ES8306181A1 - "un procedimiento para preparar insulina humana o derivados de treomina b30 de insulina humana". - Google Patents
"un procedimiento para preparar insulina humana o derivados de treomina b30 de insulina humana".Info
- Publication number
- ES8306181A1 ES8306181A1 ES514845A ES514845A ES8306181A1 ES 8306181 A1 ES8306181 A1 ES 8306181A1 ES 514845 A ES514845 A ES 514845A ES 514845 A ES514845 A ES 514845A ES 8306181 A1 ES8306181 A1 ES 8306181A1
- Authority
- ES
- Spain
- Prior art keywords
- human insulin
- preparing esters
- esters
- water
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE INSULINA HUMANA O DERIVADOS DE TREOMINA>B DE INSULINA HUMANA Y DE SUS SALES O COMPLEJOS. CONSISTE EN LA REACCION DE DES(ALA>B )-INSULINA, O UNA DE SUS SALES O COMPLEJOS, CON UN DERIVADO DE L-TREOMINA DE FORMULA THR-(R )-OR , EN LA QUE R ES UN GRUPO PROTECTOR DE CARBOXILO Y R ES HIDROGENO O UN GRUPO PROTECTOR DE HIDROXILO, O CON UNA DE SUS SALES, EN UNA MEZCLA COMPUESTA POR 10-30% DE AGUA, UN DISOLVENTE ORGANICO MISCIBLE CON AGUA Y TRIPSINA, EN PRESENCIA DE UN ACIDO, A UNA TEMPERATURA NO SUPERIOR A 37 C. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA DIABETES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK353781A DK353781A (da) | 1981-08-10 | 1981-08-10 | Fremgangsmaade til fremstilling af insulinderivater |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8306181A1 true ES8306181A1 (es) | 1983-05-01 |
| ES514845A0 ES514845A0 (es) | 1983-05-01 |
Family
ID=8124014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES514845A Granted ES514845A0 (es) | 1981-08-10 | 1982-08-09 | "un procedimiento para preparar insulina humana o derivados de treomina b30 de insulina humana". |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4489159A (es) |
| JP (1) | JPS5836399A (es) |
| AT (1) | AT374683B (es) |
| AU (1) | AU549066B2 (es) |
| BE (1) | BE894070A (es) |
| CA (1) | CA1174973A (es) |
| CH (1) | CH661746A5 (es) |
| DE (1) | DE3229674A1 (es) |
| DK (1) | DK353781A (es) |
| ES (1) | ES514845A0 (es) |
| FI (1) | FI79142C (es) |
| FR (1) | FR2511036B1 (es) |
| GB (1) | GB2105342B (es) |
| GR (1) | GR77999B (es) |
| IE (1) | IE53712B1 (es) |
| IT (1) | IT1152492B (es) |
| LU (1) | LU84327A1 (es) |
| NL (1) | NL182964C (es) |
| NO (1) | NO157506C (es) |
| SE (1) | SE451073B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776693A (en) * | 1990-06-08 | 1998-07-07 | Institut Pasteur | Specific detection of the mycobacterium tuberculosis |
| CN1276731A (zh) | 1997-10-24 | 2000-12-13 | 伊莱利利公司 | 不溶性胰岛素组合物 |
| CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US20080085298A1 (en) * | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
| US7713929B2 (en) * | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| CA2649109A1 (en) | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| KR20120044358A (ko) * | 2009-07-09 | 2012-05-07 | 바이오콘 리미티드 | 비-선형 구배에 기초한 분취용 크로마토그래피 방법 및 이 방법에 의해 정제된 산물 |
| US8883739B2 (en) | 2010-01-19 | 2014-11-11 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for male reproductive disorders |
| WO2014152497A2 (en) | 2013-03-15 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for cognitive disorders |
| CN105849273B (zh) * | 2013-12-23 | 2020-01-14 | 拜康研究有限公司 | 人胰岛素甲酯的生产方法 |
| WO2018147393A1 (ja) * | 2017-02-10 | 2018-08-16 | 三菱ケミカル株式会社 | ヒトインスリン精製用分離剤及びヒトインスリンの精製方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276961A (en) * | 1963-04-08 | 1966-10-04 | Squibb & Sons Inc | Process for preparing human insulin |
| US3903068A (en) * | 1972-12-26 | 1975-09-02 | Us Health Education & Welfare | Facile synthesis of human insulin by modification of porcine insulin |
| JPS55138393A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | Semisynthesis of insulin |
| JPS55138391A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | New synthetic method of peptide derivative |
| JPS55138392A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | Semisynthesis of insulin |
| NO153061C (no) * | 1979-04-13 | 1986-01-08 | Shionogi & Co | Fremgangsmaate for fremstilling av et b30-threonininsulin |
| US4343898A (en) * | 1980-02-11 | 1982-08-10 | Novo Industri A/S | Process for preparing esters of human insulin |
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| EP0087238A1 (en) * | 1982-02-08 | 1983-08-31 | Biogen N.V. | Am improved method for preparing human insulin from non-human insulin |
-
1981
- 1981-08-10 DK DK353781A patent/DK353781A/da unknown
-
1982
- 1982-08-09 ES ES514845A patent/ES514845A0/es active Granted
- 1982-08-09 BE BE6/47694A patent/BE894070A/fr not_active IP Right Cessation
