ES8101624A1 - Un procedimiento para la preparacion de espiroketalinas con propiedades anti-inflamatorias. - Google Patents
Un procedimiento para la preparacion de espiroketalinas con propiedades anti-inflamatorias.Info
- Publication number
- ES8101624A1 ES8101624A1 ES482253A ES482253A ES8101624A1 ES 8101624 A1 ES8101624 A1 ES 8101624A1 ES 482253 A ES482253 A ES 482253A ES 482253 A ES482253 A ES 482253A ES 8101624 A1 ES8101624 A1 ES 8101624A1
- Authority
- ES
- Spain
- Prior art keywords
- spiroketalins
- applications
- spiroketalin
- glycoside
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE ESPIROKETALINAS. CONSISTE EN HACER REACCIONAR LA CORRESPONDIENTE AGLICONA CON BROMOACETILGLUCOSA, SEPARANDOSE EL CORRESPONDIENTE TETRACETATO, QUE SE NEUTRALIZA CON UNA BASE, TAL COMO ETOXIDO SODICO. LA AGLICONA EMPLEADA SE ELIGE DE DIOSGENIL, HECOGENIL Y LIGOGENIN. SE OBTIENE UN COMPUESTO DE FORMULA GENERAL (I), SIENDO Z UN RESTO MONO O DISACARIDO Y R REPRESNTA 2 HIDROGENOS O UN OXIGENO CETONICO. *FORMULA* ACTIVIDAD ANTIINFLAMATORIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7828935 | 1978-07-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES482253A0 ES482253A0 (es) | 1980-12-16 |
ES8101624A1 true ES8101624A1 (es) | 1980-12-16 |
Family
ID=10498274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES482253A Expired ES8101624A1 (es) | 1978-07-05 | 1979-07-05 | Un procedimiento para la preparacion de espiroketalinas con propiedades anti-inflamatorias. |
Country Status (19)
Country | Link |
---|---|
US (1) | US4265886A (es) |
JP (1) | JPS5536471A (es) |
AU (1) | AU550621B2 (es) |
BE (1) | BE877511A (es) |
CA (1) | CA1140857A (es) |
CH (1) | CH641678A5 (es) |
DE (1) | DE2926463A1 (es) |
DK (1) | DK283579A (es) |
ES (1) | ES8101624A1 (es) |
FR (1) | FR2430233A1 (es) |
IL (1) | IL57729A (es) |
IT (1) | IT1116894B (es) |
LU (1) | LU81467A1 (es) |
NL (1) | NL7905258A (es) |
NZ (1) | NZ190925A (es) |
PT (1) | PT69875A (es) |
SE (1) | SE7905810L (es) |
YU (1) | YU41343B (es) |
ZA (1) | ZA793320B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5855500A (ja) * | 1981-09-25 | 1983-04-01 | Tokiwa Yakuhin Kogyo Kk | 16−デヒドロプレグネノロンの製造法 |
US4602005A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
US4602003A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia |
DE3829641A1 (de) * | 1988-09-01 | 1990-03-15 | Roecar Holdings Nv | Transdermal anwendbare pharmazeutische zubereitungen mit sterolinen und/oder spiroketalinen |
DE3838716A1 (de) * | 1988-11-15 | 1990-05-17 | Kanoldt Arzneimittel Gmbh | Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie |
AU4226593A (en) * | 1992-06-26 | 1994-01-24 | Pfizer Inc. | Steroidal glycosides for treating hypercholesterolemia |
EP0696292A1 (en) * | 1993-04-28 | 1996-02-14 | Pfizer Inc. | Spirostanyl glycosidal crystalline monohydrate |
US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
US5698526A (en) * | 1993-12-28 | 1997-12-16 | Pfizer Inc. | Steroidal glycosides |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2395339A (en) * | 1941-05-15 | 1946-02-19 | Parke Davis & Co | Sapogenin derivatives and preparation of same |
US3446751A (en) * | 1965-11-29 | 1969-05-27 | Brunswick Corp | Hemolyzing composition |
DE2027949A1 (de) * | 1970-06-06 | 1971-12-16 | Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt | Verfahren zur Herstellung von Steroidglykosiden |
GB1380253A (en) * | 1971-01-21 | 1975-01-08 | Inverni Della Beffa Spa | Prosapogenins |
DE2759171A1 (de) * | 1977-12-31 | 1979-07-12 | Roecar Holdings Nv | Arzneimittel mit wirkung als prostaglandinsynthetaseninhibitor |
-
1979
- 1979-06-30 DE DE19792926463 patent/DE2926463A1/de active Granted
- 1979-07-02 US US06/053,736 patent/US4265886A/en not_active Expired - Lifetime
- 1979-07-03 SE SE7905810A patent/SE7905810L/ not_active Application Discontinuation
- 1979-07-03 ZA ZA793320A patent/ZA793320B/xx unknown
- 1979-07-04 CA CA000331159A patent/CA1140857A/en not_active Expired
- 1979-07-04 PT PT69875A patent/PT69875A/pt unknown
- 1979-07-04 AU AU48651/79A patent/AU550621B2/en not_active Ceased
- 1979-07-04 IL IL57729A patent/IL57729A/xx not_active IP Right Cessation
- 1979-07-05 NL NL7905258A patent/NL7905258A/nl not_active Application Discontinuation
- 1979-07-05 NZ NZ190925A patent/NZ190925A/en unknown
- 1979-07-05 FR FR7917469A patent/FR2430233A1/fr active Granted
- 1979-07-05 BE BE0/196150A patent/BE877511A/xx not_active IP Right Cessation
- 1979-07-05 YU YU1638/79A patent/YU41343B/xx unknown
- 1979-07-05 ES ES482253A patent/ES8101624A1/es not_active Expired
- 1979-07-05 IT IT49665/79A patent/IT1116894B/it active
- 1979-07-05 DK DK283579A patent/DK283579A/da not_active Application Discontinuation
- 1979-07-05 JP JP8549779A patent/JPS5536471A/ja active Pending
- 1979-07-05 LU LU81467A patent/LU81467A1/xx unknown
- 1979-07-05 CH CH631779A patent/CH641678A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK283579A (da) | 1980-01-06 |
IL57729A (en) | 1983-07-31 |
LU81467A1 (fr) | 1979-10-30 |
IT1116894B (it) | 1986-02-10 |
AU4865179A (en) | 1980-02-07 |
DE2926463C2 (es) | 1988-08-11 |
NL7905258A (nl) | 1980-01-08 |
ZA793320B (en) | 1980-09-24 |
FR2430233A1 (fr) | 1980-02-01 |
US4265886A (en) | 1981-05-05 |
CH641678A5 (de) | 1984-03-15 |
YU163879A (en) | 1983-02-28 |
DE2926463A1 (de) | 1980-01-24 |
FR2430233B1 (es) | 1983-05-20 |
SE7905810L (sv) | 1980-01-06 |
JPS5536471A (en) | 1980-03-14 |
ES482253A0 (es) | 1980-12-16 |
YU41343B (en) | 1987-02-28 |
CA1140857A (en) | 1983-02-08 |
NZ190925A (en) | 1985-05-31 |
AU550621B2 (en) | 1986-03-27 |
PT69875A (en) | 1979-08-01 |
BE877511A (fr) | 1979-11-05 |
IT7949665A0 (it) | 1979-07-05 |
IL57729A0 (en) | 1979-11-30 |
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