ES8201167A1 - Procedimiento para la obtencion de derivados de cefalospori-nas - Google Patents
Procedimiento para la obtencion de derivados de cefalospori-nasInfo
- Publication number
- ES8201167A1 ES8201167A1 ES498157A ES498157A ES8201167A1 ES 8201167 A1 ES8201167 A1 ES 8201167A1 ES 498157 A ES498157 A ES 498157A ES 498157 A ES498157 A ES 498157A ES 8201167 A1 ES8201167 A1 ES 8201167A1
- Authority
- ES
- Spain
- Prior art keywords
- 6alkyl
- hydroxy
- aromatic
- carboxy
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Laminated Bodies (AREA)
- Table Devices Or Equipment (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CEFALOSPORINA Y DE SUS SALES DE ADICON DE ACIDO O DE ADICION DE BASES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES UN RADICAL C93 DE LAS DEFALOSPORINAS ANTIBACTERIANAS CONOCIDAS; R2 ES UN RADICAL CARBOXI O HETEROCICLICO CON HIDROGENO ACIDO, ! R3 Y A PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA DESPROTECCION DE COMPUESTOS DE FORMULA (I) QUE TIENEN GRUPOS PROTECTORES EN LUGAR DE ATOMOS (S) DE HIDROGENO ACIDO (S), SIGUIENDO METODOS CONVENCIONALES, Y A CONTINUACION TRATAMIENTO DEL PRODUCTO OBTENIDO CON UN ACIDO O UNA BASE FISIOLOGICAMENTE COMPATIBLES, SEGUN QUE DICHO PRODUCTO TENGA RESTOS ACIDOS O BASICOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7931616A FR2472574A1 (fr) | 1979-12-24 | 1979-12-24 | Derives de cephalosporine et composition pharmaceutique les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
ES498157A0 ES498157A0 (es) | 1981-12-01 |
ES8201167A1 true ES8201167A1 (es) | 1981-12-01 |
Family
ID=9233132
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES498157A Expired ES8201167A1 (es) | 1979-12-24 | 1980-12-24 | Procedimiento para la obtencion de derivados de cefalospori-nas |
ES502352A Expired ES8204438A1 (es) | 1979-12-24 | 1981-05-20 | Procedimiento para la obtencion de derivados de cefalospori-nas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES502352A Expired ES8204438A1 (es) | 1979-12-24 | 1981-05-20 | Procedimiento para la obtencion de derivados de cefalospori-nas |
Country Status (27)
Country | Link |
---|---|
US (1) | US4463173A (es) |
EP (1) | EP0031708B1 (es) |
JP (1) | JPS56158787A (es) |
AT (1) | ATE7918T1 (es) |
AU (1) | AU544374B2 (es) |
CA (1) | CA1175805A (es) |
CS (1) | CS226025B2 (es) |
DD (1) | DD155520A5 (es) |
DE (1) | DE3068273D1 (es) |
DK (1) | DK552480A (es) |
ES (2) | ES8201167A1 (es) |
FI (1) | FI803817L (es) |
FR (1) | FR2472574A1 (es) |
GR (1) | GR71920B (es) |
HU (1) | HU186289B (es) |
IL (1) | IL61775A (es) |
MW (1) | MW5380A1 (es) |
NO (1) | NO803903L (es) |
NZ (1) | NZ195731A (es) |
PH (1) | PH21662A (es) |
PL (2) | PL133508B1 (es) |
PT (1) | PT72265B (es) |
SU (2) | SU1031408A3 (es) |
YU (2) | YU324680A (es) |
ZA (1) | ZA807710B (es) |
ZM (1) | ZM11380A1 (es) |
ZW (1) | ZW31280A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2496666A1 (fr) * | 1980-12-22 | 1982-06-25 | Ici Pharma | Nouveaux derives de cephalosporine et composition pharmaceutique les contenant |
FR2496665A1 (fr) * | 1980-12-23 | 1982-06-25 | Ici Pharma | Nouveaux derives de penicilline et composition pharmaceutique les contenant |
AU8474382A (en) * | 1981-06-19 | 1982-12-23 | Imperial Chemical Industries Plc | Process of preparing cephalosporin antibiotics |
EP0071370A3 (en) * | 1981-07-23 | 1984-05-16 | Ici Pharma | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them |
US4504478A (en) * | 1981-09-18 | 1985-03-12 | Imperial Chemical Industries Plc | Cephalosporin-1-oxide derivatives |
EP0082648A3 (en) * | 1981-12-21 | 1984-09-26 | Imperial Chemical Industries Plc | Cephalosporin derivatives |
JPS59110695A (ja) * | 1982-12-16 | 1984-06-26 | Asahi Chem Ind Co Ltd | 経口用セフアロスポリン |
GR78718B (es) * | 1983-01-31 | 1984-09-27 | Ici Pharma | |
