ES8407009A1 - Un procedimiento para preparar -15-desoxiespergualina. - Google Patents

Un procedimiento para preparar -15-desoxiespergualina.

Info

Publication number
ES8407009A1
ES8407009A1 ES522418A ES522418A ES8407009A1 ES 8407009 A1 ES8407009 A1 ES 8407009A1 ES 522418 A ES522418 A ES 522418A ES 522418 A ES522418 A ES 522418A ES 8407009 A1 ES8407009 A1 ES 8407009A1
Authority
ES
Spain
Prior art keywords
same
deoxyspergualin
preparation
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522418A
Other languages
English (en)
Other versions
ES522418A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8407009A1 publication Critical patent/ES8407009A1/es
Publication of ES522418A0 publication Critical patent/ES522418A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR (-)-15-DESOXIESPERGUALINA.CON SISTE EN DESOXIDAR EL GRUPO HIDROXILO EN LA POSICION 15 DE UN DERIVADO DE (-) ESPERGUALINA DE FORMULA (II) Y POSTERIOR ELIMINACION DEL GRUPO DE ENMASCARAMIENTO, PARA OBTENER UN COMPUESTO DE FORMULA (I), DONDE R1 ES UN GRUPO AMINO ENMASCARADO; Y R2 Y R3 REPRESENTAN CADA UNO UN GRUPO DE ENMASCARAMIENTO.TIENE APLICACION COMO ANTIBIOTICO CARCINOSTATICO.
ES522418A 1982-05-17 1983-05-16 Un procedimiento para preparar -15-desoxiespergualina. Granted ES522418A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57081398A JPS58198455A (ja) 1982-05-17 1982-05-17 （−）−１５−デオキシスパガリンおよびその製造法並びにその中間体

Publications (2)

Publication Number Publication Date
ES8407009A1 true ES8407009A1 (es) 1984-08-16
ES522418A0 ES522418A0 (es) 1984-08-16

Family

ID=13745194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522418A Granted ES522418A0 (es) 1982-05-17 1983-05-16 Un procedimiento para preparar -15-desoxiespergualina.

Country Status (10)

Country Link
EP (1) EP0094632B1 (es)
JP (1) JPS58198455A (es)
AT (1) ATE18203T1 (es)
CA (1) CA1236484A (es)
DE (1) DE3362260D1 (es)
DK (1) DK166384C (es)
ES (1) ES522418A0 (es)
GR (1) GR77478B (es)
IE (1) IE54926B1 (es)
PT (1) PT76693B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
DE3626306A1 (de) * 1986-08-02 1988-02-11 Behringwerke Ag Verwendung von 15-deoxyspergualin als arzneimittel
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
US5196453A (en) * 1989-05-29 1993-03-23 Takara Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
YU48230B (sh) * 1989-05-29 1997-08-22 Takara Shuzo Co.Ltd. Kristalni deoksispergvalin i postupak za njegovo pripremanje
CA2183917A1 (en) * 1995-09-26 1997-03-27 Xuebao Wang Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof

Also Published As

Publication number Publication date
JPS58198455A (ja) 1983-11-18
EP0094632A1 (en) 1983-11-23
CA1236484A (en) 1988-05-10
JPH0211582B2 (es) 1990-03-14
DK166384C (da) 1993-09-27
GR77478B (es) 1984-09-24
DK217983D0 (da) 1983-05-16
ATE18203T1 (de) 1986-03-15
DK166384B (da) 1993-05-10
PT76693B (en) 1986-08-28
DK217983A (da) 1983-11-18
PT76693A (en) 1983-06-01
DE3362260D1 (en) 1986-04-03
IE54926B1 (en) 1990-03-28
ES522418A0 (es) 1984-08-16
IE831132L (en) 1983-11-17
EP0094632B1 (en) 1986-02-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980302