ES8305319A1 - "procedimiento para la preparacion de acidos antranilicos sustituidos con radicales basicos" - Google Patents
"procedimiento para la preparacion de acidos antranilicos sustituidos con radicales basicos"Info
- Publication number
- ES8305319A1 ES8305319A1 ES508757A ES508757A ES8305319A1 ES 8305319 A1 ES8305319 A1 ES 8305319A1 ES 508757 A ES508757 A ES 508757A ES 508757 A ES508757 A ES 508757A ES 8305319 A1 ES8305319 A1 ES 8305319A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- anthranilic acids
- basic groups
- acids substituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS ANTRANILICOS SUSTITUIDOS CON RADICALES BASICOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES FURILO, TIENILO O FENILO. CONSISTE EN LA REACCION DE SAPONIFICACION DE UN NITRILO DE FORMULA (II), EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I). LA SAPONIFICACION SE LLEVA A CABO CON LEJIA DE SOSA O DE POTASA ACUOSAS EN EXCESO A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. EL PRODUCTO OBTENIDO SE PRECIPITA A PH 3-4 EN FORMA DE ACIDO CARBOXILICO, QUE DESPUES DE PURIFICAR POR RESCRISTALIZACION SE TRANSFORMA EN LA SAL CORRESPONDIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO SALIDIURETICOS PARA TRATAMIENTO DE EDEMAS Y DE HIPERTONIAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813101960 DE3101960A1 (de) | 1981-01-22 | 1981-01-22 | "basisch substituierte anthranilsaeuren, verfahren zu ihrer herstellung und ihre verwendung" |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8305319A1 true ES8305319A1 (es) | 1983-04-01 |
| ES508757A0 ES508757A0 (es) | 1983-04-01 |
Family
ID=6123119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508757A Granted ES508757A0 (es) | 1981-01-22 | 1982-01-15 | "procedimiento para la preparacion de acidos antranilicos sustituidos con radicales basicos" |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4406895A (es) |
| EP (1) | EP0056970B1 (es) |
| JP (1) | JPS57142961A (es) |
| KR (1) | KR830009074A (es) |
| AT (1) | ATE12390T1 (es) |
| AU (1) | AU7971182A (es) |
| CA (1) | CA1190937A (es) |
| DE (2) | DE3101960A1 (es) |
| DK (1) | DK153395B (es) |
| ES (1) | ES508757A0 (es) |
| FI (1) | FI820172L (es) |
| GR (1) | GR74756B (es) |
| HU (1) | HU189556B (es) |
| IE (1) | IE51928B1 (es) |
| IL (1) | IL64839A (es) |
| NO (1) | NO820180L (es) |
| NZ (1) | NZ199532A (es) |
| PH (1) | PH19628A (es) |
| PT (1) | PT74319B (es) |
| YU (1) | YU15182A (es) |
| ZA (1) | ZA82393B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5111049A (en) * | 1990-12-21 | 1992-05-05 | Santa Barbara Research Center | Remote fired RF getter for use in metal infrared detector dewar |
| SG164305A1 (en) * | 2004-02-20 | 2010-09-29 | Aventis Pharma Inc | Furosemide derivatives as modulators of hm74 and their use for the treatment of inflammation |
| SG11202110950XA (en) * | 2019-04-02 | 2021-10-28 | Fondazione St Italiano Tecnologia | Modulators of intracellular chloride concentration |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3346568A (en) * | 1961-09-14 | 1967-10-10 | Ciba Geigy Corp | 2-amino-5-sulfamyl-benzoic acid hydrazides |
| CH433378A (de) * | 1962-03-09 | 1967-04-15 | Ciba Geigy | Verfahren zur Herstellung neuer Anthranilsäurederivate |
| FR5466M (es) * | 1965-06-14 | 1967-10-16 | ||
