ES8202003A1 - Un procedimiento para la preparacion de derivados de ergoli-na - Google Patents

Un procedimiento para la preparacion de derivados de ergoli-na

Info

Publication number
ES8202003A1
ES8202003A1 ES500911A ES500911A ES8202003A1 ES 8202003 A1 ES8202003 A1 ES 8202003A1 ES 500911 A ES500911 A ES 500911A ES 500911 A ES500911 A ES 500911A ES 8202003 A1 ES8202003 A1 ES 8202003A1
Authority
ES
Spain
Prior art keywords
atoms
compounds
pharmaceutical compositions
group
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500911A
Other languages
English (en)
Other versions
ES500911A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES500911A0 publication Critical patent/ES500911A0/es
Publication of ES8202003A1 publication Critical patent/ES8202003A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ERGOLINA, ASI COMO DE SUS SALES DE ADICION FISIOLOGICAMENTE COMPATIBLES CON ACIDOS ORGANICOS O INORGANICOS, DE FORMULA (I), EN LA QUE R1 ES UN ATOMO DE HIDROGENO O UN RADICAL METILO, R3 ES UN ATOMO DE HIDROGENO O UN GRUPO METOXILO Y R2, R4, R5 Y R6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R5-N = C = N-R6, EN LAS QUE R1-R6 TIENE LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE APROTICO, EN PRESENCIA DE UNA BASE ORGANICA, TAL COMO PIRIDINA O TRIETILAMINA, A UNA TEMPERATURA ENTRE 50 Y 100 C.
ES500911A 1980-04-03 1981-03-31 Un procedimiento para la preparacion de derivados de ergoli-na Expired ES8202003A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8011234 1980-04-03
GB8040575 1980-12-18

Publications (2)

Publication Number Publication Date
ES500911A0 ES500911A0 (es) 1982-01-16
ES8202003A1 true ES8202003A1 (es) 1982-01-16

Family

ID=26275073

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500911A Expired ES8202003A1 (es) 1980-04-03 1981-03-31 Un procedimiento para la preparacion de derivados de ergoli-na

Country Status (20)

Country Link
AT (1) AT375076B (es)
AU (1) AU540621B2 (es)
CA (1) CA1156648A (es)
CH (1) CH645896A5 (es)
CS (1) CS415291A3 (es)
DE (1) DE3112861A1 (es)
DK (1) DK148686C (es)
ES (1) ES8202003A1 (es)
FI (1) FI70412C (es)
FR (1) FR2479829B1 (es)
GR (1) GR74806B (es)
HK (1) HK67287A (es)
IE (1) IE51130B1 (es)
IL (1) IL62519A (es)
IT (2) IT1210473B (es)
NL (3) NL189462C (es)
NZ (1) NZ196670A (es)
PT (1) PT72785B (es)
SE (1) SE442637B (es)
YU (1) YU43011B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB0409785D0 (en) 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
GB0505965D0 (en) 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
US7939665B2 (en) 2007-05-04 2011-05-10 Apotex Pharmachem Inc. Efficient process for the preparation of cabergoline and its intermediates
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE396753B (sv) * 1970-05-18 1977-10-03 Richter Gedeon Vegyeszet Analogiforfarande for framstellning av en forening tillhorande dihydrolysergsyraserien

Also Published As

Publication number Publication date
FI70412B (fi) 1986-03-27
AT375076B (de) 1984-06-25
IT8120866A0 (it) 1981-04-01
CS415291A3 (en) 1992-06-17
DK148686C (da) 1986-03-10
SE8102131L (sv) 1981-10-04
IL62519A (en) 1984-01-31
NL930092I1 (nl) 1993-10-01
AU540621B2 (en) 1984-11-29
PT72785B (en) 1982-07-26
HK67287A (en) 1987-09-25
ES500911A0 (es) 1982-01-16
IT1205241B (it) 1989-03-15
NL8101509A (nl) 1981-11-02
DE3112861A1 (de) 1982-01-07
NL189462C (nl) 1993-04-16
IT1210473B (it) 1989-09-14
FR2479829B1 (fr) 1987-07-24
DK148686B (da) 1985-09-02
NL930091I2 (nl) 1995-01-02
IE51130B1 (en) 1986-10-15
PT72785A (en) 1981-05-01
DE3112861C2 (es) 1989-06-01
AU6893781A (en) 1981-10-08
IL62519A0 (en) 1981-05-20
DK150781A (da) 1981-10-04
YU43011B (en) 1989-02-28
GR74806B (es) 1984-07-12
FI70412C (fi) 1986-09-19
YU85181A (en) 1984-02-29
ATA148481A (de) 1983-11-15
NL930091I1 (nl) 1993-10-01
FR2479829A1 (fr) 1981-10-09
NL189462B (nl) 1992-11-16
CA1156648A (en) 1983-11-08
IT8120865A0 (it) 1981-04-01
FI811025L (fi) 1981-10-04
CH645896A5 (de) 1984-10-31
SE442637B (sv) 1986-01-20
NZ196670A (en) 1982-12-07
IE810754L (en) 1981-10-03

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Legal Events

Date Code Title Description
PC1A Transfer granted