ES8506190A1 - Un metodo para estabilizar un activador de plasminogeno de tejido. - Google Patents

Un metodo para estabilizar un activador de plasminogeno de tejido.

Info

Publication number
ES8506190A1
ES8506190A1 ES531754A ES531754A ES8506190A1 ES 8506190 A1 ES8506190 A1 ES 8506190A1 ES 531754 A ES531754 A ES 531754A ES 531754 A ES531754 A ES 531754A ES 8506190 A1 ES8506190 A1 ES 8506190A1
Authority
ES
Spain
Prior art keywords
plasminogen activator
tissue plasminogen
aqueous solution
powder containing
stable aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531754A
Other languages
English (en)
Other versions
ES531754A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Kowa Co Ltd
Asahi Chemical Industry Co Ltd
Original Assignee
Kowa Co Ltd
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd, Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Kowa Co Ltd
Publication of ES531754A0 publication Critical patent/ES531754A0/es
Publication of ES8506190A1 publication Critical patent/ES8506190A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
    • G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
    • G03C2001/0471—Isoelectric point of gelatine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/848—Lungs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

METODO PARA ESTABILIZAR UN ACTIVADOR DE PLASMINOGENO DE TEJIDO.COMPRENDE LA ADICION DE 0,0001 A 0,10 G POR ML DE DISOLUCION DE GELATINA PURIFICADA QUE TIENE UN PUNTO ISOELECTRICO DE 4,5 A 9,0 Y UN PESO MOLECULAR DE MEDIA PONDERADA DE 3.000 A 50.000, A UNA DISOLUCION ACUOSAO O UN POLVO, QUE CONTIENE UN ACTIVADOR DE PLASMINOGENO DE TEJIDO; SEGUIDA DE LA LIOFILIZACION DE LA DISOLUCION ACUOSA RESULTANTE.TIENE APLICACIONES PARA EVITAR LA ADSORCION DE SUSTANCIAS ACTIVAS SOBRE LAS PAREDES INTERIORES DE TUBOS DE ENSAYO, CUERPOS DE JERINGAS, FRASCOS PARA LIQUIDOS NUTRITIVOS, UTENSILIOS MEDICOS E INSTRUMENTOS ANALITICOS.
ES531754A 1983-04-21 1984-04-18 Un metodo para estabilizar un activador de plasminogeno de tejido. Expired ES8506190A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58069230A JPS59196824A (ja) 1983-04-21 1983-04-21 吸着防止剤

Publications (2)

Publication Number Publication Date
ES531754A0 ES531754A0 (es) 1985-07-01
ES8506190A1 true ES8506190A1 (es) 1985-07-01

Family

ID=13396714

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531754A Expired ES8506190A1 (es) 1983-04-21 1984-04-18 Un metodo para estabilizar un activador de plasminogeno de tejido.

Country Status (6)

