ES8601218A1 - 2-Quat. heterocyclyl-alkylthio substd. de:thia-penem derivs. - Google Patents
2-Quat. heterocyclyl-alkylthio substd. de:thia-penem derivs.Info
- Publication number
- ES8601218A1 ES8601218A1 ES535718A ES535718A ES8601218A1 ES 8601218 A1 ES8601218 A1 ES 8601218A1 ES 535718 A ES535718 A ES 535718A ES 535718 A ES535718 A ES 535718A ES 8601218 A1 ES8601218 A1 ES 8601218A1
- Authority
- ES
- Spain
- Prior art keywords
- penem
- derivs
- substd
- quat
- thia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001012 protector Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
- H01L27/02—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Power Engineering (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The process comprises reaction of a compound of formula (II) with a thiol of formula (III) In the formulae R2 is a carboxyl protector gp., L is a salient gp. X- is a contra-anion, R8 is H, A is a C 1-6 alkylene and R1,2,5,15 can be various types of radicals. The reaction is carried out in an inert solvent in the presence of base at -15 to +15 deg.C and yields antibiotics of carbapenem and its physiologically compatible salts of formula (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53001283A | 1983-09-09 | 1983-09-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8601218A1 true ES8601218A1 (en) | 1985-11-01 |
ES535718A0 ES535718A0 (en) | 1985-11-01 |
Family
ID=24112102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535718A Granted ES535718A0 (en) | 1983-09-09 | 1984-09-06 | A PROCEDURE FOR THE PREPARATION OF CARBAPENEM ANTIBIOTICS. |
Country Status (17)
Country | Link |
---|---|
KR (1) | KR870001743B1 (en) |
AT (1) | AT387387B (en) |
CA (1) | CA1273010A (en) |
CS (1) | CS248721B2 (en) |
DD (1) | DD232495A5 (en) |
DK (1) | DK429584A (en) |
ES (1) | ES535718A0 (en) |
FI (1) | FI843466A (en) |
GR (1) | GR80297B (en) |
HU (1) | HU192431B (en) |
LU (1) | LU85535A1 (en) |
NO (1) | NO843541L (en) |
OA (1) | OA07808A (en) |
PT (1) | PT79184B (en) |
SU (1) | SU1395142A3 (en) |
YU (1) | YU154884A (en) |
ZW (1) | ZW15184A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2945534B1 (en) | 2009-05-12 | 2012-11-16 | Sanofi Aventis | CYCLOPENTAL [c] PYRROLE-2-CARBOXYLATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52147B1 (en) * | 1980-03-27 | 1987-07-08 | Merck & Co Inc | 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation |
EP0074599A1 (en) * | 1981-09-09 | 1983-03-23 | Takeda Chemical Industries, Ltd. | 5,6-cis-Carbapenem derivatives, their production and use |
-
1984
- 1984-08-27 CA CA000461853A patent/CA1273010A/en not_active Expired - Lifetime
- 1984-09-05 GR GR80297A patent/GR80297B/en unknown
- 1984-09-05 ZW ZW151/84A patent/ZW15184A1/en unknown
- 1984-09-05 FI FI843466A patent/FI843466A/en not_active Application Discontinuation
- 1984-09-06 ES ES535718A patent/ES535718A0/en active Granted
- 1984-09-06 NO NO843541A patent/NO843541L/en unknown
- 1984-09-06 CS CS846720A patent/CS248721B2/en unknown
- 1984-09-07 PT PT79184A patent/PT79184B/en not_active IP Right Cessation
- 1984-09-07 DK DK429584A patent/DK429584A/en not_active Application Discontinuation
- 1984-09-07 YU YU01548/84A patent/YU154884A/en unknown
- 1984-09-07 SU SU843789215A patent/SU1395142A3/en active
- 1984-09-07 HU HU843392A patent/HU192431B/en not_active IP Right Cessation
- 1984-09-07 LU LU85535A patent/LU85535A1/en unknown
- 1984-09-07 OA OA58384A patent/OA07808A/en unknown
- 1984-09-07 DD DD84267116A patent/DD232495A5/en not_active IP Right Cessation
- 1984-09-07 KR KR1019840005486A patent/KR870001743B1/en not_active IP Right Cessation
- 1984-09-10 AT AT0289784A patent/AT387387B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI843466A0 (en) | 1984-09-05 |
PT79184A (en) | 1984-10-01 |
FI843466A (en) | 1985-03-10 |
DK429584D0 (en) | 1984-09-07 |
AT387387B (en) | 1989-01-10 |
PT79184B (en) | 1986-11-24 |
GR80297B (en) | 1985-01-09 |
HU192431B (en) | 1987-06-29 |
KR870001743B1 (en) | 1987-09-26 |
CA1273010A (en) | 1990-08-21 |
SU1395142A3 (en) | 1988-05-07 |
KR850002099A (en) | 1985-05-06 |
LU85535A1 (en) | 1985-04-29 |
YU154884A (en) | 1987-06-30 |
DD232495A5 (en) | 1986-01-29 |
DK429584A (en) | 1985-03-10 |
HUT34979A (en) | 1985-05-28 |
ZW15184A1 (en) | 1985-04-03 |
CS248721B2 (en) | 1987-02-12 |
ES535718A0 (en) | 1985-11-01 |
NO843541L (en) | 1985-03-11 |
OA07808A (en) | 1986-11-20 |
ATA289784A (en) | 1988-06-15 |
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