ES8505374A1 - Un procedimiento para la preparacion de un derivado de cefalosporina - Google Patents

Un procedimiento para la preparacion de un derivado de cefalosporina

Info

Publication number
ES8505374A1
ES8505374A1 ES527763A ES527763A ES8505374A1 ES 8505374 A1 ES8505374 A1 ES 8505374A1 ES 527763 A ES527763 A ES 527763A ES 527763 A ES527763 A ES 527763A ES 8505374 A1 ES8505374 A1 ES 8505374A1
Authority
ES
Spain
Prior art keywords
group
formula
furopyridinium
thieno
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527763A
Other languages
English (en)
Other versions
ES527763A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8505374A1 publication Critical patent/ES8505374A1/es
Publication of ES527763A0 publication Critical patent/ES527763A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE CEFALOSPORINA.CONSISTE EN SOMETER A REACCION DE ACILACION UN COMPUESTO DE FORMULA (II) O UN 4K-ESTER(R3) DEL MISMO, CON UN DERIVADO CARBOXI ACTIVO DE UN ACIDO DE FORMULA (III) Y SEPARACION EN SU CASO DEL GRUPO R3 Y CUALQUIER GRUPO PROTECTOR DE AMINO DEL SUSTITUYENTE R, PARA OBTENER DERIVADOS DE CEFALOSPORINA DE FORMULA (I), DONDE R ES H O UN GRUPO ACILO; Y BR1 ES UN GRUPO TIENOPIRIDINIO O FUROPIRIDINO.SE UTILIZAN PARA COMBATIR INFECCIONES BACTERIANAS.
ES527763A 1981-09-08 1983-12-02 Un procedimiento para la preparacion de un derivado de cefalosporina Granted ES527763A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30035781A 1981-09-08 1981-09-08
US34062882A 1982-01-19 1982-01-19

Publications (2)

Publication Number Publication Date
ES8505374A1 true ES8505374A1 (es) 1985-05-16
ES527763A0 ES527763A0 (es) 1985-05-16

Family

ID=26971737

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515548A Expired ES8404361A1 (es) 1981-09-08 1982-09-07 Un procedimiento para la preparacion de un derivado de cefalosporina.
ES527763A Granted ES527763A0 (es) 1981-09-08 1983-12-02 Un procedimiento para la preparacion de un derivado de cefalosporina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES515548A Expired ES8404361A1 (es) 1981-09-08 1982-09-07 Un procedimiento para la preparacion de un derivado de cefalosporina.

Country Status (17)

Country Link
EP (1) EP0074268A3 (es)
KR (1) KR840001585A (es)
CS (1) CS232735B2 (es)
DD (1) DD209633A5 (es)
DK (1) DK399282A (es)
ES (2) ES8404361A1 (es)
FI (1) FI823088L (es)
GB (1) GB2105719A (es)
GR (1) GR76701B (es)
HU (1) HU187575B (es)
IL (1) IL66726A0 (es)
NZ (1) NZ201833A (es)
PH (1) PH19756A (es)
PL (1) PL238158A1 (es)
PT (1) PT75518B (es)
RO (1) RO84456B (es)
SU (1) SU1169542A3 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE30724T1 (de) * 1982-06-28 1987-11-15 Bristol Myers Co Cephalosporinderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten.
US4480098A (en) * 1982-11-12 1984-10-30 Eli Lilly And Company Preparation of alkali metal thieno(furo)pyridines
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
EP0137442A3 (de) * 1983-10-08 1986-01-15 Hoechst Aktiengesellschaft Cephalosporinderivate und Verfahren zu ihrer Herstellung
EP0138552A3 (en) * 1983-10-17 1986-03-19 Eli Lilly And Company Improvements on or relating to 3-bicyclicpyridinium-methyl cephalosporins
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
EP0187456A1 (en) * 1984-11-29 1986-07-16 Ici Pharma Cephalosporin derivatives
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
GB8626245D0 (en) * 1985-11-27 1986-12-03 Ici Pharma Cephalosporin compounds
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates
US4918067A (en) * 1986-07-24 1990-04-17 Beecham Group P.L.C. Heterocyclic substituted penicillin antibiotics
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
NZ520696A (en) * 2000-02-10 2004-03-26 Upjohn Co Piperazine amide substituted oxazolidinone thioamides useful for treating bacteria infections
US6642238B2 (en) 2000-02-10 2003-11-04 Pharmacia And Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
EP1618114B1 (en) 2003-04-16 2010-07-14 Sandoz AG Processes for the preparations of cefepime
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
FR2440738A1 (fr) * 1978-11-13 1980-06-06 Parcor Medicament a base de derives des thieno (2,3-c) et (3,2-c) pyridines
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"

Also Published As

Publication number Publication date
KR840001585A (ko) 1984-05-07
GB2105719A (en) 1983-03-30
DK399282A (da) 1983-03-09
FI823088A0 (fi) 1982-09-07
HU187575B (en) 1986-01-28
EP0074268A3 (en) 1984-05-23
ES515548A0 (es) 1984-04-16
RO84456A (ro) 1984-06-21
ES8404361A1 (es) 1984-04-16
PT75518A (en) 1982-10-01
DD209633A5 (de) 1984-05-16
NZ201833A (en) 1985-09-13
CS650582A2 (en) 1984-06-18
IL66726A0 (en) 1982-12-31
FI823088L (fi) 1983-03-09
RO84456B (ro) 1984-08-30
PL238158A1 (en) 1984-11-19
GR76701B (es) 1984-08-29
CS232735B2 (en) 1985-02-14
SU1169542A3 (ru) 1985-07-23
PT75518B (en) 1985-11-12
PH19756A (en) 1986-06-26
ES527763A0 (es) 1985-05-16
EP0074268A2 (en) 1983-03-16

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