ES8607022A1 - Un procedimiento para la preparacion de nuevos 16-fluor-16,17-dideshidro prostanoides. - Google Patents

Un procedimiento para la preparacion de nuevos 16-fluor-16,17-dideshidro prostanoides.

Info

Publication number
ES8607022A1
ES8607022A1 ES535551A ES535551A ES8607022A1 ES 8607022 A1 ES8607022 A1 ES 8607022A1 ES 535551 A ES535551 A ES 535551A ES 535551 A ES535551 A ES 535551A ES 8607022 A1 ES8607022 A1 ES 8607022A1
Authority
ES
Spain
Prior art keywords
prostanoids
didehydro
fluoro
preparation
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535551A
Other languages
English (en)
Other versions
ES535551A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES535551A0 publication Critical patent/ES535551A0/es
Publication of ES8607022A1 publication Critical patent/ES8607022A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE PROSTAGLANDINAS SINTETICAS. CONSISTENTE EN REDUCIR EL GRUPO CARBONILO C15 EN EL COMPUESTOL DE FORMULA (II) CON UN COMPLEJO DE HIDRURO DE BORO O ALUMINIO, EN ETER DIETILICO, TETRAHIDROFURANO Y OTROS COMO DISOLVENTE, ENTRE C40JC Y LA EBULLICION DEL DISOLVENTE, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: A, TRANS, -CHFCH-, -CH2-CH2- Y OTROS; R, -OH U -OR Y OTROS; R, ALQUILO DE C 1 A 6; R1 Y R2, DISTINTOS ENTRE SI, H Y -OH; R1 Y R2, JUNTOS, UN GRUPO OXO; R3 Y R4, COMO R1 Y R2 SALVO QUE PUEDEN SER LOS DOS HIDROGENO; R7, ALQUILO DE C 1 A 6, MONOCICLOALQUILO DE C 3 A 7 Y OTROS; M, 0,1, 2, O 3; RA ES R O PROTECTOR; Y R1, R2, R3 Y R4, COMO R1, R2, R3 Y R4 RESPECTIVAMENTE. SE UTILIZAN EN FARMACOLOGIA COMO CONTROLADORES DE LA FERTILIDAD EN MAMIFEROS.
ES535551A 1983-09-07 1984-08-30 Un procedimiento para la preparacion de nuevos 16-fluor-16,17-dideshidro prostanoides. Expired ES8607022A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838324004A GB8324004D0 (en) 1983-09-07 1983-09-07 16-fluoro-16 17-didehydro prostanoids

Publications (2)

Publication Number Publication Date
ES535551A0 ES535551A0 (es) 1986-05-16
ES8607022A1 true ES8607022A1 (es) 1986-05-16

Family

ID=10548451

Family Applications (2)

Application Number Title Priority Date Filing Date
ES535551A Expired ES8607022A1 (es) 1983-09-07 1984-08-30 Un procedimiento para la preparacion de nuevos 16-fluor-16,17-dideshidro prostanoides.
ES543776A Expired ES8604135A1 (es) 1983-09-07 1985-05-31 Un procedimiento para la preparacion de nuevos 16-fluor-16, 17-dideshidro prostanoides

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES543776A Expired ES8604135A1 (es) 1983-09-07 1985-05-31 Un procedimiento para la preparacion de nuevos 16-fluor-16, 17-dideshidro prostanoides

Country Status (24)

Country Link
US (1) US4626597A (es)
JP (1) JPS6072859A (es)
KR (1) KR850002830A (es)
AU (1) AU562725B2 (es)
BE (1) BE900414A (es)
CH (1) CH662114A5 (es)
CS (1) CS259869B2 (es)
DE (1) DE3430626A1 (es)
DK (1) DK406484A (es)
ES (2) ES8607022A1 (es)
FI (1) FI843285A (es)
FR (1) FR2551436B1 (es)
GB (2) GB8324004D0 (es)
GR (1) GR80204B (es)
HU (1) HU192430B (es)
IL (1) IL72749A (es)
IT (1) IT1180210B (es)
NL (1) NL8402666A (es)
NO (1) NO843355L (es)
NZ (1) NZ209294A (es)
PT (1) PT79113B (es)
SE (1) SE8404334L (es)
SU (1) SU1442070A3 (es)
ZA (1) ZA846580B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8625326D0 (en) * 1986-10-22 1986-11-26 Glaxo Group Ltd Medicaments
US5317032A (en) * 1987-10-02 1994-05-31 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Prostaglandin cathartic
EP0310305B1 (en) * 1987-10-02 1992-07-22 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Cathartics
AU616564B2 (en) * 1988-09-29 1991-10-31 Sumitomo Chemical Company, Limited Novel pyrazole compounds, method for production thereof, use thereof and intermediates for production thereof
US5099644A (en) * 1990-04-04 1992-03-31 General Electric Company Lean staged combustion assembly
US6680339B2 (en) 1996-11-12 2004-01-20 Alcon Manufacturing, Ltd. 15-fluoro prostaglandins as ocular hypotensives
CA2269855A1 (en) * 1996-11-12 1998-05-22 Alcon Laboratories, Inc. 15-fluoro prostaglandins as ocular hypotensives
CA2477080C (en) * 2002-03-01 2010-09-28 Allergan, Inc. Preparation of prostamides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987087A (en) * 1971-07-29 1976-10-19 The Upjohn Company Phenyl-substituted prostaglandin-f type analogs
GB1396206A (en) * 1972-04-27 1975-06-04 Upjohn Co Prostaglandins and the preparation thereof
ZA744581B (en) * 1973-07-20 1975-07-30 Upjohn Co Prostoglandin analogs
US4059576A (en) * 1973-08-06 1977-11-22 Hoffmann-La Roche, Inc. 11-Substituted prostaglandins
GB1484591A (en) * 1974-04-11 1977-09-01 Ono Pharmaceutical Co Prostaglandin compositions
AU501803B2 (en) * 1975-03-21 1979-06-28 Farmitalia Carlo Erba S.P.A. Fluoro-prostaglandins
US4283417A (en) * 1976-06-14 1981-08-11 Pfizer Inc. Bronchodialation with 13,14-dihydro-15-alkenyl prostaglandins
US4268522A (en) * 1976-06-14 1981-05-19 Pfizer Inc. 13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof

Also Published As

Publication number Publication date
NO843355L (no) 1985-03-08
KR850002830A (ko) 1985-05-20
CS259869B2 (en) 1988-11-15
ES535551A0 (es) 1986-05-16
HU192430B (en) 1987-06-29
FR2551436A1 (fr) 1985-03-08
SE8404334L (sv) 1985-03-08
PT79113A (en) 1984-09-01
GB2146325B (en) 1987-04-01
HUT35638A (en) 1985-07-29
AU3223184A (en) 1985-03-14
GB2146325A (en) 1985-04-17
GB8324004D0 (en) 1983-10-12
FI843285A0 (fi) 1984-08-20
CH662114A5 (de) 1987-09-15
PT79113B (en) 1986-11-14
DE3430626A1 (de) 1985-04-04
IT1180210B (it) 1987-09-23
GR80204B (en) 1985-01-02
CS636084A2 (en) 1988-04-15
NL8402666A (nl) 1985-04-01
DK406484D0 (da) 1984-08-24
NZ209294A (en) 1988-03-30
ES8604135A1 (es) 1986-01-16
AU562725B2 (en) 1987-06-18
BE900414A (fr) 1985-02-25
IT8422159A0 (it) 1984-08-01
SE8404334D0 (sv) 1984-08-30
FI843285A (fi) 1985-03-08
IL72749A0 (en) 1984-11-30
JPS6072859A (ja) 1985-04-24
DK406484A (da) 1985-03-08
GB8421124D0 (en) 1984-09-26
ZA846580B (en) 1985-05-29
SU1442070A3 (ru) 1988-11-30
FR2551436B1 (fr) 1987-02-27
IL72749A (en) 1988-05-31
ES543776A0 (es) 1986-01-16
US4626597A (en) 1986-12-02

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