ES8601136A1 - Procedimiento para la obtencion de aminopropanderivados - Google Patents

Procedimiento para la obtencion de aminopropanderivados

Info

Publication number
ES8601136A1
ES8601136A1 ES538161A ES538161A ES8601136A1 ES 8601136 A1 ES8601136 A1 ES 8601136A1 ES 538161 A ES538161 A ES 538161A ES 538161 A ES538161 A ES 538161A ES 8601136 A1 ES8601136 A1 ES 8601136A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
hydroxy
contg
opt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538161A
Other languages
English (en)
Other versions
ES538161A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES8601136A1 publication Critical patent/ES8601136A1/es
Publication of ES538161A0 publication Critical patent/ES538161A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Machine Translation (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE AMINOPROPANDERIVADOS DE FORMULA (I). CONSISTE EN: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) SIENDO A EL RESTO DE FORMULA (III) DONDE B SIGNIFICA UN GRUPO DISOCIABLE NUCLEOFUGO CON UNA AMINA DE FORMULA HNR1R2; OB) SE HIDROGENA CATALITICAMENTE UN COMPUESTO DE FORMULA (IV) Y LOS COMPUESTOS ASI OBTENIDOS SE TRANSFORMAN EN SUS SALES DE ADICION DE ACIDO CON ACIDOS FISIOLOGICAMENTE TOLERABLES. APLICADO EN LA OBTENCION DE PRODUCTOS CON ACTIVIDAD ANTIARRITIMICA.
ES538161A 1983-12-02 1984-11-30 Procedimiento para la obtencion de aminopropanderivados Granted ES538161A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833343671 DE3343671A1 (de) 1983-12-02 1983-12-02 Aminopropanolderivate von substituierten 2-hydroxy-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel

Publications (2)

Publication Number Publication Date
ES8601136A1 true ES8601136A1 (es) 1985-11-01
ES538161A0 ES538161A0 (es) 1985-11-01

Family

ID=6215907

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538161A Granted ES538161A0 (es) 1983-12-02 1984-11-30 Procedimiento para la obtencion de aminopropanderivados

Country Status (14)

Country Link
US (1) US5118685A (es)
EP (1) EP0152556B1 (es)
JP (1) JPS60136557A (es)
AT (1) ATE25083T1 (es)
CA (1) CA1233465A (es)
CS (1) CS251090B2 (es)
DE (2) DE3343671A1 (es)
DK (1) DK158979C (es)
ES (1) ES538161A0 (es)
FI (1) FI86174C (es)
HU (1) HU192625B (es)
IL (1) IL73702A (es)
NO (1) NO164771C (es)
ZA (1) ZA849380B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2584070B1 (fr) * 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux derives de l'hydroxy alkoxy 4-phenyl propyl indole, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant.
FR2624858B1 (fr) * 1987-12-21 1990-06-01 Esteve Labor Dr Nouveaux derives de 2-propanol, leur preparation et leur application en tant que medicaments
DE3825561A1 (de) * 1988-07-28 1990-02-01 Basf Ag P-hydroxiphenon-derivate und diese enthaltende arzneimittel
AT401726B (de) * 1993-05-17 1996-11-25 Gerhard Dr Ecker O-acylaryloxypropanolamine mit tertiärem oder quartärem stickstoff als reversionsmodulatoren für p-glykoprotein mediierte multidrug-resistenz

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
DE2001431C3 (de) * 1970-01-06 1974-12-12 Helopharm W. Petrik & Co Kg, 1000 Berlin 2-(2'-Hydroxy-3'-alkylaminopropoxy)-Omega-phenyl-propiophenone und Verfahren zur Herstellung derselben
GB1560006A (en) * 1977-08-18 1980-01-30 Laroche Navarron Sa Benzoyl furan derivatives process for their preparation and therapeutic applications thereof
DE2835438A1 (de) * 1978-08-12 1980-03-06 Basf Ag Aminopropanolderivate des 2-(o-hydroxyphenyl)-pyrrols
JPS57188570A (en) * 1981-05-14 1982-11-19 Shionogi & Co Ltd Benzylazole derivative
DE3133814C2 (de) * 1981-08-25 1983-12-22 Helopharm W. Petrik & Co Kg, 1000 Berlin 2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-β-phenylpropiophenon, seine Säureadditionssalze und Arzneimittel
DE3226863A1 (de) * 1981-09-18 1983-04-07 Basf Ag, 6700 Ludwigshafen Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel

Also Published As

Publication number Publication date
FI86174B (fi) 1992-04-15
JPS60136557A (ja) 1985-07-20
ZA849380B (en) 1985-08-28
DK158979B (da) 1990-08-13
DK566684D0 (da) 1984-11-29
EP0152556B1 (de) 1987-01-21
NO844778L (no) 1985-06-03
CA1233465A (en) 1988-03-01
DE3462136D1 (en) 1987-02-26
IL73702A (en) 1988-03-31
CS251090B2 (en) 1987-06-11
ES538161A0 (es) 1985-11-01
HU192625B (en) 1987-06-29
NO164771C (no) 1990-11-14
DK158979C (da) 1991-01-07
DK566684A (da) 1985-06-03
FI844729A0 (fi) 1984-11-30
HUT36802A (en) 1985-10-28
FI86174C (fi) 1992-07-27
EP0152556A1 (de) 1985-08-28
US5118685A (en) 1992-06-02
IL73702A0 (en) 1985-03-31
ATE25083T1 (de) 1987-02-15
JPH0552305B2 (es) 1993-08-05
DE3343671A1 (de) 1985-06-20
FI844729L (fi) 1985-06-03
NO164771B (no) 1990-08-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102