ES8105998A1 - 6-Alkyl-7-phenyl-1,6-naphthyridine- 5(6H)-one derivatives - Google Patents

6-Alkyl-7-phenyl-1,6-naphthyridine- 5(6H)-one derivatives

Info

Publication number
ES8105998A1
ES8105998A1 ES493639A ES493639A ES8105998A1 ES 8105998 A1 ES8105998 A1 ES 8105998A1 ES 493639 A ES493639 A ES 493639A ES 493639 A ES493639 A ES 493639A ES 8105998 A1 ES8105998 A1 ES 8105998A1
Authority
ES
Spain
Prior art keywords
alkyl
naphthyridine
phenyl
derivatives
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493639A
Other languages
Spanish (es)
Other versions
ES493639A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8105998A1 publication Critical patent/ES8105998A1/en
Publication of ES493639A0 publication Critical patent/ES493639A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

6-Alkyl-7-phenyl-1,6-naphthyridine- 5(6H)-one derivatives having the formula I < IMAGE > wherein R1 represents C1-4alkyl, R2 represents hydrogen, C1-4alkyl, C1-4alkoxy, halogen, trifluoromethyl, C1-4alkylthio or -NR5R6, wherein each of R5 and R6 represents independently hydrogen or C1-3 alkyl, R3 represents hydrogen, C1-3alkyl, C1-3alkoxy, halogen or trifluoromethyl, and R4 represents hydrogen, C1-3alkyl, C1-3alkoxy or halogen, and acid addition salts thereof have muscle relaxant and anti-inflammatory activity and can be incorporated into pharmaceutical compositions.
ES493639A 1979-07-25 1980-07-23 A PROCEDURE FOR THE PRODUCTION OF NEW DERIVATIVES OF 6-ALKYL-7-PHENYL-1,6-NAFTIRIDIN-5 (6H) -ONE AND ITS ADDITIONAL SALTS OF ACIDS. Granted ES493639A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6072979A 1979-07-25 1979-07-25

Publications (2)

Publication Number Publication Date
ES8105998A1 true ES8105998A1 (en) 1981-07-01
ES493639A0 ES493639A0 (en) 1981-07-01

Family

ID=22031390

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493639A Granted ES493639A0 (en) 1979-07-25 1980-07-23 A PROCEDURE FOR THE PRODUCTION OF NEW DERIVATIVES OF 6-ALKYL-7-PHENYL-1,6-NAFTIRIDIN-5 (6H) -ONE AND ITS ADDITIONAL SALTS OF ACIDS.

Country Status (15)

Country Link
JP (1) JPS5620588A (en)
AU (1) AU6072080A (en)
BE (1) BE884407A (en)
DE (1) DE3027619A1 (en)
DK (1) DK318280A (en)
ES (1) ES493639A0 (en)
FI (1) FI802318A (en)
FR (1) FR2462438A1 (en)
GB (1) GB2054593A (en)
IL (1) IL60672A0 (en)
IT (1) IT8049312A0 (en)
NL (1) NL8004236A (en)
PT (1) PT71592B (en)
SE (1) SE8005303L (en)
ZA (1) ZA804524B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502831A1 (en) * 1985-01-29 1986-07-31 Gödecke AG, 1000 Berlin 1,6-NAPHTHYRIDINONE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
FR2751969B1 (en) 1996-08-01 1998-12-04 Centre Nat Rech Scient CFTR CHANNEL ACTIVATING COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP5754568B2 (en) * 2008-08-05 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Naphthyridine substituted with 4-dimethylamino-phenyl and its use as a medicament
EA201201052A1 (en) 2010-01-29 2013-02-28 Бёрингер Ингельхайм Интернациональ Гмбх SUBSTITUTED NAFTYRIDINE AND THEIR APPLICATION AS KINASE SYK INHIBITORS
BR112014001898A2 (en) 2011-07-26 2017-02-21 Boehringer Ingelheim Int substituted quinolines and their use as medicines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702600A1 (en) * 1977-01-22 1978-07-27 Thomae Gmbh Dr K NEW AMINOALCOXYPHENYL DERIVATIVES

Also Published As

Publication number Publication date
SE8005303L (en) 1981-01-26
GB2054593A (en) 1981-02-18
PT71592A (en) 1980-08-01
IT8049312A0 (en) 1980-07-24
FI802318A (en) 1981-01-26
DK318280A (en) 1981-01-26
ZA804524B (en) 1982-03-31
AU6072080A (en) 1981-01-29
PT71592B (en) 1981-08-11
BE884407A (en) 1981-01-22
DE3027619A1 (en) 1981-02-19
ES493639A0 (en) 1981-07-01
JPS5620588A (en) 1981-02-26
IL60672A0 (en) 1980-09-16
NL8004236A (en) 1981-01-27
FR2462438A1 (en) 1981-02-13

Similar Documents

Publication Publication Date Title
IE832713L (en) Indole derivatives.
ES8900045A1 (en) N-substituted 2-amino-thiazoles, process for their preparation and their therapeutical use.
IL65072A0 (en) Imidazodiazepines,their manufacture and pharmaceutical compositions containing them
IL80114A0 (en) Quinoline derivatives,their manufacture and pharmaceutical compositions containing them
DE3067201D1 (en) Quinazoline derivatives, processes for their preparation and pharmaceutical compositions containing them
ES2010284A6 (en) Thiourea derivatives
DE3169480D1 (en) Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them
ES8105998A1 (en) 6-Alkyl-7-phenyl-1,6-naphthyridine- 5(6H)-one derivatives
AU554959B2 (en) Triazolo(4,3-a) quinazolin-5-ones
ES8705421A1 (en) 4-Amino-2-phenyl quinolines, methods and intermediates for their preparation and medicaments containing them.
IE802641L (en) Peptides having analgesic activity
DK540684A (en) BENZOQUINOLICINES
IL71291A (en) Bis-(piperazinyl or homopiperazinyl)alkanes,their preparation and pharmaceutical compositions containing them
ES2003086A6 (en) Sulphonamides.
ES8706682A1 (en) Triazolopyrimidines their preparation and use in medicine
ES8103047A1 (en) Aminoisoquinoline derivatives
ES480765A1 (en) 2-Guanidinomethyl-indolines, method for their preparation and their pharmaceutical use.
ES8801212A1 (en) Isoquinoline derivatives
IE45587L (en) Diazepinoheterocyclic compounds
AU579416B2 (en) 3-Amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds