ES8300097A1 - "un procedimiento para preparar derivados de halofenil-piridil-alilamina". - Google Patents
"un procedimiento para preparar derivados de halofenil-piridil-alilamina".Info
- Publication number
- ES8300097A1 ES8300097A1 ES508065A ES508065A ES8300097A1 ES 8300097 A1 ES8300097 A1 ES 8300097A1 ES 508065 A ES508065 A ES 508065A ES 508065 A ES508065 A ES 508065A ES 8300097 A1 ES8300097 A1 ES 8300097A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- pharmaceutical preparations
- halophenyl
- pyridyl
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE HALOFENIL-PIRIDIL-ALILAMINA. CONSISTE EN AMINAR REDUCTORAMENTE UN ALDEHIDO O ACIDO CARBOXILICO DE FORMULA (I) CON METILAMINA O DIMETILAMINA EN PRESENCIA DE UN AGENTE REDUCTOR. SE OBTIENE EL COMPUESTO (II) QUE SI SE DESEA SE TRANSFORMA EN UNA SAL FARMACEUTICAMENTE ACEPTABLE Y/O EN UN ISOMERO E O Z DEL MISMO. R ES H O CH3; N ES 1 O 2, X ES UN HALOGENO TAL COMO F, CLO, BR O I, UNIDO EN UNA POSICION OPCIONAL AL GRUPO FENILO, CON LA CONDICION DE QUE CUANDO X ES BR, ESTE ESTA UNIDO EN UNA POSICION DIFERENTE A LA 4. *FORMULA*. E
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7909514A SE7909514L (sv) | 1979-11-16 | 1979-11-16 | Nya halofenyl-pyridyl-allylaminderivat |
Publications (2)
Publication Number | Publication Date |
---|---|
ES508065A0 ES508065A0 (es) | 1982-10-01 |
ES8300097A1 true ES8300097A1 (es) | 1982-10-01 |
Family
ID=20339337
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES496859A Expired ES8204721A1 (es) | 1979-11-16 | 1980-11-14 | Un procedimiento para preparar derivados de halofenil-piri- dilalilamina |
ES508065A Expired ES8300097A1 (es) | 1979-11-16 | 1981-12-16 | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". |
ES508064A Expired ES8300096A1 (es) | 1979-11-16 | 1981-12-16 | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". |
ES508063A Expired ES8300095A1 (es) | 1979-11-16 | 1981-12-16 | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". |
ES508062A Expired ES8300094A1 (es) | 1979-11-16 | 1981-12-16 | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES496859A Expired ES8204721A1 (es) | 1979-11-16 | 1980-11-14 | Un procedimiento para preparar derivados de halofenil-piri- dilalilamina |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES508064A Expired ES8300096A1 (es) | 1979-11-16 | 1981-12-16 | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". |
ES508063A Expired ES8300095A1 (es) | 1979-11-16 | 1981-12-16 | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". |
ES508062A Expired ES8300094A1 (es) | 1979-11-16 | 1981-12-16 | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". |
Country Status (17)
Country | Link |
---|---|
US (1) | US4418065A (es) |
EP (2) | EP0029420A1 (es) |
JP (1) | JPS56501524A (es) |
AU (1) | AU538087B2 (es) |
CA (1) | CA1155128A (es) |
DK (1) | DK300781A (es) |
ES (5) | ES8204721A1 (es) |
FI (1) | FI812196L (es) |
GR (1) | GR72129B (es) |
NO (1) | NO812401L (es) |
NZ (1) | NZ195558A (es) |
PL (3) | PL129369B1 (es) |
PT (1) | PT72066B (es) |
SE (1) | SE7909514L (es) |
SU (4) | SU1103794A3 (es) |
WO (1) | WO1981001407A1 (es) |
ZA (1) | ZA807102B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1150269A (en) * | 1980-11-14 | 1983-07-19 | Carl B. J. Ulff | Process for preparing 3-(4-bromophenyl)-3-(3-pyridyl)-allylamines |
US4610995A (en) * | 1984-07-27 | 1986-09-09 | Coker Geoffrey G | Certain 1,1-diaryl-propenyl-3-(1-pyrrolidino-2-carboxylic acids, derivatives thereof and their anti-histaminic properties |
GB8814639D0 (en) * | 1988-06-20 | 1988-07-27 | Ici Plc | Heterocyclic tertiary alcohol derivatives |
US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6800652B2 (en) | 2002-08-16 | 2004-10-05 | Pfizer Inc. | Diaryl compounds |
GB0219154D0 (en) * | 2002-08-16 | 2002-09-25 | Pfizer Ltd | Diaryl compounds |
WO2015067923A1 (en) | 2013-11-05 | 2015-05-14 | Astrazeneca Ab | Nmda antagonist prodrugs |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2676964A (en) * | 1950-06-07 | 1954-04-27 | Schering Corp | 3-pyridyl propylamine antihistamine substances |
DE966534C (de) * | 1951-03-22 | 1957-08-22 | Schering Corp | Verfahren zur Herstellung von basisch substituierten Pyridinverbindungen |
GB850298A (en) | 1956-10-30 | 1960-10-05 | Maggioni & C Societa Per Azion | ª‡,ª‡[(p-chlorophenyl)-(4-pyridyl)] carbinols and method of preparing same |
