ES8603893A1 - Procedimiento de desalquilacion de alcaloides e intermedia- rios - Google Patents

Procedimiento de desalquilacion de alcaloides e intermedia- rios

Info

Publication number
ES8603893A1
ES8603893A1 ES543338A ES543338A ES8603893A1 ES 8603893 A1 ES8603893 A1 ES 8603893A1 ES 543338 A ES543338 A ES 543338A ES 543338 A ES543338 A ES 543338A ES 8603893 A1 ES8603893 A1 ES 8603893A1
Authority
ES
Spain
Prior art keywords
alcaloids
dealkylation
intermediates
hydroxymorphinanes
coch3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543338A
Other languages
English (en)
Other versions
ES543338A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8603893A1 publication Critical patent/ES8603893A1/es
Publication of ES543338A0 publication Critical patent/ES543338A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE DESALQUILACION DE ALCALOIDES 14-HIDROXIMORFINANOS. COMPRENDE EL PROVOCAR LA REACCION DE UN DERIVADO 14-HIDROXILMORFINANO CON CLOROFORMIATO DE ETILO EN EXCESO, EN PRESENCIA DE CARBOMATO POTASICO EN EL SENO DE UN DISOLVENTE, SOMETIENDO A CONTINUACION EL CARBAMATO CONSEGUIDO A HIDROLISIS EN MEDIO ACIDO FUERTE. COMO APLICACION SE CITA LA DESMETILACION DE LA TEBAINA.
ES543338A 1984-05-25 1985-05-21 Procedimiento de desalquilacion de alcaloides e intermedia- rios Granted ES543338A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8408273A FR2564838B1 (fr) 1984-05-25 1984-05-25 Procede de dealkylation d'alcaloides et intermediaires

Publications (2)

Publication Number Publication Date
ES8603893A1 true ES8603893A1 (es) 1986-01-01
ES543338A0 ES543338A0 (es) 1986-01-01

Family

ID=9304425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543338A Granted ES543338A0 (es) 1984-05-25 1985-05-21 Procedimiento de desalquilacion de alcaloides e intermedia- rios

Country Status (12)

Country Link
EP (1) EP0164290B1 (es)
JP (1) JPS60258183A (es)
AT (1) ATE46163T1 (es)
AU (1) AU577379B2 (es)
CA (1) CA1244825A (es)
DE (1) DE3572819D1 (es)
DK (1) DK160048C (es)
ES (1) ES543338A0 (es)
FR (1) FR2564838B1 (es)
NO (1) NO164981C (es)
NZ (1) NZ212193A (es)
PT (1) PT80519B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
GB2438400A (en) * 2006-05-25 2007-11-28 Alpharma Aps N-Demethylation of 14-hydroxy morphinans with alpha-chloroethyl chloroformate
GB2471803B (en) * 2006-05-25 2011-02-16 Alpharma Chemical process
GB2438401A (en) * 2006-05-25 2007-11-28 Alpharma Aps Preparation of morphinan derivatives comprising N-demethylation, reductive amination and O-demethylation steps
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en) 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
AU2008338971B2 (en) * 2007-12-17 2013-08-29 SpecGx LLC Processes for the preparation of normorphinan salts
US9131649B2 (en) 2008-03-07 2015-09-15 Tasmanian Alkaloids Pty. Ltd Papaver somniferum strain with high concentration of thebaine
JP2011516464A (ja) * 2008-03-31 2011-05-26 サン・ファーマシューティカル・インダストリーズ・リミテッド モルフィナン類似体の改良された調製方法
EP2995614B8 (en) 2010-06-11 2018-03-28 Rhodes Technologies Inc. Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
BR112013028467A2 (pt) * 2011-05-06 2016-08-16 Univ Brock processo para a preparação de análogos de morfina através da n-demetilação/funcionalização catalisada por metal e transferência de grupo intramolecular

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141807A (en) * 1977-03-01 1979-02-27 Stauffer Chemical Company Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds
DE2727805A1 (de) * 1977-06-21 1979-01-04 Goedecke Ag Verfahren zur herstellung von oxynormorphon
US4390699A (en) * 1981-07-16 1983-06-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 6-Keto-morphinans belonging to the 14-hydroxy-series
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
EP0104984B1 (fr) * 1982-09-24 1990-05-16 Societe Nationale Des Poudres Et Explosifs Procédé de préparation des carbamates vinyliques et nouveaux carbamates vinyliques

Also Published As

Publication number Publication date
DK227685D0 (da) 1985-05-22
DK227685A (da) 1985-11-26
PT80519A (fr) 1985-06-01
PT80519B (pt) 1988-01-22
NZ212193A (en) 1988-10-28
CA1244825A (en) 1988-11-15
FR2564838A1 (fr) 1985-11-29
NO164981C (no) 1990-12-05
DE3572819D1 (en) 1989-10-12
ES543338A0 (es) 1986-01-01
NO164981B (no) 1990-08-27
NO852091L (no) 1985-11-26
ATE46163T1 (de) 1989-09-15
DK160048B (da) 1991-01-21
AU4284385A (en) 1985-11-28
EP0164290A1 (fr) 1985-12-11
DK160048C (da) 1991-06-17
FR2564838B1 (fr) 1986-11-07
EP0164290B1 (fr) 1989-09-06
JPS60258183A (ja) 1985-12-20
AU577379B2 (en) 1988-09-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303