ES8501979A1 - Procedimiento para preparar un concentrado de factor antihemofilico - Google Patents
Procedimiento para preparar un concentrado de factor antihemofilicoInfo
- Publication number
- ES8501979A1 ES8501979A1 ES524768A ES524768A ES8501979A1 ES 8501979 A1 ES8501979 A1 ES 8501979A1 ES 524768 A ES524768 A ES 524768A ES 524768 A ES524768 A ES 524768A ES 8501979 A1 ES8501979 A1 ES 8501979A1
- Authority
- ES
- Spain
- Prior art keywords
- ahf
- concentrate
- preparation
- highly purified
- radius
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 229960002661 human antihemophilic factor Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102100026735 Coagulation factor VIII Human genes 0.000 abstract 10
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 abstract 10
- 239000012141 concentrate Substances 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 238000005349 anion exchange Methods 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000011026 diafiltration Methods 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN CONCENTRADO DE FACTOR ANTIHEMOFILICO.COMPRENDE: A) OBTENER UN CONCENTRADO DE FACTOR ANTIHEMOFILICO TOTAL O PARCIALMENTE EXENTO DE PROTEINAS COMPLEJAS DE PROTOMBINA, FIBRONOGENO Y ALBUMINA; B) SOMETER EL CONCENTRADO DE FACTOR ANTIHEMOFILICO A SEPARACION EN BASE DEL RADIO DE STOKE ELEVADO, DE OTRAS PROTEINAS; C) TRATAR EL CONCENTRADO DE FACTOR ANTIHEMOFILICO PARA COMBINAR EL RADIO EFECTIVO DE STOKE DE LA MOLECULA DE FACTOR ANTIHEMOFILICO A UN VALOR BAJO; D) SOMETER EL CONCENTRADO DE FACTOR ANTIHEMOFILICO A SEPARACION EN BASE DEL RADIO DE STOKE PARA SEPARAR, DE LAS OTRAS PROTEINAS, FACTOR ANTIHEMOFILICO DE VALOR DE RADIO DE STOKE BAJO; Y E) SOMETER EL CONCENTRADO DE FACTOR ANTIHEMOFILICO A CROMATOGRAFIA EN UN MEDIO DE INTERCAMBIO DE ANIONES PARA OBTENER EL CONCENTRADO HOMOGENEO Y ALTAMENTE PURIFICADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/405,456 US4495175A (en) | 1982-08-05 | 1982-08-05 | Preparation of highly purified human antihemophilic factor |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8501979A1 true ES8501979A1 (es) | 1984-12-16 |
ES524768A0 ES524768A0 (es) | 1984-12-16 |
Family
ID=23603775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524768A Granted ES524768A0 (es) | 1982-08-05 | 1983-08-05 | Procedimiento para preparar un concentrado de factor antihemofilico |
Country Status (8)
Country | Link |
---|---|
US (1) | US4495175A (es) |
EP (1) | EP0104356B1 (es) |
JP (1) | JPS5944322A (es) |
AU (1) | AU567683B2 (es) |
CA (1) | CA1213214A (es) |
DE (1) | DE3369143D1 (es) |
ES (1) | ES524768A0 (es) |
MX (1) | MX7309E (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4614795A (en) * | 1982-08-05 | 1986-09-30 | University Of Rochester | Deglycosylated Human Factor VIII:C |
DE3481109D1 (de) * | 1983-05-09 | 1990-03-01 | Novo Nordisk As | Antihaemophilie-faktor-viii-konzentrat und dessen herstellungsverfahren. |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US5043428A (en) * | 1984-08-31 | 1991-08-27 | Behringwerke Aktiengesellschaft | Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production |
US4543210A (en) * | 1984-10-04 | 1985-09-24 | Miles Laboratories, Inc. | Process for producing a high purity antihemophilic factor concentrate |
SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
GB8505882D0 (en) * | 1985-03-07 | 1985-04-11 | Central Blood Lab Authority | Purification of blood coagulation factor viii |
JPS61280866A (ja) * | 1985-06-07 | 1986-12-11 | アルフア・セラピユ−テイツク・コ−ポレイシヨン | 人血液凝固第8因子の分離方法 |
AT391808B (de) * | 1986-11-03 | 1990-12-10 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion |
EP0321835B1 (en) * | 1987-12-21 | 1994-09-28 | Miles Inc. | Gel filteration of factor VIII |
US5177191A (en) * | 1987-12-21 | 1993-01-05 | Miles, Inc. | Gel filtration of factor VIII |
WO1989009784A1 (en) * | 1988-04-08 | 1989-10-19 | Commonwealth Serum Laboratories Commission | Production of heat-stable factor viii concentrate |
DE3878245D1 (de) | 1988-11-05 | 1993-03-18 | Octapharma Ag | Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie. |
FR2644064B1 (fr) * | 1989-02-17 | 1994-05-27 | Aquitaine Dev Transf Sanguine | Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant |
DE3926034C3 (de) * | 1989-08-07 | 1996-11-21 | Behringwerke Ag | Verfahren zur Herstellung eines stabilen Faktors VIII |
FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
DK162233C (da) * | 1989-11-09 | 1992-03-16 | Novo Nordisk As | Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii |
IT1248723B (it) * | 1990-06-12 | 1995-01-26 | Scalvo S P A | Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo |
FR2681867B1 (fr) * | 1991-09-26 | 1993-12-31 | Pasteur Merieux Serums Vaccins | Procede de purification du facteur viii et preparations obtenues. |
US5516509A (en) * | 1993-03-31 | 1996-05-14 | International Beauty Design, Inc. | Quick-drying nail coating for use over nail polish |
US5407666A (en) * | 1993-04-05 | 1995-04-18 | International Beauty Design, Inc. | Removable, hard, durable, nail coating |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
US7244824B2 (en) * | 1995-01-19 | 2007-07-17 | Quadrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
US7253262B2 (en) * | 1995-01-19 | 2007-08-07 | Quandrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
US6077940A (en) * | 1997-12-24 | 2000-06-20 | Genentech, Inc. | Free solution ligand interaction molecular separation method |
JP2002526557A (ja) | 1998-10-07 | 2002-08-20 | シグマ−アルドリッチ・カンパニー | トロンボプラスチン試薬ならびにそのような試薬の製造および使用方法 |
PT1820516E (pt) | 1999-02-22 | 2013-10-31 | Baxter Int | Novas formulações de factor viii isentas de albumina |
BRPI0921429B1 (pt) | 2008-11-07 | 2022-07-12 | Takeda Pharmaceutical Company Limited | Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4188318A (en) * | 1975-06-16 | 1980-02-12 | Edward Shanbrom | Simplified method for preparation of high yield, high purity Factor VIII concentrate |
US4278594A (en) * | 1979-06-19 | 1981-07-14 | David Amrani | Process for separation and isolation of AHF, von Willebrand's ristocetin cofactor (VWF:RCF) and fibronectin from blood plasma |
US4364861A (en) * | 1980-05-27 | 1982-12-21 | Cutter Laboratories, Inc. | Blood-coagulation-promoting products and methods of preparing them |
CA1178887A (en) * | 1981-10-01 | 1984-12-04 | Gail A. Rock | Factor viii concentrates prepared from heparinized plasma by the application of a cold precipitation technique |
US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4397841A (en) * | 1982-06-28 | 1983-08-09 | Monsanto Company | Production of blood coagulation factor VIII:C |
AU555305B2 (en) * | 1982-09-29 | 1986-09-18 | Bayer Corporation | Antihemophilic factor concentrate |
-
1982
- 1982-08-05 US US06/405,456 patent/US4495175A/en not_active Expired - Lifetime
-
1983
- 1983-07-28 EP EP83107420A patent/EP0104356B1/en not_active Expired
- 1983-07-28 DE DE8383107420T patent/DE3369143D1/de not_active Expired
- 1983-07-29 CA CA000433578A patent/CA1213214A/en not_active Expired
- 1983-08-01 AU AU17472/83A patent/AU567683B2/en not_active Ceased
- 1983-08-03 JP JP58141256A patent/JPS5944322A/ja active Pending
- 1983-08-04 MX MX8310732U patent/MX7309E/es unknown
- 1983-08-05 ES ES524768A patent/ES524768A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
DE3369143D1 (en) | 1987-02-19 |
EP0104356B1 (en) | 1987-01-14 |
CA1213214A (en) | 1986-10-28 |
AU567683B2 (en) | 1987-12-03 |
AU1747283A (en) | 1984-02-09 |
JPS5944322A (ja) | 1984-03-12 |
EP0104356A1 (en) | 1984-04-04 |
MX7309E (es) | 1988-05-10 |
ES524768A0 (es) | 1984-12-16 |
US4495175A (en) | 1985-01-22 |
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