ES8504706A1 - Un procedimiento para la preparacion de un derivado del indol. - Google Patents

Un procedimiento para la preparacion de un derivado del indol.

Info

Publication number
ES8504706A1
ES8504706A1 ES520783A ES520783A ES8504706A1 ES 8504706 A1 ES8504706 A1 ES 8504706A1 ES 520783 A ES520783 A ES 520783A ES 520783 A ES520783 A ES 520783A ES 8504706 A1 ES8504706 A1 ES 8504706A1
Authority
ES
Spain
Prior art keywords
group
alkyl
compounds
hydrogen atom
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520783A
Other languages
English (en)
Other versions
ES520783A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8504706A1 publication Critical patent/ES8504706A1/es
Publication of ES520783A0 publication Critical patent/ES520783A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE INDOL, DE FORMULA GENERAL (I), EN LA QUE R1, R3, R4, R6 Y R7 REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; R2 SIGNIFICA HIDROGENO O ARILO; R5 SIGNIFICA ALQUILO O ALQUENILO; Y ALK REPRESENTA UNA CADENA ALQUILENICA, Y SUS SALES, SOLVATOS Y BIOPRECURSORES DE LOS MISMOS FISIOLOGICAMENTE ACEPTABLES.CONSISTE EN SOMETER A UNA REACCION DE HIDROLISIS UN NITRILO DE FORMULA GENERAL (II) CON UN ACIDO O CON UN ALCALI EN CONDICIONES CONTROLADAS.DE APLICACION EN COMPOSICIONES MEDICINALES.
ES520783A 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol. Granted ES520783A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026286 1980-08-12

Publications (2)

Publication Number Publication Date
ES8504706A1 true ES8504706A1 (es) 1985-05-01
ES520783A0 ES520783A0 (es) 1985-05-01

Family

ID=10515410

Family Applications (5)

Application Number Title Priority Date Filing Date
ES504693A Granted ES504693A0 (es) 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol.
ES513933A Expired ES8402268A1 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Granted ES520785A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520783A Granted ES520783A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES504693A Granted ES504693A0 (es) 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol.
ES513933A Expired ES8402268A1 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Granted ES520785A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Country Status (16)

Country Link
US (1) US4650810A (es)
JP (1) JPS5764669A (es)
AU (1) AU548467B2 (es)
BE (1) BE889929A (es)
CA (1) CA1169428A (es)
CH (1) CH651551A5 (es)
DE (1) DE3131728A1 (es)
DK (1) DK157920C (es)
ES (5) ES504693A0 (es)
FR (1) FR2488607A1 (es)
IE (1) IE51491B1 (es)
IT (1) IT1171449B (es)
NL (1) NL8103769A (es)
NZ (1) NZ197996A (es)
SE (1) SE454880B (es)
ZA (1) ZA815540B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (es) * 1982-06-07 1984-10-22 Glaxo Group Ltd
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
EP0225726B1 (en) * 1985-11-08 1991-04-17 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
IL98392A (en) * 1990-06-07 1996-01-19 Wellcome Found History of indole, their preparation and the pharmaceutical preparations containing them
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
US5254383A (en) * 1992-09-14 1993-10-19 Allied-Signal Inc. Composites having improved penetration resistance and articles fabricated from same
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
JP4897221B2 (ja) * 2002-12-20 2012-03-14 チバ ホールディング インコーポレーテッド アミン類の合成及びその合成のための中間体
US8148377B2 (en) 2007-02-11 2012-04-03 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
CL2008000838A1 (es) * 2007-03-23 2008-10-10 Neuraxon Inc Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios
US8293781B2 (en) 2007-03-29 2012-10-23 Daiichi Sankyo Company, Limited Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US9399053B2 (en) 2011-07-22 2016-07-26 The University Of Chicago Treatments for migraine and related disorders
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
SE8104781L (sv) 1982-02-13
DK357081A (da) 1982-02-13
CA1169428A (en) 1984-06-19
DK157920B (da) 1990-03-05
IE811830L (en) 1982-02-12
AU7399481A (en) 1982-02-18
BE889929A (fr) 1982-02-11
IT8149084A0 (it) 1981-08-11
ZA815540B (en) 1983-03-30
FR2488607A1 (fr) 1982-02-19
DE3131728A1 (de) 1982-03-11
ES8301210A1 (es) 1982-12-01
AU548467B2 (en) 1985-12-12
IT1171449B (it) 1987-06-10
NZ197996A (en) 1985-08-16
SE454880B (sv) 1988-06-06
JPS5764669A (en) 1982-04-19
ES8500903A1 (es) 1984-11-01
NL8103769A (nl) 1982-03-01
DE3131728C2 (es) 1992-04-30
JPH0247462B2 (es) 1990-10-19
ES520783A0 (es) 1985-05-01
US4650810A (en) 1987-03-17
ES520785A0 (es) 1984-11-01
CH651551A5 (fr) 1985-09-30
DK157920C (da) 1990-08-06
FR2488607B1 (es) 1984-11-16
ES8500902A1 (es) 1984-11-01
ES520784A0 (es) 1984-11-01
IE51491B1 (en) 1987-01-07
ES513933A0 (es) 1984-01-16
ES8402268A1 (es) 1984-01-16
ES504693A0 (es) 1982-12-01

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