ES8601218A1 - 2-Quat. heterocyclyl-alkylthio substd. de:thia-penem derivs. - Google Patents

2-Quat. heterocyclyl-alkylthio substd. de:thia-penem derivs.

Info

Publication number
ES8601218A1
ES8601218A1 ES535718A ES535718A ES8601218A1 ES 8601218 A1 ES8601218 A1 ES 8601218A1 ES 535718 A ES535718 A ES 535718A ES 535718 A ES535718 A ES 535718A ES 8601218 A1 ES8601218 A1 ES 8601218A1
Authority
ES
Spain
Prior art keywords
penem
derivs
substd
quat
thia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535718A
Other languages
Spanish (es)
Other versions
ES535718A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8601218A1 publication Critical patent/ES8601218A1/en
Publication of ES535718A0 publication Critical patent/ES535718A0/en
Granted legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/02—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Power Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The process comprises reaction of a compound of formula (II) with a thiol of formula (III) In the formulae R2 is a carboxyl protector gp., L is a salient gp. X- is a contra-anion, R8 is H, A is a C 1-6 alkylene and R1,2,5,15 can be various types of radicals. The reaction is carried out in an inert solvent in the presence of base at -15 to +15 deg.C and yields antibiotics of carbapenem and its physiologically compatible salts of formula (I).
ES535718A 1983-09-09 1984-09-06 A PROCEDURE FOR THE PREPARATION OF CARBAPENEM ANTIBIOTICS. Granted ES535718A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53001283A 1983-09-09 1983-09-09

Publications (2)

Publication Number Publication Date
ES8601218A1 true ES8601218A1 (en) 1985-11-01
ES535718A0 ES535718A0 (en) 1985-11-01

Family

ID=24112102

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535718A Granted ES535718A0 (en) 1983-09-09 1984-09-06 A PROCEDURE FOR THE PREPARATION OF CARBAPENEM ANTIBIOTICS.

Country Status (17)

Country Link
KR (1) KR870001743B1 (en)
AT (1) AT387387B (en)
CA (1) CA1273010A (en)
CS (1) CS248721B2 (en)
DD (1) DD232495A5 (en)
DK (1) DK429584A (en)
ES (1) ES535718A0 (en)
FI (1) FI843466A (en)
GR (1) GR80297B (en)
HU (1) HU192431B (en)
LU (1) LU85535A1 (en)
NO (1) NO843541L (en)
OA (1) OA07808A (en)
PT (1) PT79184B (en)
SU (1) SU1395142A3 (en)
YU (1) YU154884A (en)
ZW (1) ZW15184A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945534B1 (en) 2009-05-12 2012-11-16 Sanofi Aventis CYCLOPENTAL [c] PYRROLE-2-CARBOXYLATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0074599A1 (en) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-cis-Carbapenem derivatives, their production and use

Also Published As

Publication number Publication date
FI843466A0 (en) 1984-09-05
PT79184A (en) 1984-10-01
FI843466A (en) 1985-03-10
DK429584D0 (en) 1984-09-07
AT387387B (en) 1989-01-10
PT79184B (en) 1986-11-24
GR80297B (en) 1985-01-09
HU192431B (en) 1987-06-29
KR870001743B1 (en) 1987-09-26
CA1273010A (en) 1990-08-21
SU1395142A3 (en) 1988-05-07
KR850002099A (en) 1985-05-06
LU85535A1 (en) 1985-04-29
YU154884A (en) 1987-06-30
DD232495A5 (en) 1986-01-29
DK429584A (en) 1985-03-10
HUT34979A (en) 1985-05-28
ZW15184A1 (en) 1985-04-03
CS248721B2 (en) 1987-02-12
ES535718A0 (en) 1985-11-01
NO843541L (en) 1985-03-11
OA07808A (en) 1986-11-20
ATA289784A (en) 1988-06-15

Similar Documents

Publication Publication Date Title
AR241528A1 (en) Alkylsulfonamidophenylalkylamines
AU521853B2 (en) Article carrier + sleeve therefor
AU8062487A (en) New substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents
ATE74346T1 (en) ALKENIC ACID DERIVATIVES.
ES8601218A1 (en) 2-Quat. heterocyclyl-alkylthio substd. de:thia-penem derivs.
AU5276779A (en) Chuck with retractable workpiece locating stop
AU567163B2 (en) B-carbolin-3-carboxylic acid derivatives
EP0470431A3 (en) Use of phosphomycin and the pharmaceutically acceptable salts thereof as a topical cicatrizer
AU556292B2 (en) N-(1,3-dithiolan-2-ylidene) anilines
ES8603849A1 (en) Process for producing aminothiazolylpropendicarboxylic acid monoesters.
ES435003A1 (en) Process for N-acylation of 7 amino cephem compounds
FI102831B1 (en) Process for the preparation of astaxanthin and intermediate
AU524795B2 (en) Beta-lactam series compound
DE3680725D1 (en) Propanolabkoemmlinge.
ATE26449T1 (en) ISOLATION AND PURIFICATION OF CEPHALOSPORINS.
ES8603873A1 (en) Beta-lactam cpds.
AU517673B2 (en) 2-benzothiazolyl sulphenic acid morpholides
DE3379224D1 (en) 3-methoxy-n-methylmorphinane : theophyllinacetic acid (1:2) complex, process for preparing the same and said complex for therapeutical use
GR81626B (en)
JO973B1 (en) penicillanic acid derivatives
EG15885A (en) Process for preparing p-chlorophenoxyacetyl-piperonylpiperazine
JPS54128997A (en) Method of reducing ticl4 with reducing agent denatured by lowis base
GR78826B (en)
ES8707184A3 (en) Phenoxy-propylamine deriv. prepn.
AU5041879A (en) Isopropyl amine compounds