JPS55138392A - Semisynthesis of insulin - Google Patents
Semisynthesis of insulinInfo
- Publication number
- JPS55138392A JPS55138392A JP4570979A JP4570979A JPS55138392A JP S55138392 A JPS55138392 A JP S55138392A JP 4570979 A JP4570979 A JP 4570979A JP 4570979 A JP4570979 A JP 4570979A JP S55138392 A JPS55138392 A JP S55138392A
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- tripsinlike
- enzyme
- protecting group
- tripsin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: The condensation reaction between des-B30-insulin and a threonine derivative is effected in the presence of tripsin or tripsinlike enzyme to produce insulin.
CONSTITUTION: The condensation reaction between des-B30-insulin, where the arginine in the 22 position of the B chain is modified with a protecting group and the amino acid in the 30 position of the B chain is lack, and a L-threonine derivative of Thr(R1)(R2) (Thr is L-threonine residue; R1 is H, or protecting group for hydroxyl; R2 is protecting group for carboxyl) is conducted in the presence of tripsin or tripsinlike enzyme, such as a tripsinlike enzyme extracted from Streptomyces bacterium and then protecting groups are removed.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4570979A JPS55138392A (en) | 1979-04-13 | 1979-04-13 | Semisynthesis of insulin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4570979A JPS55138392A (en) | 1979-04-13 | 1979-04-13 | Semisynthesis of insulin |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56175029A Division JPS57118546A (en) | 1981-10-30 | 1981-10-30 | Insulin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55138392A true JPS55138392A (en) | 1980-10-29 |
JPS5718798B2 JPS5718798B2 (en) | 1982-04-19 |
Family
ID=12726873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4570979A Granted JPS55138392A (en) | 1979-04-13 | 1979-04-13 | Semisynthesis of insulin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55138392A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2511036A1 (en) * | 1981-08-10 | 1983-02-11 | Novo Industri As | PROCESS FOR PREPARING INSULIN DERIVATIVES AND PRODUCTS OBTAINED |
EP0087238A1 (en) * | 1982-02-08 | 1983-08-31 | Biogen N.V. | Am improved method for preparing human insulin from non-human insulin |
JPS58501455A (en) * | 1981-09-15 | 1983-09-01 | ノルデイスク インシユリンラボラトリユ−ム | Method for producing human insulin or its B-30 ester |
CN110343689A (en) * | 2019-08-23 | 2019-10-18 | 四川大学 | A kind of novel streptomycete trypsin GM2938 and its heterogenous expression |
-
1979
- 1979-04-13 JP JP4570979A patent/JPS55138392A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2511036A1 (en) * | 1981-08-10 | 1983-02-11 | Novo Industri As | PROCESS FOR PREPARING INSULIN DERIVATIVES AND PRODUCTS OBTAINED |
NL8203137A (en) * | 1981-08-10 | 1983-03-01 | Novo Industri As | PROCESS FOR PREPARING INSULIN DERIVATIVES. |
JPS58501455A (en) * | 1981-09-15 | 1983-09-01 | ノルデイスク インシユリンラボラトリユ−ム | Method for producing human insulin or its B-30 ester |
EP0087238A1 (en) * | 1982-02-08 | 1983-08-31 | Biogen N.V. | Am improved method for preparing human insulin from non-human insulin |
JPH0526469B2 (en) * | 1982-06-07 | 1993-04-16 | Norudeisuku Inshurin Lab | |
CN110343689A (en) * | 2019-08-23 | 2019-10-18 | 四川大学 | A kind of novel streptomycete trypsin GM2938 and its heterogenous expression |
CN110343689B (en) * | 2019-08-23 | 2021-11-05 | 四川大学 | Streptomyces trypsin GM2938 and heterologous expression thereof in bacillus subtilis |
Also Published As
Publication number | Publication date |
---|---|
JPS5718798B2 (en) | 1982-04-19 |
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