ATE22552T1 - Verfahren zur herstellung von propargylaminen. - Google Patents

Verfahren zur herstellung von propargylaminen.

Info

Publication number: ATE22552T1
Authority: AT; Austria
Prior art keywords: general formula; amine; water; phase; general
Prior art date: 1982-07-14

Application number

AT83401429T

Other languages

English (en)

Inventor

Zoltan Dr Ecsery

Eva Dr Somfai

Nee Voeroes Hermann

Lajos Nagy

Gabor Dr Szabo

Otto Orban

Laszlo Arvai

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-14

Filing date

1983-07-11

Publication date

1986-10-15

1983-07-11 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1986-10-15 Application granted granted Critical

1986-10-15 Publication of ATE22552T1 publication Critical patent/ATE22552T1/de

Links

238000000034 method Methods 0.000 title abstract 3
150000001412 amines Chemical class 0.000 abstract 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
239000012071 phase Substances 0.000 abstract 3
239000003513 alkali Substances 0.000 abstract 2
150000004820 halides Chemical class 0.000 abstract 2
FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical group OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000012074 organic phase Substances 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000007900 aqueous suspension Substances 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000354 decomposition reaction Methods 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
IKXNIQJDNKPPCH-UHFFFAOYSA-N hydron;prop-2-yn-1-amine;chloride Chemical class [Cl-].[NH3+]CC#C IKXNIQJDNKPPCH-UHFFFAOYSA-N 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000011031 large-scale manufacturing process Methods 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)

AT83401429T 1982-07-14 1983-07-11 Verfahren zur herstellung von propargylaminen. ATE22552T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU822278A HU187775B (en)	1982-07-14	1982-07-14	New process for producing propargile-amines of pharmaceutical activity
EP83401429A EP0099302B1 (de)	1982-07-14	1983-07-11	Verfahren zur Herstellung von Propargylaminen

Publications (1)

Publication Number	Publication Date
ATE22552T1 true ATE22552T1 (de)	1986-10-15

Family

ID=10958648

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83401429T ATE22552T1 (de)	1982-07-14	1983-07-11	Verfahren zur herstellung von propargylaminen.

Country Status (12)

Country	Link
US (1)	US4564706A (de)
EP (1)	EP0099302B1 (de)
JP (1)	JPS5967249A (de)
AT (1)	ATE22552T1 (de)
CA (1)	CA1215394A (de)
DE (1)	DE3366589D1 (de)
DK (1)	DK163143C (de)
ES (1)	ES8501361A1 (de)
FI (1)	FI78457C (de)
GR (1)	GR79594B (de)
HK (1)	HK46691A (de)
HU (1)	HU187775B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3528548A1 (de) *	1985-08-08	1987-02-19	Dow Chemical Gmbh	Herstellung eines allylamins und quaternaerer diallylammoniumverbindungen daraus
CS269271B1 (en) *	1988-05-30	1990-04-11	Hajicek Josef	Method of selegiline's hydrochloride production
US5151449A (en) *	1990-08-31	1992-09-29	Deprenyl Animal Health, Inc.	Use of L-deprenyl for retention of specific physiological functions
CA2039194C (en) *	1990-08-31	1997-01-28	Norton W. Milgram	Uses of l-deprenyl and compositions for same
US5225446A (en) *	1990-08-31	1993-07-06	Deprenyl Animal Health, Inc.	Use of 1-deprenyl for retention of specific physiological functions
US5561163A (en) *	1990-08-31	1996-10-01	Deprenyl Animal Health, Inc.	Treating hearing loss with deprenyl
US5192808A (en) *	1990-08-31	1993-03-09	Deprenyl Animal Health, Inc.	Therapeutic effect of L-deprenyl in the management of pituitary-dependent hyperadrenocorticism (cushing's disease)
US5565495A (en) *	1990-08-31	1996-10-15	Deprenyl Animal Health, Inc.	Method for survival curve shifting in dogs
HU209605B (en) *	1991-04-15	1994-09-28	Chinoin Gyogyszer Es Vegyeszet	Process for production of wather-free transdermal preparation
IES940271A2 (en) *	1993-12-16	1994-11-16	Russinsky Ltd	"A process for producing pharmaceutical compounds"
DE4410360A1 (de) *	1994-03-25	1995-09-28	Basf Ag	Verfahren zur Herstellung von Arylbenzylaminen
DE4432610C1 (de) *	1994-09-13	1996-02-01	Knoll Ag	Verfahren zur Herstellung von Selegilin-Hydrochlorid
HU218927B (hu) *	1994-11-22	2000-12-28	Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt.	Eljárás propargil-ammónium-klorid-származékok előállítására
US6348208B1 (en) *	1995-01-13	2002-02-19	Somerset Pharmaceuticals, Inc.	Methods and pharmaceutical compositions employing desmethylselegiline
US6033682A (en) *	1995-01-13	2000-03-07	Somerset Pharmaceuticals, Inc.	S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions
US6299901B1 (en)	1995-01-13	2001-10-09	Somerset Pharmaceuticals, Inc.	Methods and pharmaceutical compositions employing desmethylselegiline
US6319954B1 (en)	1995-01-13	2001-11-20	Somerset Pharmaceuticals, Inc.	S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions
AU3759697A (en) *	1996-10-01	1998-04-09	Rohm And Haas Company	Process for amines
AU2006265639A1 (en) *	2005-07-01	2007-01-11	Jenrin Discovery	MAO-B inhibitors useful for treating obesity
PL2285769T3 (pl)	2008-06-02	2015-01-30	Generics Uk Ltd	Sposób otrzymywania enancjomerycznie czystych amin
IT201700008702A1 (it)	2017-01-26	2018-07-26	Dipharma Francis Srl	Metodo di sintesi di selegilina base

