ES8501361A1 - Procedimiento de preparar cloruros de propargilamonio - Google Patents

Procedimiento de preparar cloruros de propargilamonio

Info

Publication number
ES8501361A1
ES8501361A1 ES524076A ES524076A ES8501361A1 ES 8501361 A1 ES8501361 A1 ES 8501361A1 ES 524076 A ES524076 A ES 524076A ES 524076 A ES524076 A ES 524076A ES 8501361 A1 ES8501361 A1 ES 8501361A1
Authority
ES
Spain
Prior art keywords
formula
amine
water
iii
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524076A
Other languages
English (en)
Other versions
ES524076A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES524076A0 publication Critical patent/ES524076A0/es
Publication of ES8501361A1 publication Critical patent/ES8501361A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CLORUROS DE PROPARGILAMONIO, DE FORMULA (I), EN LA QUE N VALE 0 O 1.CONSISTE EN LA REACCION DEL D-TARTRATO DEL 1-ISOMERO DE UNA AMINA DE FORMULA (II), EN LA QUE N VALE 0 O 1, EN SUSPENSION ACUOSA, CON UN ALCALI, DISOLVER LA BASE EN UN DISOLVENTE ORGANICO NO MISCIBLE EN AGUA Y HACERLA REACCIONAR CON UN HALURO DE F FORMULA X-CH2-CFCH. DESPUES DE SEPARACION SE TRATA LA AMINA FORMADA CON CLORURO DE HIDROGENO, PRECIPITANDO LA SAL.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO DE INHIBICION DE MAO Y ANTIPARKINSON.
ES524076A 1982-07-14 1983-07-13 Procedimiento de preparar cloruros de propargilamonio Expired ES8501361A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822278A HU187775B (en) 1982-07-14 1982-07-14 New process for producing propargile-amines of pharmaceutical activity

Publications (2)

Publication Number Publication Date
ES524076A0 ES524076A0 (es) 1984-12-01
ES8501361A1 true ES8501361A1 (es) 1984-12-01

Family

ID=10958648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524076A Expired ES8501361A1 (es) 1982-07-14 1983-07-13 Procedimiento de preparar cloruros de propargilamonio

Country Status (12)

Country Link
US (1) US4564706A (es)
EP (1) EP0099302B1 (es)
JP (1) JPS5967249A (es)
AT (1) ATE22552T1 (es)
CA (1) CA1215394A (es)
DE (1) DE3366589D1 (es)
DK (1) DK163143C (es)
ES (1) ES8501361A1 (es)
FI (1) FI78457C (es)
GR (1) GR79594B (es)
HK (1) HK46691A (es)
HU (1) HU187775B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3528548A1 (de) * 1985-08-08 1987-02-19 Dow Chemical Gmbh Herstellung eines allylamins und quaternaerer diallylammoniumverbindungen daraus
CS269271B1 (en) * 1988-05-30 1990-04-11 Hajicek Josef Method of selegiline's hydrochloride production
US5561163A (en) * 1990-08-31 1996-10-01 Deprenyl Animal Health, Inc. Treating hearing loss with deprenyl
US5225446A (en) * 1990-08-31 1993-07-06 Deprenyl Animal Health, Inc. Use of 1-deprenyl for retention of specific physiological functions
US5151449A (en) * 1990-08-31 1992-09-29 Deprenyl Animal Health, Inc. Use of L-deprenyl for retention of specific physiological functions
US5565495A (en) * 1990-08-31 1996-10-15 Deprenyl Animal Health, Inc. Method for survival curve shifting in dogs
CA2039194C (en) * 1990-08-31 1997-01-28 Norton W. Milgram Uses of l-deprenyl and compositions for same
US5192808A (en) * 1990-08-31 1993-03-09 Deprenyl Animal Health, Inc. Therapeutic effect of L-deprenyl in the management of pituitary-dependent hyperadrenocorticism (cushing's disease)
HU209605B (en) * 1991-04-15 1994-09-28 Chinoin Gyogyszer Es Vegyeszet Process for production of wather-free transdermal preparation
IES61604B2 (en) * 1993-12-16 1994-11-16 Russinsky Ltd A process for producing pharmaceutical compounds
DE4410360A1 (de) * 1994-03-25 1995-09-28 Basf Ag Verfahren zur Herstellung von Arylbenzylaminen
DE4432610C1 (de) * 1994-09-13 1996-02-01 Knoll Ag Verfahren zur Herstellung von Selegilin-Hydrochlorid
HU218927B (hu) * 1994-11-22 2000-12-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Eljárás propargil-ammónium-klorid-származékok előállítására
US6319954B1 (en) 1995-01-13 2001-11-20 Somerset Pharmaceuticals, Inc. S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions
US6348208B1 (en) 1995-01-13 2002-02-19 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US6299901B1 (en) 1995-01-13 2001-10-09 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US6033682A (en) * 1995-01-13 2000-03-07 Somerset Pharmaceuticals, Inc. S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions
AU3759697A (en) * 1996-10-01 1998-04-09 Rohm And Haas Company Process for amines
AU2006265639A1 (en) * 2005-07-01 2007-01-11 Jenrin Discovery MAO-B inhibitors useful for treating obesity
CN103896779B (zh) * 2008-06-02 2015-12-30 基因里克斯(英国)有限公司 用于制备对映异构纯胺的方法
IT201700008702A1 (it) 2017-01-26 2018-07-26 Dipharma Francis Srl Metodo di sintesi di selegilina base

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121857A (en) * 1965-01-05 1968-07-31 Science Union & Cie New phenylisopropylamine derivatives and process for their preparation and pharmaceutical preparations of such derivatives
US3397236A (en) * 1965-12-29 1968-08-13 Norwich Pharma Co Nu-2, 3-butadienyl-nu-methylbenzylamine or the 2-chloro-derivative thereof
US3496195A (en) * 1966-05-11 1970-02-17 Chinoin Gyogyszer Es Vegyeszet D-o-bromo-phenyl-isopropyl-methylpropinylamine and its salts
FR2371196A1 (fr) * 1976-11-17 1978-06-16 Roussel Uclaf Nouveaux derives de l'aminomethyl benzocycloheptene, ainsi que leurs sels, procede de preparation et application a titre de medicaments de ces nouveaux produits
US4156017A (en) * 1977-02-22 1979-05-22 Schering Aktiengesellschaft Pesticides

Also Published As

Publication number Publication date
ES524076A0 (es) 1984-12-01
CA1215394A (en) 1986-12-16
FI78457B (fi) 1989-04-28
GR79594B (es) 1984-10-31
DK323683D0 (da) 1983-07-13
JPS5967249A (ja) 1984-04-16
FI78457C (fi) 1989-08-10
DK163143C (da) 1992-06-22
DK323683A (da) 1984-01-15
ATE22552T1 (de) 1986-10-15
DK163143B (da) 1992-01-27
EP0099302B1 (en) 1986-10-01
JPS6121938B2 (es) 1986-05-29
HK46691A (en) 1991-06-21
FI832538L (fi) 1984-01-15
EP0099302A2 (en) 1984-01-25
EP0099302A3 (en) 1984-09-19
DE3366589D1 (en) 1986-11-06
HU187775B (en) 1986-02-28
US4564706A (en) 1986-01-14
FI832538A0 (fi) 1983-07-12

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