ES8604546A1 - Procedimiento para preparar nuevos derivados de acidos feni-laceticos - Google Patents

Procedimiento para preparar nuevos derivados de acidos feni-laceticos

Info

Publication number
ES8604546A1
ES8604546A1 ES545881A ES545881A ES8604546A1 ES 8604546 A1 ES8604546 A1 ES 8604546A1 ES 545881 A ES545881 A ES 545881A ES 545881 A ES545881 A ES 545881A ES 8604546 A1 ES8604546 A1 ES 8604546A1
Authority
ES
Spain
Prior art keywords
group
general formula
methyl
compound
piperidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545881A
Other languages
English (en)
Other versions
ES545881A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8604546A1 publication Critical patent/ES8604546A1/es
Publication of ES545881A0 publication Critical patent/ES545881A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Lubricants (AREA)
  • Glass Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS FENILACETICOS, DE FORMULA GENERAL (I), EN LA QUE R1 SIGNIFICA UN GRUPO ALQUILENIMINO CON 4 A 6 ATOMOS DE CARBONO; R2 SIGNIFICA UN ATOMO DE HIDROGENO, HALOGENO O UN GRUPO METILO; R3 SIGNIFICA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; Y W SIGNIFICA UN GRUPO METILO, HIDROXIMETILO O FORMILO, Y SUS ENANTIOMEROS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SEPARAR UN RADICAL PROTECTOR A PARTIR DE UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1 HASTA R3 TIENEN LOS SIGNIFICADOS YA MENCIONADO; W TIENE EL MISMO SIGNIFICADO QUE W O REPRESENTA UN GRUPO PROTECTOR PARA UN GRUPO HIDROXI; Y R5 REPRESENTA UN GRUPO PROTECTOR PARA UN GRUPO HIDROXI. DE APLICACION EN EL TRATAMIENTO DE LA DIABETES MELLITUS.
ES545881A 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos Expired ES8604546A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833347565 DE3347565A1 (de) 1983-12-30 1983-12-30 Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19853522604 DE3522604A1 (de) 1983-12-30 1985-06-25 Neue feste formen von 2-(gamma)thoxy-4-(n-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl)-benzoesaeure, diese formen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8604546A1 true ES8604546A1 (es) 1986-02-01
ES545881A0 ES545881A0 (es) 1986-02-01

Family

ID=37847099

Family Applications (7)

Application Number Title Priority Date Filing Date
ES539078A Expired ES8605500A1 (es) 1983-12-30 1984-12-27 Procedimiento para preparar derivados de acidos fenilaceticos.
ES545881A Expired ES8604546A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545880A Expired ES8604545A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545882A Expired ES8604547A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545883A Expired ES8604548A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545879A Expired ES8604544A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES556495A Expired ES8802145A1 (es) 1983-12-30 1986-06-24 Procedimiento para preparar dos nuevas formas solidas de acido 2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)-aminocarbonilmetil)-benzoico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES539078A Expired ES8605500A1 (es) 1983-12-30 1984-12-27 Procedimiento para preparar derivados de acidos fenilaceticos.

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES545880A Expired ES8604545A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545882A Expired ES8604547A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545883A Expired ES8604548A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545879A Expired ES8604544A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES556495A Expired ES8802145A1 (es) 1983-12-30 1986-06-24 Procedimiento para preparar dos nuevas formas solidas de acido 2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)-aminocarbonilmetil)-benzoico

Country Status (26)