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1121857A (en) *	1965-01-05	1968-07-31	Science Union & Cie	New phenylisopropylamine derivatives and process for their preparation and pharmaceutical preparations of such derivatives
US3397236A (en) *	1965-12-29	1968-08-13	Norwich Pharma Co	Nu-2, 3-butadienyl-nu-methylbenzylamine or the 2-chloro-derivative thereof
US3496195A (en) *	1966-05-11	1970-02-17	Chinoin Gyogyszer Es Vegyeszet	D-o-bromo-phenyl-isopropyl-methylpropinylamine and its salts
FR2371196A1 (fr) *	1976-11-17	1978-06-16	Roussel Uclaf	Nouveaux derives de l'aminomethyl benzocycloheptene, ainsi que leurs sels, procede de preparation et application a titre de medicaments de ces nouveaux produits
US4156017A (en) *	1977-02-22	1979-05-22	Schering Aktiengesellschaft	Pesticides

1982
- 1982-07-14 HU HU822278A patent/HU187775B/hu unknown
1983
- 1983-07-11 DE DE8383401429T patent/DE3366589D1/de not_active Expired
- 1983-07-11 AT AT83401429T patent/ATE22552T1/de not_active IP Right Cessation
- 1983-07-11 EP EP83401429A patent/EP0099302B1/de not_active Expired
- 1983-07-12 FI FI832538A patent/FI78457C/fi not_active IP Right Cessation
- 1983-07-13 DK DK323683A patent/DK163143C/da not_active IP Right Cessation
- 1983-07-13 CA CA000432358A patent/CA1215394A/en not_active Expired
- 1983-07-13 ES ES524076A patent/ES8501361A1/es not_active Expired
- 1983-07-13 GR GR71930A patent/GR79594B/el unknown
- 1983-07-14 JP JP58128687A patent/JPS5967249A/ja active Granted
- 1983-07-14 US US06/514,149 patent/US4564706A/en not_active Expired - Lifetime
1991
- 1991-06-11 HK HK466/91A patent/HK46691A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR79594B (de)	1984-10-31
FI78457B (fi)	1989-04-28
JPS6121938B2 (de)	1986-05-29
DK323683A (da)	1984-01-15
HK46691A (en)	1991-06-21
EP0099302A2 (de)	1984-01-25
EP0099302B1 (de)	1986-10-01
ES524076A0 (es)	1984-12-01
DK163143B (da)	1992-01-27
ES8501361A1 (es)	1984-12-01
JPS5967249A (ja)	1984-04-16
FI832538A0 (fi)	1983-07-12
DK163143C (da)	1992-06-22
FI78457C (fi)	1989-08-10
DK323683D0 (da)	1983-07-13
CA1215394A (en)	1986-12-16
FI832538L (fi)	1984-01-15
DE3366589D1 (en)	1986-11-06
US4564706A (en)	1986-01-14
HU187775B (en)	1986-02-28
EP0099302A3 (en)	1984-09-19

Legal Events

Date	Code	Title	Description
1987-01-15	UEP	Publication of translation of european patent specification
2003-10-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE22552T1 (de)	1986-10-15	Verfahren zur herstellung von propargylaminen.
KR920701119A (ko)	1992-08-11	무기염을 상분리제로서 사용하여 디니트로톨루엔을 제조하는 방법
ES444129A1 (es)	1977-04-16	Procedimiento para la obtencion de poliaminas aromaticas po-linucleares.
Berliner	1931	The chemistry of chloramines
KR890700574A (ko)	1989-04-25	아지리딘의 제조방법
KR850004403A (ko)	1985-07-15	지르코늄 동위원소의 분리방법
EP0487578B1 (de)	1999-10-13	Verfahren zur herstellung von tertiären amin-schwefel-trioxydkomplexen
Coleman et al.	1929	THE FORMATION OF PRIMARY AMINES FROM GRIGNARD REAGENTS AND MONOCHLORO-AMINE. II
ES2119990T3 (es)	1998-10-16	Procedimiento mejorado para la preparacion de derivados de cloruro de propargilamonio.
US2455932A (en)	1948-12-14	Process of making aryl amines
US3492354A (en)	1970-01-27	Recovery of hexamethylene diamine
US3875231A (en)	1975-04-01	Recovery of reaction products of hydrazine and carbonyl compounds
US2623069A (en)	1952-12-23	Method of producing 4-chlorobutane-1-sulfonyl chloride
US3452096A (en)	1969-06-24	Process for the separation of isomers of dichloroaniline
JPS58213738A (ja)	1983-12-12	エチレンアミン類の回収方法
US3436420A (en)	1969-04-01	Process of making aliphatic amines
US2821556A (en)	1958-01-28	Process for amine salt isolation
ES2003321A4 (es)	1988-11-01	Un procedimiento para obtener oxido ferrico y sales de amonio, y aparato para llevar a cabo dicho procedimiento.
US3079438A (en)	1963-02-26	Preparation of lower tetraalkyl quaternary ammonium nitrate
JPS594421B2 (ja)	1984-01-30	Ｎ−置換カルバミン酸リチウムの製法
KR830003405A (ko)	1983-06-20	α-할로게노-β-아미노프로피오니트릴, 이의 광산염 및 이들의 제조방법
ATE848T1 (de)	1982-04-15	Verfahren zur herstellung von methylenbruecken aufweisenden polyarylaminen.
JPS61259760A (ja)	1986-11-18	触媒の回収方法
US3821295A (en)	1974-06-28	Process for the production of alpha-amino-acid hydrohalides
KR850003412A (ko)	1985-06-17	아미노산과 5베타-콜라닉 산의 개량된 축합방법