Country Link
US (1) US4552760A (es)
EP (1) EP0123304B1 (es)
JP (1) JPS59196824A (es)
CA (1) CA1206434A (es)
DE (1) DE3483917D1 (es)
ES (1) ES8506190A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001355A (en) * 1982-12-14 1999-12-14 Dowdle; Eugene Bernard Davey Pro-tPA for the treatment of thrombosis, embolism and related conditions
US4757005A (en) * 1984-04-19 1988-07-12 Miles Inc. Method and cell line for obtaining plasminogen activators
JPS61176532A (ja) * 1985-01-30 1986-08-08 Green Cross Corp:The プラスミノ−ゲンアクチベ−タ−前駆体の安定化方法
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
NZ216306A (en) * 1985-05-28 1989-10-27 Wellcome Found Pharmaceutical compositions containing tissue plasminogen activator
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
ATE83153T1 (de) * 1985-09-10 1992-12-15 Eisai Co Ltd Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
JPS62153221A (ja) * 1985-12-27 1987-07-08 Wakamoto Pharmaceut Co Ltd ヒト子宮筋正常組織由来樹立化細胞ｋｗ株及びその培養によるプラスミノ−ゲンアクチベ−タ−の製造法
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
DK237187A (da) * 1986-05-12 1987-11-13 Wellcome Found Farmaceutisk anvendelse af t-pa
EP0252004A1 (de) * 1986-06-26 1988-01-07 Ciba-Geigy Ag Pharmazeutische Zusammensetzungen für die parenterale Applikation
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
JPH08840B2 (ja) * 1986-11-14 1996-01-10 興和株式会社 抗ｐｃｉモノクローナル抗体、これを用いた抗ｐｃｉの精製法及び免疫学的測定法
HU209955B (en) * 1987-07-01 1994-12-28 Genentech Inc Process for producing pharmaceutical compositions containing tissue- -plasminogen-activator of poor solubility for inhibiting production and regeneration of deformities
WO1989002747A1 (en) * 1987-10-05 1989-04-06 The American National Red Cross Therapeutic thrombolytic composition
US5151359A (en) * 1988-05-19 1992-09-29 Mitsui Toatsu Chemicals Incorporated Method for producing of human tissue type plasminogen activator
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
AU635541B2 (en) * 1989-05-17 1993-03-25 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
US5681814A (en) * 1990-06-07 1997-10-28 Genentech, Inc. Formulated IGF-I Composition
DE59005286D1 (de) * 1990-10-04 1994-05-11 Kallies Import Export Vertrieb Stabilisiertes Thrombin, seine Herstellung und seine Verwendung als Thrombinzeitreagens.
JPH11507918A (ja) * 1995-06-10 1999-07-13 ペンタファルム・アーゲー コラーゲンペプチドフラクション及びその使用
JP4958777B2 (ja) * 2004-07-30 2012-06-20 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド 物理的／物理化学的刺激により処理される非晶質細胞送達ビヒクル
US8748007B2 (en) * 2006-05-02 2014-06-10 Ppg Industries Ohio, Inc. Coating compositions exhibiting corrosion resistance properties, related coated articles and methods
WO2021058660A1 (en) * 2019-09-24 2021-04-01 Universiteit Gent Anti-adsorption solution

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB802069A (en) * 1956-01-23 1958-09-24 Nat Drug Co Proteolytic enzyme compositions
US2930736A (en) * 1957-01-07 1960-03-29 Nat Drug Co Stabilized trypsin compositions containing partially hydrolyzed gelatin and method of making
DE1183629B (de) * 1962-12-21 1964-12-17 Behringwerke Ag Verfahren zur Stabilisierung biologisch aktiven Materials
US3296094A (en) * 1966-05-05 1967-01-03 Baxter Laboratories Inc Stabilized aqueous enzyme solutions
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
US4151161A (en) * 1976-06-14 1979-04-24 Canada Packers Limited Preparation of high-quality gelatine having low chromium content from chromed waste stock
US4245051A (en) * 1978-03-30 1981-01-13 Rockefeller University Human serum plasminogen activator
US4264493A (en) * 1978-10-18 1981-04-28 Battista Orlando A Natural protein polymer hydrogels
GB2038337B (en) * 1978-12-21 1983-01-19 Green Cross Corp Process which comprises separation of urokinases having different molecular weights
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
JPS57169425A (en) * 1981-04-10 1982-10-19 Eisai Co Ltd Composition and method for preventing adsorption of secretin
JPS5896026A (ja) * 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
GR79202B (es) * 1982-05-05 1984-10-22 Genentech Inc
JPS58224687A (ja) * 1982-06-24 1983-12-27 Toubishi Yakuhin Kogyo Kk プラスミノ−ゲン活性化酵素剤及びその新規製造方法
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
EP0112940B1 (en) * 1982-12-30 1986-10-15 Kowa Company, Ltd. Method of producing a tissue plasminogen activator and composition comprising same

Also Published As

Publication number Publication date
EP0123304B1 (en) 1991-01-16
US4552760A (en) 1985-11-12
EP0123304A3 (en) 1987-03-04
CA1206434A (en) 1986-06-24
ES531754A0 (es) 1985-07-01
JPS59196824A (ja) 1984-11-08
DE3483917D1 (de) 1991-02-21
EP0123304A2 (en) 1984-10-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201