US4855420A (en) * | 1983-06-03 | 1989-08-08 | Ici Pharma | Cephalosporin derivatives |
GB8316589D0 (en) * | 1983-06-17 | 1983-07-20 | Ici Plc | Crystalline salts |
US4547573A (en) * | 1983-12-02 | 1985-10-15 | Ici Pharma | Process for preparing cephalosporin derivatives |
AU583419B2 (en) * | 1985-09-09 | 1989-04-27 | Higuchi, Yoshinari | 2-oxa-isocephem compounds, compositions containing same and processes for preparing same |
US4760140A (en) * | 1986-10-20 | 1988-07-26 | American Cyanamid Company | 3-substituted-7-[5-substituted-2-thiazolyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, diphenylmethyl esters |
US6476220B2 (en) * | 2000-11-27 | 2002-11-05 | Aurobindo Pharma Limited | Process for the preparation of furaca |
US20030135041A1 (en) | 2002-01-04 | 2003-07-17 | Orchid Chemicals & Pharmaceuticals Limited, India | Synthesis of ceftiofur intermediate |
AU2009296820B2 (en) * | 2008-09-26 | 2014-03-20 | Merck Sharp & Dohme Llc | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2015042438A1 (en) * | 2013-09-19 | 2015-03-26 | The Florida International Board Of Trustees Modesto A. Maidique Campus | Selective inhibition of bacterial topoisomerase i |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2430375A1 (de) * | 1973-06-26 | 1975-03-20 | Leo Pharm Prod Ltd | 7-amino-delta hoch 3 -cephem-4-carbonsaeure-derivate |
US4255424A (en) * | 1979-04-27 | 1981-03-10 | Merck & Co., Inc. | 7-N-Heterocyclyl 1-oxa, 1-aza, and 1-carbadethiacephalosporins |
US4358447A (en) * | 1979-04-27 | 1982-11-09 | Merck & Co., Inc. | 7-N-Heterocyclyl cephalosporins |
DE3071707D1 (en) * | 1979-04-27 | 1986-09-25 | Merck & Co Inc | 7-n-heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same |
US4282219A (en) * | 1979-08-01 | 1981-08-04 | Merck & Co., Inc. | 7-N-Heterocyclyl cephalosporins and antibiotic pharmaceutical compositions containing them |
-
1979
- 1979-12-24 FR FR7931616A patent/FR2472574A1/fr not_active Withdrawn
-
1980
- 1980-12-01 GR GR63516A patent/GR71920B/el unknown
- 1980-12-03 NZ NZ195731A patent/NZ195731A/en unknown
- 1980-12-05 AU AU65134/80A patent/AU544374B2/en not_active Ceased
- 1980-12-09 FI FI803817A patent/FI803817L/fi not_active Application Discontinuation
- 1980-12-09 ZA ZA00807710A patent/ZA807710B/xx unknown
- 1980-12-17 HU HU803021A patent/HU186289B/hu unknown
- 1980-12-18 ZW ZW312/80A patent/ZW31280A1/xx unknown
- 1980-12-19 MW MW53/80A patent/MW5380A1/xx unknown
- 1980-12-20 PH PH24974A patent/PH21662A/en unknown
- 1980-12-21 IL IL61775A patent/IL61775A/xx unknown
- 1980-12-22 YU YU03246/80A patent/YU324680A/xx unknown
- 1980-12-22 EP EP80304674A patent/EP0031708B1/en not_active Expired
- 1980-12-22 NO NO803903A patent/NO803903L/no unknown
- 1980-12-22 DE DE8080304674T patent/DE3068273D1/de not_active Expired
- 1980-12-22 PT PT72265A patent/PT72265B/pt unknown
- 1980-12-22 AT AT80304674T patent/ATE7918T1/de not_active IP Right Cessation
- 1980-12-23 CS CS809244A patent/CS226025B2/cs unknown
- 1980-12-23 PL PL1980232847A patent/PL133508B1/pl unknown
- 1980-12-23 DK DK552480A patent/DK552480A/da not_active Application Discontinuation
- 1980-12-23 ZM ZM113/80A patent/ZM11380A1/xx unknown
- 1980-12-23 CA CA000367478A patent/CA1175805A/en not_active Expired
- 1980-12-23 SU SU803219703A patent/SU1031408A3/ru active
- 1980-12-23 DD DD80226584A patent/DD155520A5/de unknown
- 1980-12-23 PL PL1980228757A patent/PL132587B1/pl unknown
- 1980-12-24 JP JP18365980A patent/JPS56158787A/ja active Granted
- 1980-12-24 ES ES498157A patent/ES8201167A1/es not_active Expired
- 1980-12-24 US US06/219,879 patent/US4463173A/en not_active Expired - Lifetime
-
1981
- 1981-04-24 SU SU813274748A patent/SU1077573A3/ru active
- 1981-05-20 ES ES502352A patent/ES8204438A1/es not_active Expired
-
1982
- 1982-12-31 YU YU02926/82A patent/YU292682A/xx unknown
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