ES8105998A1 - Un procedimiento para la produccion de nuevos derivados de 6-alquil-7-fenil-1,6-naftiridin-5(6h)-ona y sus sales de adi-cion de acidos. - Google Patents
Un procedimiento para la produccion de nuevos derivados de 6-alquil-7-fenil-1,6-naftiridin-5(6h)-ona y sus sales de adi-cion de acidos.Info
- Publication number
- ES8105998A1 ES8105998A1 ES493639A ES493639A ES8105998A1 ES 8105998 A1 ES8105998 A1 ES 8105998A1 ES 493639 A ES493639 A ES 493639A ES 493639 A ES493639 A ES 493639A ES 8105998 A1 ES8105998 A1 ES 8105998A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- naphthyridine
- phenyl
- derivatives
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 6-ALQUIL-FENIL-1,6-NAFTIRIDIN-5(6H)-ONA DE FORMULA (I) Y DE SUS SALES DE ADICION DE ACIDOS, EN LA QUE R1 ES UN RADICAL ALQUILICO C1-4 Y R2, R3 Y R4 PUEDEN SE VARIOS TIPOS DE RADICALES. SE SOMETE A UNA REACCION DE DESHIDRATACION UN COMPUESTO DE FORMULA (II) O (III) O UNA MEZCLA DE LOS MISMOS, EN LAS QUE R1, R2, R3 Y R4 SON LOS MISMOS QUE EN LA FORMULA (I), EN PRESENCIA DE UN AGENTE DESHIDRATANTE, QUE PUEDE SER UN ACIDO ORGANICO FUERTE O UN ACIDO MINERAL, EN UN DISOLVENTE INERTE, A TEMPERATURAS DESDE 0 GC HASTA AL DE REFLUJO DE LA MEZCLA DE REACCION. LOS PRODUCTOS OBTENIDOS SE SEPARAN Y PURIFICAN POR METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD RELAJANTE DE LOS MUSCULOS Y ANTINFLAMATORIA. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6072979A | 1979-07-25 | 1979-07-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES493639A0 ES493639A0 (es) | 1981-07-01 |
ES8105998A1 true ES8105998A1 (es) | 1981-07-01 |
Family
ID=22031390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES493639A Expired ES8105998A1 (es) | 1979-07-25 | 1980-07-23 | Un procedimiento para la produccion de nuevos derivados de 6-alquil-7-fenil-1,6-naftiridin-5(6h)-ona y sus sales de adi-cion de acidos. |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS5620588A (es) |
AU (1) | AU6072080A (es) |
BE (1) | BE884407A (es) |
DE (1) | DE3027619A1 (es) |
DK (1) | DK318280A (es) |
ES (1) | ES8105998A1 (es) |
FI (1) | FI802318A (es) |
FR (1) | FR2462438A1 (es) |
GB (1) | GB2054593A (es) |
IL (1) | IL60672A0 (es) |
IT (1) | IT8049312A0 (es) |
NL (1) | NL8004236A (es) |
PT (1) | PT71592B (es) |
SE (1) | SE8005303L (es) |
ZA (1) | ZA804524B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3502831A1 (de) * | 1985-01-29 | 1986-07-31 | Gödecke AG, 1000 Berlin | 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung |
US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
FR2751969B1 (fr) * | 1996-08-01 | 1998-12-04 | Centre Nat Rech Scient | Composes activateurs du canal cftr, et compositions pharmaceutiques les contenant |
EP2313406B1 (de) * | 2008-08-05 | 2015-02-25 | Boehringer Ingelheim International GmbH | 4-dimethylaminophenyl-substituierte napththyridine und ihre verwendung als arzneimittel |
CA2786245A1 (en) | 2010-01-29 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Substituted naphthyridines and their use as syk kinase inhibitors |
EP2736886B1 (en) | 2011-07-26 | 2016-09-14 | Boehringer Ingelheim International GmbH | Substituted quinolines and their use as medicaments |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2702600A1 (de) * | 1977-01-22 | 1978-07-27 | Thomae Gmbh Dr K | Neue aminoalkoxyphenyl-derivate |
-
1980
- 1980-07-21 DE DE3027619A patent/DE3027619A1/de not_active Withdrawn
- 1980-07-22 SE SE8005303A patent/SE8005303L/xx unknown
- 1980-07-22 BE BE1/9900A patent/BE884407A/fr unknown
- 1980-07-22 GB GB8023935A patent/GB2054593A/en not_active Withdrawn
- 1980-07-23 ES ES493639A patent/ES8105998A1/es not_active Expired
- 1980-07-23 PT PT71592A patent/PT71592B/pt unknown
- 1980-07-23 NL NL8004236A patent/NL8004236A/nl not_active Application Discontinuation
- 1980-07-23 AU AU60720/80A patent/AU6072080A/en not_active Abandoned
- 1980-07-23 FI FI802318A patent/FI802318A/fi not_active Application Discontinuation
- 1980-07-23 IL IL60672A patent/IL60672A0/xx unknown
- 1980-07-23 DK DK318280A patent/DK318280A/da unknown
- 1980-07-24 JP JP10063780A patent/JPS5620588A/ja active Pending
- 1980-07-24 IT IT8049312A patent/IT8049312A0/it unknown
- 1980-07-25 ZA ZA00804524A patent/ZA804524B/xx unknown
- 1980-07-25 FR FR8016438A patent/FR2462438A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
GB2054593A (en) | 1981-02-18 |
ZA804524B (en) | 1982-03-31 |
DK318280A (da) | 1981-01-26 |
ES493639A0 (es) | 1981-07-01 |
PT71592A (en) | 1980-08-01 |
SE8005303L (sv) | 1981-01-26 |
DE3027619A1 (de) | 1981-02-19 |
PT71592B (en) | 1981-08-11 |
BE884407A (fr) | 1981-01-22 |
AU6072080A (en) | 1981-01-29 |
NL8004236A (nl) | 1981-01-27 |
FI802318A (fi) | 1981-01-26 |
IT8049312A0 (it) | 1980-07-24 |
JPS5620588A (en) | 1981-02-26 |
IL60672A0 (en) | 1980-09-16 |
FR2462438A1 (fr) | 1981-02-13 |
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