DE1468359A1 (de) * | 1963-10-23 | 1968-11-28 | Merck & Co Inc | Verfahren zur Herstellung von Dibenzocycloheptehderivaten |
US3396224A (en) * | 1965-09-09 | 1968-08-06 | Lilly Co Eli | Controlling phytopathogenic fungi on plants with 3-pyridyl methane derivatives |
US3423510A (en) * | 1966-08-31 | 1969-01-21 | Geigy Chem Corp | 3-(p-halophenyl) - 3 - (2'-pyridyl-n-methylpropylamine for the treatment of depression |
US3471505A (en) * | 1967-02-01 | 1969-10-07 | Ciba Geigy Corp | 1-(alkoxyphenyl)-1-(3-pyridyl)-carbinols |
SE361663B (es) * | 1971-04-28 | 1973-11-12 | Haessle Ab | |
US3928369A (en) * | 1971-04-28 | 1975-12-23 | Haessle Ab | Compounds useful as antidepressive agents, and a process for their preparation |
US3928613A (en) * | 1971-04-28 | 1975-12-23 | Haessle Ab | Compounds useful as antidepressive agents |
SE373850B (es) | 1972-11-16 | 1975-02-17 | Haessle Ab | |
US4094908A (en) * | 1973-08-15 | 1978-06-13 | Richter Gedeon Vegyeszeti Gyar Rt. | Alpha-substituted benzhydrol derivatives |
GB1480593A (en) * | 1973-11-30 | 1977-07-20 | Kefalas As | Xanthene and thioxanthene derivatives having pharmaceutical activity |
US4102887A (en) * | 1974-11-21 | 1978-07-25 | Per Arvid Emil Carlsson | Intermediates used in the preparation of phenyl-pyridylamine derivatives |
US4186202A (en) * | 1974-11-21 | 1980-01-29 | Astra Lakemedel Aktiebolag | Phenyl-pyridylamine derivatives |
SE388854B (sv) | 1974-11-21 | 1979-03-26 | Astra Laekemedel Ab | Forfarande for framstellning av fenylpyridylaminderivat |
SE418291B (sv) * | 1976-05-17 | 1981-05-18 | Astra Laekemedel Ab | 4-bromfenyl-3-pyridylderivat som mellanprodukter vid framstellning av fenylpyridylaminer |
SE418399B (sv) * | 1976-05-21 | 1981-05-25 | Astra Laekemedel Ab | Forfarande for framstellning av n,n-dimetyl-3-(4 bromfenyl)-3-(3-pyridyl)allylamin |
SE409706B (sv) * | 1976-05-21 | 1979-09-03 | Astra Pharma Prod | Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat |
SE409860B (sv) * | 1977-07-04 | 1979-09-10 | Astra Laekemedel Ab | En ny mellanprodukt for framstellning av terapeutiskt aktiva pyridinforeningar |
EP0000322B1 (en) * | 1977-07-04 | 1982-05-05 | Astra Läkemedel Aktiebolag | Compounds having an anti-depressive or tranquilizing activity, pharmaceutical compositions containing them, and processes and intermediates for their preparation |
SE409861B (sv) * | 1977-07-04 | 1979-09-10 | Astra Laekemedel Ab | Ett nytt forfarande for framstellning av en terapeutisk aktiv pyridinforening |
-
1979
- 1979-11-16 SE SE7909514A patent/SE7909514L/xx not_active Application Discontinuation
-
1980
- 1980-11-14 PL PL1980232732A patent/PL129369B1/pl unknown
- 1980-11-14 AU AU64378/80A patent/AU538087B2/en not_active Ceased
- 1980-11-14 ZA ZA00807102A patent/ZA807102B/xx unknown
- 1980-11-14 NZ NZ195558A patent/NZ195558A/en unknown
- 1980-11-14 PL PL1980232731A patent/PL129370B1/pl unknown
- 1980-11-14 US US06/232,043 patent/US4418065A/en not_active Expired - Fee Related
- 1980-11-14 EP EP80850172A patent/EP0029420A1/en not_active Withdrawn
- 1980-11-14 PT PT72066A patent/PT72066B/pt unknown
- 1980-11-14 WO PCT/SE1980/000286 patent/WO1981001407A1/en active Application Filing
- 1980-11-14 JP JP50260380A patent/JPS56501524A/ja active Pending
- 1980-11-14 ES ES496859A patent/ES8204721A1/es not_active Expired
- 1980-11-14 EP EP83200107A patent/EP0081478A3/en not_active Withdrawn
- 1980-11-14 CA CA000364712A patent/CA1155128A/en not_active Expired
- 1980-11-14 GR GR63358A patent/GR72129B/el unknown
- 1980-11-14 PL PL1980227849A patent/PL128457B1/pl unknown
-
1981
- 1981-07-07 DK DK300781A patent/DK300781A/da not_active Application Discontinuation
- 1981-07-10 FI FI812196A patent/FI812196L/fi not_active Application Discontinuation
- 1981-07-13 NO NO812401A patent/NO812401L/no unknown
- 1981-07-15 SU SU813306852A patent/SU1103794A3/ru active
- 1981-12-16 ES ES508065A patent/ES8300097A1/es not_active Expired
- 1981-12-16 ES ES508064A patent/ES8300096A1/es not_active Expired
- 1981-12-16 ES ES508063A patent/ES8300095A1/es not_active Expired
- 1981-12-16 ES ES508062A patent/ES8300094A1/es not_active Expired
-
1982
- 1982-04-13 SU SU823419750A patent/SU1149875A3/ru active
- 1982-04-13 SU SU823419749A patent/SU1149874A3/ru active
- 1982-12-30 SU SU823530055A patent/SU1138021A3/ru active
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