ES8505719A1 - Procedimiento de preparar mutantes de delecion vivos y metodo de preparar vacunas - Google Patents
Procedimiento de preparar mutantes de delecion vivos y metodo de preparar vacunasInfo
- Publication number
- ES8505719A1 ES8505719A1 ES536681A ES536681A ES8505719A1 ES 8505719 A1 ES8505719 A1 ES 8505719A1 ES 536681 A ES536681 A ES 536681A ES 536681 A ES536681 A ES 536681A ES 8505719 A1 ES8505719 A1 ES 8505719A1
- Authority
- ES
- Spain
- Prior art keywords
- deletion
- herpesvirus
- virus
- mutants
- deletion mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000037430 deletion Effects 0.000 title abstract 7
- 238000012217 deletion Methods 0.000 title abstract 7
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 208000032420 Latent Infection Diseases 0.000 abstract 1
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 abstract 1
- 108020004440 Thymidine kinase Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/815—Viral vaccine for porcine species, e.g. swine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/822—Drug, bio-affecting and body treating compositions involving tk- virus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE MUTANTES DE DELECION VIVOS Y METODOS PARA LA PREPARACION DE VACUNAS, EN PARTICULAR PARA LA PREPARACION DE MUTANTES DE DELECION VIVOS DE UN VIRUS HERPES.EL PROCEDIMIENTO CONSISTE EN DIGERIR FRAGMENTOS CLONADOS O NO CLONADOS DE SUBGENOMA CON ENDONUCLEASAS DE RESTRICCION Y DESPUES RELIGAR PARTE DE LOS FRAGMENTOS ASI GENERADOR, CON LO CUAL SE PRODUCE UNA DELECION DE UN FRAGMENTO O FRAGMENTOS EN EL RESPECTIVO FRAGMENTO DE SUBGENOMA. UN FRAGMENTO ASI MODIFICADO SE INTRODUCE EN CELULAS SUSCEPTIBLES, PARA PRODUCIR EL VIRUS MODIFICADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8303501A NL8303501A (nl) | 1983-10-12 | 1983-10-12 | Deletiemutant van een herpesvirus en vaccin, dat dit virus bevat. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES536681A0 ES536681A0 (es) | 1985-06-16 |
ES8505719A1 true ES8505719A1 (es) | 1985-06-16 |
Family
ID=19842541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536681A Expired ES8505719A1 (es) | 1983-10-12 | 1984-10-11 | Procedimiento de preparar mutantes de delecion vivos y metodo de preparar vacunas |
Country Status (9)
Country | Link |
---|---|
US (2) | US4680176A (es) |
EP (1) | EP0141458B1 (es) |
JP (1) | JP2519201B2 (es) |
AU (1) | AU574724B2 (es) |
DE (1) | DE3483512D1 (es) |
DK (1) | DK172285B1 (es) |
ES (1) | ES8505719A1 (es) |
NL (1) | NL8303501A (es) |
PT (1) | PT79348B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8303501A (nl) * | 1983-10-12 | 1985-05-01 | Centraal Diergeneeskundig Inst | Deletiemutant van een herpesvirus en vaccin, dat dit virus bevat. |
US4514497B1 (en) * | 1983-12-30 | 1998-02-24 | Novagene Inc | Modified live pseudorabies viruses |
US4859587A (en) * | 1984-06-04 | 1989-08-22 | Institut Merieux | Recombinant herpes simplex viruses, vaccines and methods |
DE3505148A1 (de) * | 1985-02-15 | 1986-10-30 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Polypeptide des rhinovirusstammes hrv2 sowie die hierfuer codierenden dna-molekuele |
EP0263207B1 (en) * | 1986-10-08 | 1991-11-27 | The Upjohn Company | Virus vaccine |
DE3677494D1 (de) * | 1985-07-29 | 1991-03-14 | Upjohn Co | Virus-impfstoff. |
US5128128A (en) * | 1985-07-29 | 1992-07-07 | The Upjohn Company | Virus vaccine |
US5275934A (en) * | 1985-07-29 | 1994-01-04 | The Upjohn Company | Method of detecting viral infection in vaccinated animals |
US5068192A (en) * | 1986-01-27 | 1991-11-26 | Prutech Research And Development Partnership | Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence |
US5834305A (en) * | 1985-09-06 | 1998-11-10 | Syntro Corporation | Attenuated herpesvirus, herpesvirus which include foreign DNA encoding an amino acid sequence and vaccines containing same |
US6121043A (en) * | 1985-09-06 | 2000-09-19 | Syntro Corporation | Recombinant herpesvirus of turkeys comprising a foreign DNA inserted into a non-essential region of the herpesvirus of turkeys genome |
US5223424A (en) * | 1985-09-06 | 1993-06-29 | Prutech Research And Development | Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence |
US5763269A (en) * | 1985-09-06 | 1998-06-09 | Syntro Corporation | Recombinant infectious bovine rhinotrocheitis virus |
US4877737A (en) * | 1985-09-06 | 1989-10-31 | Prutech Research And Development Partnership | Attenuated pseudorabies virus which has a deletion in at least a portion of a repeat sequence and vaccine containing same |
US5352575A (en) * | 1985-10-04 | 1994-10-04 | The Upjohn Company | Pseudorabies virus protein |
US4703011A (en) * | 1985-11-12 | 1987-10-27 | Novagene, Inc. | Thymidine kinase deletion mutants of bovine herpesvirus-1 |
