ES8706683A1 - Metodo para preparar un derivado de dihidroimidazo(1,2-a)pi-rimidina - Google Patents
Metodo para preparar un derivado de dihidroimidazo(1,2-a)pi-rimidinaInfo
- Publication number
- ES8706683A1 ES8706683A1 ES543361A ES543361A ES8706683A1 ES 8706683 A1 ES8706683 A1 ES 8706683A1 ES 543361 A ES543361 A ES 543361A ES 543361 A ES543361 A ES 543361A ES 8706683 A1 ES8706683 A1 ES 8706683A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- compounds
- hydrogen
- aralkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
METODO DE PREPARA UN DERIVADO DE DIHIDROIMIDAZO-[1,2-A]PIRIMIDINA. CONSISTE EN SOMETER A AMINOMETILACION UN COMPUESTO DE FORMULA (II), A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DEL PUNTO DE EBULLICION DEL DISOLVENTE EMPLEADO, DURANTE 30 MINUTOS A 24 HORAS, EN PRESENCIA DE UN ALCANOL INFERIOR, UN HIDROCARBURO AROMATICO Y OTROS, PARA OBTENER DERIVADOS DE DIHIDROIMIDAZO-[1,2-A]PIRIMIDINA DE FORMULA (I) DONDE R ES UN ATOMO DE H, UN GRUPO ALQUILO DE C 1 A 5 Y OTROS; R ELEVADO A 1 ES UN GRUPO CIANO, UN GRUPO ALCOXICARBONILO DE C 1 A 4 Y OTROS; R ELEVADO A 2 ES UN GRUPO ALQUILO DE C 1 A 4, UN GRUPO ALCOXICARBONILO DE C 1 A 4 Y OTROS; R ELEVADO A 3 ES UN GRUPO ALQUILO DE C 1 A 4 Y OTROS; R ELEVADO A 4 ES H Y OTROS; Y N ES UN ENTERO DE 1 A 3 U OXIGENO. ES UTIL PARA PREPARAR COMPOSICIONES FARMACEUTICAS. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59104257A JPS60246387A (ja) | 1984-05-22 | 1984-05-22 | ジヒドロイミダゾ〔1,2−a〕ピリミジン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES543361A0 ES543361A0 (es) | 1987-07-01 |
ES8706683A1 true ES8706683A1 (es) | 1987-07-01 |
Family
ID=14375875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543361A Expired ES8706683A1 (es) | 1984-05-22 | 1985-05-21 | Metodo para preparar un derivado de dihidroimidazo(1,2-a)pi-rimidina |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0163240A3 (es) |
JP (1) | JPS60246387A (es) |
KR (1) | KR850008488A (es) |
CA (1) | CA1271751A (es) |
ES (1) | ES8706683A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4918074A (en) * | 1984-03-12 | 1990-04-17 | Yoshitomi Pharmaceutical Industries, Ltd. | Polyazaheterocycle compounds |
EP0217142A3 (en) * | 1985-09-30 | 1988-01-07 | Yoshitomi Pharmaceutical Industries, Ltd. | A polyazaheterocyclic compound |
US4746656A (en) * | 1986-07-21 | 1988-05-24 | E. R. Squibb & Sons, Inc. | 1,2,4,7-tetrahydro-2-oxopyrazolo[1,5-a]pyrimidine derivatives |
US4883872A (en) * | 1987-11-25 | 1989-11-28 | E. R. Squibb & Sons, Inc. | 3-oxo-1,2,4-triazolo(4,3-A) pyrimidine-6-carboxylic acid esters |
US4859676A (en) * | 1988-01-19 | 1989-08-22 | E. R. Squibb & Sons, Inc. | 2-Oxo-1-sulfonyl pyrazolo(1,5-a) pyrimidine-6-carboxylic acid esters |
US4870072A (en) * | 1988-01-19 | 1989-09-26 | E. R. Squibb & Sons, Inc. | 2-oxo-1-substituted pyrazolo[1,5-A]pyrimidine-6-carboxylic acid esters as blood pressure reducing agents |
GB8905130D0 (en) * | 1989-03-07 | 1989-04-19 | Pfizer Ltd | Therapeutic agents |
US6194419B1 (en) | 1997-12-26 | 2001-02-27 | Takeda Chemical Industries, Ltd. | Nitrogen-containing heterocyclic compounds, their production and use |
MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
US7772232B2 (en) | 2004-04-15 | 2010-08-10 | Bristol-Myers Squibb Company | Quinazolinyl compounds as inhibitors of potassium channel function |
CA2606017A1 (en) * | 2005-05-12 | 2006-11-23 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
PE20080403A1 (es) * | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
US20090012103A1 (en) | 2007-07-05 | 2009-01-08 | Matthew Abelman | Substituted heterocyclic compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3244717A (en) * | 1964-06-18 | 1966-04-05 | Searle & Co | 5-hydroxy-2-methyl-7-phenylimidazo [1, 2-a] pyrimidines |
DE3234684A1 (de) * | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
JPS5965089A (ja) * | 1982-10-05 | 1984-04-13 | Shionogi & Co Ltd | ジヒドロピラゾロ〔3,4−b〕ピリジン誘導体およびその製造法 |
-
1984
- 1984-05-22 JP JP59104257A patent/JPS60246387A/ja active Granted
-
1985
- 1985-05-16 CA CA000481703A patent/CA1271751A/en not_active Expired - Fee Related
- 1985-05-21 KR KR1019850003488A patent/KR850008488A/ko not_active Application Discontinuation
- 1985-05-21 EP EP85106208A patent/EP0163240A3/en not_active Ceased
- 1985-05-21 ES ES543361A patent/ES8706683A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
KR850008488A (ko) | 1985-12-18 |
JPH0240067B2 (es) | 1990-09-10 |
ES543361A0 (es) | 1987-07-01 |
CA1271751A (en) | 1990-07-17 |
EP0163240A2 (en) | 1985-12-04 |
EP0163240A3 (en) | 1987-04-22 |
JPS60246387A (ja) | 1985-12-06 |
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