ES479570A1 - Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina. - Google Patents

Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina.

Info

Publication number
ES479570A1
ES479570A1 ES479570A ES479570A ES479570A1 ES 479570 A1 ES479570 A1 ES 479570A1 ES 479570 A ES479570 A ES 479570A ES 479570 A ES479570 A ES 479570A ES 479570 A1 ES479570 A1 ES 479570A1
Authority
ES
Spain
Prior art keywords
group
alkyl
unsubstituted
substituents
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479570A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES479570A1 publication Critical patent/ES479570A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Derivados de 7alfa-metoxicefalosporina de fórmula general (I): **(Fórmula)** donde: R1 representa un grupo hidroxi; un grupo alcoxi C1-C4; un grupo aciloxi alifático C2-C3; un grupo benzoiloxi que no está sustituido o contiene uno o más sustituyentes alquilo C1-C4, alcoxi C1-C4, nitro o halógeno; un grupo bencenosulfoniloxi que no está sustituido o contiene uno o más sustituyentes alquilo C1-C4; o un grupo alcanosulfoniloxi C1-C3 que no está sustituido o contiene uno o más sustituyentes alcoxi C1-C3, ciano, nitro, halógeno o alcoxicarbonilo C2-C4; R2 representa un átomo de hidrógeno, un grupo alquilo C1-C4, un átomo de halógeno, un grupo carboxilo, un grupo alcoxicarbonilo C2-C5, un grupo carbamoílo, un grupo alquilcarbamoílo donde el radical alquilo contiene de 1 a 3 átomos de carbono, un grupo di (alquil-C1-C3) carbamoílo o un grupo ciano; R3 representa un átomo de hidrógeno; un grupo acetoxi; un grupo carbamoiloxi; o un grupo tetrazoliltio, tiadiazoliltio u oxadiazoliltio que no está sustituido o contiene uno o más sustituyentes alquilo C1-C3, sulfometilo o di (alquil C1 o C2) amino (alquilo C1-C3); m es 0 o 1 y n es 0 o 2, presentan intensa actividad antibacteriana y, por lo tanto, son útiles como medicinas. Los derivados pueden prepararse por reacción del correspondiente derivado de 7 alfa-metoxicefalosporina con un grupo amino en la posición 7beta con un haluro de ácido correspondiente al grupo acetilo sustituido que se desea unir al grupo amino de la posición 7 beta o por reacción de cefamicina C con el mismo haluro de ácido
ES479570A 1978-04-11 1979-04-11 Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina. Expired ES479570A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53042360A JPS6052713B2 (ja) 1978-04-11 1978-04-11 ７−メトキシセフアロスポリン化合物、その製法及びその化合物を主成分とする抗菌剤

Publications (1)

Publication Number Publication Date
ES479570A1 true ES479570A1 (es) 1979-12-01

Family

ID=12633858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479570A Expired ES479570A1 (es) 1978-04-11 1979-04-11 Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina.

Country Status (7)

Country Link
US (1) US4247548A (es)
JP (1) JPS6052713B2 (es)
DE (1) DE2914843A1 (es)
ES (1) ES479570A1 (es)
FR (1) FR2422667A1 (es)
GB (1) GB2018247B (es)
NL (1) NL7902863A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793968A (en) * 1980-11-11 1982-06-11 Sankyo Co Ltd Carbamic acid ester and insecticide containing the same
US4394504A (en) 1981-10-07 1983-07-19 American Home Products Corporation Cephalosporin derivatives
US4562187A (en) * 1985-01-22 1985-12-31 Hoechst-Roussel Pharmaceuticals Inc. (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use
JPH0282123U (es) * 1988-12-09 1990-06-25
US5656573A (en) * 1989-09-11 1997-08-12 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazoles
US5650533A (en) * 1989-09-11 1997-07-22 Rhone-Poulenc Agriculture Ltd. Intermediates to herbicidal 4-substituted isoxazoles
GB9017539D0 (en) * 1990-08-10 1990-09-26 Rhone Poulenc Agriculture New compositions of matter
US5747424A (en) * 1989-09-11 1998-05-05 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1348985A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Esters of cephalosporin compounds
US4010264A (en) * 1970-11-06 1977-03-01 Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V. 7-[3-Substituted isoxazol-5-yl]-acetamido-cephalosporanic acids and their anti-bacterial use
GB1364453A (en) * 1970-11-06 1974-08-21 Gist Brocades Nv Penicillanic and cepholosporanic acid derivatives
AU6620274A (en) * 1973-03-02 1975-09-04 Gist Brocades Nv Penicillanic and cephalosporanic acid derivatives
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives
US3960845A (en) * 1974-03-22 1976-06-01 Sankyo Company Limited Process for preparing 7β-acylamino-7α-alkoxycephalosporins or 6β-acylamino-6α-alkoxypenicillins
JPS5165789A (en) * 1974-11-30 1976-06-07 Sankyo Co 77 metokishisefuarosuhorinkagobutsuno seiho

Also Published As

Publication number Publication date
US4247548A (en) 1981-01-27
JPS6052713B2 (ja) 1985-11-20
JPS54138590A (en) 1979-10-27
GB2018247A (en) 1979-10-17
GB2018247B (en) 1982-09-02
FR2422667B1 (es) 1982-12-03
NL7902863A (nl) 1979-10-15
DE2914843A1 (de) 1979-10-18
FR2422667A1 (fr) 1979-11-09

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