DE3483917D1 - Verfahren zur stabilisierung eines gewebeplasminogenaktivators und diesen enthaltende stabile waessrige loesung oder pulver. - Google Patents

Verfahren zur stabilisierung eines gewebeplasminogenaktivators und diesen enthaltende stabile waessrige loesung oder pulver.

Info

Publication number
DE3483917D1
DE3483917D1 DE8484104514T DE3483917T DE3483917D1 DE 3483917 D1 DE3483917 D1 DE 3483917D1 DE 8484104514 T DE8484104514 T DE 8484104514T DE 3483917 T DE3483917 T DE 3483917T DE 3483917 D1 DE3483917 D1 DE 3483917D1
Authority
DE
Germany
Prior art keywords
stabilizing
aqueous solution
powder containing
plasminogen activator
tissue plasminogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484104514T
Other languages
English (en)
Inventor
Akira Murakami
Hideo Yoshizaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Kowa Co Ltd
Asahi Chemical Industry Co Ltd
Original Assignee
Kowa Co Ltd
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd, Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of DE3483917D1 publication Critical patent/DE3483917D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
    • G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
    • G03C2001/0471—Isoelectric point of gelatine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/848—Lungs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
DE8484104514T 1983-04-21 1984-04-19 Verfahren zur stabilisierung eines gewebeplasminogenaktivators und diesen enthaltende stabile waessrige loesung oder pulver. Expired - Lifetime DE3483917D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58069230A JPS59196824A (ja) 1983-04-21 1983-04-21 吸着防止剤

Publications (1)

Publication Number Publication Date
DE3483917D1 true DE3483917D1 (de) 1991-02-21

Family

ID=13396714

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484104514T Expired - Lifetime DE3483917D1 (de) 1983-04-21 1984-04-19 Verfahren zur stabilisierung eines gewebeplasminogenaktivators und diesen enthaltende stabile waessrige loesung oder pulver.

Country Status (6)

Country Link
US (1) US4552760A (de)
EP (1) EP0123304B1 (de)
JP (1) JPS59196824A (de)
CA (1) CA1206434A (de)
DE (1) DE3483917D1 (de)
ES (1) ES8506190A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001355A (en) * 1982-12-14 1999-12-14 Dowdle; Eugene Bernard Davey Pro-tPA for the treatment of thrombosis, embolism and related conditions
US4757005A (en) * 1984-04-19 1988-07-12 Miles Inc. Method and cell line for obtaining plasminogen activators
JPS61176532A (ja) * 1985-01-30 1986-08-08 Green Cross Corp:The プラスミノ−ゲンアクチベ−タ−前駆体の安定化方法
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
ES8706443A1 (es) * 1985-05-28 1987-07-01 Wellcome Found Un procedimiento para preparar una solucion parenteral de activador de plasminogeno de tejido (t-pa)
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
ATE83153T1 (de) * 1985-09-10 1992-12-15 Eisai Co Ltd Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
JPS62153221A (ja) * 1985-12-27 1987-07-08 Wakamoto Pharmaceut Co Ltd ヒト子宮筋正常組織由来樹立化細胞ｋｗ株及びその培養によるプラスミノ−ゲンアクチベ−タ−の製造法
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
NZ220260A (en) * 1986-05-12 1990-07-26 Wellcome Found Synergistic combination of t-pa and sod and pharmaceutical formulation
EP0252004A1 (de) * 1986-06-26 1988-01-07 Ciba-Geigy Ag Pharmazeutische Zusammensetzungen für die parenterale Applikation
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
JPH08840B2 (ja) * 1986-11-14 1996-01-10 興和株式会社 抗ｐｃｉモノクローナル抗体、これを用いた抗ｐｃｉの精製法及び免疫学的測定法
HU209955B (en) * 1987-07-01 1994-12-28 Genentech Inc Process for producing pharmaceutical compositions containing tissue- -plasminogen-activator of poor solubility for inhibiting production and regeneration of deformities
WO1989002747A1 (en) * 1987-10-05 1989-04-06 The American National Red Cross Therapeutic thrombolytic composition
US5151359A (en) * 1988-05-19 1992-09-29 Mitsui Toatsu Chemicals Incorporated Method for producing of human tissue type plasminogen activator
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
WO1990014078A1 (en) * 1989-05-17 1990-11-29 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
US5681814A (en) * 1990-06-07 1997-10-28 Genentech, Inc. Formulated IGF-I Composition
DE59005286D1 (de) * 1990-10-04 1994-05-11 Kallies Import Export Vertrieb Stabilisiertes Thrombin, seine Herstellung und seine Verwendung als Thrombinzeitreagens.
EP0837882A1 (de) * 1995-06-10 1998-04-29 Pentapharm A.G. Kollagen peptid fraktion und deren verwendung
KR101247028B1 (ko) * 2004-07-30 2013-03-25 더 브리검 앤드 우먼즈 하스피털, 인크. 물리적/물리화학적 자극으로 처리된 무정형 세포 전달 매체
US8748007B2 (en) * 2006-05-02 2014-06-10 Ppg Industries Ohio, Inc. Coating compositions exhibiting corrosion resistance properties, related coated articles and methods
US20230089604A1 (en) * 2019-09-24 2023-03-23 Universiteit Gent Anti-adsorption solution

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB802069A (en) * 1956-01-23 1958-09-24 Nat Drug Co Proteolytic enzyme compositions
US2930736A (en) * 1957-01-07 1960-03-29 Nat Drug Co Stabilized trypsin compositions containing partially hydrolyzed gelatin and method of making
DE1183629B (de) * 1962-12-21 1964-12-17 Behringwerke Ag Verfahren zur Stabilisierung biologisch aktiven Materials
US3296094A (en) * 1966-05-05 1967-01-03 Baxter Laboratories Inc Stabilized aqueous enzyme solutions
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
US4151161A (en) * 1976-06-14 1979-04-24 Canada Packers Limited Preparation of high-quality gelatine having low chromium content from chromed waste stock
US4245051A (en) * 1978-03-30 1981-01-13 Rockefeller University Human serum plasminogen activator
US4264493A (en) * 1978-10-18 1981-04-28 Battista Orlando A Natural protein polymer hydrogels
GB2038337B (en) * 1978-12-21 1983-01-19 Green Cross Corp Process which comprises separation of urokinases having different molecular weights
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
JPS57169425A (en) * 1981-04-10 1982-10-19 Eisai Co Ltd Composition and method for preventing adsorption of secretin
JPS5896026A (ja) * 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
JPS58224687A (ja) * 1982-06-24 1983-12-27 Toubishi Yakuhin Kogyo Kk プラスミノ−ゲン活性化酵素剤及びその新規製造方法
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
DE3273732D1 (en) * 1982-12-30 1986-11-20 Kowa Co Method of producing a tissue plasminogen activator and composition comprising same

Also Published As

Publication number Publication date
US4552760A (en) 1985-11-12
ES531754A0 (es) 1985-07-01
JPS59196824A (ja) 1984-11-08
CA1206434A (en) 1986-06-24
EP0123304A2 (de) 1984-10-31
EP0123304A3 (en) 1987-03-04
ES8506190A1 (es) 1985-07-01
EP0123304B1 (de) 1991-01-16

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee