PT85226A - Process for the preparation of novel trombolytic proteins - Google Patents
Process for the preparation of novel trombolytic proteinsInfo
- Publication number
- PT85226A PT85226A PT8522687A PT8522687A PT85226A PT 85226 A PT85226 A PT 85226A PT 8522687 A PT8522687 A PT 8522687A PT 8522687 A PT8522687 A PT 8522687A PT 85226 A PT85226 A PT 85226A
- Authority
- PT
- Portugal
- Prior art keywords
- trombolytic
- proteins
- novel
- preparation
- consensus
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
A thrombolytic protein (I) having tissue plasminogen activator-type activity is characterised by a peptide sequence the same as that of human t-PA in which (a) Arg-275 is deleted or is replaced by a different amino acid and (b) at least one of the consensus N-linked glycosylation sites is modified to other than a consensus N-linked glycosylation site. Also claimed is a thrombolytic protein having tPA-type activity characterised by a peptide sequence the same as that of human t-PA,in which one or more amino acids in the region Gly-(-3) to Thr-91 are deleted or replaced with different.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/882,051 US5002887A (en) | 1986-01-31 | 1986-07-03 | Truncated thrombolytic proteins |
PCT/US1987/000257 WO1987004722A1 (en) | 1986-01-31 | 1987-01-30 | Novel thrombolytic proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
PT85226A true PT85226A (en) | 1987-08-01 |
PT85226B PT85226B (en) | 1990-03-30 |
Family
ID=26775504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT8522687A PT85226B (en) | 1986-07-03 | 1987-07-01 | PROCESS FOR THE PREPARATION OF NEW THROMBOLITIC PROTEINS |
Country Status (3)
Country | Link |
---|---|
ES (1) | ES2004438A6 (en) |
GR (1) | GR871052B (en) |
PT (1) | PT85226B (en) |
-
1987
- 1987-07-01 PT PT8522687A patent/PT85226B/en not_active IP Right Cessation
- 1987-07-01 ES ES8701920A patent/ES2004438A6/en not_active Expired
- 1987-07-03 GR GR871052A patent/GR871052B/en unknown
Also Published As
Publication number | Publication date |
---|---|
GR871052B (en) | 1987-11-09 |
ES2004438A6 (en) | 1989-01-01 |
PT85226B (en) | 1990-03-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69031127T2 (en) | ACTIVABLE FIBRINOLYTIC AND ANTITHROMBOTIC PROTEINS | |
EP0259475A4 (en) | Recombinant human endothelial cell growth factor. | |
EP0191827A4 (en) | Method of removing n-terminal amino acid residues from eucaryotic polypetide analogs and polypeptides produced thereby. | |
ES8501979A1 (en) | Highly purified human antihemophilic factor and method for the preparation thereof. | |
EP0230945A3 (en) | Thrombin-binding substance and process for preparing thethrombin-binding substance and process for preparing the same same | |
NZ503235A (en) | Amino-terminally truncated RANTES as chemokine antagonists | |
DE69126049D1 (en) | Vectors and compositions for the expression of glycosylation mutants of human protein-C | |
Nakano et al. | Purification and characterization of a gelatinase produced by fibroblasts from human gingiva | |
EP0210279A4 (en) | Stabilized human prourokinase. | |
HUT50195A (en) | New peptites hindering the activity of immune system and medical compositions containing them and process for production of these peptides and compositions | |
FI93843C (en) | Process for producing an angiogenic factor | |
EP0330700A4 (en) | Human prourokinase-like polypeptide. | |
PT85226A (en) | Process for the preparation of novel trombolytic proteins | |
ES8605296A1 (en) | Recominant factor VIII-R. | |
ES2033212A6 (en) | Ancrod proteins, their production and use. | |
EP0272894A3 (en) | Recombinant human lymphotoxin | |
Fridberger et al. | The amino terminal sequences of boar sperm proacrosin and active acrosin are identical | |
HUT60133A (en) | Process for producing protein-based pharmaceutical composition having t-pa-activity and suitable for treating blood clots | |
EP0386240A4 (en) | Novel polypeptide compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19920331 |