Country Link
EP (2) EP0147850B1 (es)
JP (2) JPH0623200B2 (es)
KR (1) KR900005320B1 (es)
AT (1) ATE44027T1 (es)
AU (2) AU577815B2 (es)
BG (1) BG61519B2 (es)
CA (2) CA1225398A (es)
CS (1) CS409791A3 (es)
DD (1) DD231348A5 (es)
DE (4) DE3347565A1 (es)
DK (2) DK167439B1 (es)
ES (7) ES8605500A1 (es)
FI (2) FI80447C (es)
GR (2) GR82614B (es)
HK (1) HK87492A (es)
HU (1) HU194548B (es)
IE (1) IE57700B1 (es)
IL (2) IL73963A (es)
LU (1) LU90301I2 (es)
MX (1) MX9202772A (es)
NL (1) NL980034I1 (es)
NO (3) NO162819C (es)
NZ (2) NZ210657A (es)
PT (2) PT79772B (es)
SG (1) SG55492G (es)
ZA (2) ZA8410103B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE184279T1 (de) * 1991-06-21 1999-09-15 Boehringer Ingelheim Pharma Verwendung von (s)(+)-2-äthoxy-4-(n-(1-(2- piperidino-phenyl)-3-methyl-1- butyl>aminocarbonylmethyl>-benzoesäure zur herstellung eines langzeitantidiabetikums
WO1993000337A1 (de) * 1991-06-21 1993-01-07 Dr. Karl Thomae Gmbh (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure
FR2763590B1 (fr) * 1997-05-22 2000-03-24 Synthelabo Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
ATE346613T1 (de) 2000-01-21 2006-12-15 Novartis Pharma Gmbh Zusammensetzungen bestehend aus dipeptidylpeptidase-iv inhibitoren und antidiabetica
WO2004018442A1 (en) * 2002-08-23 2004-03-04 Dr. Reddy's Laboratories Limited Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof
US7915421B2 (en) 2003-05-14 2011-03-29 Cilag Ltd. Method for preparing phenyl acetic acid derivatives
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
US7582766B2 (en) * 2003-06-09 2009-09-01 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus
FR2875805B1 (fr) * 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
CN1305863C (zh) * 2004-12-27 2007-03-21 浙江大学 (s)－异丙基－(2－哌啶)苯基－甲基胺的合成方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
MY159522A (en) 2005-09-14 2017-01-13 Takeda Pharmaceuticals Co Administration of dipeptidyl peptidase inhibitors
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
BRPI1012852A2 (pt) 2009-05-15 2018-06-19 Novartis Ag derivados de benzoxazolona como inibidores da sintase de aldoesterona
SI2429995T1 (sl) 2009-05-15 2014-05-30 Novartis Ag Arilpiridini kot inhibitorji aldosteron sintaze
NZ596304A (en) 2009-05-28 2014-01-31 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
EP2993169B1 (en) 2009-11-17 2017-12-20 Novartis AG Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8575160B2 (en) 2009-11-30 2013-11-05 Novartis Ag Imidazole derivatives as aldosterone synthase inhibitors
US8802695B2 (en) 2010-02-03 2014-08-12 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012095548A2 (es) 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compuestos para el tratamiento de enfermedades neurodegenerativas
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
LT2956464T (lt) 2013-02-14 2018-07-10 Novartis Ag Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai
KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
MX2016001021A (es) 2013-07-25 2016-08-03 Novartis Ag Bioconjugados de polipeptidos de apelina sinteticos.
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
DE3100535A1 (de) * 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
EP0099017B1 (de) * 1982-07-06 1988-03-02 Dr. Karl Thomae GmbH Neue Phenylessigsäure-Derivate, ihre Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2554875B1 (fr) * 1983-11-10 1986-02-28 Dba Amplificateur hydraulique de freinage
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
CA1292000C (en) 1991-11-12
IL73963A (en) 1989-01-31
KR850004590A (ko) 1985-07-25
NO862532D0 (no) 1986-06-24
ES545880A0 (es) 1986-02-01
NZ216640A (en) 1989-02-24
FI845145A0 (fi) 1984-12-28
IL73963A0 (en) 1985-03-31
AU583631B2 (en) 1989-05-04
NO162819C (no) 1990-02-21
NO1999016I1 (no) 1999-07-20
ES545882A0 (es) 1986-02-01
ES8604545A1 (es) 1986-02-01
IE57700B1 (en) 1993-03-10
HK87492A (en) 1992-11-13
ES8604547A1 (es) 1986-02-01
PT79772B (de) 1987-01-05
NO845282L (no) 1985-07-01
HU194548B (en) 1988-02-29
ZA8410103B (en) 1986-09-24
ATE44027T1 (de) 1989-06-15
ES8604548A1 (es) 1986-02-01
DK167439B1 (da) 1993-11-01
FI80447C (fi) 1990-06-11
ES8802145A1 (es) 1988-04-01
NO862532L (no) 1986-12-29
FI862650A0 (fi) 1986-06-23
DK296686A (da) 1986-12-26
FI82689B (fi) 1990-12-31
EP0147850B1 (de) 1989-06-14
AU5913986A (en) 1987-01-08
PT82832A (de) 1986-07-01
JPS62474A (ja) 1987-01-06
DK296686D0 (da) 1986-06-24
NO168302B (no) 1991-10-28
DE3478682D1 (en) 1989-07-20
FI82689C (fi) 1991-04-10
JPH0623200B2 (ja) 1994-03-30
GR82614B (en) 1985-05-02
CS409791A3 (en) 1992-07-15
BG61519B2 (bg) 1997-10-31
FI845145L (fi) 1985-07-01
JPS60158171A (ja) 1985-08-19
ES545879A0 (es) 1986-02-01
DK167573B1 (da) 1993-11-22
ES545883A0 (es) 1986-02-01
FI80447B (fi) 1990-02-28
DE3347565A1 (de) 1985-07-11
AU577815B2 (en) 1988-10-06
DK613184A (da) 1985-07-01
GR861558B (en) 1986-10-17
HUT37773A (en) 1986-02-28
EP0207331B1 (de) 1990-05-23
DE3522604A1 (de) 1987-01-08
PT82832B (pt) 1988-12-15
ES539078A0 (es) 1986-03-16
IL79217A (en) 1991-01-31
AU3721084A (en) 1985-08-01
MX9202772A (es) 1992-06-30
NO168302C (no) 1992-02-05
LU90301I2 (fr) 1998-12-21
ES556495A0 (es) 1988-04-01
IE843349L (en) 1985-06-30
NZ210657A (en) 1988-10-28
ES8605500A1 (es) 1986-03-16
ZA864695B (en) 1988-02-24
IL79217A0 (en) 1986-09-30
DK613184D0 (da) 1984-12-20
JPH0739405B2 (ja) 1995-05-01
DD231348A5 (de) 1985-12-24
PT79772A (de) 1985-01-01
EP0147850A3 (en) 1985-08-07
DE19875044I2 (de) 2002-07-18
ES8604544A1 (es) 1986-02-01
KR900005320B1 (ko) 1990-07-27
ES545881A0 (es) 1986-02-01
NL980034I1 (nl) 1999-02-01
EP0207331A1 (de) 1987-01-07
CA1225398A (en) 1987-08-11
EP0147850A2 (de) 1985-07-10
SG55492G (en) 1992-10-02
FI862650A (fi) 1986-12-26
NO162819B (no) 1989-11-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051128