- 1982-08-09 CH CH4775/82A patent/CH661746A5/de not_active IP Right Cessation
- 1982-08-09 SE SE8204627A patent/SE451073B/sv not_active IP Right Cessation
- 1982-08-09 NO NO822704A patent/NO157506C/no unknown
- 1982-08-09 NL NLAANVRAGE8203137,A patent/NL182964C/xx not_active IP Right Cessation
- 1982-08-09 IT IT22784/82A patent/IT1152492B/it active
- 1982-08-09 LU LU84327A patent/LU84327A1/de unknown
- 1982-08-09 GR GR68986A patent/GR77999B/el unknown
- 1982-08-09 US US06/406,571 patent/US4489159A/en not_active Expired - Lifetime
- 1982-08-09 FR FR8213868A patent/FR2511036B1/fr not_active Expired
- 1982-08-09 DE DE19823229674 patent/DE3229674A1/de active Granted
- 1982-08-09 GB GB08222914A patent/GB2105342B/en not_active Expired
- 1982-08-09 IE IE1911/82A patent/IE53712B1/en not_active IP Right Cessation
- 1982-08-09 CA CA000408994A patent/CA1174973A/en not_active Expired
- 1982-08-09 FI FI822773A patent/FI79142C/fi not_active IP Right Cessation
- 1982-08-09 AU AU86974/82A patent/AU549066B2/en not_active Ceased
- 1982-08-09 AT AT0303582A patent/AT374683B/de active
- 1982-08-10 JP JP57138095A patent/JPS5836399A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE8204627D0 (sv) | 1982-08-09 |
| DK353781A (da) | 1983-02-11 |
| DE3229674C2 (es) | 1992-07-09 |
| FR2511036A1 (fr) | 1983-02-11 |
| CA1174973A (en) | 1984-09-25 |
| AU549066B2 (en) | 1986-01-09 |
| FI79142B (fi) | 1989-07-31 |
| JPH0587239B2 (es) | 1993-12-15 |
| CH661746A5 (de) | 1987-08-14 |
| FR2511036B1 (fr) | 1986-08-22 |
| NO822704L (no) | 1983-02-11 |
| FI822773L (fi) | 1983-02-11 |
| BE894070A (fr) | 1983-02-09 |
| FI79142C (fi) | 1989-11-10 |
| GR77999B (es) | 1984-09-26 |
| ATA303582A (de) | 1983-10-15 |
| IT8222784A0 (it) | 1982-08-09 |
| NL8203137A (nl) | 1983-03-01 |
| NO157506C (no) | 1988-03-30 |
| LU84327A1 (de) | 1983-06-07 |
| JPS5836399A (ja) | 1983-03-03 |
| AT374683B (de) | 1984-05-25 |
| SE8204627L (sv) | 1983-02-11 |
| SE451073B (sv) | 1987-08-31 |
| IE53712B1 (en) | 1989-01-18 |
| IE821911L (en) | 1983-02-10 |
| US4489159A (en) | 1984-12-18 |
| NL182964C (nl) | 1988-06-16 |
| IT1152492B (it) | 1986-12-31 |
| NO157506B (no) | 1987-12-21 |
| AU8697482A (en) | 1983-02-17 |
| ES514845A0 (es) | 1983-05-01 |
| FI822773A0 (fi) | 1982-08-09 |
| GB2105342A (en) | 1983-03-23 |
| GB2105342B (en) | 1985-06-26 |
| DE3229674A1 (de) | 1983-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8306181A1 (es) | "un procedimiento para preparar insulina humana o derivados de treomina b30 de insulina humana". | |
| DK54081A (da) | Fremgangsmaade til fremstilling af insulinderivater | |
| DK32684A (da) | Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor | |
| DE3460035D1 (en) | 1'-ethoxycarbonyloxyethyl ester of valproic acid, its preparation and formulations containing it | |
| JPS5340760A (en) | Preparation of unsaturated imide esters | |
| JPS5232999A (en) | Process for preparing unsaturated epoxy esters having improved curabil ity | |
| ES8106276A1 (es) | Un procedimiento para la preparacion de amidas del acido po-liprenilcarboxilico | |
| ES8307704A1 (es) | Procedimiento mejorado para obtener acidos carboxilicos opticamente activos. | |
| IL68103A (en) | Process for converting preproinsulin analogs into insulins | |
| DE3574018D1 (en) | Process for the preparation of n1-methyl-10alpha-methoxylumilysergol and esters thereof, and intermediates for their preparation | |
| AU581185B2 (en) | Process for the racemization of optically active aminoacids | |
| ES486851A1 (es) | Un procedimiento de preparacion de acido 3a,7b-dihidroxico- lanico | |
| JPS5256193A (en) | Process for copolyesterpolyol | |
| JPS52106857A (en) | Preparation of 1,3-disubstituted-2-azetidinones | |
| JPS5365875A (en) | Preparation of benzenesulfone amide derivs. | |
| IE41605L (en) | A tetrapeptide amide | |
| JPS5424846A (en) | Preparation of substituted phenylacetic acid | |
| JPS57118546A (en) | Insulin derivative | |
| JPS5419950A (en) | Synthetic method of methylenebisbenzophenone derivative | |
| JPS535158A (en) | Preparation of optical active alpha-alkylvenzylalcohol and its intermediates | |
| ES475527A1 (es) | Un procedimiento para la preparacion de amida de dl-fenil- glicina | |
| JPS5436211A (en) | Preparation of sebacic acid | |
| JPS57154165A (en) | N-(diphenylmethylene) tryptophan ester | |
| JPS53103412A (en) | Preparation of farnesyl acetic acid or its ester | |
| JPS5217447A (en) | Process for preparation of trans-4- aminomethylcyclohexane-carboxylic acid ester |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990225 |