ES8401079A1 - Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico. - Google Patents

Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.

Info

Publication number
ES8401079A1
ES8401079A1 ES516593A ES516593A ES8401079A1 ES 8401079 A1 ES8401079 A1 ES 8401079A1 ES 516593 A ES516593 A ES 516593A ES 516593 A ES516593 A ES 516593A ES 8401079 A1 ES8401079 A1 ES 8401079A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
esters
cephalosporin esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516593A
Other languages
English (en)
Other versions
ES516593A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8401079A1 publication Critical patent/ES8401079A1/es
Publication of ES516593A0 publication Critical patent/ES516593A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DEL ACIDO 7B-2-(2-AMINO-4-TIAZOLIL)-2-(SIN)-METOXIIMINOAC ETAMIDO-3-CEFEM-4-CARBOXILICO, Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O ALQUILO INFERIOR; R2 ES ALQUILO INFERIOR; Y AM ES AMINO.CONSISTE EN LA REACCION DE ESTERIFICACION DEL GRUPO CARBOXILO EN LA POSICION 4 DEL ANILLO CEFEM, EN CASO DADO EN FORMA DE SAL, DEL COMPUESTO DE FORMULA (II), POR TRATAMIENTO CON UN AGENTE DE ESTERIFICACION DE FORMULA XCHR1-O-COOR2, EN LAS QUE X ES UN HIDROXI ESTERIFICADO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADOQUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE TAL COMO DIMETILFORMAMIDA, EN PRESENCIA DE UN ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE -40JC Y 100JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS ANTIBACTERIALES.
ES516593A 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico. Granted ES516593A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH919680 1980-12-12

Publications (2)

Publication Number Publication Date
ES8401079A1 true ES8401079A1 (es) 1983-11-16
ES516593A0 ES516593A0 (es) 1983-11-16

Family

ID=4349398

Family Applications (6)

Application Number Title Priority Date Filing Date
ES507907A Expired ES8303424A1 (es) 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.
ES516593A Granted ES516593A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516591A Granted ES516591A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516590A Granted ES516590A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516594A Granted ES516594A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES507907A Expired ES8303424A1 (es) 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES516591A Granted ES516591A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516590A Granted ES516590A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516594A Granted ES516594A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.

Country Status (18)

Country Link
EP (1) EP0054512A3 (es)
JP (1) JPS57123190A (es)
KR (1) KR830007683A (es)
AR (1) AR231984A1 (es)
AU (1) AU7846681A (es)
DD (1) DD208155A5 (es)
DK (1) DK550081A (es)
ES (6) ES8303424A1 (es)
FI (1) FI813946L (es)
GB (1) GB2111043B (es)
GR (1) GR76967B (es)
HU (1) HU185985B (es)
IE (1) IE52008B1 (es)
IL (1) IL64506A (es)
NO (1) NO814232L (es)
NZ (1) NZ199255A (es)
PT (1) PT74119B (es)
ZA (1) ZA818622B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK554481A (da) * 1980-12-15 1982-06-16 Fujisawa Pharmaceutical Co Fremgangsmaade til fremstilling af cephalosporansyrederivater
JPS57156495A (en) * 1981-03-23 1982-09-27 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and remedy for microbism used in oral administration
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
JPS59116291A (ja) * 1982-12-06 1984-07-05 Fujisawa Pharmaceut Co Ltd ７−置換−３−セフエム−４−カルボン酸エステルおよびその製法
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates
EP0497978B1 (en) * 1989-10-28 1997-04-16 Kyoto Pharmaceutical Industries, Ltd. Cephalosporin compounds and production thereof
ATE240339T1 (de) * 1996-07-26 2003-05-15 Gilead Sciences Inc Nukleotidanaloga
ES2308136T3 (es) 2003-01-14 2008-12-01 Gilead Sciences, Inc. Composiciones y procedimientos para la politerapia antiviral.
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965099A (en) * 1974-06-26 1976-06-22 Smithkline Corporation Cephalosporin esters with antibacterial activity
JPS5321192A (en) * 1976-08-10 1978-02-27 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
MA18686A1 (fr) * 1978-07-07 1980-10-01 Ciba Geigy Ag Composes aminothiazoliques
ZA793391B (en) * 1978-07-07 1980-06-25 Ciba Geigy Ag Aminothiazole compounds
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
GR78221B (es) * 1980-02-01 1984-09-26 Ciba Geigy Ag

Also Published As

Publication number Publication date
AU7846681A (en) 1982-06-17
HU185985B (en) 1985-04-28
ES507907A0 (es) 1983-02-01
ES8401077A1 (es) 1983-11-16
PT74119B (de) 1983-12-19
JPS57123190A (en) 1982-07-31
IE812915L (en) 1982-06-12
ES516592A0 (es) 1983-08-01
ES516590A0 (es) 1983-11-16
NZ199255A (en) 1985-08-30
ES8401080A1 (es) 1983-11-16
PT74119A (de) 1982-01-01
AR231984A1 (es) 1985-04-30
NO814232L (no) 1982-06-14
ES8401078A1 (es) 1983-11-16
ES8307820A1 (es) 1983-08-01
ES516591A0 (es) 1983-11-16
EP0054512A3 (de) 1983-08-03
ZA818622B (en) 1982-10-27
FI813946L (fi) 1982-06-13
DD208155A5 (de) 1984-03-28
ES516594A0 (es) 1983-11-16
JPH0314038B2 (es) 1991-02-25
GB2111043A (en) 1983-06-29
ES8303424A1 (es) 1983-02-01
IL64506A0 (en) 1982-03-31
EP0054512A2 (de) 1982-06-23
ES516593A0 (es) 1983-11-16
IL64506A (en) 1985-05-31
KR830007683A (ko) 1983-11-04
GB2111043B (en) 1985-02-06
GR76967B (es) 1984-09-04
IE52008B1 (en) 1987-05-13
DK550081A (da) 1982-06-13

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