| US3565920A (en) * | 1966-12-29 | 1971-02-23 | Ciba Geigy Corp | 5-sulfamyl-anthranilic acids |
| US3678039A (en) * | 1967-04-27 | 1972-07-18 | Lincoln Harvey Werner | 4-trifluoromethyl-anthranilic acids |
| GB1260155A (en) * | 1969-04-29 | 1972-01-12 | Leo Pharm Prod Ltd | Sulphonamido anthranilic acid derivatives |
| BE768706A (fr) * | 1970-06-18 | 1971-12-20 | Leo Pharm Prod Ltd | Nouveaux acides sulfamoylbenzoiques |
| US3758522A (en) * | 1970-06-18 | 1973-09-11 | Leo Pharm Prod Ltd | Certain sulfamylbenzoic acids, esters thereof, and pharmaceutically acceptable salts thereof |
| DE2232457A1 (de) * | 1972-07-01 | 1974-01-10 | Boehringer Mannheim Gmbh | Neue 3-alkyl-4-sulfamoylanilinderivate |
| DE2453548A1 (de) * | 1973-09-07 | 1976-03-18 | Hoechst Ag | Substituierte aminobenzoesaeurederivate und verfahren zu ihrer herstellung |
| DE2406972C3 (de) * | 1974-02-14 | 1979-07-19 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von 5-Sulfamoylanthranilsäuren |
-
1981
- 1981-01-22 DE DE19813101960 patent/DE3101960A1/de not_active Withdrawn
-
1982
- 1982-01-15 ES ES508757A patent/ES508757A0/es active Granted
- 1982-01-19 AT AT82100335T patent/ATE12390T1/de active
- 1982-01-19 EP EP82100335A patent/EP0056970B1/de not_active Expired
- 1982-01-19 DE DE8282100335T patent/DE3262732D1/de not_active Expired
- 1982-01-20 GR GR67065A patent/GR74756B/el unknown
- 1982-01-20 HU HU82154A patent/HU189556B/hu unknown
- 1982-01-20 US US06/341,006 patent/US4406895A/en not_active Expired - Fee Related
- 1982-01-20 KR KR1019820000228A patent/KR830009074A/ko unknown
- 1982-01-20 FI FI820172A patent/FI820172L/fi not_active Application Discontinuation
- 1982-01-20 PH PH26764A patent/PH19628A/en unknown
- 1982-01-21 CA CA000394605A patent/CA1190937A/en not_active Expired
- 1982-01-21 ZA ZA82393A patent/ZA82393B/xx unknown
- 1982-01-21 YU YU00151/82A patent/YU15182A/xx unknown
- 1982-01-21 DK DK025982A patent/DK153395B/da not_active Application Discontinuation
- 1982-01-21 PT PT74319A patent/PT74319B/pt unknown
- 1982-01-21 AU AU79711/82A patent/AU7971182A/en not_active Abandoned
- 1982-01-21 JP JP57006887A patent/JPS57142961A/ja active Pending
- 1982-01-21 IE IE118/82A patent/IE51928B1/en unknown
- 1982-01-21 NO NO820180A patent/NO820180L/no unknown
- 1982-01-22 IL IL64839A patent/IL64839A/xx unknown
- 1982-06-20 NZ NZ199532A patent/NZ199532A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL64839A0 (en) | 1982-03-31 |
| PT74319B (de) | 1983-10-25 |
| FI820172L (fi) | 1982-07-23 |
| JPS57142961A (en) | 1982-09-03 |
| EP0056970B1 (de) | 1985-03-27 |
| NO820180L (no) | 1982-07-23 |
| KR830009074A (ko) | 1983-12-17 |
| IL64839A (en) | 1985-11-29 |
| DK25982A (da) | 1982-07-23 |
| PT74319A (de) | 1982-02-01 |
| ZA82393B (en) | 1982-12-29 |
| DK153395B (da) | 1988-07-11 |
| HU189556B (en) | 1986-07-28 |
| US4406895A (en) | 1983-09-27 |
| YU15182A (en) | 1984-12-31 |
| PH19628A (en) | 1986-06-04 |
| ATE12390T1 (de) | 1985-04-15 |
| ES508757A0 (es) | 1983-04-01 |
| NZ199532A (en) | 1984-10-19 |
| AU7971182A (en) | 1982-07-29 |
| GR74756B (es) | 1984-07-11 |
| EP0056970A1 (de) | 1982-08-04 |
| IE51928B1 (en) | 1987-04-29 |
| DE3262732D1 (en) | 1985-05-02 |
| IE820118L (en) | 1982-07-22 |
| CA1190937A (en) | 1985-07-23 |
| DE3101960A1 (de) | 1982-09-02 |
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