WO1987004463A1 (en) * | 1986-01-27 | 1987-07-30 | Syntro Corporation | Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same |
US5593873A (en) * | 1986-01-27 | 1997-01-14 | Syntro Corporation | Recombinant infectious bovine rhinotracheitis virus |
US4711850A (en) * | 1986-01-28 | 1987-12-08 | Novagene, Inc. | Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same |
US6172186B1 (en) | 1986-03-26 | 2001-01-09 | Pharmacia & Upjohn Company | Pseudorabies virus protein |
ZA872532B (en) * | 1986-04-21 | 1987-11-25 | Akzo Nv | Combined vaccine |
US4999296A (en) * | 1986-04-29 | 1991-03-12 | Novagene, Inc. | Thymidine kinase negative insertion mutants of pseudorabies virus and methods for the production of same |
FR2601689B1 (fr) * | 1986-07-17 | 1992-10-16 | Syntro Corp | Herpes virus attenues, herpes virus qui renferment de l'adn etranger codant pour une sequence d'amino-acides, et vaccins les contenant |
US5004693A (en) * | 1986-07-18 | 1991-04-02 | E. I. Du Pont De Nemours And Company | Pseudorabies virus recombinants and their use in the production of proteins |
US5037742A (en) * | 1986-07-18 | 1991-08-06 | E. I. Du Pont De Nemours And Company | Pseudorabies virus recombinants and their use in the production of proteins |
WO1989001040A1 (en) * | 1987-07-27 | 1989-02-09 | Syntro Corporation | Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same |
US5672344A (en) * | 1987-12-30 | 1997-09-30 | The Regents Of The University Of Michigan | Viral-mediated gene transfer system |
US5151267A (en) * | 1988-07-15 | 1992-09-29 | University Of Saskatchewan | Bovine herpesvirus type 1 polypeptides and vaccines |
US5585264A (en) * | 1988-07-15 | 1996-12-17 | University Of Saskatchewan | Nucleotide sequences encoding recombinant bovine herpesvirus type-1 GI, GIII and GIV polypeptides |
NL8902087A (nl) * | 1989-08-17 | 1991-03-18 | Stichting Tech Wetenschapp | Niet-natuurlijk voorkomend pseudorabiesvirus en vaccins die dit bevatten. |
US5695765A (en) * | 1989-08-17 | 1997-12-09 | Stichting Voor De Technische Wetenschappen | Mutant pseudorabies virus, and vaccines containing the same |
US5240703A (en) * | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
JP3206767B2 (ja) * | 1992-02-20 | 2001-09-10 | 北海道 | 欠失rna遺伝子を用いたbnyvv弱毒ウイルスの作出とその利用 |
US5352596A (en) * | 1992-09-11 | 1994-10-04 | The United States Of America As Represented By The Secretary Of Agriculture | Pseudorabies virus deletion mutants involving the EPO and LLT genes |
US6342501B1 (en) | 1994-02-25 | 2002-01-29 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d] pyrimidines as antiviral agents |
US6455506B1 (en) | 1997-07-30 | 2002-09-24 | Smithkline Beecham Corporation | Lyxofuranosyl benzimidazoles as antiviral agents |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3122669A1 (de) * | 1980-06-12 | 1982-02-11 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | "verfahren zur herstellung von neuen mutanten von herpes simplex-viren typ 1 und typ 2" |
EP0074808A3 (en) * | 1981-09-16 | 1984-07-04 | University Patents, Inc. | Recombinant method and materials |
ZA84467B (en) * | 1983-02-01 | 1984-09-26 | Upjohn Co | Pseudorabies vaccine |
NL8303501A (nl) * | 1983-10-12 | 1985-05-01 | Centraal Diergeneeskundig Inst | Deletiemutant van een herpesvirus en vaccin, dat dit virus bevat. |
US4514497B1 (en) * | 1983-12-30 | 1998-02-24 | Novagene Inc | Modified live pseudorabies viruses |
-
1983
- 1983-10-12 NL NL8303501A patent/NL8303501A/nl not_active Application Discontinuation
-
1984
- 1984-10-11 AU AU34141/84A patent/AU574724B2/en not_active Expired
- 1984-10-11 DK DK486684A patent/DK172285B1/da not_active IP Right Cessation
- 1984-10-11 PT PT7934884A patent/PT79348B/pt unknown
- 1984-10-11 ES ES536681A patent/ES8505719A1/es not_active Expired
- 1984-10-12 DE DE8484201474T patent/DE3483512D1/de not_active Expired - Lifetime
- 1984-10-12 US US06/660,097 patent/US4680176A/en not_active Ceased
- 1984-10-12 JP JP21402384A patent/JP2519201B2/ja not_active Expired - Lifetime
- 1984-10-12 EP EP19840201474 patent/EP0141458B1/en not_active Expired - Lifetime
-
1987
- 1987-07-28 US US07/078,751 patent/US5028426A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NL8303501A (nl) | 1985-05-01 |
AU3414184A (en) | 1985-04-18 |
ES536681A0 (es) | 1985-06-16 |
EP0141458A1 (en) | 1985-05-15 |
EP0141458B1 (en) | 1990-10-31 |
JP2519201B2 (ja) | 1996-07-31 |
AU574724B2 (en) | 1988-07-14 |
DK486684D0 (da) | 1984-10-11 |
DK486684A (da) | 1985-04-13 |
JPS60221081A (ja) | 1985-11-05 |
US4680176A (en) | 1987-07-14 |
DK172285B1 (da) | 1998-02-23 |
DE3483512D1 (de) | 1990-12-06 |
PT79348A (en) | 1984-11-01 |
PT79348B (en) | 1986-09-08 |
US5028426A (en) | 1991-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20050409 |