-03 | "un procedimiento para preparar derivados de pirazinona" |
ES530024A Granted ES530024A0 (es) | 1982-06-05 | 1984-02-24 | Un procedimiento para preparar derivados de pirazinona |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522962A Expired ES8500244A1 (es) | 1982-06-05 | 1983-06-03 | "un procedimiento para preparar derivados de pirazinona" |
Country Status (15)
Country | Link |
---|---|
US (2) | US4556711A (es) |
EP (1) | EP0096517A3 (es) |
KR (1) | KR840005111A (es) |
AU (1) | AU1527583A (es) |
DD (1) | DD209818A5 (es) |
DK (1) | DK247783A (es) |
ES (2) | ES8500244A1 (es) |
FI (1) | FI831998L (es) |
GR (1) | GR79299B (es) |
JO (1) | JO1255B1 (es) |
NO (1) | NO832016L (es) |
PL (1) | PL242354A1 (es) |
PT (1) | PT76791B (es) |
RO (1) | RO86851B (es) |
ZW (1) | ZW12783A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657906A (en) * | 1982-06-05 | 1987-04-14 | Smith Kline & French Laboratories Ltd. | Heterocyclic compounds having inotropic activity |
GB8332313D0 (en) * | 1983-12-02 | 1984-01-11 | Smith Kline French Lab | Chemical compounds |
US4595766A (en) * | 1984-10-26 | 1986-06-17 | Ciba-Geigy Corporation | Process for the preparation of an indoline carboxylic acid |
US4697016A (en) * | 1984-10-26 | 1987-09-29 | Ciba-Geigy Corporation | Intermediates for the preparation of a carboxylic acid |
JPS62198671A (ja) * | 1986-02-25 | 1987-09-02 | Toyo Jozo Co Ltd | 1−置換アルキル1,2−ジヒドロ−2−ピラジノン誘導体 |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
CA2770454A1 (en) * | 2009-08-19 | 2011-02-24 | Ambit Biosciences Corporation | Biaryl compounds and methods of use thereof |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
CA2874953A1 (en) | 2012-06-12 | 2013-12-19 | Abbvie Inc. | Pyridinone and pyridazinone derivatives |
EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3745161A (en) * | 1970-04-20 | 1973-07-10 | Merck & Co Inc | Phenyl-hydroxy-pyrazine carboxylic acids and derivatives |
-
1983
- 1983-05-27 EP EP83303059A patent/EP0096517A3/en not_active Withdrawn
- 1983-06-01 AU AU15275/83A patent/AU1527583A/en not_active Abandoned
- 1983-06-01 JO JO19831255A patent/JO1255B1/en active
- 1983-06-01 GR GR71530A patent/GR79299B/el unknown
- 1983-06-01 DK DK247783A patent/DK247783A/da not_active Application Discontinuation
- 1983-06-01 PT PT76791A patent/PT76791B/pt unknown
- 1983-06-02 US US06/500,486 patent/US4556711A/en not_active Expired - Lifetime
- 1983-06-02 US US06/500,484 patent/US4514568A/en not_active Expired - Fee Related
- 1983-06-03 RO RO111170A patent/RO86851B/ro unknown
- 1983-06-03 ES ES522962A patent/ES8500244A1/es not_active Expired
- 1983-06-03 PL PL24235483A patent/PL242354A1/xx unknown
- 1983-06-03 ZW ZW127/83A patent/ZW12783A1/xx unknown
- 1983-06-03 NO NO832016A patent/NO832016L/no unknown
- 1983-06-03 FI FI831998A patent/FI831998L/fi not_active Application Discontinuation
- 1983-06-03 DD DD25173683A patent/DD209818A5/de unknown
- 1983-06-04 KR KR1019830002511A patent/KR840005111A/ko not_active Application Discontinuation
-
1984
- 1984-02-24 ES ES530024A patent/ES530024A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
DK247783D0 (da) | 1983-06-01 |
US4556711A (en) | 1985-12-03 |
EP0096517A3 (en) | 1985-04-03 |
NO832016L (no) | 1983-12-06 |
DD209818A5 (de) | 1984-05-23 |
KR840005111A (ko) | 1984-11-03 |
DK247783A (da) | 1983-12-06 |
ES522962A0 (es) | 1984-10-01 |
RO86851B (ro) | 1985-05-31 |
GR79299B (es) | 1984-10-22 |
ZW12783A1 (en) | 1983-08-24 |
EP0096517A2 (en) | 1983-12-21 |
JO1255B1 (en) | 1985-04-20 |
PT76791B (en) | 1986-01-24 |
ES8500244A1 (es) | 1984-10-01 |
RO86851A (ro) | 1985-05-20 |
PL242354A1 (en) | 1984-12-17 |
PT76791A (en) | 1983-07-01 |
AU1527583A (en) | 1983-12-08 |
ES530024A0 (es) | 1985-12-01 |
FI831998L (fi) | 1983-12-06 |
US4514568A (en) | 1985-04-30 |
FI831998A0 (fi) | 1983-06-03 |
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