ES8105998A1 - Un procedimiento para la produccion de nuevos derivados de 6-alquil-7-fenil-1,6-naftiridin-5(6h)-ona y sus sales de adi-cion de acidos. - Google Patents

Un procedimiento para la produccion de nuevos derivados de 6-alquil-7-fenil-1,6-naftiridin-5(6h)-ona y sus sales de adi-cion de acidos.

Info

Publication number
ES8105998A1
ES8105998A1 ES493639A ES493639A ES8105998A1 ES 8105998 A1 ES8105998 A1 ES 8105998A1 ES 493639 A ES493639 A ES 493639A ES 493639 A ES493639 A ES 493639A ES 8105998 A1 ES8105998 A1 ES 8105998A1
Authority
ES
Spain
Prior art keywords
alkyl
naphthyridine
phenyl
derivatives
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493639A
Other languages
English (en)
Other versions
ES493639A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES493639A0 publication Critical patent/ES493639A0/es
Publication of ES8105998A1 publication Critical patent/ES8105998A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 6-ALQUIL-FENIL-1,6-NAFTIRIDIN-5(6H)-ONA DE FORMULA (I) Y DE SUS SALES DE ADICION DE ACIDOS, EN LA QUE R1 ES UN RADICAL ALQUILICO C1-4 Y R2, R3 Y R4 PUEDEN SE VARIOS TIPOS DE RADICALES. SE SOMETE A UNA REACCION DE DESHIDRATACION UN COMPUESTO DE FORMULA (II) O (III) O UNA MEZCLA DE LOS MISMOS, EN LAS QUE R1, R2, R3 Y R4 SON LOS MISMOS QUE EN LA FORMULA (I), EN PRESENCIA DE UN AGENTE DESHIDRATANTE, QUE PUEDE SER UN ACIDO ORGANICO FUERTE O UN ACIDO MINERAL, EN UN DISOLVENTE INERTE, A TEMPERATURAS DESDE 0 GC HASTA AL DE REFLUJO DE LA MEZCLA DE REACCION. LOS PRODUCTOS OBTENIDOS SE SEPARAN Y PURIFICAN POR METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD RELAJANTE DE LOS MUSCULOS Y ANTINFLAMATORIA. *FORMULA*
ES493639A 1979-07-25 1980-07-23 Un procedimiento para la produccion de nuevos derivados de 6-alquil-7-fenil-1,6-naftiridin-5(6h)-ona y sus sales de adi-cion de acidos. Expired ES8105998A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6072979A 1979-07-25 1979-07-25

Publications (2)

Publication Number Publication Date
ES493639A0 ES493639A0 (es) 1981-07-01
ES8105998A1 true ES8105998A1 (es) 1981-07-01

Family

ID=22031390

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493639A Expired ES8105998A1 (es) 1979-07-25 1980-07-23 Un procedimiento para la produccion de nuevos derivados de 6-alquil-7-fenil-1,6-naftiridin-5(6h)-ona y sus sales de adi-cion de acidos.

Country Status (15)

Country Link
JP (1) JPS5620588A (es)
AU (1) AU6072080A (es)
BE (1) BE884407A (es)
DE (1) DE3027619A1 (es)
DK (1) DK318280A (es)
ES (1) ES8105998A1 (es)
FI (1) FI802318A (es)
FR (1) FR2462438A1 (es)
GB (1) GB2054593A (es)
IL (1) IL60672A0 (es)
IT (1) IT8049312A0 (es)
NL (1) NL8004236A (es)
PT (1) PT71592B (es)
SE (1) SE8005303L (es)
ZA (1) ZA804524B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502831A1 (de) * 1985-01-29 1986-07-31 Gödecke AG, 1000 Berlin 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
FR2751969B1 (fr) * 1996-08-01 1998-12-04 Centre Nat Rech Scient Composes activateurs du canal cftr, et compositions pharmaceutiques les contenant
EP2313406B1 (de) * 2008-08-05 2015-02-25 Boehringer Ingelheim International GmbH 4-dimethylaminophenyl-substituierte napththyridine und ihre verwendung als arzneimittel
CA2786245A1 (en) 2010-01-29 2011-08-04 Boehringer Ingelheim International Gmbh Substituted naphthyridines and their use as syk kinase inhibitors
EP2736886B1 (en) 2011-07-26 2016-09-14 Boehringer Ingelheim International GmbH Substituted quinolines and their use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702600A1 (de) * 1977-01-22 1978-07-27 Thomae Gmbh Dr K Neue aminoalkoxyphenyl-derivate

Also Published As

Publication number Publication date
GB2054593A (en) 1981-02-18
ZA804524B (en) 1982-03-31
DK318280A (da) 1981-01-26
ES493639A0 (es) 1981-07-01
PT71592A (en) 1980-08-01
SE8005303L (sv) 1981-01-26
DE3027619A1 (de) 1981-02-19
PT71592B (en) 1981-08-11
BE884407A (fr) 1981-01-22
AU6072080A (en) 1981-01-29
NL8004236A (nl) 1981-01-27
FI802318A (fi) 1981-01-26
IT8049312A0 (it) 1980-07-24
JPS5620588A (en) 1981-02-26
IL60672A0 (en) 1980-09-16
FR2462438A1 (fr) 1981-02-13

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