ES8608885A1 - Procedimiento para distinguir celulas normales de malignas, en una mezcla de las mismas - Google Patents

Procedimiento para distinguir celulas normales de malignas, en una mezcla de las mismas

Info

Publication number
ES8608885A1
ES8608885A1 ES545258A ES545258A ES8608885A1 ES 8608885 A1 ES8608885 A1 ES 8608885A1 ES 545258 A ES545258 A ES 545258A ES 545258 A ES545258 A ES 545258A ES 8608885 A1 ES8608885 A1 ES 8608885A1
Authority
ES
Spain
Prior art keywords
human
htnf
necrosis factor
conjunction
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545258A
Other languages
English (en)
Other versions
ES545258A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Original Assignee
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research filed Critical Sloan Kettering Institute for Cancer Research
Publication of ES8608885A1 publication Critical patent/ES8608885A1/es
Publication of ES545258A0 publication Critical patent/ES545258A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

METODO PARA DISTINGUIR CELULAS NORMALES DE MALIGNAS EN MEZCLAS DE LAS MISMAS. COMPRENDE LA PRODUCCION Y PURIFICACION DE FACTOR DE NECROSIS TUMORAL HUMANO A PARTIR DE LINEAS CELULARES HUMANAS, SIN AÑADIR BCG O ENDOTOXINA, TOTALMENTE LIBRE DE ENDOTOXINA EXOGENA, BACTERIAS Y CONTAMINANTES DE SUERO; TRATAMIENTO DE MEZCLAS QUE PUEDEN CONTENER CELULAS NORMALES O MALIGNAS CON DICHO FACTOR DE NECROSIS TUMORAL HUMANO PURIFICADO; Y OBSERVAR EL EFECTO INHIBIDOR DEL CRECIMIENTO SOBRE LAS CELULAS MALIGNAS. TIENE APLICACIONES PARA EL TRATAMIENTO DE CANCER HUMANO.
ES545258A 1983-06-27 1985-07-16 Procedimiento para distinguir celulas normales de malignas, en una mezcla de las mismas Expired ES8608885A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50847283A 1983-06-27 1983-06-27

Publications (2)

Publication Number Publication Date
ES8608885A1 true ES8608885A1 (es) 1986-07-16
ES545258A0 ES545258A0 (es) 1986-07-16

Family

ID=24022900

Family Applications (2)

Application Number Title Priority Date Filing Date
ES533767A Expired ES8603949A1 (es) 1983-06-27 1984-06-27 Procedimiento para la produccion de factor de necrosis tumoral humana (htnf) purificado
ES545258A Expired ES8608885A1 (es) 1983-06-27 1985-07-16 Procedimiento para distinguir celulas normales de malignas, en una mezcla de las mismas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES533767A Expired ES8603949A1 (es) 1983-06-27 1984-06-27 Procedimiento para la produccion de factor de necrosis tumoral humana (htnf) purificado

Country Status (15)

Country Link
EP (1) EP0131789A3 (es)
JP (1) JPS6036420A (es)
KR (1) KR850000528A (es)
AU (1) AU587959B2 (es)
CA (1) CA1265444A (es)
DD (3) DD241271A5 (es)
DK (1) DK311984A (es)
ES (2) ES8603949A1 (es)
FI (1) FI842560A (es)
GR (1) GR82260B (es)
HU (2) HU197358B (es)
NO (1) NO842572L (es)
NZ (1) NZ208648A (es)
PT (1) PT78773B (es)
ZA (1) ZA844377B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920196A (en) * 1982-07-30 1990-04-24 Genentech, Inc. Human lymphotoxin
JPS59141519A (ja) * 1983-01-31 1984-08-14 Otsuka Pharmaceut Co Ltd 制ガン作用を有する蛋白質
US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
JPS60243018A (ja) * 1984-05-17 1985-12-03 Yamanouchi Pharmaceut Co Ltd ヒト内来性癌制御因子
DE3423234A1 (de) * 1984-06-23 1986-02-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Synergistische mischungen von interferonen und tumor-nekrose-faktor
US4650674A (en) * 1984-07-05 1987-03-17 Genentech, Inc. Synergistic cytotoxic composition
GR851626B (es) * 1984-07-05 1985-11-26 Genentech Inc
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
IL76591A0 (en) * 1984-10-05 1986-02-28 Bioferon Biochem Substanz Pharmaceutical compositions containing ifn-ypsilon and processes for the preparation thereof
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
ATE73856T1 (de) * 1984-12-21 1992-04-15 Biogen Inc Reinigung, herstellung und verwendung von tumor- nekrosisfaktoren.
EP0205038A1 (en) * 1985-05-29 1986-12-17 Suntory Limited Polypeptide, process for preparing it, microorganism and pharmaceutical use
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
NZ219027A (en) * 1986-01-24 1989-09-27 Genentech Inc Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin
CA1290249C (en) * 1986-04-09 1991-10-08 Cetus Corporation COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR
US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
IL80005A (en) * 1986-09-10 1992-11-15 Yeda Res & Dev Compositions for modulating the effect of tnf and il-1
US4894225A (en) * 1987-03-02 1990-01-16 Cetus Corporation Combination therapy using antitumor immunotoxins with tumor necrosis factor
DE102012024749A1 (de) 2012-12-11 2014-06-26 Martin Röcken Tumorprävention und -therapie durch Induktion einer Tumorseneszenz

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204382L (sv) * 1981-07-21 1983-01-22 Hayashibara Biochem Lab Sett att framstella malcellysfaktor och anvendning derav
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ
GR851626B (es) * 1984-07-05 1985-11-26 Genentech Inc

Also Published As

Publication number Publication date
HUT34775A (en) 1985-04-28
DD241271A5 (de) 1986-12-03
HU197358B (en) 1989-03-28
PT78773A (en) 1984-07-01
GR82260B (es) 1984-12-13
FI842560A0 (fi) 1984-06-26
NZ208648A (en) 1989-07-27
EP0131789A3 (en) 1986-12-03
AU587959B2 (en) 1989-09-07
EP0131789A2 (en) 1985-01-23
JPS6036420A (ja) 1985-02-25
DD241268A5 (de) 1986-12-03
ES545258A0 (es) 1986-07-16
AU2933784A (en) 1985-01-03
ES533767A0 (es) 1986-01-01
DK311984D0 (da) 1984-06-26
CA1265444A (en) 1990-02-06
ES8603949A1 (es) 1986-01-01
NO842572L (no) 1984-12-28
ZA844377B (en) 1985-05-29
FI842560A (fi) 1984-12-28
KR850000528A (ko) 1985-02-27
HU201680B (en) 1990-12-28
PT78773B (en) 1986-06-26
DK311984A (da) 1984-12-28
DD229713A5 (de) 1985-11-13

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